Professional Documents
Culture Documents
MYOMA
In Partial Fulfillment Of
Nursing Care Management 201
Related Learning Experience
Submitted by:
BSN 3-A
GROUP 3
Date of Defend:
October 23, 2009
1
Introduction
2
Fibroids or uterine myomas are benign, non-cancerous growths
inside the uterus or in its muscular wall. Fibroids can vary enormously
in size, from that of a pea to that of a melon. Multiple growths may be
present at the same time, anywhere in the uterus. They are classified
according to their location:
Myomas of the uterus are the most common solid pelvic tumours
in women, and are present in 20 to 25% of women aged 35 years.
Myomas are associated with infertility, the causal relationship in this
regard appearing to be more evident for submucosal myomas. Indeed,
myomas represent an increasing medical problem in women
attempting to conceive at a more advanced age, when the rate of
development of these lesions is also increased.
3
The aim of this retrospective study was to assess the pregnancy rate
compared with the improvement of menstrual pattern in menorrhagic
women after hysteroscopic resection of submucosal myomas
performed in infertile patients.
4
Gordon’s
Functional
Health Pattern
5
CHIEF COMPLAINTS: Vaginal bleeding, Dysmenorrhea
FAMILY HISTORY:
Patient’s mother passed away of unknown cause. The patient is
the second of the nine siblings of which six are females and three are
males. She is married to a fisherman from San Isidro, Villaba Leyte who
sometimes earns less than 1 thousand pesos a day. They were blessed
with six children; all of them are still living. She claimed her family to
be healthy.
6
GENOGRAM:
Legends:
X - Client
7
HEALTH PERCEPTION & HEALTH MANAGEMENT:
As stated by the client, she perceived herself as a healthy
individual even before she had a surgery. Right now her normal
activities are affected due to her post-surgical operation. She can
ambulate with the aid of her significant others.
Whenever the patient has a health problem, she just takes a rest
or seeks medical assistance to their Barangay Health Center. To keep
healthy, the patient does exercises, such as walking and doing
household chores.
The patient claimed that she doesn’t know how to do self
physical exams, specifically Breast Self Examination, and cannot recall
her last immunization.
The patient used to drink alcohol and smoke occasionally. One
year ago, she stopped smoking.
SLEEP-REST PATTERN:
8
The client usually sleeps 6 to 8 hours every night She usually
naps in the afternoon for 15 minutes only. But now that she is
hospitalized, her sleeping pattern is altered due to heat and
discomforts with her environment and present condition.
9
BEC (Basic Ecclesial Community), but recently, she is not active, due to
her surgery. She also participated in “PINTAKASI” in their community.
Obstetric History
No. of Pregnancy: 5
Outcome of Pregnancy: Normal
Sex and Ages of Children:
10
Physical
Assessment
11
MENTAL STATUS AND GENERAL APPEARANCE
Patient is 43 years old, female with fair complexion, with a
height of 5’5 feet, and weighs 49 kilos. She can ambulate but with
assistance; with stomach binder due to post-surgical incision. Vital
signs as of first assessment dated October 6, 2009, are as follows:
temperature 37.2°C axillary; heart rate 91 bpm; respiratory rate 26
cpm; BP 110/70 mmHg, taken at the left arm.
Patient is conscious and alert to all questions being asked. She’s
able to answer promptly, but not able to expand her answers. Oriented
to time, place, person and present situation. She’s also able to recall
both long term and short term memories.
EYES
Eyebrows are slightly brown in color and thin, symmetrical and
evenly distributed. Eyelashes are short and straight, no lesions,
swelling and secretions noted on the eyelids and on both inner and
outer cantus. No edema on the lacrimal glands. Both eyes can move in
coordination, with the outer cantus parallel with the pinna of the ears.
12
auricles and earlobes. Tympanic membrane is pearly gray color. They
are symmetrical, firm and not tender. Voice tones are equally heard by
both ears.
