SYSTEMIC LUPUS ERYTHEMATOSUS

Handayani Lidiawati*, Aryaningrum Eunike*, Kurniati Nova **

*Resident of Internal Medicine, Medical Faculty of Sriwijaya University/RSMH Palembang

**Division of Allergy-Immunology, Department of Internal Medicine Sriwijaya
University/RSMH Palembang

Introduction. Systemic lupus erythematosus is the prototypic multisystem autoimmune

disorder with a broad spectrum of clinical presentations encompassing almost all organs and
tissues. Clinical manifestation of SLE can be lupus nephritis, neuropsychiatric,
mucocutaneous lesion,etc.

Case. a 22 years woman came to the emergency room RSMH with chief complaint........
Pasien mengeluh BAK sedikit sekitar 200 cc/24 jam, warna kuning, nyeri sendi, rambut
rontok. On physical examination, we found sariawan, rambut rontok, moonface, edem
pretibial. In laboratorium we found elevated ureum 158 mg/dl, elevated creatinine 1,35
mg/dL, proteinuria (+). In head CT scan we found atrophy cerebri (neuropsychiatry lupus). In
Chest x-ray we found cardiomegaly. In echocardiography we found HHD, preserve LVEF.

Discussion. Diagnosis SLE dengan manifestasi lupus nefritis dan neuropsikiatri SLE
ditegakkan sesuai dengan kriteria MEX SLEDAI, proteinuria dalam urinalisa, dengan
peningkatan ureum dan kreatinin. Neuropsikiatri SLE dengan ditemukan adanya atropi
cerebri.

Conclusion. Nefritis lupus dan keterlibatan sistem syaraf pada SLE merupakan komplikasi
yang cukup serius dengan prognosis yang buruk.