DRUGS TO BE AVOIDED BY CONGENITAL LONG QT PATIENTS

CredibleMeds® has reviewed all available evidence and has placed the following drugs in
designated risk categories for their risk of causing torsades de pointes (TdP): Known Risk
of TdP (KR), Possible Risk of TdP (PR), Conditional Risk of TdP (CR) or Special Risk
(SR). The full description of these categories can be found on the CredibleMeds website.
We recommend that patients with Congenital Long QT Syndrome avoid use of these
medicines if at all possible or take them under close medical observation.
Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name
Albuterol (salbutamol) Bepridil (KR) Vascor Delamanid (PR) Deltyba
Proventil and others
(SR)
Bortezomib (PR) Velcade and others Desipramine (PR) Pertofrane and others
Alfuzosin (PR) Uroxatral
Bosutinib (PR) Bosulif Dexmedetomidine
Precedex and others
Amantadine (CR) Symmetrel and others (PR)
Buprenorphine (PR) Butrans and others
Amiodarone (KR) Cordarone and others Dexmethylphenidate
Capecitabine (PR) Xeloda Focalin and others
(SR)
Amisulpride (CR) Solian and others
Ceritinib (PR) Zykadia
Dextroamphetamine
Elavil (Discontinued Dexedrine and others
Amitriptyline (CR) Aquachloral and (Dexamfetamine) (SR)
6/13) and others Chloral hydrate (CR)
others
Diphenhydramine
Amphetamine Benadryl and others
Adderal-XR and others Chloroquine (KR) Aralen (CR)
(Amfetamine) (SR)
Chlorpromazine (KR) Thorazine and others Disopyramide (KR) Norpace
Amphotericin B (CR) Fungilin and others
Cilostazol (KR) Pletal Dobutamine (SR) Dobutrex
Anagrelide (KR) Agrylin and others
Ciprofloxacin (KR) Cipro and others Dofetilide (KR) Tikosyn
Apomorphine (PR) Apokyn and others
Cisapride (KR) Propulsid Dolasetron (PR) Anzemet
Arformoterol (SR) Brovana
Citalopram (KR) Celexa and others Domperidone (KR) Motilium and others
Aripiprazole (PR) Abilify and others
Clarithromycin (KR) Biaxin and others Donepezil (KR) Aricept
Arsenic trioxide (KR) Trisenox
Clomipramine (PR) Anafranil Dopamine (SR) Intropine
Artenimol+piperaquine
Eurartesim
(PR) Clozapine (PR) Clozaril and others Doxepin (CR) Sinequan and others
Asenapine (PR) Saphris and others Cocaine (KR) Cocaine Dronedarone (KR) Multaq
Astemizole (KR) Hismanal Crizotinib (PR) Xalkori Droperidol (KR) Inapsine and others
Atazanavir (CR) Reyataz and others Cyamemazine Droxidopa (SR) Northera
(cyamepromazine) Tercian
Atomoxetine (PR) Strattera Efavirenz (PR) Sustiva and others
(PR)
Azithromycin (KR) Zithromax and others Ephedrine (SR) Rynatuss and others
Dabrafenib (PR) Tafinlar
Bedaquiline (PR) Sirturo Epinephrine
Dasatinib (PR) Sprycel Primatene and others
(adrenaline) (SR)
Bendamustine (PR) Treanda and others
Degarelix (PR) Firmagon
Eribulin mesylate (PR) Halaven
Bendroflumethiazide or
Aprinox
bendrofluazide (CR) Erythromycin (KR) E.E.S. and others

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Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name
Escitalopram (KR) Cipralex and others Ibogaine (KR) None Metaproterenol
Metaprel and others
(orciprenaline) (SR)
Esomeprazole (CR) Nexium and others Ibutilide (KR) Corvert
Methadone (KR) Dolophine and others
Ezogabine (Retigabine) Iloperidone (PR) Fanapt and others
Potiga and others
(PR) Methamphetamine
Imipramine (melipramine) Desoxyn and others
Tofranil (Metamfetamine) (SR)
Famotidine (PR) Pepcid and others (PR)
Methylphenidate (SR) Ritalin and others
Felbamate (PR) Felbatol Arcapta Neohaler (US) and
Indacaterol (SR)
others Metoclopramide (CR) Reglan and others
Fenfluramine (SR) Pondimin and others
Indapamide (CR) Lozol and others Metronidazole (CR) Flagyl and many others
Fingolimod (PR) Gilenya
Isoproterenol (SR) Medihaler-Iso and others Midodrine (SR) ProAmatine and others
Flecainide (KR) Tambocor and others
Isradipine (PR) Dynacirc Mifepristone (PR) Korlym and others
Fluconazole (KR) Diflucan and others
Itraconazole (CR) Sporanox and others Mirabegron (PR) Myrbetriq
Fluoxetine (CR) Prozac and others
Ivabradine (CR) Procoralan and others Mirtazapine (PR) Remeron
Flupentixol (PR) Depixol and others
Ketanserin (PR) Sufrexal Moexipril/HCTZ (PR) Uniretic and others
Fluvoxamine (CR) Faverin and others
Ketoconazole (CR) Nizoral and others Moxifloxacin (KR) Avelox and others
Formoterol (SR) Foradil and others
Lansoprazole (CR) Prevacid Necitumumab (PR) Portrazza
Furosemide (frusemide)
Lasix and others
(CR) Lapatinib (PR) Tykerb and others Nelfinavir (CR) Viracept
Galantamine (CR) Reminyl and others Lenvatinib (PR) Lenvima Nicardipine (PR) Cardene
Garenoxacin (CR) Geninax Leuprolide (PR) Lupron and others Nilotinib (PR) Tasigna
Gatifloxacin (KR) Tequin Levalbuterol (levsalbutamol) Norepinephrine (SR) Levophed
Xopenex and others
(SR)
Gemifloxacin (PR) Factive Norfloxacin (PR) Noroxin and others
Levofloxacin (KR) Levaquin and others
Granisetron (PR) Kytril and others Nortriptyline (PR) Pamelor and others
Levomepromazine (KR) Nosinan and others
Grepafloxacin (KR) Raxar Nusinersen (PR) Spinraza
Levomethadyl acetate (KR) Orlaam
Halofantrine (KR) Halfan Ofloxacin (PR) Floxin
Levosulpiride (KR) Lesuride and others
Haldol (US & UK) and Olanzapine (CR) Zyprexa and others
Haloperidol (KR)
others Lisdexamfetamine (SR) Vyvanse
Olodaterol (SR) Striverdi Respimat
Hydrochlorothiazide (CR) Apo-Hydro and others Lithium (PR) Eskalith and others
Omeprazole (CR) Losec and others
Hydrocodone - ER (PR) Hysinglaâ„¢ ER and others Imodium and many other
Loperamide (CR) Ondansetron (KR) Zofran and others
OTC and Rx brands
Hydroxychloroquine (CR) Plaquenil and others
Osimertinib (PR) Tagrisso
Melperone (PR) Bunil and others
Hydroxyzine (CR) Atarax and others
Mesoridazine (KR) Serentil