NECK
No tenderness, nodules or lumps were noted in the neck. The
muscles in the neck are equal in size, head is centered, and have
coordinated smooth movements with no discomforts felt. Head flexes
at 45°, hyperextends at 60°, head laterally flexes at 40° and head
laterally rotates at least 70°.
The lymph nodes are not palpable. The trachea is in normal
placement in the midline of the neck and spaces are equal on both
sides. The thyroid gland is not visible on inspection. The gland ascends
normally during swallowing.
13
apex of the lungs. She has quiet, rhythmic, and slightly fast
respirations and full symmetric excursion.
MOTOR FUNCTION
Patient was sitting on bed with legs slightly flexed with evident
weakness on it. Movements are limited but can reposition herself on
bed on her own but with slight facial grimace. She’s able to walk but
needs assistance.
14
Laboratories
15
HEMATOLOGY LABORATORY REPORT
9/19/09
LABORATORY REPORT
9/20/09
16
HEMATOLOGY LABORATORY REPORT
9/30/09
ROENTGENELOGIC REPORT
9/19/09
17
ULTRASOUND REPORT
GYNECOLOGY
Uterus: 7.3x4.0x4.9 cm
Cervix: 2.4x3.1x3.7 cm
Endometrium: 1.0 cm
Right Ovary: 2.3x2.0x1.7 cm lateral
Left Ovary: 2.4x2.0x1.8 cm posterolateral
Other: No free fluid in the cul de sac
18
Anatomy
and
Physiology
19
20
21
EXTERNAL GENITALS
Vulva
Mons Veneris
Labia Majora
The labia majora are the outer "lips" of the vulva. They are
pads of loose connective and adipose tissue, as well as some smooth
muscle. The labia majora wrap around the vulva from the mons pubis
to the perineum. The labia majora generally hides, partially or entirely,
the other parts of the vulva. There is also a longitudinal separation
called the pudendal cleft. These labia are usually covered with pubic
hair. The color of the outside skin of the labia majora is usually close
to the overall color of the individual, although there may be some
variation. The inside skin is usually pink to light brown. They contain
numerous sweat and oil glands. It has been suggested that the scent
from these oils are sexually arousing.
22
Labia Minora
Medial to the labia majora are the labia minora. The labia
minora are the inner lips of the vulva. They are thin stretches of
tissue within the labia majora that fold and protect the vagina,
urethra, and clitoris. The appearance of labia minora can vary widely,
from tiny lips that hide between the labia majora to large lips that
protrude. There is no pubic hair on the labia minora, but there are
sebaceous glands. The two smaller lips of the labia minora come
together longitudinally to form the prepuce, a fold that covers part of
the clitoris. The labia minora protect the vaginal and urethral
openings. Both the inner and outer labia are quite sensitive to touch
and pressure.
Clitoris
The clitoris, visible as the small white oval between the top of
the labia minora and the clitoral hood, is a small body of spongy tissue
that functions solely for sexual pleasure. Only the tip or glans of the
clitoris shows externally, but the organ itself is elongated and
branched into two forks, the crura, which extend downward along the
rim of the vaginal opening toward the perineum. Thus the clitoris is
much larger than most people think it is, about 4" long on average.
Urethra
Perineum
23
The perineum is the short stretch of skin starting at the bottom
of the vulva and extending to the anus. It is a diamond shaped area
between the symphysis pubis and the coccyx. This area forms the floor
of the pelvis and contains the external sex organs and the anal
opening. It can be further divided into the urogenital triangle in front
and the anal triangle in back.
24
INTERNAL GENITALS
Vagina
25
Cervix
26
Uterus
The uterus is shaped like an upside-down pear, with a thick lining and
muscular walls. Located near the floor of the pelvic cavity, it is hollow
to allow a blastocyte, or fertilized egg, to implant and grow. It also
allows for the inner lining of the uterus to build up until a fertilized egg
is implanted, or it is sloughed off during menses.
The uterus is only about three inches long and two inches wide, but
during pregnancy it changes rapidly and dramatically. The top rim of
the uterus is called the fundus and is a landmark for many doctors to
track the progress of a pregnancy. The uterine cavity refers to the
fundus of the uterus and the body of the uterus.
