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®

TM
DR. STUART TITUS
Co-Founder and President of
Medical Marijuana, Inc.

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STUART TITUS
Co-Founder and President of Medical Marijuana, Inc.

• Stuart began his association with our family of companies in 2008,


playing a pivotal role in raising capital for Medical Marijuana Inc. 

(OTC: MJNA), among several other duties.
• Stuart practiced as a British physiotherapist for fifteen years, running
clinics specializing in pain management and injury rehabilitation.
• Stuart has unique first-hand experience with hemp oil products as
nutritional supplements.

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CBD, Formerly Called “The Hippie’s
Disappointment” Takes on New Life in 2011

Entrepreneurs were still believers in the potential and developed a delivery for
cannabinoids (CBD) in other than smokable form

• Proof of Concept products fall of 2011

• First products on US and world markets 2012

• Our management team are considered the Founders of the current


CBD Evolution / Revolution

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CBD Nutraceuticals Hit the Market in mid-2012

• European Hemp Crops Grown from 2007 – 2011


• Each Year Gradually Higher Concentrations of CBD
• Fall of 2011 – Enough CBD to Possibly Have Benefit
• Crop was Harvested, Oils Extracted (Raw “Paste”)
• Eventually Exported to US
• Final Formulations Made and Marketed mid-2012

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Intro to Medical Benefits of CBD/Cannabis

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Brief History of Cannabis

• Cannabis has been part of human evolution


since the beginning of recorded history.

• In ancient Chinese times, cannabis was used as a


medicine, including its oils, tinctures and 

cannabis-based preparations.

• Today’s presentation concerns the recent


developments in clinical research regarding the
re-establishment of “Cannabis” uses.

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1930’s and Cannabis’ Demise

• Up until the late 1930’s cannabis based medications: oils, tinctures and preparations were
routinely used by American doctors and physicians worldwide. The following pictures
depict some of the many types of cannabis-based medicinal products that were available.

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The Parent Plant
Cannabis
Would Be
Considered the
Parent Plant

Hemp Marijuana
One Offspring Would Be The Other Would Be
Hemp (non-psychoactive) Marijuana (psychoactive)

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Hemp vs. Marijuana - Part I (Understanding the Differences)

Hemp Marijuana
• Tall and lengthy (can grow 10-20 feet high) • Short and bushy (grows about waist high)
• High concentration of CBD (non-psychoactive) • High concentration of THC (psychoactive)
• Around the world, it is grown mostly for fiber, • Grown for psychoactive effect
and used in textiles • No industrial application
• Hemp seeds are the seed from the plant known
as Cannabis sativa 10
Hemp vs. Marijuana - Part II (Understanding the Differences)

Hemp Marijuana
• Hemp food products are federally legal in the • Remains illegal at federal level
USA • 30 US states, plus Washington D.C. legalize
• Hemp food products are regularly found in US for medical purposes
health food stores • 17 US states approve CBD forms of marijuana
• Hemp seed, hemp oil, hemp protein powder for epilepsy children
• 9 US states + D.C. have legalized for recreational usage
Hemp - Worldwide Benefits to Mankind

The world stands to significantly benefit from industrial


hemp, as there are a huge number of known uses – that
are all sustainable and renewable.

This will greatly benefit world economies – and as we


grow significantly more hemp around the globe – the
entrepreneurial spirit of the newer generations will likely
find increasing uses for this amazing plant.

Particularly as we achieve “economies of scale” through


significantly increased hemp production.

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of
cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
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Hemp - Numerous Industrial Applications

The list of industrial applications for industrial hemp include:


• Clean biofuels produced from the significant biomass

• Hemp textiles

• Hemp-based bio-plastics

• Hemp-based building and construction materials:


• Hemp-Board
• Hemp-Concrete or “Hempcrete”

• Hemp batteries and capacitors to store energy

• Hemp seed as food and nutrition

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of
cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
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Hemp
Hemp - Numerous Industrial Applications

• Biomass for bio-fuels, textiles, building and construction materials,


bio-plastics that actually bio-degrade in landfills, food and
nutrition are many of the significant industrial applications.

• Hemp can provide numerous benefits for the American economy –


potentially adding percentage points back to our nation’s GDP

• Bringing back to America – agricultural practices and economic


benefits that are sustainable and renewable!

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of
cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
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Hemp
Hemp - Hemp Based Bio Fuels

• Biomass can be used to fuel electrical generation power plants – in Brazil they use the sugar cane crop
to produce an ethanol for gasoline, but this has inherent environmental toxins

• Hemp can provide clean energy that is fully carbon negative - Hemp can provide a similar or greater
biomass than sugar cane

• Reduces dependence upon petroleum based fossil fuels

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of
cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
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Hemp
Hemp - Hemp Textiles

• Hemp fibers can be developed into quality clothes and textile


products

• The fashion industry ranks second, only behind the petroleum


industry, as the largest environmental polluters (per EcoWatch)

• Organic cotton is much more sustainable but is considerably


more expensive to grow – only 1% of all cotton is organic

• Conventional cotton has a wholesome image but requires 10% of


the world’s agro-chemicals. Most is GMO.

• Synthetic fibers like polyester and nylon are not biodegradable

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of
cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
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New Hemp Technology

Companies in Washington State and


Colorado have developed mobile hemp
processing technology and plan to load
MOBILE DECORATION MACHINES onto
trucks - taking the equipment on a 

20-State tour of hemp farms in the USA.
This will make hemp fiber for textile and
related products.