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 Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name
Oxaliplatin (KR) Eloxatin Quinidine (KR) Quinaglute and others Telavancin (PR) Vibativ
Oxytocin (PR) Pitocin and others Quinine sulfate (CR) Qualaquin Telithromycin (PR) Ketek
Paliperidone (PR) Invega and others Ranolazine (CR) Ranexa and others Terbutaline (SR) Brethine and others
Panobinostat (PR) Farydak Ribociclib (PR) Kisqali Terfenadine (KR) Seldane
Pantoprazole (CR) Protonix and others Rilpivirine (PR) Edurant and others Terlipressin (KR) Teripress and others
Papaverine HCl (Intra- Risperidone (PR) Risperdal Terodiline (KR) Micturin and others
none
coronary) (KR)
Ritodrine (SR) Yutopar Tetrabenazine (PR) Nitoman and others
Paroxetine (CR) Paxil and others
Ritonavir (CR) Norvir Thioridazine (KR) Mellaril and others
Pasireotide (PR) Signifor
Romidepsin (PR) Istodax Tiapride (PR) Tiapridal and others
Pazopanib (PR) Votrient
Roxithromycin (KR) Rulide and others Tizanidine (PR) Zanaflex and others
Pentamidine (KR) Pentam
Salmeterol (SR) Serevent and others Tolterodine (PR) Detrol and others
Perflutren lipid
Definity and others Saquinavir (PR) Invirase(combo) Torasemide (CR) Demadex and others
microspheres (PR)
Sertindole (PR) Serdolect and others Toremifene (PR) Fareston
Perphenazine (PR) Trilafon and others
Sertraline (CR) Zoloft and others Desyrel (discontinued 6/13)
Phentermine (SR) Adipex P and others Trazodone (CR)
and others
Sevoflurane (KR) Ultane and others
Phenylephrine (SR) Neosynephrine
Trimethoprim-
Sibutramine (SR) Meridia Septra and others
Phenylpropanolamine (SR) Acutrim and others Sulfamethoxazole (SR)
Solifenacin (CR) Vesicare
Pilsicainide (PR) Sunrythm Trimipramine (PR) Surmontil and others
Sorafenib (PR) Nexavar
Pimavanserin (PR) Nuplazid Tropisetron (PR) Navoban and others
Sotalol (KR) Betapace and others
Pimozide (KR) Orap Vandetanib (KR) Caprelsa
Sparfloxacin (KR) Zagam
Pipamperone (PR) Dipiperon (E.U) and others Vardenafil (PR) Levitra
Sulpiride (KR) Dogmatil and others
Posaconazole (CR) Noxafil and others Vemurafenib (PR) Zelboraf
Sultopride (KR) Barnetil and others
Probucol (KR) Lorelco Venlafaxine (PR) Effexor and others
Sunitinib (PR) Sutent
Procainamide (KR) Pronestyl and others Vilanterol/fluticasone furoate
Breo Ellipta
Tacrolimus (PR) Prograf and others (SR)
Promethazine (PR) Phenergan
Nolvadex(discontinued Voriconazole (CR) VFend
Propofol (KR) Diprivan and others Tamoxifen (PR)
6/13) and others
Vorinostat (PR) Zolinza
Prothipendyl (PR) Dominal and others
Telaprevir (CR) Incivo and others
Ziprasidone (CR) Geodon and others
Pseudoephedrine (SR) PediaCare and others
Zotepine (PR) Losizopilon and others
Quetiapine (CR) Seroquel

Note: Medicines on this list are reviewed on an ongoing basis to assure that the available evidence supports their continued placement on this list. The list changes
regularly and we recommend checking the website at crediblemeds.org for the most up-to-date information. There may be many additional brand names that are not listed
on this form.

Disclaimer and Waiver: The information presented is intended solely for the purpose of providing general information about health-related matters. It is not intended for
any other purpose, including but not limited to medical advice and/or treatment, nor is it intended to substitute for the users relationships with their own health care
providers. To that extent, by use of this website and the information it contains, the user affirms the understanding of the purpose and releases AZCERT, Inc. from any
claims arising out of his/her use of the website and its lists. The absence of drugs from these lists should not be considered an indication that they are free of risk of QT
prolongation or torsades de pointes. Many medicines have not been tested for this risk in patients, especially those with congenital long QT syndrome.

Generated: June 16, 2017. List last revised: May 17, 2017