Helping support the uterus are ligaments that attach from the body of
the uterus to the pelvic wall and abdominal wall. During pregnancy the
ligaments prolapse due to the growing uterus, but retract after
childbirth. In some cases after menopause, they may lose elasticity
and uterine prolapse may occur. This can be fixed with surgery.
27
Fallopian Tubes
28
LOCATION &
STRUCTURE FUNCTION
DESCRIPTION
29
region
Provides an environment for
Ovaries maturation of oocyte.
Pelvic region on either
(female Synthesizes and secretes sex
side of the uterus.
gonads) hormones (estrogen and
progesterone).
Short stretch of skin
starting at the bottom
Perineum
of the vulva and
extending to the anus.
Pelvic cavity above
Urethra Passage of urine.
bladder, tilted.
To house and nourish
Uterus Center of pelvic cavity.
developing human.
Receives penis during mating.
Pathway through a womans
body for the baby to take during
Canal about 10-8 cm childbirth. Provides the route for
long going from the the menstrual blood (menses)
Vagina
cervix to the outside of from the uterus, to leave the
the body. body. May hold forms of birth
control, such as an IUD,
diaphragm, neva ring, or female
condom
Surround entrance to
the reproductive tract.
Vulva
(encompasses all
external genitalia)
Contains glands that secrete
The innermost layer of
Endometrium fluids that bathe the utrine
uterine wall.
lining.
Smooth muscle in Contracts to help expel the
Myometrium
uterine wall. baby.
30
Pathophysiology
31
Risk Factors:
32
pain sensation
Ideal Signs
and
Symptoms
33
IDEAL S/S PATIENT’S MANIFESTATION
SCIENTIFICBASIS
34
defecation
Summary of
Significant
Findings
35
SIGNIFICANT FINDINGS NURSING DIAGNOSIS
Health History:
Physical Assessment:
36
• Dry Skin Self-care deficit r/t inability to
Perform ADL.
Laboratories:
37
Hgb Fluid volume deficit r/t active
fluid
Loss secondary to bleeding
38
Drug Study
CLASSIFICATION
Anticholinergic, Antiemetic, Anti-motion sickness drug,
antimuscarinic, antiparkinsonian, Antispasmodic, Belladona alkaloid,
Parasympatholytic
Therapeutic actions
MECHANISMS OF ACTIONS
Anti motion-sickness, drug not understood; antiemetic action
may be mediated by interference with cholinergic impulses to the
vomiting center, has sedative and amnesia-ionducing properties,
blocks effects of acetylcholine at Muscarinic, cholinergic receptors that
mediate effects of parasympathetic postganglionic impulses, thus
depressing salivary and bronchial secretions, inhibiting vagal
influences on the heart, relaxingthe GI and Gi tracts, inhibiting gastric
secretions, relaxing the pupil of the eye (mediatric effect), and
preventing accommodation of near vision. (cycloplegic effect)
INDICATIONS
39
Transdermal system: prevention and control of nausea and
vomiting associated with motion sickness and recovery from surgery.
Adjunctive therapy with antacids and H2 anqtihistamines in peptic
ulcer supportive treatment of functional GI disorder (diarrhea,
pylorospasm, hypermobility, IBC, spastic colon, acute intrcolitis,
panscreatitis, infant colic).
Pre-anesthetic medication to control bronchial, nasal, pharyngeal and
salivary secretions: prevent bronchospasm and laryngospasm; block
cardiac vagal inhibitory reflexes during introduction and intubation;
produce sedation.
Introduction of obstetric amnesia with analgesic calming delirium.
Treatment of postencephalitic parkinsonism and paralysis
agitants;relief of symptoms in spastic states.
CONTRAINDICATIONS
Contraindicated with hypersensitivity to anticholinergic drugs;
glaucoma; adhesive between iris and lens; sterosing peptic ulcer,
pyloroduodenal obstruction, paralytic, intestinal atony, severe
ulcerative colitis, toxic megacolon, symptomatic prostatic hypertrophy,
bladder neck obstruction+, bronchial asthma, COPD, cardia arethmias,
tachycardia, myocardial ischemia; impaired metabolic, liver, renal
function ( increase likelihood of adverse CNS effects); myasthenia
gravis, pregnancy ( causes resp.depression in neonates, contributes to
neonatal hemorrhage); lactation period.
