26 Longevity Boosting Supplements & Drugs To Increase Lifespan

8/8/2018 26 Longevity Boosting Supplements & Drugs to Increase Lifespan - Selfhacked
26 Longevity Boosting Supplem

Nutrients  Natural Substances  Herbs  Drugs and Nootropics  Conditions 
Drugs to Increase Lifespan

Healthy Interventions  Testing  Biohacking Science 
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Early 2015, doctor and SA investor
L E S PJoon
A G EYun
- launched
the Palo Alto Longevity prize, a one million dollar
B/?
award for any scientist who could “hack the code of
life” and nd a way to P keep
_ N Ahumans
ME=SH S & aging.
from P _ I DIn
=HEA
the past year, there has been a surge of new research
into longevity enhancement in an attempt to win this
illustrious prize. This article will explore the science to
uncover the various supplements and drugs that can
help you tap into the elusive fountain of youth.
https://www.selfhacked.com/blog/23-longevity-boosting-supplements-drugs-increase-lifespan/ 1/51
C O N T E N T S [ HIDE]
1) Aspirin
2) C60
3) Lithium
4) Curcumin
5) Oxaloacetate
6) Rhodiola
7) Carnitine
8) NAC
9) Carnosine
10) Melatonin
11) Lactic acid
12) Gluconic Acid
13) NAD+
14) Malate
16) Acetate
17) Pyruvate
18) Activated charcoal
19) Lutein
20) Thea avins
21) Inositol
22) Metformin
23) Deprenyl – MAOBI
24) Butyrate
25) Glucosamine
26) Resveratrol
Health Tools I Wish I Had When I Was Sick
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1) Aspirin
Age-related diseases and general aging are often

caused by chronic in ammation
(https://www.selfdecode.com/disease/in ammation/?
utm_source=seo&utm_medium=selfhacked&utm_cam
In animal studies, using aspirin to quell
in ammation resulted in extended lifespans, more
physical capability and increased stress
resistance [R
(https://www.ncbi.nlm.nih.gov/pubmed/26305987), R
(https://www.ncbi.nlm.nih.gov/pubmed/23485446)].
Aspirin increased the lifespan of mice by 18-21% at

doses of 400mg/kg [R
One study surprisingly found that aspirin was more

effective at increasing maximum lifespan than
metformin
(https://www.selfdecode.com/chemical/metformin/?
(see below) [R
The high doses used in these studies might lead to

serious intestinal problems [R
2) C60
French biologists found that rats given C60 (a

fullerene molecule), dissolved in olive oil
(https://www.selfhacked.com/blog/olive-oil/) at doses
of 1.7 mg/kg of body weight, lived nearly twice as
long as control groups and had a reduction of age-
related diseases, even though the rats were a middle
age at the start of the study. Rats have never lived as
long in any study [R
(http://www.owndoc.com/pdf/C60-Fullerene.pdf)].
None of the rats treated with C60 got cancer

(https://www.selfdecode.com/disease/neoplasms/?
so studies looking at C60 and cancer prevention are
currently underway [R
The longevity (https://www.selfhacked.com/blog/23-

longevity-boosting-supplements-drugs-increase-
lifespan/) mechanisms of C60 are currently not fully
understood, but C60 is known to be bioactive in a
number of ways, such as affecting DNA expression
and protein folding [R
C60 easily crosses the blood-brain barrier. It

concentrates in the mitochondria where it functions
as a free radical
(https://www.selfhacked.com/blog/oxidative-
stress-101/) scavenger i.e. it detoxi es the by-
products from the cell’s energy metabolism [R
C60 molecules have the potential to block the

replication of the HIV-1 virus so could prove to be an
important weapon against AIDs [R
C60 has never been tested on humans.
3) Lithium
Many people think that the most effective anti-aging
strategies start by addressing the mitochondria.
Lithium (https://www.selfhacked.com/blog/the-
bene ts-of-lithium/) treatment on worms increased
both lifespan and healthspan and improved
mitochondrial energy output [R
Lithium might improve mitochondrial function by

increasing the turnover of dysfunctional
mitochondria [R
However, a recent study of ies found the opposite

outcome: lithium exposure did not extend lifespan
and actually reduced the female y’s lifespan
advantage [R
A correlation was found when researchers measured

the longevity (https://www.selfhacked.com/blog/23-
longevity-boosting-supplements-drugs-increase-
lifespan/) of people and lithium in their water. There
was a decreased risk for all causes of death in
Japanese neighborhoods with higher lithium levels.
The study concluded that “long-term low-dose

exposure to lithium may exert anti-aging capabilities
and unambiguously decreases mortality in
evolutionary distinct species” [R
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151375
One mechanism might be that lithium should

theoretically increase NAD+
(https://www.selfhacked.com/blog/nad-and-sirt1-
their-role-in-chronic-health-issues/), which is
associated with longevity.
(Lithium inhibits mir-34a, which in turn inhibits

NAMPT (https://www.selfdecode.com/gene/nampt/?
the enzyme that makes NAD+ [R
R
(https://en.wikipedia.org/wiki/Nicotinamide_phosphorib
Therefore, lithium probably increases NAD+.)
See my lithium post