Link found here


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Pilgrim Overboard – Saved by A Hemp Rope

John Howland, Mayflower survivor fell overboard during a storm. A Hemp based rope saved
his life and the John Howland – Elizabeth Tilley family lineage now, 16 generations later, has
over 1.6 million Americans in the family tree. 18
Hemp
Hemp - Hemp Based Bio-Plastics

• Natural crop fibers are being used in Europe to produce car parts: door panels,
dashboards

• Henry Ford originally developed a car made from inter-twining hemp fibers.
The car’s body was far stronger than steel but much lighter

• Hemp bio-plastics may replace oil-based plastic water bottles

• Bio-plastics offer a biodegradable advantage to alleviate the


current environmental problems afflicting many landfills

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of
cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
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Hemp
Hemp - Hemp Construction Materials

• Hemp building materials are durable, non-toxic, and carbon


negative

• An average tree takes 20 years to grow; a hemp board can


be harvested in 120 days

• A hemp-home was built in Asheville, NC as the parents


wanted to do all they could for their daughter who had
multiple chemical sensitivities

• Hemp is naturally anti-bacterial, anti-microbial and anti-


fungal, plus hemp is an excellent insulator

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of
cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
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Hemp Houses

New York Times mentions Hemp Houses


Hemp Houses 8.3 pH makes for a
“healthy environment” Working in a
hemp facility decreased employee
absenteeism by 70%

Link found here


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Hempcrete

Link found here


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Hemp
Hemp - Hemp Food Products

• One can sustain life on the hemp see as it


contains essential nutrients

• Essential nutrients include:


• Essential Amino acids
• Essential Fatty acids

• Immunogloublins – supports the immune system

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of
cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
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Hemp
Hemp - Hemp Batteries

• Chemical engineers, including a Dr. David Mitlin (of Clarkson


University in New York), have found that hemp holds amazing
electrical properties – both in conducting electricity as well as
in storing it (capacitors).

• Hemp is especially good as an electrical capacitor – with


potential benefit for hybrid autos and solar power.

• These all-natural sustainable, renewable batteries may rival


the best metals-based graphene batteries for energy storage
– all at 1/100th the cost!

The following information is presented for educational purposes only. Medical Marijuana Inc. provides this information to provide an understanding of the potential applications of
cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Medical Marijuana Inc. and none should be inferred.
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Marijuana Shows Increasing Popularity

Vermont Legalizes for Recreational Use via LEGISLATIVE initiative.


• The 9th US State with legal recreational cannabis laws
LINK: https://www.yahoo.com/finance/news/vermont-becomes-ninth-state-legalize-231940566.html

Congressional Representatives See That CANNABIS MEANS VOTES


• Link: https://www.usatoday.com/story/news/2018/01/21/marijuana-money-increasingly-flowing-republican-lawmakers/1042239001/?mc_cid=892fe21f6e&mc_eid=4df55d7da2

Recent DEA Threats To The Cannabis Industry Are Having A Reverse Effect
• Politicians are scrambling to put up protective legislative barriers to any Federal
intervention

REFER Act Introduced Into US House of Representatives


• The Act Bars Federal interference with US State Legal Cannabis Markets US Senator
Elizabeth Warren (D-Mass) Also Has a Senate Bill
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Marijuana Shows Increasing Popularity Part II

90% + of Americans Favor Legalization of Medical Cannabis


Most Believe It Is Safer Than: Alcohol, Tobacco or Sugar
• The TRUE Substance that should be federally controlled because of no medicinal use
and with significant harm / significant risk of addiction: SUGAR
Link: https://www.marijuanamoment.net/marijuana-safer-alcohol-tobacco-sugar-americans-say-new-poll/

Trends Are Worldwide as German Media Reports Dramatic Increase in Cannabis


• Patients Covered by Insurance
Link: https://www.cannabisindustryjournal.com/feature_article/german-media-reports-dramatic-increase-in-cannabis-patients-covered-by-insurance/

Canada Licensed Producers Are Raising Millions of $ Based on Recreational Legalization Slated
• for July 2018
Link: http://business.financialpost.com/investing/canadian-cannabis-companies-on-2-billion-fundraising-spree-as-legalization-looms

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Canada – Sun Life Financial to Cover 6
Million Canadians for Cannabis

TORONTO — Sun Life Financial Inc. is adding


medical marijuana as an option for its group
benefits health insurance plans, marking an
industry shift and the latest sign of growing
public acceptance of cannabis.

Sun Life’s CEO said the move was influenced


by rising interest from Sun Life’s employer
clients. Sun Life boasts 22,300 corporate
accounts with 3,000,000 Canadians plus
families covered by Sun Life health insurance.
This totals 1 in 6 individuals or 6 million
Canadians.

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Link found here
Canada Fueling Explosive Growth in
Cannabis Financing

First 6 weeks First 6 weeks


2017 2018

Total Capital
$218 Million $1.4 Billion
Raised

Average Deal
$5.6 Million $18.7 Million
Size

# of Deals 39 74

Link found here


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Lesotho Legalizes Cannabis

Lesotho has become the first African country to


permit the legal cultivation of cannabis – but
the production of the drug has been restricted
to two foreign-owned companies, while rural
farmers and the wider population continue to
be prohibited from harvesting their own.
Lesotho is a landlocked country, entirely
encircled by South Africa, with a population of a
little over two million.