Use cautiously with down syndrome, brain damage, spasticity,
hypertension, hyperthyroidism; glaucoma or tendency to glaucoma
ophthalmic solution.
SIDE EFFECTS
CCNS=pupil dilation, photophobia, blurred vision, headache,
drowsiness, dizziness, mental confusion, excitement, restlessness,
hallucinations delirium the presence of pain.
CV=palpitations, tachycardia
GI=dry mouth, constipation, paralytic ileus, altered taste perception,
nausea, vomiting dysphagia, heartburn.
GU=urinary resistancy and retention, impotence
40
NURSING INTERVENTIONS
1) Ensure adequate hydration; provide environmental control to
prevent hyperpyrexia.
2) Teaching points
3) Take as prescribed, 30-60 mins. Before meals, avoid excessive
dosage
4) Avoid hot environment. You will be heat intolerant, and dangerous
reactions may occur.
5) Avoid alcohol; serious sedation may occur.
6) When using transdermal system, take care to wash hands
thoroughly after handling patch and dispose of patch properly to
avoid contact with children ad pets.
7) You may experience these side effects:dizziness, sedations,
drowsiness (use caution driving or performing task that requires
alertness)constipation (ensure adequate fluid intake, proper diet)
dry mouth, blurred vision, sensitivity to light ( reversible, avoid task
that require acute vision, wear sunglasses);impotence (reversible);
difficulty urinating (empty bladder before taking drug)
8) Report rash, flushing, eye pain, difficulty breathing, tremors, loss of
coordination, regular heartbeat, abdominal distention,
hallucinations, severe or persistent dry mouth, difficulty urinating,
constipation, sensitivity to light
CLASSIFICATION
Antibacterial, antibiotic, antiprotozoal, Amobacide
MECHANISM OF ACTION
Bactericidal; inhibits DNA synthesis in specific amoerobes,
causing cell death; antiprotozoal-trichomonacidal, amebicidal.
INDICATION
1) Acute infection susceptible anaerobic bacteria.
2) Acute intestinal amoebiasis
3) Amoebic liver abscess
4) Trichomoniasis (acute and partners of patient with acute infection)
5) Bacterial vaginosis
6) Preoperative, intra-operative, post-operative prophylaxis for patient
undergoing colorectal surgery.
7) Topical application; Treatment of inflammatory papules, pustules
and erythema of rosacea.
41
8) Unlabeled uses; Prophylaxis for patient undergoing gynecologic
abdomen surgery.
CONTRAINDICATION:
1) Contraindicated with hypersensitivity to metronidazole; pregnancy
(do not use in 1st trimester)
2) Use cautiously with CNS disease, hepatic disease, candidiasis, blood
dyscrasis, and lactation.
SIDE EFFECTS
CNS=Headache, dizziness, vertigo, insomnia, incoordiantion, seizures,
peripheral neuropathy, fatigue.
GI=Unpleasant metallic taste, anorexia, nausea, vomiting, diarrhea,
GI upset and cramps.
GU=Dysuria, incontinence, darkening of the urine.
LOCAL=thrombophlebitis, redness, burning dryness and skin irritation.
OTHER=Severe, disufiram-like interaction with alcohol, candidiasis
(super infection)
NURSING INTERVENTION:
1) Administer oral doses with food.
2) Apply topically (metrogel) after cleansing the area. Advise patient
that cosmetics may be used over the area after application.
3) Reduce dosage in hepatic disease.
CLASSIFICATION
Antibiotic, Cephalosporine (2nd generation)
MECHANISM OF ACTION
Bactericidal; inhibits synthesis of bacterial cell wall, causing cell
death.
INDICATION
1. Oral
-Pharyngitis, tonsillitis caused by streptococcus pyogens.
