Department of Biological Sciences

College of Science
University of Santo Tomas

Course Number & Title: Bio 205-Lec

Fundamental Genetics-Lecture

Grading Scheme Class Standing - 50%

Preliminary / Final examination - 30%
Course Inquiry Project - 20%

Course Outline
Unit 1: The science of genetics Unit 9: DNA Structure and Analysis
A. Definition and scope A. Characteristics of the genetic material
B. Historical background B. DNA as the genetic material
C. Molecular basis of genetics C. Structural analysis of DNA
D. Approaches in genetics study D. The Watson and Crick model
E. Genetics and human affairs E. Forms of DNA
Unit 2: Physical basis of heredity F. Analysis of DNA/RNA
A. Cell structure Unit 10: DNA replication and Synthesis
B. Chromosome structure and numbers A. DNA replication
C. Mitosis and cell division B. DNA polymerases
D. Cell cycle control C. Telomeres and telomerase
E. Meiosis and sexual reproduction D. DNA recombination
F. Spermatogenesis and oogenesis Unit 11: Chromosome Structure
Long Examination 1 A. Viral and Bacterial Chromosomes
Unit 3: Mendelian genetics B. Mitochondria and chloroplast DNA
A. Gregor Mendel C. Chromosomes in eukaryotes
B. Monohybrid cross D. Eukaryotic genomes
C. Dihybrid, trihybrid & polyhybrid cross Long Examination 5
D. Mendel’s postulates Unit 12: Genetic Code and Transcription
Unit 4: Modifications of Mendelian inheritance A. The genetic code
A. Incomplete dominance B. Transcription in prokaryotes and eukaryotes
B. Codominance C. Post-transcriptional modifications
C. Multiple alleles Unit 13: Translation and Proteins
D. Lethal genes E. Translation in prokaryotes and eukaryotes
E. Gene (factor) interaction F. Protein structure and biological diversity
F. X-linked genes G. Post-translational modifications
G. Sex limited & sex-influenced inher. Long Examination 6
Long Examination 2 Unit 13: Gene mutations and DNA repair
Unit 5: Sex determinations & sex chromosomes A. Classifications of mutations
A. Sexual differentiation and life cycles B. Detection of mutation
B. X and Y chromosomes C. UV and high energy radiation
C. Sex determinations D. Mutations in humans
D. Sexual abnormalities E. Detection of mutagenecity
E. Sex ration in humans F. Repair systems for DNA damage
Unit 6: Quantitative genetics G. Site-directed mutagenesis
A. Polygenic inheritance H. Knock-out genes and transgenes
B. Continuous and discontinuous traits I. Transposable genetic elements
C. Analysis of polygenic traits Unit 14: Regulation of gene expression
Long Examination 3 A. Lac operon
Unit 7: Chromosomal aberrations B. Trp operon
A. Variation in chromosome no. C. Regulatory elements and transcription factor
B. Non-disjunction D. Gene regulation by steroid hormones
C. Monosomy E. Post-transcriptional regulation
D. Trisomy Long Examination 7
E. Polyploidy Unit 15: Population genetics
F. Deletions A. Populations and gene pools
G. Duplications B. Allele frequencies
H. Inversions C. The Hardy-Weinberg Law
I. Translocations D. Factors affecting allele frequencies
J. Fragile sites in human chromosomes E. Natural selection
Unit 8: Linkage and chromosome mapping F. Mutation
A. Linkage vs independent assort G. Migration
B. Incomplete linkage H. Genetic drift
C. Crossing over & chromosome mapping I. Non-random mating
D. Three-point cross Long Examination 8
E. Determining gene sequence Final Examination
F. Interference and coefficient of coincidence
Long Examination 4
Preliminary Examination

Textbook
Klug, W.S., et al.. Essentials of Genetics, (9th edition). Pearson Education Pte Ltd, Singapore.

John Donnie A. Ramos, Ph.D.

Email: jaramos@yahoo.com

Department of Biological Sciences Molecular Diagnostics Lab (Rm. 708)

College of Science Central Laboratories
University of Santo Tomas Research Center for the Natural and Applied
Espana, Manila, Philippines Sciences, University of Santo Tomas
Tel. No. 4061611 / 7313101 local 8297 Tel.No. 4061611 / 7313101 local 4056