(https://www.selfhacked.com/blog/the-bene ts-of-
lithium/).
4) Curcumin
Curcumin
(https://www.selfhacked.com/blog/curcumin-
cures-top-15-scienti cally-proven-health-bene ts-
with-references/) increased the median and
maximum lifespan of ies by up to 25.8%. The
optimal dose of curcumin for male ies (0.5mg/g of
diet) was lower than for females (1mg/g of diet) [R
Lifespan extension with curcumin has been

attributed to its ability to decrease expression of age-
related genes (including mTOR
(https://www.selfhacked.com/blog/mtor-natural-
mtor-inhibitors/)).
Curcumin supplementation also acts as a potent

antioxidant in the cell [R
The increase in lifespans did not change if the ies

were also calorie restricted, suggesting that curcumin
and caloric restriction act on the same biological
pathways [R
I nd that curcumin is the most multifunctional

supplement available. But not all curcumin
supplements are created equal. Many are not
bioavailable and do not reach the brain.
See here for full info on bene ts of curcumin and

which types to buy
(https://www.selfhacked.com/blog/curcumin-cures-
top-15-scienti cally-proven-health-bene ts-with-
references/).
5) Oxaloacetate
Oxaloacetate (https://www.selfhacked.com/blog/16-
scienti cally-proven-bene ts-oxaloacetate/)
supplementation increased lifespan in worms by
stimulating the same longevity pathways as calorie
restriction [R
Accumulation of proteins is a common cause of

aging. Oxaloacetate might increase lifespan by
reducing the build-up of methylglyoxal (MG) – an
important source of protein toxicity and general

biological dysfunction [R
A build-up of glutamate
(https://www.selfhacked.com/blog/glutamate/) can
be toxic to cells. It causes serious brain damage after a
concussion or stroke and is the favorite energy source
for many cancers [R
Consumption of oxaloacetate can lower blood

glutamate levels by 40%. Rats given oxaloacetate
had a 237% increase in brain tumor survival rates [R
Oxaloacetate also increases NAD+

their-role-in-chronic-health-issues/).
Oxaloacetate is a cellular metabolite and so is not

available from a dietary source. It must be taken in
supplement form.
I recommend taking it in the morning or afternoon

with meals. For me to notice a bene t, I need to take
3 pills a day, but since it’s expensive, I take one daily.
I nd this work well:

Oxaloacetate (http://www.iherb.com/Advanced-Orthomolecular-Research-AOR-Advanced-Series-
benaGene-30-Veggie-Caps/33089?rcode=COH780)
6) Rhodiola
Rhodiola
(https://www.selfhacked.com/blog/rhodiola/) rosea is
an adaptogenic herb commonly used to improve
stress resilience.
R. rosea can extend lifespan in ies, worms, and yeast

[R
Rhodiola was shown to extend lifespan in both sexes

regardless of diet, suggesting that it works on
different longevity pathways to caloric restriction [R
Rhodiola is a supplement that I like to take

frequently. There are many options, but I do better
when the rhodiola’s that have a higher salidroside
percentage.
Here are the best options:

Rhodiola (http://www.iherb.com/Paradise-Herbs-Dual-Action-Rhodiola-60-Veggie-Caps/4908?
rcode=coh780) or Rhodiola (http://www.iherb.com/Nature-s-Plus-Herbal-Actives-Rhodiola-Extended-
Release-1000-mg-30-Veggie-Tabs/51492?rcode=coh780)
7) Carnitine
Mitochondrial decay is a signi cant factor in aging,
caused, in part, by the release of reactive oxygen
species (ROS
(https://www.selfhacked.com/blog/oxidative-stress-
101/)) as by-products of mitochondrial electron
transport.
Supplementing with carnitine

(https://www.selfhacked.com/blog/top-18-science-
based-health-effects-carnitine/) can improve
mitochondrial health and ef ciency by enhancing
electron ow [R
(http://www.pnas.org/content/99/4/1870.full)].
In one study supplemental carnitine prolonged the

aging of yeast cells [R
(http://www.wellnessresources.com/studies/acetyl-l-
carintine_offsets_mtiochondrial_aging/)].
The increased electron ow from carnitine also

increases the formation of reactive oxygen species. It
might be a wise idea to take an antioxidant, such as
lipoic acid, along with carnitine [R
(http://www.pnas.org/content/99/4/1870.full)].
Buy: Acetyl L Carnitine (http://www.iherb.com/Doctor-s-Best-Acetyl-L-Carnitine-500-mg-120-Veggie-
Caps/7779?rcode=coh780)
8) NAC
N-acetylcysteine (NAC
(https://www.selfhacked.com/blog/top-25-science-
based-health-bene ts-n-acetyl-cysteine-nac/)) is a
modi ed sulfur-containing amino acid that acts as a
potent cellular antioxidant [R
NAC extended the lives of ies. Flies fed NAC lived