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Link found here
Big Tobacco Buys In
A publicly traded U.S. tobacco company has
bought controlling stakes in two Canadian
marijuana producers and invested in a North
Carolina hemp grower, making what is believed
to be the first foray by a significant tobacco
business into the cannabis industry.

Alliance One International, which trades on the


NYSE under the ticker symbol AOI, said it
acquired a 75% equity position in Canada’s
Island Garden and an 80% stake in Goldleaf
Pharm.

This adds to other NYSE listed companies who


are already in the cannabis space.  Scotts
Miracle Gro (NYSE: SMG) and Constellation
Brands (NYSE: STZ) are also involved with the
cannabis arena.  Scotts Miracle Gro has
previously invested $500 million and
Constellation Brands has invested $200 million
into the emerging cannabis space.
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Link found here
Marijuana sales overtake alcohol in US city for first time

• Sales of marijuana have overtaken alcohol in a city


in Colorado, three years after the state became the
first in the US to legalise recreational use of the drug.

• Licensed vendors in the ski resort of Aspen raked in


$11.3m (£8.2m) income from cannabis last year,
compared to $10.5m (£7.6m) brought in by off-
licences (alcohol)

• It is believed to be the first time legal marijuana sales


have eclipsed those of alcohol anywhere in the US.

http://www.independent.co.uk/topic/marijuana
Link found here

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Medical Marijuana Laws Reduced Alcohol Consumption

A study by Georgia State University last year


found alcohol sales had tumbled 15 per cent in US
states where medical marijuana had been
legalized. Counties where cannabis could be
legally obtained had 20 per cent lower alcohol
sales than neighbouring counties across state
borders where it was still outlawed.

Link found here

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More than 30,700 Americans Died From
Alcohol-induced Causes in 2014.

• There have been zero documented deaths from


marijuana use alone.

• Marijuana appears to be significantly less addictive


than alcohol.


• Alcohol is strongly linked with several types of cancer;


marijuana is not


• Both drugs may be linked with risks while driving, but


alcohol is worse.


• Several studies link alcohol with violence, particularly


at home. That has not been found for cannabis.


• Alcohol appears to be linked more closely with weight


gain, despite weed's tendency to trigger the munchies.


• All things considered, alcohol's effects seem markedly


more extreme — and riskier — than marijuana’s.

Link found here


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More re Marijuana and Cannabis

A Recent Study Shows Marijuana Legalization Causes Violent Crime to Fall in the US
MMJ Legalization for Medical Purposes Has Led to a Significant Decline in Violent Crime in
• Several US States Bordering Mexico
LINK: http://www.independent.co.uk/news/world/americas/medical-marijuana-legalisation-cannabis-us-states-violent-crime-drop-numbers-study-
california-new-a8160311.html?mc_cid=24ae56ec95&mc_eid=4df55d7da2

Another Study Shows Great Potential Economic Impact of LegalizationNew Frontier Data
Research Shows:
Legalizing Marijuana Nationwide Could Generate $132 Billion in NEW FEDERAL TAX
• REVENUE to our nation
This Legalization Would Also Create in Excess of 1.1 Million NEW JOBS within five years time
Link: http://www.chicagotribune.com/news/nationworld/ct-legal-marijuana-revenue-jobs-20180110-story.html

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Growing Cannabis Use In The U.S.

Since 2011, more than 7.5 million adults have


joined the ranks of now 22.4 million regular
cannabis users in the USA.

64% of Americans, according to recent PEW


survey support cannabis legalization for
recreational usage. Over 90% by some polls
support the medicinal usage of cannabis.

Link found here


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Cannabis & Skincare

Forbes article re cannabis based skin care:


“The problem is the US Federal Government.
We are going to see countries like Israel and
Canada take the lead if we continue to have
these regulatory hurdles”.

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Link found here
Cannabis Banking

One bank recently won conditional approval


to bank cannabis ancillary a “Master
Account” by the Federal Reserve system.

Link found here


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Colorado Marijuana Sales Break Another Record

Based on Colorado figures, we estimate the overall


US market for Marijuana - the illegal, illicit Black
Market totals $120 Billion in annual sales and
worldwide Black Market sales of Marijuana totals
$240 Billion.

Link found here 38


Potential Therapeutic Benefits of CBD

The World Health Organization Seeks to Remove Cannabis from the United Nations Single
Convention Treaty on Narcotics
• Further Meetings in May 2018
The WHO Is Taking the Lead in World Wide Cannabis Reform and ARE NOT Waiting for The US
Government to Act

Recent WHO CBD Hearings in Geneva Switzerland Nov 2017 Show:


CBD Is Safe and Will NOT Be Scheduled as a Drug Thus WHO Approves CBD’s
Nutraceutical / Nutritional Benefits
• Conclusion of WHO CBD Meeting:
CBD May Be A Useful Treatment For A Number Of Medical Conditions
Link: https://newfrontierdata.com/marijuana-insights/who-to-doj-re-cbd-its-all-medicinally-good/?
utm_source=New+Frontier+Newsletter&utm_campaign=9f98750ae3-
EMAIL_CAMPAIGN_2017_11_01&utm_medium=email&utm_term=0_e61e943a42-9f98750ae3-98552857&mc_cid=9f98750ae3&mc_eid=4df55d7da2

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CBD In The Emergency Room

Link found here 40


Newsweek: Is Marijuana the World’s Best
Treatment for Autism?

1 in 68 children have Autism Spectrum


Disorder (ASD)

…”It’s the plant’s CBD that relaxes them (ASD


children) and counters anxiety, making it
relevant to epilepsy and autism” Newsweek.

