Professional Documents
Culture Documents
F-Xavier Lescure
Infectious dieases specialist
Bichat hospital, Paris
Antibiotics
Prescription right
3 Lescure - Antibiotherapy
Antibiotics, main principles for efficacy
Optimal Reconsider
dosing allergy notion
4 Lescure - Antibiotherapy
Antibiotics, main principles for control damage
Asymptomatic bacteriuria
Fever alone
Biological inflammation alone
6 Lescure - Antibiotherapy
Antibiotics, improvement by duration
≤ 1 week of treatment
Pneumonia
Urinary tract infection in women
Non-necrotizing skin and soft tissue infections
Diarrhea (except C. difficile colitis)
Bacteremia (except due to S. aureus)
The majority of operated infections
7 Lescure - Antibiotherapy
Antibiotics, improvement by ecological vision
Broad or
Gut elimination anaerobes including
spectrum of activity
Carbapenems
3GC Fluoroquinolones
Metronidazole Clindamycin
BL + inhibitors
8 Lescure - Antibiotherapy
Antibiotics, some examples of overuse
Community
ATB treatment in pharyngitis or rhinosinusitis
25-30 % Glinz D et al . JAC 2017
Hospital
ATB treatment of asymptomatic bacteriuria
45 % Flokas ME et al . OFID 2017
9 Lescure - Antibiotherapy
Antibiotics, human consumption 2005-2014, OECD
UnitedDefined
KingdomDaily
ATB planDose
sinceper
2013
Dedicated funding
1000
Franceinhabitants
ATB planper day2002
since
No dedicated funding
OECD 2016
10 Lescure - Antibiotherapy
Antibiotics, carbapenems consumption, 2005-2010
Pakistan
Egypt
India
11 Lescure - Antibiotherapy
Antibiotics, new drug application approvals…
ATB R&D ?
ATB alternatives ?