26.6% longer than normal [R
Similarly, the lifespan of worms was extended by up

to 30.5% with supplemental NAC. The same study
showed that NAC signi cantly increased resistance to
a variety of environmental stressors [R
Because NAC is an antioxidant it may slow the aging

process by protecting the organism against free
radical-induced damage [R
NAC effects on longevity might also involve its impact

on the expression of speci c mRNA genes [R
NAC is widely available in supplemental form. I

suggest capsules as loose crystals taste disgusting.
I recommend NAC (http://www.iherb.com/Doctor-s-Best-Best-NAC-Detox-Regulators-60-Veggie-
Caps/41653?rcode=coh780)
9) Carnosine
(https://www.selfhacked.com/blog/carnosine/)
Carnosine is an antioxidant and has been shown to
reduce the brain damage from oxidative stress [R
Male ies that were given carnosine lived on average

20% longer than normal. No increase in lifespan was
noted in female ies taking carnosine [R
I recommend taking this right upon awakening or a

half hour before food. Carnosine binds to divalent
metals like magnesium
(https://www.selfhacked.com/blog/21-proven-science-
based-reasons-magnesium-amazing-including-
drawbacks/) and calcium and others, so you don’t
want to take this with meals.
Buy: Carnosine (https://www.iherb.com/pr/Paradise-Herbs-L-Carnosine-60-Veggie-Caps/4241?
rcode=coh780)
10) Melatonin
(https://www.selfhacked.com/blog/melatonin/)
Melatonin is an important regulator of circadian

rhythms (https://www.selfhacked.com/blog/what-it-
means-to-keep-to-a-circadian-rhythm/) and is a
potent anti-in ammatory compound [R

Increases in the longevity of fruit ies, mice and rats

have been observed when melatonin was given
supplementally or added to their food [R
In both mice and rats, melatonin acts as a potent

antioxidant and inhibits free radical damage [R
Melatonin has effects on the expression of genes that

govern the cell cycle, cell/organism defense, protein
expression and transport, and mitochondrial
function. It might also activate the same sirtuin
pathways as caloric restriction (SIRT1
their-role-in-chronic-health-issues/)) [R
One of the best ways to increase melatonin is to

minimize exposure to arti cial light after sunset [R
There are many types of melatonin, and people will

differ in which kind works for them. Here are some
interesting types of melatonin.
Buy: Melatonin Cream (http://www.iherb.com/Life-Flo-Health-Melatonin-Body-Cream-2-oz-57-g/9224?

rcode=coh780), Melatonin Drops, Melatonin (http://www.iherb.com/Natrol-Melatonin-TR-Time-Release-1-
mg-90-Tablets/41639?rcode=coh780)-time release, Melatonin (http://www.iherb.com/Now-Foods-
Melatonin-3-mg-180-Capsules/328?rcode=coh780)
11) Lactic acid

Feeding lactic acid
(https://www.selfhacked.com/blog/the-brains-secret-
backup-generator/) to fruit ies increased median
lifespan by 12-15% depending on what stage of life
supplementation began [R
(https://www.sciencedirect.com/science/article/pii/05315
It is proposed that lactic acid increases lifespan by

removing hydroxyl radicals [R
See here (https://www.selfhacked.com/blog/the-

brains-secret-backup-
generator/#My_Top_5_Sources_of_Lactate) for the
best ways to increase lactic acid.
12) Gluconic Acid
Gluconic acid
(https://www.selfdecode.com/chemical/gluconic-
acid/) increased the lifespan of ies by 12-22%
depending on what stage of life supplementation
began [R
In another study dietary gluconic acid slowed the

normal age-related accumulation of copper
(https://www.selfhacked.com/blog/copper/) in adult
ies and lead to an increased lifespan of 21.6% [R
(https://www.ncbi.nlm.nih.gov/pubmed/?
term=gluconic+acid+longevity)].
Like lactic acid, gluconic acid increases lifespan by

removing hydroxyl radicals [R
Kombucha
(https://www.selfhacked.com/blog/kombucha/) is a
good source of gluconic acid.
Potassium gluconate is a good form of potassium

and gluconic acid.
Potassium Gluconate Powder (http://www.iherb.com/Now-Foods-Potassium-Gluconate-100-Pure-Powder-
1-lb-454-g/13939?rcode=coh780)
13) NAD+
Supplemental NAD led to an extension of lifespan in
yeast by activating SIRT1
their-role-in-chronic-health-issues/) [R
Niagen is a good way to increase NAD levels:

Nicotinamide Riboside – Niagen NAD (https://www.iherb.com/pr/Life-Extension-NAD-Cell-Regenerator-
Nicotinamide-Riboside-100-mg-30-Veggie-Capsules/62199?rcode=coh780)
This is a relatively new supplement, but my guess is

it’s going to become more popular because of its
noticeably powerful effect on improving energy and
mitochondria. Its only downside is its expense.
14) Malate
Malate was found to extend the lifespan and stress
tolerance in worms through activation of gene
pathways that code for longevity (DAF-16 and SIRT1
their-role-in-chronic-health-issues/)) [R
(http://journals.plos.org/plosone/article?
id=10.1371/journal.pone.0058345)].
Malate did not extend the lifespan of worms that

were also calorie restricted.
Malate can be synthesized from fumarate. Hence,

taking fumarate also extends lifespan [R
Malic acid is also good for chelating heavy metals and

to increase energy production.
Buy:
Malic Acid (https://iherb.co/5agTpBSQ)
16) Acetate
Acetic acid
(https://www.selfdecode.com/chemical/acetic-acid/?
increases the lifespan of worms (by increasing DAF-
16). This extension of lifespan was 30-40%
greater when acetic acid was combined with Reishi
(https://www.selfhacked.com/blog/reishi/) extract [R
(https://www.ncbi.nlm.nih.gov/pubmed/19837596/)].
Vinegar (https://www.selfhacked.com/blog/vinegar/) is
a good source of acetic acid.
Apple Cider Vinegar (http://www.iherb.com/Bragg-Organic-Apple-Cider-Vinegar-with-The-Mother-Raw-