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Link found here
Cannabinoid Science / Cannabis Education

Cannabinoid Science, The Endogenous Cannabinoid System and a Basic


• Cannabis Education are NOT Taught in Medical Schools Today.

Only ONE in SEVEN Medical Schools in the US Even Mentions The Endogenous
• Cannabinoid System, Much Less Teach Anything About It.

To Get An Education – Doctors Need To Take Continuing Medical Education


Programs re Cannabis and Cannabinoid Science. In The Following Slides, We
• Will Review Some Of The Basic Concepts So EVERYBODY Can Get A Basic
Understanding and Knowledge

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What Are Cannabinoids?

• Cannabinoids are special compounds found in the Cannabis plant family, and there are
at least 80, possibly up to 100, known cannabinoids.

• There are nearly 400 other chemical compounds in cannabis that are common to all plants 

— like chlorophyll, terpenoids, flavonoids and plant waxes.

• Cannabinoids and cannabinoid like compounds are found in a handful of other plants
such as Echinacea, flax, common tea, kava and hops.

• One of these cannabinoid like compounds, called Beta-caryophyllene, is a terpenoid that


appears to behave like a cannabinoid in the body. It can be found in dozens of plants
consumed every day (black pepper, hops, rosemary, oregano, basil, lavender, cinnamon and
more). Beta-caryophyllene exhibits antioxidant properties, partly by acting on the
endocannabinoid system.
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Cannabinoids Extracts

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What is the Endocannabinoid System?

• Our bodies have an entire regulatory system called the endocannabinoid system
(ECS), or the endogenous cannabinoid system. In fact, this endocannabinoid
system is the largest, self regulating system within our bodies. The ECS uses
cannabinoids to transmit certain signals and regulate homeostasis within us - it
serves to balance our mood, appetite, sleep and hormone production.

• Plant based cannabinoids have analogues in the human body, meaning that our
bodies produce cannabinoids too. Our cells have receptor sites for cannabinoids
(CB-1 and CB-2, described below), and this helps regulate our immune system.

• The major endogenous cannabinoids are Anandamide (AEA) and 2-AG

• Please see Dr. David Allen's review of the endocannabinoid system here.
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What is the Endocannabinoid System?

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What is the Endocannabinoid System?

• The CB1 neurotransmitter receptor site in the brain has more


receptor sites than ALL OF THE OTHER neurotransmitter
sites… COMBINED!

• Thus, our bodies are designed to accept plant based


cannabinoids – in fact, these are the foods of our “Biological
Adaptation”.

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Additional Cannabinoid Receptor Sites

• G Protein Coupled Receptor Sites Controls the function of 800 human genes
(4% of the entire human genomic sequence)
• Vanilloid Pain Receptor Sites
• Internal Organs, including fat cells of the Liver Controls metabolism
• Also Lungs, Kidneys
• Glands Pituitary, Hypothalamus, Thymus, Thyroid, Adrenal
• The ECS is present from Day 16 of Gestation and regulates the development of the
entire Central Nervous System

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CB1 Receptors in the Brain

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CB1 Receptors in the Brain

These are where one finds the


opioid receptors in close
proximity to the brain’s
autonomic breathing reflex
thus when one overdoses on
opioids they “forget” to breathe
many then die of asphyxiation

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More than a third of U.S adults prescribed
opioids in 2015

Link found here 51


Opioid CDC Prescriptions Per State

In some US States there are as many as 143


Opioid prescriptions written for every 100
individuals - i.e. many patients receive MULTIPLE
opioid prescriptions from their doctor

Link Found Here 52


Opioid Epidemic Costs Skyrocketing

The opioid epidemic has cost the U.S. more than a


trillion dollars since 2001, according to a new
study, and may exceed another $500 billion over
the next three years.

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Link Found Here
Focus On Law Enforcement

The Trump administration quietly renewed the


declaration recently. But it has given no signs it's
developing a comprehensive strategy to address
an epidemic that claims more than 115 lives every
day. The president now says that to combat
opioids, he's focused on enforcement, not
treatment.

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Link Found Here
Study finds medical cannabis is effective 

at reducing opioid addiction

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Link found here
Senator Calls Out Big Pharma For Opposing
Legal Marijuana

A prominent Democratic U.S. senator is slamming


pharmaceutical companies for opposing
marijuana legalization.
"To them it's competition for chronic pain, and
that's outrageous because we don't have the crisis
in people who take marijuana for chronic pain
having overdose issues," Sen. Kirsten Gillibrand of
New York said. "It's not the same thing. It's not as
highly addictive as opioids are."
"On the federal level, we really need to say it is a
legal drug you can access if you need it," she said.

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Link found here
Solution for Opioid Epidemic May Come
from Cannabis

For millions of Americans, pain pills have consumed their


lives.

In states like California with legal marijuana, there is another


option, cannabis.

“One of the top reasons patients are using cannabis is to


reduce their use of other pharmaceuticals including opioid,”
said Kimberley Cargile of A Therapeutic Alternative.

But what about people already addicted. How can they get
off the pills?

“The goal number one here is to come up with something


which will be a much safer alternative to what is available
today,” said George Anastassov of Axim Biotechnologies.

“Cannabinoids have a lot to offer in the field of pain and


inflammation,” said Anastassov, “it’s just a question of
which one and what form of delivery it should be presented.”
Link found here
Democrats Forming Marijuana 

Legalization Consensus

“Legalizing marijuana isn’t a matter of if, it’s a


matter of when," Sen. Cory Booker (D-NJ) said
about the legislation, the Marijuana Justice Act,
which he introduced last August.

