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You can find on Mitch’s medical record that his plasma glucose was over 200
mg/dl; stated on chart on 4/12 it was measured to be at 1524 and the following
day at 475. Hemoglobin A1C was higher than 6.5 % and measured at 15.2%.
FPG was 475 mg/dL. Thus; Mitch has more than 2 of the criteria to diagnose
a pt with T2DM.
As per Krause (2012) risk factors for T2DM is having a BMI of over 25, physical
inactivity, first degree relative with diabetes, member of high-risk race/ethnicity, diagnosed
with gestational diabetes, hypertension of >140/90 mmHg, HDL cholesterol level <35 mg/dL
and or triglyceride level of >250mg/dl, women with polycystic ovary syndrome, other
clinical conditions associated with insulin resistance, history of CVD, older than 45 years of
age (ADA, table 2.2). You can find on Mitch’s medical record that he was at high risk as he
is 53 years old, his BMI is 31.6, mildly obese, previously dx with HTN, first degree family
member with T2DM, diagnosed with hyperglycemia.
2. Mitch was previously diagnosed with T2DM. His admits that he often does not take his
medications. For each of his diabetes pills, metformin and glyburide, state the class of
medication and mechanism of action; list potential drug side effects (i.e nausea, etc) and
drug-nutrient interactions (i.e. foods or nutrients to be added or avoided) for each drug.
(6)
Metformin is in a class of drugs called binguanides which decreases hepatic glucose
production and increases insulin uptake by muscles. Potential drug side effects
include: GI problems, headaches, flushing, nail changes, muscle pain (Medline).
Drug-nutrient interactions may include: decreased folate, calcium and vitamin B
absorption (Jackson-Michel, 2013). Also alcohol should be avoided.
Glyburide belongs to a class of medications labeled second generation sulfonylureas
which stimulates insulin secretion (Medline). Side effects can include:
Hypoglycemia, nausea, constipation, yellowing of skin/eyes, pain in stomach,
diarrhea, fever, and sore throat, swelling of eyes, lips, tongue or throat (Medline).
Drug-nutrient interactions should be noted and alcohol should be avoided.
3. Mitch also takes other medications, Dyazide and Lipitor. List their mechanisms,
potential side effects and drug-nutrient interactions.
He is beginning insulin. For his prescribed insulins, state type; time of onset, peak,
duration; potential side-effect. (5)
Name: Marie Salvador
Case 17 - Adult Type 2 Diabetes Mellitus: Transition to Insulin
1. Dyazide: Mechanisms of action: Used for edema and HTN; prevents absorption of salt
to prevent fluid retention. Also acts as a diuretic limiting salt absorption and thus also
preventing fluid retention. Possible side effects: bradycardia, tachycardia, arrhythmia,
weight gain, anorexia, headaches weakness, abnormal potassium levels, nausea,
vomiting, bleeding, diarrhea, constipation, or other. Drug-Nutrient interactions:
alcohol should be avoided, potassium supplements should be prescribed, avoid of salt for
drug effectiveness (Medline).
B. Glargine: time of onset: 2- 4 hours, peak- none, duration: 20-24 hours; potential side-
effect-seizures, headaches, weakness, unconsciousness, tachycardia, irritability
(Medline).
4. Mitch experienced symptoms and subsequent admission to the ER with the diagnosis of
uncontrolled T2DM with HHS.
1. Describe what led to his severe hyperglycemia.
2. State Mitch’s signs and symptoms of dehydration.
3. Define HHS, its etiology and symptoms.
4. State Mitch’s signs and symptoms of HHS. (8)
1. Describe what led to his severe hyperglycemia.
This pt was previously diagnosed with T2DM; but states that does not take
medications regularly; thus, glucose/ insulin are not under control. In addition to not
taking his medications, he is not educated on nutrition for diabetes as he states that he
doesn’t follow any strict diet except for staying away from high sugar desserts, not
adding salt and avoiding high cholesterol foods. His diet recall also shows that his
ignorance of diet and diabetes led to his severe hyperglycemia. He states he eats
carbs in mid -morning, lunch, dinner and fat is not controlled either.
2. State Mitch’s signs and symptoms of dehydration.
Dark colored urine, hypotension: 90/70mm, dry mucous membranes, poor turgor,
decreased urine output, low sodium levels, his confusion/ change in mental state, high
specific gravity of urine, osmolality is also high at 360 mmol/kg/h2o and high
BUN/Creatine levels.