-Otitis media caused by streptococcus pneumonae, S. pyogens,
haemophilus influenzae, moraxella catarrhalis.
-Low respiratory infections caused by S. pneumonae,
haemophilus parainfluenzae.
-UTI caused by Escherichia coli, klebsiella pneumonae.
42
-Uncomplicated gonorrhea
-Skin and skin structure infections, including impetigo caused by
S. aureus, S. pyogens.
-Treatment of early lymedisease.
2. Parenteral
-Lower respiratory infections caused by S. pneumonae, S.
aureus, E. coli, klebsiella pneumonae, H. influenzae, S. pyogens.
-Dermatologic infections caused by S. aureus, S. pyogens, E.coi,
pneumonae, enterobacter.
-UTI’s caused by E. coli, K. pneumonae
-Uncomplicated and disseminated gonorrhea caused by
N.gonorrhea
-Septicemia caused by S. pneumonae, S. aureus, E. coli, K.
pneumonae, h. influenzae.
-Meningitis caused by S. pneumonae, H. influenzae, S. aureus,
N. meningitides.
-Bone and joint infections due to S. aureus.
-Pre-operative prophylaxis
SIDE EFFECTS:
CNS=Headache, dizziness, lethargy, paresthesis.
GI=Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence,
pseudomembranous.
GU=Nephotoxicity
HEMATOLOGIC Bone marrow depression (decrease WBC, decrease
platelet, decrease hematocrit)
HYPERSENSITIVITY= Ranging from rash to fever to anaphylaxis;
serum sickness reaction.
LOCAL Pain, abcess at injection site, phlebitis, inflammation at IV site
OTHER=Superinfections, disulfram-like readction with alcohol.
NURSING INTERVENTIONS
1. Culture infection and a range for sensitivity test before and
during therapy if expected response is not seen.
2. Give oral drug with food to decrease GI upset and enhance
absorption.
3. Give oral drug to children who can swallow tablet; crushing the
drug results in a bitter unpleasant taste.
4. Have vitamin K available in case hypoprothrombinimia occurs.
5. Discontinue if hypersensitivity reaction occurs.
43
CLASSIFICATION
Histamine2 (H2) antagonist
MECHANISM OF ACTION
Competitively inhibits the action of histamine at the H2 receptors
of the parietal cells of the stomach, inhibiting basal gastric acid
secretion and gastric acid secretion that is stimulated by food, insulin,
histamine, cholinergic agonists, gastrin and pentogastrin.
INDICATION
1. Short term treatment of active duodenal ulcer at reduced
dosage.
2. Maintenance therapy for duodenal ulcer at reduced dosage.
3. Short term treatment of active, benign gastric ulcer
4. Short term treatment of GERD
5. Pathologic hypersecretory conditions
6. Treatment of erosive esophagitis
7. Treatment of heartburn, acid indigestion, sour stomach.
CONTRAINDICATIONS
Contraindicated with allergy to ranitidine, lactation.
Use cautiously with impaired renal or hepatic function
pregnancy.
SIDE EFFECTS:
CNS=Headache, malaise, dizziness, somnolence, insomnia, vertigo.
CV=Tachycardia, Bradycardia, PVC (Rapid IV Administration)
Dermatologic= Rash and alopecia.
GI=Constipation, diarrhea, nausea, vomiting, abdominal pain,
hepatitis, increase ALT level.
GU=Gynecomastia, impotence or decreased libido.
HEMATOLOGIC=Leukopenia, granulocytopenia, thrombocytopenia
and pancytopenia.
LOCAL=Pain at IM site, local burning or itching at IV site.
NURSING INTERVENTIONS:
1. Administer oral drug with meals and at bedtime.
2. Decrease doses in renal and liver failure.
3. Provide concurrent antacid therapy to relieve pain.
4. Administer IM dose undiluted, deep into large muscle group.
5. Arrange for regular follow up, including blood tests to evaluate
effects.