Sen. Kirsten Gillibrand (D-NY), who signed onto


the bill as a cosponsor on Wednesday and did a
Facebook Live chat with Booker about it, called
cannabis legalization "a social justice issue and a
moral issue that Congress needs to address.”

Senator Elizabeth Warren (D-Mass) has her own


bill in Congress.

Support for marijuana legalization is quickly


becoming a mainstream consensus position in the
Democratic Party.

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Link found here
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To supplement the LARGEST self-regulatory system within
the human body, take plant based phyto-cannabinoids daily!

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Endocannabinoid System Facts

Did You Know:

• The "Runner's High" is a phenomena created by production and


release of the endogenous cannabinoid, Anandamide, as well as
Endorphins - both are "feel good" neurotransmitters. Only Anandamide
crosses the blood-brain barrier, thus responsible for the "Runner's
High" effect.

• That a mother's breast milk contains significant quantities of


cannabinoids

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Clinical Endocannabinoid Deficiency Syndrome

• First postulated by a Dr. Ethan Russo, a famous cannabis researcher.

• If one is deficient in cannabinoids, one may develop numerous “treatment


resistant conditions", such as migraine headache, fibromyalgia, and chronic
fatigue syndrome

• Subsequent research has confirmed that underlying endocannabinoid


deficiencies indeed play a role in migraine, fibromyalgia, irritable bowel syndrome
and a growing list of other medical conditions. Clinical experience is bearing this
out.


• Further research and, especially, clinical trials will further demonstrate the
usefulness of medical cannabis/ medical hemp including non-psychoactive CBD .
As legal barriers fall and scientific bias fades this will become more apparent.

• Recently the US Drug Enforcement Administration (DEA) has relaxed barriers to


CBD research - this as of Dec 23, 2015 63
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Mitochondria – What You Need to Know by
Dr. Mercola

• When it comes to health and disease prevention, your mitochondrial


health and function simply cannot be overstated. If your mitochondria
are not functioning well, nothing else will either. Optimization of
mitochondria is also a central key for life extension.

• In simple terms, mitochondria are the powerhouse of your cells,


producing about 90 percent of the energy being generated in your body

• Everything that happens in your body, each and every muscle


contraction and relaxation, biochemical cascade, cellular regeneration,
detoxification and so on requires energy

• Free radicals formed at the level of the mitochondria are typically


extremely harmful, which is why you need to minimize them.
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Link found here

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The Entourage Effect

• All 500 chemical compounds native in


cannabis act synergistically to produce a
far greater effect than that of single or
double active ingredient extraction.

• Thus, natural, botanical cannabinoids


and natural, botanical products may have
significantly greater effects for patients
than synthetic, pharmaceutical versions.

• An excellent explanation by Dr. Sanjay


Gupta may be viewed here.

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U.S. Government Patent #6,630,507

• Regarding the therapeutic usage of cannabinoids,


titled: Cannabinoids as Antioxidants and
Neuroprotectants

• Patent awarded in 2003 to a team headed by Nobel


Prize Winning Laureate, Dr. Julius Axelrod

• Cannabinoids are useful in the treatment of a wide


range of oxidative-related conditions.

• In the treatment of neurodegenerative diseases.

• Non-psychoactive cannabinoids, such as cannabidiol


(CBD) are particularly advantageous as they avoid
toxicity related issues of psychoactive cannabinoids.

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Traumatic Brain Injury

• Research from UCLA Medical Center in Torrance, California involved 446


young adults who suffered auto accidents and related traumatic brain
injury.

• Interestingly, the regular cannabis users among this group of young


adults were 80% more likely to survive.

• Research was published in The American Surgeon

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Traumatic Brain Injury

We feel that every young "at-risk-for


head-injury" athlete should be taking
non-psychoactive plant based
cannabinoids.

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Increase in the Occurrence of Neurological Diseases

• We have seen a recent news release from Mayo Clinic researchers (June 21 2016) who had been studying
neurological trends for the past 30 years and reported their findings in JAMA Neurology.

• This report cited the significant increase in Parkinson’s disease and “parkinsonism” particularly in men over
the age of 70 years. This is the first study to suggest such a trend, according to researchers.

The numbers:

For every 10 calendar years of life:


• Men of all ages have a 17% higher risk of developing “parkinsonism”
and
• Men of all ages have a 24% higher risk of developing Parkinson’s disease

• Dr. Rodolfo Savica, MD, PhD, the study lead author mentions that “we have evidence to suggest that there
has been a genuine increase in the risk of Parkinson’s disease.”

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Huntington's Disease/Other Neurological Disorders on The Rise as Well

• The prevalence of Huntington’s disease, another neurological disorder – may need to be revised upwards as
genetic markers point to a statistically significant increase among the general population.

• Although there are numerous stories of sick people and health-challenged children receiving assistance from
CBD – we truly feel that healthy people can take a daily “maintenance regimen” and then potentially avoid
some of the potential degenerative risks that are mentioned in the Mayo Clinic’s article.

• We believe that this trend exists beyond the article and into other neurological disorders – as we are
continually challenged by our environment, our excessive usage of cell phones and other factors.

• Please see this article for more on this alarming trend.