Un ltered-16- -oz-473-ml/5817?rcode=coh780)
17) Pyruvate
Worms with the slcf-1 gene mutation had increased
blood pyruvate levels and a 40% increase in
lifespan [R
There are Pyruvate

(https://www.selfdecode.com/chemical/pyruvic-acid/?
supplements that you can take.
18) Activated charcoal
Activated charcoal
(https://www.selfhacked.com/blog/activated-
charcoal/) is able to absorb substances from the
digestive tract. It can be used to eliminate toxic
substances and can alter the fat and protein content
of the gut.
Rats were given an activated carbon compound live

an average of 37-60% longer. By absorbing toxic
substances in the digestive tract carbon was found to
delay age-related structural changes in the organs
and tissues [R
(http://ngcrussia.org/Mamai_1996_e.pdf)].
Here is the source I often recommend:

Activated Charcoal (http://www.iherb.com/Nature-s-Way-Charcoal-Activated-280-mg-100-Capsules/1846?
rcode=coh780)
19) Lutein
Lutein (https://www.selfdecode.com/chemical/lutein/?
is an abundant carotenoid in fruits and vegetables.
Lutein prolonged the average lifespan of fruit ies by

63% [R
Lutein extends lifespan by increasing antioxidant

enzyme activity and up-regulating the expression of
certain genes that correspond to longevity (SOD1,
SOD2 (https://www.selfhacked.com/blog/the-brain-
fog-gene-rs4880-or-sod2/) & CAT
(https://www.selfdecode.com/gene/CAT/?
[R
You can get lutein by eating lots of fruits and veg, but
I also like to supplement.
20) Thea avins

The lifespan of ies was extended by approximately
10% when given a supplemental black tea extract
rich in thea avins
(https://www.selfhacked.com/blog/thea avins/). The
ies given BTE also showed an increased resistance
to the negative effects of a high-fat diet [R
The longevity-enhancing effects of BTE are likely

controlled, at least in part, by its impact on the gene
expression of SOD
(https://www.selfhacked.com/blog/the-brain-fog-
gene-rs4880-or-sod2/) and CAT
I nd this one by Life Extension to be effective:

Thea avins (http://www.iherb.com/Life-Extension-Thea avin-Standardized-Extract-30-Veggie-Caps/10451?
rcode=coh780)
21) Inositol
D-chiro-inositol
(https://www.selfhacked.com/blog/myoinositol/) slowed
the aging process and enhanced longevity in ies [R
High levels of blood glucose inhibit cell growth and

encourage cell aging. Myoinositol protects against
the damage done by high glucose levels [R
D-chiro-inositol/Pinitol is found in carob.
I use 5g per a day of inositol. These are good options:

Inositol (https://www.iherb.com/pr/Jarrow-Formulas-Inositol-Powder-8-oz-227-g/126?rcode=coh780)
D-Chiro Inositol (http://www.iherb.com/Discover-Nutrition-DCI-D-Chiro-Inositol-60-Veggie-Caps/23454?
rcode=coh780)
Carob (http://www.iherb.com/Now-Foods-Real-Food-Carob-Powder-12-oz-340g/16493?rcode=coh780)
22) Metformin
Metformin
(https://www.selfdecode.com/chemical/metformin/?
belongs to a family of drugs called biguanides that
have been shown to increase lifespan. For
example, Metformin extended the lifespan of
worms by 40% (median) and signi cantly increased
the lifespan of mice [R
(https://www.ncbi.nlm.nih.gov/pubmed/20090912/%20
Like many other life-extending drugs, metformin

induces many of the bene ts of calorie restriction,
such as improved physical performance, increased
insulin sensitivity, and reduced LDL
(https://www.selfdecode.com/measurement/low-
density-lipoprotein-cholesterol-measurement/?
utm_source=seo&utm_medium=selfhacked&utm_ca
and cholesterol levels without actual calorie

restriction [R
Metformin might extend lifespan by behaving as a

metabolic stressor that activates an oxidative stress
and detoxi cation response (involving AMPK
(https://www.selfhacked.com/blog/natural-ampk-
activators/)) [R
(https://www.ncbi.nlm.nih.gov/pubmed/24889636/), R
In animal models, deactivation of IGF-1