44
GENERIC NAME: TRAMADOL HYDROCHLORIDE
CLASSIFICATION
Analgesic (Centrally acting)
MECHANISM OF ACTION
Binds to un-opioid receptors and inhibits the reuptake of
norephinephrine and serotonin; causes many effects similar to the
opioids-dizziness, somnolence, nausea, constipation but does not have
the respiratory depressant effects.
INDICATION
1. Relief of moderate to moderately severe pain.
2. Relief of moderate to severe chronic pain in adults who need
around the clock treatment for extended period (ER tablets).
CONTRAINDICATIONS
1. Contraindicated with allergy to tramadol or opioids or acute
intoxication with alcohol, opioids, or psychoactive drugs.
2. Use cautiously in pregnancy; lactation; seizures; concomitant
use of CNS depressants, MAOI, SSRI, TCA; renal impairment;
hepatic impairment.
SIDE EFFECTS
CNS= Sedation, dizziness or vertigo, headache, confusion, dreaming,
sweating, anxiety, seizures.
CV= Hypotension, tachycardia, bradycardia.
DERMATOLOGIC= sweating, pruritus, rash, pallor, flatulence.
OTHER= Potential for abuse, anaphylactoid reactions.
NURSING INTERVENTIONS
Control environment (temperature, lighting) if sweating or CNS
effects occur.
CLASSIFICATION
Antiemetic, Dopaminergic, GI stimulant
MECHANISM OF ACTION
Stimulate motility of upper GI tract without stimulating gastric,
biliary, or pancreatic secretions; ppears to sensitize tissues to action of
45
acetylcholine; relaxes pyloric sphincter, which, when combined with
effects on motility, accelerates gastric emptying and intestinal transit;
little effect on gallbladder or colon motility; increases lower esophageal
sphincter pressure; has sedative properties; induces release of
prolactin.
INDICATION
1. Relief of symptoms of acute and recurrent diabetic gastroparesis
2. Short term therapy (4-12 weeks) for adults with sympathetic
gastroesophageal reflux who fail to respond to conventional
therapy.
3. Parenteral: prevention of nausea and vomiting associated with
emetogenic cancer chemotherapy.
4. Prophylaxis of postoperative nausea and vomiting when
nasogastric suction is undesirable.
5. Single-dose parenteral use: Stimulation of gastric emptying and
intestinal transit of barium when delayed emptying interferes
with radiologic examination of the stomach or small intestine.
CONTRAINDICATION
1. Contraindicated with allergy to metoclopromide; GI hemorrhage,
mechanical obstruction or perforation; pheochromocytoma;
epilepsy.
2. Use cautiously with previously defected breast cancer (one third
of such tumors are prolactin dependent); lactation, pregnancy;
fluid overload; renal impairment.
SIDE EFFECT
CNS=Restlessness, drowsiness,fatigue, lassitude, insomnia,
extrapyramidal reactions, parkinsonism-like reactions, akathisia,
dystonia, myoclonus, dizziness, anxiety.
CV=Transient hypertension
GI=Nausea, diarrhea
NURSING INTERVENTIONS
1. Monitor blood pressure carefully during IV administration.
2. Monitor for extrapyramidal reactions, and consult physician if
they occur.
3. Monitor diabetic patients, arrange for alteration in insulin dose or
timing if diabetic control is compromised by alterations in timing
of food absorption.
46
CLASSIFICATION
Antipyretic, Analgesic
MECHANISM OF ACTION
Paracetamol has long been suspected of having a similar
mechanism of action to aspirin because of the similarity in structure.
That is, it has been assumed that paracetamol acts by reducing
production of prostaglandins, which are involved in the pain and fever
processes, by inhibiting the cyclooxygenase (COX) enzyme.
INDICATION
The preparation is indicated in diseases manifesting with pain
and fever: headache, toothache, mild and moderate postoperative and
injury pain, high temperature, infectious diseases and chills (acute
catarrhal inflammations of the upper respiratory tract, flu, small-pox,
parotitis, etc.).
CONTRAINDICATIONS
Paracetamol should not be used in hypersensitivity to the
preparation and in severe liver diseases.