73
“New” Forms of Toxic Exposure to Humans

Cell Phone and Electro-Magnetic Stressors Affect Our Health


• Cell Phone Radiation is Carcinogenic
• TV, Microwave, Military, Airport and Medical EMF’s
• Our bodies act as antenna picking up EMF
• EMF weakens our Central Nervous System

74
Cell Phone Radiation

Two new major studies from the National


Institutes of Health (NIH) are suggesting
that cell phone radiation can pose a risk of
certain cancers. The pair of studies are the
largest the National Toxicology Program
has ever conducted about the carcinogenic
effects of cell phone radiation.1 (It was
their preliminary findings that caused
California to issue their warning.)

Although the authors admit more study is


needed, the findings are concerning.

Link found here


75
Cell Phone Radiation

“ Smartphones and other wireless devices


put out small amounts of low frequency
microwave radiation when they connect
networks and transmit information.

This energy is not nearly as strong as


ultraviolet radiation or X-ray energy, but
the new studies add to the mounting


evidence that even microwave radiation,

in high doses, can pose some health risks.

Microwave radiation works by heating water. Muscle tissue, like the heart, is 75 percent water. So, if the cancer
was shown in rats, the risk is even higher for humans because- rather counter intuitively- bigger animals are
more sensitive to radiation. (Which is why pregnant female rats were also more sensitive to radiation.)

Link found here 76


“New” Forms of Toxic Exposure to Humans

Environmental Toxins
• Air pollution, particulate matter
• Agricultural Toxins
• Pesticides & Herbicides show
up in urine samples
• Dr. Mercola says “Monsanto is
Inside Everything”

77
Monsanto is Inside Everything

Glyphosate (an agricultural chemical) is


showing up virtually everywhere: in blood
and urine samples, breast milk, drinking
water, and more…

Wheat, oats, lentils, potatoes and many


other crops may be sprayed with
glyphosate just days prior to harvest…

78
Link found here
Environmental Neurotoxins

Exposure to the (commonly used in agriculture)


herbicide known as Paraquat is associated
with an increased risk of Parkinson’s disease.
Exposure to these types of environmental
toxins… can contribute to neurodegeneration.

Link found here 79


“New” Forms of Toxic Exposure to Humans

Sugar
• Artificial Sugar / Aspartame
is a proven Neuro-Toxin

Before CBD we had no real way to protect ourselves from environmental damage to
our central nervous system. Now we have a fighting chance, thanks to the researched
neuro-protective effects of cannabinoids.
80
A Company of Firsts®

• Medical Marijuana Inc. was the FIRST publicly traded company in the US to engage with the
legal cannabis space.

• We created the CBD hemp oil category along with the FIRST pipeline from Europe, and
introduced the FIRST natural botanical hemp-based CBD products into US markets.

• We were the FIRST to bring legal cannabis product into Brazil, Puerto Rico (where we now
hold 12 product registrations), and now Mexico.
• First in Direct Selling

• We take our place in history very seriously because the path we blazed has
revolutionized the way people think about both hemp and cannabis.

• In short: the legal hemp-based CBD industry in the United States did not exist until
Medical Marijuana Inc. and our subsidiaries developed it.

81
World Anti-Doping Standards

• Pure CBD is the first cannabis based


product that would qualify under World
Anti-Doping Standards in Direct Selling.

• These World Anti-Doping Standards


show that 207 compounds are banned.

• Our Pure CBD does not contain or metabolize


into ANY of these 207 compounds.

82
Post-Chemotherapy Dr. Abrams

• Pain, depression, nausea, vomiting, loss of


appetite, sleep

• Can Rx 6 different meds all with varying


side effects and potential harmful drug


interactions

• Or just Rx Cannabis

• CBD may have a significant role here

83
CBD Studies

If you were a parent, which product would you want your child to be taking...?

DR. AGUIRRE BOTANICAL CBD DR. DEVINSKY EPIDIOLEX


Informational Survey Pharmaceutical Grade CBD Formal
Pharma Study 2015

DOSING: DOSING:
• 1 - 4mg CBD/kg body weight 
 • 25 - 50mg CBD/kg body weight 

Not taken every day Taken daily

MEDIAN SEIZURE REDUCTION MEDIAN SEIZURE REDUCTION


REPORTED: REPORTED:
• 67% reduction in motor seizures • 36.5% reduction in motor seizures
• Also note that 67% report better than a • No reports of over 50% 

50% reduction in seizures in the 
 seizure reduction
Aguirre Study

84
CBD Studies

DR. AGUIRRE BOTANICAL CBD DR. DEVINSKY EPIDIOLEX


Informational Survey Pharmaceutical Grade CBD
Formal Pharma Study 2015
QUALITY OF LIFE IMPROVEMENTS: QUALITY OF LIFE IMPROVEMENTS:
• 83% improvement in Emotion • None reported
• 88% improvement in Cognition • None reported
• 77% improvement in Sleep • None reported
• 60% improvement in Appetite/Feeding • None reported
SIDE EFFECTS, ADVERSE: SIDE EFFECTS, ADVERSE:
• None reported • 30% experienced Serious Adverse Events
including one death
SIDE EFFECTS, MODEST:
• 19% increase in appetite SIDE EFFECTS, MODEST
• 9.5% fractionated sleep • None reported
• 7.5% flatulence
• 5.6% diarrhea

85
CBD Studies

If you were a parent, which product would you want your child to be taking...?