(https://www.selfhacked.com/blog/the-truth-about-
igf-1-top-10-bene ts-and-potential-drawbacks/)
genes increases lifespan. Metformin decreases IGF-1
(https://www.selfhacked.com/blog/the-truth-
about-igf-1-top-10-bene ts-and-potential-
drawbacks/) [R
As already mentioned, blood sugar regulation is an

important factor in aging. Metformin lowers blood
sugar by increasing insulin sensitivity in liver and
muscles. It might also work by suppressing glucose
production in the liver [R
Metformin mitigates the high risk of diabetics getting

cardiovascular disease and brain issues.
Diabetics
(https://www.selfdecode.com/disease/diabetes-
mellitus/?
who take metformin are at decreased risk of
developing a range of cancers. It is unclear whether
these cancer prevention properties would apply to
non-diabetics [R
Metformin changes the microbiome in a way that

promotes health and longevity, possibly by altering
microbial Folate and Methionine Metabolism [R
R
Metformin promotes mobility in old age, decreases

the fat build up, and increases stress resilience in
response to oxygen deprivation [R
Metformin is a prescription drug, so speak with your

doctor before you take it.
23) Deprenyl – MAOBI

Deprenyl’s
(https://www.selfdecode.com/chemical/selegiline/)
positive effects on longevity have been tested in at
least ve different animal species by independent
research groups.
Rats treated with .25mg/kg of deprenyl lived an

average of 30% longer than the control groups [R
Deprenyl given at 1 mg/kg signi cantly prolonged the

lifespan of middle-aged dogs when taken for a
minimum of six months [R
Deprenyl might increase longevity by raising

antioxidant enzymes such as superoxide dismutase
gene-rs4880-or-sod2/) (SOD
gene-rs4880-or-sod2/)) and catalase
(CAT) in certain brain regions [R
24) Butyrate
(https://www.selfhacked.com/blog/butyrate-
health-bene ts-butyrate-derivatives-sodium-
butyrate-phenylbutyrate-trybutyrine-butyric-
acid-butyrate-prodrugs-butyrate-producing-
bacteria/)
Butyrate is a short chain fatty acid produced during
fermentation by the gut microbiota
(https://www.selfhacked.com/blog/how-your-gut-
microbiota-can-make-you-fat-or-thin/).
Feeding a form of butyrate to ies increased their

maximum lifespan by 30-50% [R
(http://journal.frontiersin.org/Journal/10.3389/fgene.2012
Similar life extension properties of butyrate have been

observed in worms [R
(http://www.fasebj.org/content/28/1_Supplement/1025.1
One of the primary mechanisms by which Butyrate

extends lifespan is by altering the copying of genes
that code for longevity (e.g glutathione S-transferase
(https://www.selfdecode.com/gene/gst/?
& superoxide dismutase) [R
(http://journal.frontiersin.org/Journal/10.3389/fgene.2012
Internal Butyrate levels can be increased via

supplementation, or by eating more resistant starch
and non-digestible bers that encourage colonic
fermentation.
I recommend:
Butyrate (http://www.iherb.com/Nutricology-ButyrAid-100-Tablets/8510?rcode=coh780)
Hi-Maize resistant starch at 50g/day to start
25) Glucosamine
(https://www.selfhacked.com/blog/glucosamin
In worm and mouse studies, glucosamine has
extended lifespan through creating new
mitochondria [R
In people, glucosamine supplements were associated

with a lower risk of dying [R
(http://ajcn.nutrition.org/content/91/6/1791)].
Glucosamine has an inhibitory effect on tumors [R

(https://www.sciencedirect.com/science/article/pii/S000
Buy: Glucosamine (https://iherb.co/iwRNdN2)
26) Resveratrol
Resveratrol (https://www.selfhacked.com/blog/top-15-
scienti c-health-bene ts-of-resveratrol-with-
references/) has been found to increase lifespan in
yeast, worms, ies, bees, sh, and rodents [R
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13 () COMMENTS
TOM Submitted June 2, 2018 09:29AM
A second test of c60 was to end Feb 2017. It was

never reported on so I assume it was a failure.
REPLY
KONING Submitted April 6, 2018 03:13AM
LS!
Thank you so much for your post! I usually try for
the last twenty years with pumpkin sweet potato
curry extra virgin olive oil soup for the alpha
carotene and daily a pot of organic white tea Pai
Mu Tan. And lots of nutritional supplements. I am
almost 60 and my hands still look baby-young,
hands betray your age, don’t they?
REPLY
CAROL CLOSE Submitted February 5, 2018 05:03PM
https://www.researchgate.net/publication/3173163
82_Current_Perspective_in_the_Discovery_of_An
ti-aging_Agents_from_Natural_Products#pf44
(https://www.researchgate.net/publication/3173163
82_Current_Perspective_in_the_Discovery_of_An
ti-aging_Agents_from_Natural_Products#pf44)
To add to your longevity booster list. Check out a

total of 212 anti aging agents in this research
paper, including 62 clinical medicines with anti-
aging activity including rapamyacin, metformin,
aspirin, berberine, huperzine A, minocycline,
phenformin, vitamin E, buformin, melatonin,

