Inadequate ventilation resulting from the inability of the lungs to Ashen skin adequately maintain arterial oxygenation or eliminate carbon Rapid breathing dioxide Cold, clammy skin Pathophysiology Asymmetrical chest movement Primarily hypercapnic respiratory failure: Results from inadequate alveolar Decreased tactile fremitus over obstructed bronchi or a pleural ventilation effusion Primarily hypoxemic respiratory failure: Results from inadequate Increased tactile fremitus over consolidated lung tissue exchange Hyperresonance of oxygen between the alveoli and capillaries Diminished or absent breath sounds Combined hypercapnic and hypoxemic respiratory failure common Wheezes (in asthma) Causes Rhonchi (in bronchitis) Accumulated secretions secondary to cough suppression Crackles (in pulmonary edema) Airway irritants Diagnostic test results Any condition that increases the work of breathing and decreases Laboratory the respiratory drive of patients with chronic obstructive pulmonary ABG analysis reveals hypercapnia and hypoxemia. disease Serum white blood cell count is increased in bacterial infections. Bronchospasm Serum hemoglobin and hematocrit show decreased oxygen- carrying Central nervous system depression capacity. Endocrine or metabolic disorders Serum electrolyte results reveal hypokalemia and hypochloremia. Gas exchange failure Blood cultures, Gram stain, and sputum cultures show the Heart failure pathogen. (See Identifying respiratory failure.) Myocardial infarction (MI) Imaging Pulmonary emboli Chest X-rays may show underlying pulmonary diseases or Respiratory tract infection conditions, such Thoracic abnormalities as emphysema, atelectasis, lesions, pneumothorax, infiltrates, and effusions. Ventilatory failure Diagnostic procedures Incidence Electrocardiography may show arrhythmias, cor pulmonale, or Acute respiratory failure occurs in patients with hypercapnia or myocardial hypoxemia. ischemia. The disorder occurs in patients who have an acute deterioration Pulse oximetry may show decreased arterial oxygen saturation. in arterial blood gas (ABG) values. Pulmonary artery catheterization may show pulmonary or cardiovascular Complications causes of acute respiratory failure. Tissue hypoxia Identifying respiratory failure Chronic respiratory acidosis Use these measurements to identify respiratory failure: Metabolic alkalosis vital capacity less than 15 cc/kg Respiratory and cardiac arrest tidal volume less than 3 cc/kg Assessment negative inspiratory force less than –25 cm H History respiratory rate more than twice the normal rate 2 Precipitating events O Infection diminished partial pressure of arterial oxygen despite increased Accumulated pulmonary secretions secondary to cough fraction of suppression inspired oxygen
Trauma elevated partial pressure of arterial carbon dioxide, with pH
lower than MI 7.25. Heart failure Pulmonary emboli Exposure to irritants (smoke or fumes) Myxedema Metabolic acidosis Physical findings Cyanosis of the oral mucosa, lips, and nail beds Yawning and use of accessory muscles