DR. SAÚL GARZA MORALES DR. DEVINSKY EPIDIOLEX


Lennox Gastaut Syndrome Pharmaceutical Grade CBD Formal
Pharma Study 2015

DOSING: DOSING:
• 5-7mg CBD/kg body weight Not • 25 - 50mg CBD/kg body weight
taken every day
 Taken daily
MEDIAN SEIZURE REDUCTION MEDIAN SEIZURE
REPORTED: REDUCTION REPORTED:
• 86% reduction in motor seizures • 36.5% reduction in motor
seizures
• Note that 55% report better than a
75% reduction in seizures • No reports of over 50%
seizure reduction
• 13% Report a Full or 100% Elimination
of ALL Seizures Over a 4 Month
Period

86
CBD Studies

DR. SAÚL GARZA MORALES DR. DEVINSKY EPIDIOLEX


Lennox Gastaut Syndrome Pharmaceutical Grade CBD
Formal Pharma Study 2015

QUALITY OF LIFE IMPROVEMENTS: QUALITY OF LIFE IMPROVEMENTS:


• 43% improvement in Alertness • None reported
• 40% improvement in Social Interaction • None reported
• 30% improvement in Attention • None reported
SIDE EFFECTS, ADVERSE: • None reported
• None reported SIDE EFFECTS, ADVERSE:
CONCLUSION: • 30% experienced Serious Adverse Events
• Treatment with cannabidol is a good including one death
alternative for patients with LGS SIDE EFFECTS, MODEST
• None reported

87
Stanford University Study Points to Endocannabinoid Deficiency

as Cause of Alzheimer’s

• A new study led by investigators at the


Stanford University School of Medicine has
implicated the blocking of endocannabinoids 

— signaling substances that are the brain’s
internal versions of the psychoactive
chemicals in marijuana and hashish — in the
early pathology of Alzheimer’s disease.

88
“Great spirits have
always encountered
violent opposition from
mediocre minds.”

- Albert Einstein

89
The Remake of Hemp Vap
Although preferred by the younger generation for "entertainment" we have
seen great anecdotal feedback from the Kannaway Brand Ambassadors.

It is extremely exciting to show this new product now with:


* 100 mgs CBD in the new cartridge
* Refill cartridges available
* More CBD, More "puff for your buck"
* Potential Health & Wellness Benefits too..!

90
Everyone Breathes
An often overlooked characteristic of all living humans is that we all breathe and
can potentially benefit from this unique "delivery method".

A medical researcher at Temple University mentions that "all pharmaceutical


medications should be inhaled by vaporization" as this would not go through the
digestive tract. Here, the liver metabolism creates havoc with traditional
pharmaceutical medications - thus "unwanted side effects" of many traditional
medications. 

We are looking at clinical research and development programs with this type of
Vaporized delivery - and we look forward to hearing your anecdotal stories of
success with patients.

91
Vape Shows Immediate Uptake

Immediate health and wellness effects can be seen - particularly in terms of


relaxation and focus. The lungs have CB1 receptor sites and potential immediate
entry into the cardio-pulmonary system may hold future "therapeutic" promise.

Potentially there are benefits for the brain as well, again with the seemingly
"immediate uptake". 

Our research will show this potential benefit and to this, we have hired a
pedigreed pharmaceutical development expert to assist us in better quantifying
these health and wellness benefits. We look forward to further presentations to
our growing team of Kannaway Brand Ambassadors...! 

92
Hemp Vap Terpenes and Info
HempVAP New Cartridge Contains:
100 mgs CBD in the new HempVAP cartridge

Pure CBD Oil plus MCT Oil

Essential Oils:
• Alpha-Pinene
• Myrcene
• Limonene
• Linalool

NONE OF THESE:
• Propylene-glycol
• Glycerin
• Other additives
93
Hemp Vap Terpenes
Our new HempVAP line contains the following common
Cannabis Plant terpenes:

Alpha-Pinene Myrcene Limonene Linalool

94
Hemp Vap Terpenes
Alpha-Pinene (Pine trees – characteristic scent; found in Rosemary and Cannabis)
Characteristics:
• Pine scent, a common terpene in the plant world
• Found in cannabis marijuana strains: Jack Herer and Bubba Kush

Notes:
CRUCIAL for humans as it forms the base for increased CB2 receptor (immune system) activity in our
Endogenous Cannabinoid System

Uses:
Bronchodilator by increasing airflow to the lungs

95
Hemp Vap Terpenes
Myrcene (the most abundant of the cannabis terpenes)

Characteristics: Medicinal application:


• Found in hops, heavily hopped beers, basil, • Increases the permeability of brain cells
mango’s and cannabis membranes to cannabinoids
• Responsible for the “sleep / couch-lock” • Sedative properties
effect of cannabis, especially in edibles
• Many cannabis users eat a ripe mango ½
hour before consuming cannabis
• This increases the “effect” of cannabis

Notes:
Folk remedy for diabetes, dysentery, diarrhea,
and hypertension

Uses:
Has been shown to synergize the anti-biotic
potential of other terpenes
96
Hemp Vap Terpenes
Limonene (rinds of the citrus fruit) but common to be found in cannabis

Characteristics:
Citrus odor and flavor

Notes:
Stimulates the immune system in potential anti-cancer benefits, particularly Glioblastoma

Uses:
Used in perfumes and household cleaners

Medicinal applications:
• Promotes weight loss
• Aids in Digestion
• Prevents gastric distress
• Anti-fungal
• Aids with mood health
• Helps reduce stress & tension
97
Hemp Vap Terpenes
Linalool (Lavender Plant) – found in cannabis

Characteristics:
Carries a distinct scent and flavor

Notes:
• Linalool is crucial in the body’s production of
Vitamin E which improves immune function
• GW Pharmaceutical’s Sativex product
contains significant amounts of Linalool
• Cannabis strain Grandaddy Purp contains
significant amounts of Linalool

Uses:
Used in aromatherapy as a sleep aid, relaxant
and reduce stress & tension

98
Kannaway Pure Gold - Liquid MCT Oil

Full-spectrum hemp-based CBD oil, meaning that there


are significant amounts of “entourage botanicals” (i.e.
terpenoids, flavonoids, plant waxes, chlorophyll, etc.) but
THC-FREE. Thus safe for those who are regularly drug
screened / tested.