ivabradine, acarbose, metoprolol, nebibolol,
cortisone, myriocin, caffeine, and more.
Interestingly, the anti-aging mechanism of most
drugs here are different from their clinical
applications.
These are just a few of the many anti-aging natural
plant sources listed, plus one bug, one yeast, two
bacteria and bee by products: Yellow mealworm
extract, cinnamon, Mexican Willow primrose,
jujube, cranberry, Rosa damasceana flower extract,
blueberry, Siberian ginseng, Oriental arborvitae
leaf extract, Reishi mushroom, Mon Tsai Tai (Asian
greens with purple stems used in stir fry), KPE-7
(Rosemary, thyme, curcumin, licorice, grapeseed,
Siberian ginseng, silk protein, marigold), Er Chen
Wa (ginger, poria, tangerine rind), Huan Shao Dan
(Cistanche, Morinda root, licorice, Rehmannia,
dogwood fruit, Eucomiae, Poria, Discoraea,
schizandra, polygala, jujube), Liu Wei Huang Wan
(Rehmannia, dogwood fruit, maten, Discorea,
Poria, Alismetis), Sheng mai Wan (ginseng,
Ophiopogon, Schizandra, Codonopsis), Shi Quan
Dobu Wan (Astragalus, cinnamon, Rehmannia,
peony, Ligustrum, Angelica, ginseng, Poria,
licorice, Astactodes), mulberry leaf, Urn orchid,
currant, curcumin, Rhodiola, Indian Gooseberry, a
leaf tea from a bamboo called Sassa senanensis,
green vegetables, hydrolyzed maize protein,
ferula, Stereospermum suavalens, vitamin E,

Premna integrifolia, common hop, broccoli, ginkgo
biloba, extra virgin olive oil, royal jelly, propolis,
walnut, Pinus densiflorus (Scots pine), Pinus
sylvestris (Red Pine), Abies grandes (fir), garlic,
Plumbago zeylanica, burdock, legumes, alfalfa, a
bacteria called Bacillus subrillisvar and the
penicillin bacteria, milk thistle, strawberry,
raspberry, Tree of Heaven, nuts, black tea, green
tea, onions, grapes, Eucalyptus leaf, a yeast called
Saccharomyces cerevisiae, Thunder God vine,
olive leaf, Eklonia cava, soybeans, Ophiopogon
japonicas tuber, Chinese Lacquer tree, Korean
mistletoe extract, Neem leaf extract, apple, cocoa,
gastrodin from an orchid, stinging nettle, black
cumin seed, Chinese Tea Tree Mushroom,
Cordyceps mushroom, Cynomerium songaricum,
resveratrol from Polygonum cuspidatum, Chinese
Skullcap, tomatoes, carrots, wheat, coffee, algae,
berberry, Horny Goat Weed, grape seed, olive,
grape juice, sesame seed, pomegranate, sage,
rosemary, thyme, oregano, peppermint, spearmint,
basal, red algae, Adzuki bean, Sargassum
seaweed, Euonymous seeds, and saffron. These
anti-aging agents are amino acids: creatine, lysine,
arginine, alanine, leucine, glutamine, asparagine,
theanine, cysteine, histidine, proline, serine,
ornithine, homocysteine, isoleucine, methionine,
carnosine, spermidine, taurine, threonine, valine,
tyrosine, tryptophan. These anti-aging agents are

nucleotides: guanosine, nicotinomide riboside,
nicotinamide mononucleotide. These anti-aging
agents are hormones: pregnenolone, estradiol,
cholesterol, vitamin D3. Here are more anti-aging
agents: lithochollic acid, butein, citrus, hydrogen
sulfide, withanolide, trehalose, quercetin,
kaempferol, fisetin, lutein, chlorophyll, genistein,
guanosine, TA-65, alpha lipoic acid, astxanthin,
catechin, fucoxanthin, rosmarinic acid, gallic acid,
glycerol, lactate, vitexin, urolithin A., Baicelain,
catalpol, chlorogenic acid, caffeoyl, carotenoids,
coQ10, inositol, glucosamine, acetic acid, natural
polyamines, vinegars, ketoglutarate, and more.
They list the chemical structure, clinical
application, source, and the anti-aging activity and
proposed anti-aging mechanism, plus the
percentage increase in life extension. Check out
more. This is just a partial list of 212 anti-aging
agents.
In the last 20 years, pharmaceutical companies

have been enthusing their drug development
strategy of high throughput screening and
combinatorial synthesis of enormous synthetic
libraries of small molecules. The achievement of
new lead discovery and new drug approval has
been very disappointing. They neglected natural
products. Compared to synthetic compounds,
natural products are secondary metabolites,

evolutionarily optimized with biologically relevant
chemical space and preferred ligand binding motif,
and are not only biologically active but have a high
degree of bioavailability, suitable for functional and
phenotypic assays. Natural products are an
invaluable source and provide great promise for
developing anti-aging medicine.
REPLY
ROBERT ZUIDGEEST Submitted December 27, 2017 02:20PM
I’ve been reluctant to try C 60 , I’ve never felt

comfortable with a quality source. Would be very
appreciative of any suggestions. Thanks
REPLY
CAROL CLOSE Submitted July 8, 2017 02:06PM
Delaying the Chronological Aging of the Yeast

