Professional Documents
Culture Documents
Phosphorylation may occur on serine, threonine, tyrosine, and histidine residues in eukaryotic
organisms. Among these four types of phosphorylation, tyrosine phosphorylation is most rare,
but very crucial. The most famous tyrosine kinase receptor is in the very upstream of the
MAPK pathway, and regulates Ras and other kinase, initiating the phosphorylation cascade.
Creative Proteomics has established a highly sensitive HPLC-MS/MS pipeline that can
analyze multiple kinds of phosphorylation in both eukaryotic and prokaryotic organisms. In
addition, we have optimized our protocol, enabling more fast and sensitive site mapping
service for histidine and tyrosine phosphorylation.