QUIZ NPNs

1. Urea is produced from: d. If the plasma Urea concentration is

a. Oxidation of pyrimidines decreased
b. Oxidation of purines 7. Congestive heart failure (A)
c. The catabolism of proteins and amino 8. Dehydration (A)
acids 9. Urinary tract obstruction (C)
d. The breakdown of complex 10. Liver disease (D)
carbohydrates 11. Renal calculi (B)
2. Which product is measured in the coupling step 12. It is the final breakdown of purine catabolism in
of the urease- UV method for BUN? humans and is considered as a weak acid.
a. CO2 a. Blood Urea Nitrogen
b. Dinitrophenylhydrazine b. Blood Uric Acid
c. Diphenylcarbazone c. Creatinine
d. NAD+ d. Ammonia
3. In the ultraviolet enzymatic method for BUN, the 13. A disease found primarily in males manifested by
urease reaction is coupled to a second enzymatic pain and inflammation of the joints.
reaction using: a. Gout
a. AST b. Acute Inflammatory Arthritis
b. Glutamate dehydrogenase c. Nephrolithiasis
c. Glutamine synthetase d. Hyperuricemia
d. ALT 14. Uric acid is derived from the following EXCEPT:
4. Urea concentration is calculated from the BUN by a. Catabolism of ingested nucleoproteins
multiplying by a factor of: b. Catabolism of exogenous
a. 0.5 nucleoproteins
b. 2.14 c. Directs transformation of endogenous
c. 88.4 purine nucleotides
d. 0.059 d. AOTA
5. Which of the statements below about serum urea 15. Disease correlated to hyperuricemia involving the
is the? deficiency of hypoxanthine- guanine
a. Levels are independent of diet phosphoribosyl transferase.
b. Urea is not reabsorbed by the renal a. Chronic Renal Disease
tubules b. Gout
c. High BUN levels can result from necrotic c. Lesch- Nyhan Syndrome
liver disease d. Waldenstrom’s macroglobulinemia
d. BUN is elevated in prerenal as well as 16. Uric acid is stable in both serum and urine for 3
renal failure days at room temperature.
6. Decreased renal function due to damage of a. True
filtering structure of kidney cause increased blood b. False
urea due to poor excretion. 17. Fasting sample is preferred to analyze blood
a. Renal Azotemia specimen for uric acid.
b. Pre renal Azotemia a. True
c. Post renal Azotemia b. False
d. Uremia 18. Hyporuricemia is seen in case of:
a. Fanconi’s syndrome
With the following conditions, choose: (7- 11) b. Hodgkin’s disease
c. Both A and B
a. If the plasma Urea concentration is d. Neither A and B
increased due to Pre- Renal azotemia
b. If the plasma Urea concentration is 19. It is considered as the reference method for BUA
increased due to Renal azotemia determination.
c. If the plasma Urea concentration is a. Caraway Method
increased due to Post- renal azotemia b. IDMS Method
QUIZ NPNs
c. Folin- Brown Method d. Not significant to measure
d. Uricase Method 29. Specimen used for creatinine clearance
20. It is major product of adenine and guanine measurement
catabolism. a. Random urine specimen
a. Blood Uric Acid b. 1st morning urine specimen
b. Urea c. afternoon urine specimen
c. Ammonia d. 24 hours urine specimen
d. Creatinine 30. How does ammonia formed?
21. In Jaffe reaction, creatinine reacts with: a. From deamination of proteins
a. Alkaline sulfasalazine solution to b. From deamination of amino acids
produce an orange yellow complex c. From nucleic acid catabolism
b. Potassium iodide to form a reddish d. AOTA
purple complex e. NOTA
c. Sodium nitroferricyanide to yield a 31. Which of the following statements is NOT true
reddish brown color about ammonia?
d. Alkaline picrate solution to yield an a. It is produced by bacterial catabolism in
orange red complex gastrointestinal tract
22. Creatinine clearance is used to estimate the: b. It is toxic
a. Tubular secretion of creatinine c. It is not normally found in plasma
b. Glomerular secretion of creatinine d. NOTA
c. Renal glomerular and tubular mass e. AOTA
d. Glomerular filtration rate 32. Ammonia is converted to urea in which body
23. Which organ synthesizes creatine? organ?
a. Intestines a. Kidney
b. Pancreas b. Liver
c. Liver c. Blood
d. Kidney d. Lungs
24. Plasma creatinine is inversely related to GFR. e. AOTA
a. True 33. Ammonia is excreted as ammonium ion by which
b. False organ?
25. Plasma creatinine is directly proportional to a. Kidney
creatinine clearance. b. Liver
a. True c. Blood
b. False d. Lungs
26. In pre- renal azotemia, creatinine levels are
expected to be:
a. Normal
b. Increased
c. Decreased
d. Not significant to measure
27. In renal azotemia, creatinine levels are expected
to be:
a. Normal
b. Increased
c. Decreased
d. Not significant to measure
28. In post- renal azotemia, creatinine levels are
expected to be:
a. Normal
b. Increased
c. Decreased