Saccharomyces cerevisiae by Six Plant Extracts
REPLY
CAROL CLOSE Submitted July 6, 2017 03:38PM
28 plant extracts (tea, astragalus, rhodiola,

polygonum, mik thistle, chocolate, ashwagandha,
ginseng, strawberry, apple, olive leaf, black currant,
Chinese yam, cinnamon, soy, calendula, bugbane,
ginger, skullcap, acai, kudzu, Echinacea, more)
greatly delayed aging, but 6 supplements

significantly extended lifespan- Black cohosh,
Valerian, Celery seed, Passion Flower, Gingko and
White Willow bark which white willow increased
the mean and maximum chronological lifespan of
yeast by 475% and 369%, respectively. White
Willow bark represents a much greater effect than
rapamycin and metformin, the two best drugs
known for their anti-aging effects.Yeast were
chosen in this study because aging progresses
similarly in both yeast and humans. The budding
yeast Saccharomyces cerevisiae is a beneficial
model organism for the discovery of genes,
signaling pathways and chemical compounds that
slow cellular and organismal aging in eukaryotes
across phyla.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49
41334/
41334/) Discovery of plant extracts that greatly
delay yeast chronological aging and have different
effects on longevity-defining cellular processes
[biofoundations] Delaying the Chronological Aging

of the Yeast Saccharomyces cerevisiae by Six
Plant Extracts
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52
39441/#R3
39441/#R3) Six plant extracts delay yeast
chronological aging through different signaling
pathways
REPLY
BIOWOLLE20VUH Submitted June 23, 2017 02:55AM
Bio Baumwolle Neugeborene Handschuhe

(https://amzn.to/2nD6Xsh) – Bio Baumwolle
Neugeborene Handschuhe
REPLY
JOHN NEMES Submitted April 11, 2017 11:15PM
You forgotten: vitamin K2

REPLY
BRIAN Submitted February 22, 2017 06:29AM
Hi Joe
came here looking for info on pyruvate after
yesterday’s video from Ron Davis on his latest
research breakthrough into CFS [Youtube]
Would be great if you could do a more focused
look into pyruvate.
REPLY
KYUNG Submitted May 13, 2016 03:08AM
Curcumin is actually early acting life span

mediator. Feeding from early age to mid-life would
be life-enhancing and after mid-life feeding may be
opposite.
Also, C60 study is too preliminary to draw the life-
span-enhancing effects. It seems to mimic
hormesis like response while damaging to DNA
strands and mitochondria in a genomic level. Net
outcomes of pro-oxidant and anti-oxidant effects
are also unknown. Its effect also depends on other
characteristics of C60 such as lipophilic,
hydrophilic properties, and purity factors of other
components(C70 content) etc… In other words,
there have been concerns regarding to the right
form and dosage which yields the beneficial
effects.
Carnosine is also a problematic supplement, which
oral supplementation is not effective as
carnosinase intervenes. Some people try to
decrease this enzyme to maximize the plasma
serum, but its safety and plausibility are unknown.
Yet too early to draw conclusions of life-extension.
REPLY
JOHN SEVILLE Submitted April 12, 2016 05:43PM
You omitted the Real # 1, D-Glucosamine, the

dietary supplement marketed for cartilage
degradation,which incidentally it really is in
effective for. Study after study has shown its ability

to mimic a low carbohydrate diet. In worm and
mouse studies it has shown to extend lifespan
through mitochondrial biogenesis. Because of it’s
safety, dosing is NOT an issue as with most other
substances. It’s anti-inflammatory properties has
been proven in humans by substantial reduction in
cancer across the board, including a substantial
35% decrease in the infamous Lung cancer, with
just basically 1500mg 4 times weekly, according to
studies. The number of studies indicating the long
list of its attributes is quite long and can easily be
found in Pubmed, but I will include just a few for
your perusal.
http://ajcn.nutrition.org/content/91/6/1791
(http://ajcn.nutrition.org/content/91/6/1791)
http://www.sciencedirect.com/science/article/pii/S
0006291X07014064
(https://www.sciencedirect.com/science/article/pii/
S0006291X07014064)
http://www.ncbi.nlm.nih.gov/pubmed/24714520
(https://www.ncbi.nlm.nih.gov/pubmed/24714520)
REPLY
JOSEPH M. COHEN Submitted April 12, 2016 10:05PM
Thanks.
REPLY
FRED Submitted October 8, 2016 05:30AM
also….
The bottom line is that glucosamine

supplementation lowers human mortality
Glucosamine and Chondroitin Sulfate have

already been shown in a large epidemiological
study to lower overall mortality and reduce
cancer risks – a 5-year study of 77,719 elderly
residents of Washington State. We found
several publications based on different
analyses of data based on this population.
Conclusions:
For most of the supplements we examined,

there was no association with total mortality.
Use of glucosamine and use of chondroitin
were each associated with decreased
mortality.”
Both of these papers were done on the same

group of 77,719 people. We note that this is as
great an effect as combining vegan diet and
fish consumption! We find this quite surprising.
Glucosamine appears to have a comparable or

greater effect on mortality reduction and
lifespan extension than Metformin, Rapamycin,
2DG, Veganism, and Resveratrol in nematodes
and rodents.
RESULTS: Persons reporting use of