3. Define HHS, its etiology and symptoms.
HHS or Hyperglycemic Hyperosmolar state is a complication of T2DM, resulting in extreme
high blood sugar level above 600mg/dl without presence of ketones, osmolality greater than 320
mOsm/kg of water. Results of rise of glucose and then high osmolality in blood and ultimately
dehydration. Etiology is by high blood sugar levels, lack of hydration, and poor management of
Name: Marie Salvador
Case 17 - Adult Type 2 Diabetes Mellitus: Transition to Insulin
diabetes, stopping insulin or other medicines that lower glucose levels. Symptoms may include:
fever higher than 100.4F, low systolic BP, increased thirst, feeling weak, nausea, weight loss, dry
mouth, fever, seizures, confusion, and/or coma (Medline).
4. State Mitch’s signs and symptoms of HHS.
Mitch’s medical record shows that he had symptoms of HHS; some which included that his
plasma glucose was extremely high at 1524mg/dl; osmolality of 360 mOsm/kg of water, Temp:
of 100.5F, confusion, and low systolic BP.
5. HHS and DKA are metabolic complications associated with diabetes. Define DKA, its
precipitating factors and signs /symptoms. What characteristics of Mitch’s condition
indicate HHS as opposed to DKA? (5)
DKA is diabetic ketoacidosis, problem that can occur in patients with diabetes and it is life
threathening. It happens when body cannot use glucose as a fuel source because there is not
enough insulin (Medline). Fat is used for fuel instead. When fat is broken down to fuel the
body, ketones build up (Medline). Symptoms may include: decreased alertness, deep rapid
breathing, flushing, frequent urination, fruity smelling breath, headache, muscle ache, nausea
and vomiting, stomach pain (medline).Mitch’s condition indicate it’s HHS as opposed to
DKA is the absence of complain of abdominal pain or fruity breath. Mitch’s symptoms
mostly match HHS rather than DKA due to dehydration symptoms high osmolality found in
labs.
6. Mitch was started on normal saline with potassium as well as an insulin drip. Why are
these fluids a component of his rehydration and correction of the HHS? (3)
These fluids are a component of his rehydration and correction of HHS because the saline with
potassium is aiming to correct pt’s electrolyte levels so osmolality goes back to normal levels in
the body and thus also correct all the complications that resulted from dehydration; thus, BP will
normalize as sodium and potassium normalize as well as other complications from HHS. Insulin
drip in the other hand will correct elevated glucose levels to also compliment for the
normalization of osmolality in the body resulted from HHS.
7. Describe the initial insulin therapy that was started for Mitch and his planned insulin
regimen. When would a patient be started on insulin, based on the recommendations of
the ADA? How likely is it that Mitch will need to continue insulin therapy? (3)
The initial insulin therapy started and planned regimen for Mitch was: Rehydration,
Lispro 0.5 u every 2 hours until glucose is 150-200 mg/dL. At night begin glargine 19 u.
Progress Lispro using ICR 1: 15. As per ADA (2016), if noninsulin therapy does not achieve
or maintain the A1C target over 3 months, then add a second oral agent a glucagon-like
peptide 1 receptor agonist, or basal insulin (ADA). Mitch is very likely to need continued
insulin therapy due; considering his current glucose levels and the fact that in the past he was
diagnosed with T2DM and failed to take medications. However, if patient is aggressive with
lifestyle changes it might help him a lot.
II. Nutrition Assessment
8. Assess Mitch’s desirable body weight and BMI. What would be a healthy weight range
for Mitch? (3)
Mitch is 214#, 53 year old male, 5’9 or 69inches in height.
Name: Marie Salvador
Case 17 - Adult Type 2 Diabetes Mellitus: Transition to Insulin
BMI: (214 lb/ 69 𝑖𝑛2 ) x 703= 31.59 BMI indicates Obesity!
DBW using Hamwi: Males: 106# for 5 + 6# for each inch >60
DBW=106# + (6# x 9)= 160 lbs
DBW range 160+/- 10%= 144# to 176# would be a healthier weight range than current
weight
9. For each lab value, state its abnormal value upon admission and what the value means /
indicates. How did glucose, sodium, phosphate and osmolality change - state the changed
value and why it changed. (16)
Initial lab values:
o Glucose: 1524 mg/dL at admission
Means: Extremely high glucose indicates patient has severe hyperglycemia. No insulin or
very low insulin to clear glucose. Glucose is out of control and not properly used.
o Creatinine:1.9 mg/dL
High creatinine means kidney is not functioning properly due to dehydration and
imbalance of solutes/ electrolytes.
Changed values:
A. Glucose: 475 mg/dL from 1524 mg/dL
Value decreased because md prescribed rapid-acting insulin to aid in the
hyperglycemia that pt presented at admission. Thus, rapid insulin is clearing glucose
of the body.
10. Determine Mitch’s energy requirements for weight maintenance using Mifflin St. Jeor
equation; state why this equation is an appropriate choice; use AF and SF as
appropriate. Determine Mitch’s protein requirements justifying the use of DBW vs.