SIDE EFFECTS
In rare cases hypersensitivity reactions, predominantly skin
allergy (itching and rash), may appear. Long-term treatment with high
doses may cause a toxic hepatitis with following initial symptoms:
nausea, vomiting, sweating, and discomfort. Occasionally a
gastrointestinal discomfort may be seen.
NURSING INTERVENTIONS
Assessment & Drug Effects
1. Monitor for S&S of: hepatotoxicity, even with moderate
acetaminophen doses, especially in individuals with poor
nutrition or who have ingested alcohol over prolonged periods;
poisoning, usually from accidental ingestion or suicide attempts;
potential abuse from psychological dependence (withdrawal has
been associated with restless and excited responses).
2. Patient & Family Education
3. Do not take other medications (e.g., cold preparations)
containing acetaminophen without medical advice; overdosing
and chronic use can cause liver damage and other toxic effects.
4. Do not self-medicate adults for pain more than 10 d (5 d in
children) without consulting a physician.
47
5. Do not use this medication without medical direction for: fever
persisting longer than 3 d, fever over 39.5° C (103° F), or
recurrent fever.
6. Do not give children more than 5 doses in 24 h unless prescribed
by physician.
7. Do not breast feed while taking this drug without consulting
physician.
CLASSIFICATION
Nucleotides
MECHANISM OF ACTION
Treatment with high doses of nicotinamide (niacinamide, vitamin
B3) prevents or delays insulin-deficient diabetes in several animal
models of type 1 diabetes and protects islet cells against cytotoxic
actions in vitro. In recent-onset type 1 diabetes, nicotinamide
administration improves beta-cell function, without significantly
decreased insulin requirements. This review discusses the possible
mechanism of action of nicotinamide in vivo. It is proposed that the
key target of nicotinamide is the poly(ADP-ribose)polymerase (PARP),
and to a lesser extent (mono)ADP-ribosyl transferases (ADPRTs).
Suppression of PARP activity by nicotinamide not only decreases
consumption of NAD+, the substrate of PARP, but also has major
regulatory effects on gene expression, as shown for the major
histocompatibility complex class II gene. In addition, PARP activity
controls early steps of apoptosis. The possible suppression of ADPRTs
by nicotinamide would also affect CD38, a membrane-bound external
ADP-ribosyl transferase with potent immunoregulatory properties.
Taken together, it is proposed that high doses of nicotinamide
primarily affect ADP-ribosylation reactions in beta-cells as well as in
immune cells and the endothelium. As a consequence, cell death
pathways and gene expression patterns are modified, leading to
improved beta-cell survival and an altered immunoregulatory balance.
INDICATION
Indicated for non-pregnant patients with acne vulgaris, rosacea
or other inflammatory skin disorders who are deficient in, or at risk of
deficiency in, one or more of the components of Nicomide®.
48
CONTRAINDICATIONS
Nicomide® is contraindicated in patients with hypersensitivity to
any of its components. Supplemental copper is contraindicated in
those with Wilson's disease (hepatolenticular degeneration) a disease
of abnormal copper accumulation.
SIDE EFFECTS
Allergic sensitization has been reported rarely following oral and
parenteral administration of Folic Acid.
At recommended doses, Nicomide® is expected to be well tolerated.
Gastrointestinal distress such as nausea or vomiting have been
associated with the administration of nicotinamide or zinc at doses
greater than the recommended dose of Nicomide®.
49
Discharge Plan
50
HEALTH VISIT:
ACTIVITY LEVEL:
51
Foul smelling discharges
Presence of pus around the area of incision
MEDICATION:
INCISION CARE:
NUTRITION:
52
EDUCATION:
53
Nursing Care
Plans
54
Table of Contents
Submucosal Myoma
• Introduction 1
• Gordon’s Functional 4
Health Pattern
• Physical 10
Assessment
• Laboratory Findings 14
• Anatomy and 18
Physiology
29
• Pathophysiology
31
• Ideal Signs and
Symptoms 33
• Summary of
Significant Findings 36
• Drug Study 48
• Discharge Plan 52
• Nursing Care Plans
55