glucosamine + chondroitin on 4+ days/week for
3+ years had a non-statistically significant 45 %
lower Colorectal Cancer risk than non-users
Epidemiological evidence exists that

glucosamine and chondroitin supplementation
reduces inflammatory biomarkers.
Glucosamine supplementation may be

protective against lung cancer.
* A 2010 publication suggests that taking high

doses of glucosamine or prolonged use it
glucosamine reduces levels of SIRT1, leads to
apoptosis of pancreatic cells and could
increase the risk of developing diabetes.
* keep dosage under 750 mg?
REPLY
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R E L AT E D A R T I C L E S
PHARMACEUTICALS
11 USES OF D EPAKOTE
( VA LPROIC ACID) + SIDE
EF F ECTS & DOSAG E
( HTTPS://WW W.SEL FHAC K ED. C
OM/BLOG/D EPAKOTE/)
Depakote (Valproic Acid) is an anti-seizure drug that has been
used for almost fty years. It is also used to manage bipolar
disorder, schizophrenia, and migraines. But it can cause a
number of side effects ranging from nausea to liver
damage. Read on to discover more on the uses and side effects
of Depakote.
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CONDITIONS
HYPERCAPNIA AN D
RESPIRATORY ACIDOSIS:
CAU SES & SYMPTOMS
OM/BLOG/H YPER CAPN I A / )
b di id i h d
https://www.selfhacked.com/blog/23-longevity-boosting-supplements-drugs-increase-lifespan/ d b di 47/51
Carbon dioxide is everywhere around us and our bodies are

constantly at work to balance its concentration in our blood.
However, some illness or other factors can throw off this balance
and cause respiratory acidosis or hypercapnia, when our blood
becomes too acidic from too much carbon dioxide. Read on to
learn more about how […]
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BLOOD TESTS
ODDS ARE YOU SUFFER FROM

ODDS ARE YOU SUFFER FROM

ON E OF THE SE N UTR ITI ONA L
DEF ICIENCIES
OM/BLOG/NUTR IEN T-
DEF ICIENCIES/)
We often take our nutritional status for granted, but it can have a
signi cant impact on our health. Even if you eat a healthy, well-
balanced diet, you may still fall short of essential vitamins and
minerals. Your age, health conditions, chronic stress, the
medications you use, and where your food is grown can rob you
[…]
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26 Longevity Boosting Supplements & Drugs To Increase Lifespan

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8/8/2018 26 Longevity Boosting Supplements & Drugs to Increase Lifespan - Selfhacked

26 Longevity Boosting Supplem

Drugs to Increase Lifespan

BUY THE SELFHACKED BOOK

Age-related diseases and general aging are often

Aspirin increased the lifespan of mice by 18-21% at

One study surprisingly found that aspirin was more

The high doses used in these studies might lead to

French biologists found that rats given C60 (a

None of the rats treated with C60 got cancer

The longevity (https://www.selfhacked.com/blog/23-

C60 easily crosses the blood-brain barrier. It

C60 molecules have the potential to block the

C60 has never been tested on humans.

Lithium might improve mitochondrial function by

However, a recent study of ies found the opposite

A correlation was found when researchers measured

The study concluded that “long-term low-dose

One mechanism might be that lithium should

(Lithium inhibits mir-34a, which in turn inhibits

See my lithium post

Lifespan extension with curcumin has been

Curcumin supplementation also acts as a potent

The increase in lifespans did not change if the ies

I nd that curcumin is the most multifunctional

See here for full info on bene ts of curcumin and

Accumulation of proteins is a common cause of

important source of protein toxicity and general

Consumption of oxaloacetate can lower blood

Oxaloacetate also increases NAD+

Oxaloacetate is a cellular metabolite and so is not

I recommend taking it in the morning or afternoon

I nd this work well:

R. rosea can extend lifespan in ies, worms, and yeast

Rhodiola was shown to extend lifespan in both sexes

Rhodiola is a supplement that I like to take

Here are the best options:

Supplementing with carnitine

In one study supplemental carnitine prolonged the

The increased electron ow from carnitine also

NAC extended the lives of ies. Flies fed NAC lived

Similarly, the lifespan of worms was extended by up

Because NAC is an antioxidant it may slow the aging

NAC effects on longevity might also involve its impact

NAC is widely available in supplemental form. I

Male ies that were given carnosine lived on average

I recommend taking this right upon awakening or a

Melatonin is an important regulator of circadian

potent anti-in ammatory compound [R

Increases in the longevity of fruit ies, mice and rats

In both mice and rats, melatonin acts as a potent

Melatonin has effects on the expression of genes that

One of the best ways to increase melatonin is to

There are many types of melatonin, and people will

Buy: Melatonin Cream (http://www.iherb.com/Life-Flo-Health-Melatonin-Body-Cream-2-oz-57-g/9224?

11) Lactic acid

It is proposed that lactic acid increases lifespan by

See here (https://www.selfhacked.com/blog/the-

12) Gluconic Acid

In another study dietary gluconic acid slowed the

Like lactic acid, gluconic acid increases lifespan by

Potassium gluconate is a good form of potassium