ABW and g protein / kg. What daily energy intake would you recommend for an
appropriate rate of weight loss? Justify your recommendation. (3)
Mitch is 214#/ 97.27kg in weight, 53 year old male, 5’9 or 69inches or 175.26 cm in height.
Mifflin st. Jeor: Male: kcal/d= 10(wg in Kg) + 6.25(ht in cm)-5 (age) +5
10(97.27 kg) + 6.25 (175.26) -5(53) +5
972.7+ 1095.4 – 265 +5
EER= 1,808 kcal/day
EER * 1.3 (Activity factor) =2,350 kcal/day is required for Mitch
This equation is an appropriate choice for Mitch since it has previously shown less error
(~10%) when compared to HBE when used in Obese patient’s like Mitch.
PRO: .8g * (ABW) 97.27kg= 77.818 g PRO for ABW
PRO: .8 * (DBW) 75.57kg= 60.45g PRO for DBW
Name: Marie Salvador
Case 17 - Adult Type 2 Diabetes Mellitus: Transition to Insulin
2,350 kcal/ day - 500 kcal/ day= 1850 kcal/ day is recommended for Mitch if he is
willing to lose weight. As per ADA (2016), 500kcal / day is safe to abstain to
maintain energy requirements and aim to lose weight at the same time.
12. Mitch was prescribed an initial ICR 1:15. Explain what this means.
Outline the general principles for nutrition therapy, to assist in control of DM, for:
meals and snacks, carbohydrate, sugar substitutes, fats and weight reduction. Cite the
ADA’s Clinical Practice Recommendations for Medical Nutrition Therapy – 2016. (5)
An ICR 1:15 means that Mitch was prescribed with an insulin to carbohydrate ratio of 1 to 15
(ADA). Meaning that, 1 unit of insulin covers 15 grams of CHO. This is the ratio he has to use
to count his carbohydrate intake and so he is safe that insulin will clear the glucose in his intake.
As per ADA recommendations, healthy eating is encouraged with 3 meals and
planned snacks, reducing portion size, encouraging water consumption and
reducing juice intake, increasing consumption of fruits and vegetables (ADA,
2016).
Glycemic control can improve with knowledge of using CHO counting or
estimation to determine mealtime insulin (ADA, 2016). As there is no single
ideal distribution of kcal among macronutrients for people with diabetes,
macronutrient distribution should be individualized while keeping metabolic and
calorie goals in mind (ADA, 2016).
Added sugars should be discouraged (ADA, 2016).
Total ideal fat consumption is inconclusive, however should focus on eating fats
rich in monounsaturated fats to improve glucose metabolism and lower CVD risk
(ADA, 2016). Eating foods rich in long-chain omega-3 fatty acids recommended
(ADA, 2016). Distribution of fats should be 20 -35% of total EER (ADA, 2016).
Insulin resistance may improve with weight reduction…(ADA, 2016). Reductions
in body weight has shown improvement of glycemic control (ADA, 2016).
Weight loss can be achieved with reducing 500- 750 kcal/day energy (ADA,
Name: Marie Salvador
Case 17 - Adult Type 2 Diabetes Mellitus: Transition to Insulin
2016). Benefits can be seen with 5% weight loss, greater than 7% is optimal
(ADA, 2016).
Inadequate fluid intake NI-3.1 related to vomiting and T2DM as evidenced by patient’s
abnormal laboratory values of high bun, creatinine, glucose, osmolality, HbA1c, protein
and abnormally low values of sodium and phosphate.
V. Nutrition Intervention
14. Determine Mitch’s initial CHO prescription using his diet history as well as your
assessment of his energy requirements for weight loss: State daily kcal intake, percent
kcal from CHO, g CHO, number of CHO choices per day; Suggest the number of CHO
choices you would recommend for 3 meals and 2 snacks based on his diet history and
medication. Cite Choose Your Foods: Exchange Lists for Meal Planning/Food Choices.
(5)
1850 kcal/ day is recommended for Mitch if he is aiming to lose weight. As per
ADA (2016), 500kcal / day is safe to abstain to maintain energy requirements and
aim to lose weight at the same time.
1850 kcal/day (55% CHO) = 1,017 kcal/day CHO
1,017 kcal/day CHO / 4kcal/g= 254 grams of CHO
254 grams of CHO/15grams= 17 choices of CHO Per Day.
3 meals / 2 snacks I would recommend based on his previous diet and preference:
15. Identify two initial nutrition goals to assist with weight-loss. (4)
Increase vegetable and fruit intake: one per meal.
Increase physical activity: to exercising at least 30 minutes 5 times a week.