This golden colored, high CBD oil is combined with


medium-chain triglyceride oil to create a shelf-stable,
easy to pour liquid that is safe for use by your entire
family. Kannaway Pure Gold Liquid is an excellent daily
source of CBD, essential vitamins, minerals, fatty acids,
fiber and protein.

99
Kannaway Pure Gold - Liquid MCT Oil

Our product is decarboxylated as well as filtered


to remove some of the plant material, thus Supplement Facts
concentrating the CBD to approximately 24%. Serving Size: 3/4 tsp
Servings Per Bottle: Approx. 32
Each bottle contains 1000 mgs CBD.
Amount Per Serving %DV
from stalk of hemp plant
Suggested serving size is ¾ teaspoon once or Cannabidiol (CBD) 31 mg †
twice daily. Each serving provides 31 mgs CBD.
Medium Chain Triglycerides 3g†

1 Serving per day = a 30-day supply Sugar 0 mg 0% Fu


2 Servings per day = a 15-day supply. † Daily Value not established

% Daily Values are based on a 2,000 calorie


diet.

In order to preserve
freshness, keep away from
heat, light and humidity.

100
Kannaway SuperGreens
Kannaway SuperGreens Powder includes 40+ nutritional
ingredients including:
Healthy Greens Blend
Antioxidant Blend
Fiber Blend
Probiotic / Digestive Blend
Bi-Bong Herbal Digestive Blend

AMAZING to have all these ingredients in ONE PACKAGE –


this could easily have been five different powdered
formulations – all with SIGNIFICANTLY HIGHER COST.
Kannaway SuperGreens offers more than 40 different
Superfoods along with nutrient dense ingredients to boost
your lifestyle.

101
Kannaway SuperGreens
Serving: Simply put one scoop of SuperGreens into 8
Super Green Alkaline Blend (5.6 grams)
oz. of your favorite beverage: water, fruit juice, milk, Organic Spirulina, Organic Wheat Grass, Organic Supplement Facts
Barley Grass, Organic Alfalfa Grass, Broccoli, Serving Size: 1 Scoop
etc. With a few seconds of time and minimal effort, Organic Spirulina, Organic Spinach, Organic
Chlorella (Cracked Cell Wall), Kale, Organic Kelp Servings Per Bottle: about 30
(8 grams)

you will be adding 40 + nutritional ingredients to your Antioxidant Boosting Blend (1.2 grams)
Amount Per Serving %DV
daily health and wellness routine. Acai, Organic Maca, Carrot, Organic Beet,
Organic Moringa Leaf, Organic Rosehips, Apple, Calories 20
n
Pineapple, Organic Turmeric, Organic Black Calories from Fat 0*
Pepper
Total Carbohydrates 3g 1%
NO SUGAR added, naturally sweetened with stevia for Super Fiber Blend (700 mg) Sugars (Total Sugar) <1g †
Organic Hemp Flour, Organic Flax Seed, Organic
a wonderful taste and flavor. The Bi-Bong addition of Chia, Apple Pectin Protein 2g 4%
Sodium 60mg 2%
digestive herbs adds to the unique benefit of our Probiotic Gut Health Blend (67 mg)

SuperGreens
Lactobacillus Acidophilus, Protease (Aspergillus
Potassium 160mg 5%
Iron 2.06mg* 10%
product. Vitamins, minerals, fiber and protein are now
S
oryzae), Lipase (Aspergillus niger), Cellulase
(Aspergillus niger), Amylase (Aspergillus oryzae), Calcium 52.5mg 5%
simple to get in an effortless way. Today’s food is FOS (Fructooligosaccharides from Chicory Root) Vitamin K
Vitamin C
78mcg
125mg
100%
210%
Simple.
seriously Clean.
deficient Nutritious.
in vitamins and minerals, thus Bi-Bong Vitality Herbal Blend (250 mg)
Green Tea Extract, Organic Atractylodes, Organic
Vitamin A (as beta carotene)
Dietary Fiber
1211 IU
2g
25%
8%
Licorice Root, Organic Ginseng, Organic
Kannaway offers a wonderful nutritional product to Astragalus, Organic Goji Berry, Organic Reishi,
† Daily Value not established
% Daily Values are based on a 2,000 calorie diet.
Organic Lovage Root, Organic Angelica (Dong
add health and wellness to your lifestyle. Quai) Root, Organic Aged Orange Peel, Organic
In order to preserve freshness, keep
Cinnamon, Organic Peppermint away from heat, light and humidity.
Other ingredients: Silica, Stevia Extract Kannaway.com
All Natural
NET WT. 8 OZ.

102
Industry Advances

Randy & Samantha Schroeder have


achieved the rank of Crown Ambassador
Elite, Achieving $1 Million in monthly
business volume.

Link found here 103


104
®

TM