16. Mitch also has hypertension and high cholesterol levels. State the recommendations for
the lipid profile, LDL, HDL, Cholesterol and Triglycerides for people with diabetes
Describe nutrition recommendations for fiber, types of fat and sodium for Mitch and
why. (4)
This pt’s other ailments of HTN and high cholesterol can be reduced with diet prescribed for
diabetes, since it requires pt to eat healthier and to maintain physical activity. Recommendations
for lipid profile include LDL of <130 mg/dL, HDL >40 mg/dL, cholesterol of <200 mg/dL,
Name: Marie Salvador
Case 17 - Adult Type 2 Diabetes Mellitus: Transition to Insulin
triglycerides of < 150 mg/dL. Fiber: 14 grams fiber per 1000 kcal in intake w/ less than 5 grams
per serving. Sodium: <2,300 mg/day. However, lowering sodium intake to approximately
1,500 mg/day may benefit blood pressure sometimes and for some populations (ADA). Fats: 20-
35% total kcal of Fats, rich in monosaturated fats because it can improve glycemic control and
blood lipids (ADA, 2016). Trans fat should be avoided (ADA, 2016). Following nutritional
recommendations will aid Mitch control glycemic levels and maintain a healthier life.
Chewing / swallowing problem / sore mouth Factors affecting food intake: Past 12-24 hours
vomiting, T2DM, HTN, Cholesterol
Nausea / vomiting / diarrhea / constipation
Social / cultural / religious / financial: single; 16
Food intolerance / allergies: N/A years education, full time job, lives alone, N/A
religion
Diet prior to admit: normal, no added salt, tries to
limit high cholesterol foods and high sugar desserts. Other: Alcohol 3-4 drinks per week
O – Objective
Current Diet Order:
NPO, only ice chips and Rx. After 12 hrs clear liquids, if stable Then progress to consistent-
carbohydrate diet. Dietitian for consult.
Medical Diagnosis: T2DM uncontrolled, HHS Pertinent Medical History: T2DM 1 year dx,
HTN, hyperlipidemia, gout
Nutrition Focused Physical Signs & Symptoms: 4/12 Hyperglycemia, emesis, high temp: 100.5, BP: 90/70,
Pulse: 105, Rapid respiration rate: 26 ; dry mucous membranes, poor skin turgor, warm/dry skin,
Age: 53 Gender: Ht: Wt: Admit DBW: 160# BMI: 31.6 %
years Male 5’9 214# Range: 144# to 176#
old Female Current
% UBW: N/A % wt : N/A % DBW: 133.75% Other:
Nutritionally Relevant Laboratory Data: Glucose: 1524 mg/dL- high; Creatinine:1.9 mg/dL- high;
Sodium: 132 mEq/L- low; Phosphate: 1.8 mg/dL- low; Cholesterol: 205 mg/dL- high; HbA1c: 15.2 %-
high; C-peptide: 1.10 ng/mL-WNL; Osmolality: 360 mmol/kg/H2O-high; Specific gravity: 1.045- high;
BUN: 31 mg/dL- high; Glucose in urine: Positive- high; Protein in urine: Positive- high
Name: Marie Salvador
Case 17 - Adult Type 2 Diabetes Mellitus: Transition to Insulin
1. Inadequate bioactive substance intake NI-4.1 related to high blood glucose levels as evidenced by
patient’s statement that he does not take diabetes medications regularly regardless of being diagnosed
with T2DM previously.
2. Inadequate fluid intake NI-3.1 related to vomiting and T2DM as evidenced by patient’s abnormal
laboratory values of high bun, creatinine, glucose, osmolality, HbA1c, protein and abnormally low
values of sodium and phosphate.
List Nutrition Interventions. Use Nutrition Intervention Terminology sheet. (The intervention(s) must address
the problems (diagnoses).
Goal(s):
References
ADA (2016). Standards of Medical Care in Diabetes. (2016). Diabetes Care,37 (Supplement_1).
Retrieved from http://care.diabetesjournals.org/content/suppl/2015/12/21/39.Supplement_1.DC2/2016-
Standards-of-Care.pdf
Name: Marie Salvador
Case 17 - Adult Type 2 Diabetes Mellitus: Transition to Insulin
Jackson-Michel, N. D. (2013, October 09). Vitamin Interactions with Metformin. Retrieved March 18,
2017, from http://www.livestrong.com/article/144857-what-are-the-nutrient-drug-interactions-for-
metformin/
Mahan, L. K. (2012). Krause's Food the nutrition care process. Philadelphia: Saunders.
Nelms, M. N., & Roth, S. L. (2013). Case 17: Adult Type 2 Diabetes Mellitus: Transition to Insulin.
Medical Nutrition Therapy: A Case Study Approach (4thEd). Belmont, CA: Cengage Learning.