1

2
3
4
5
6

DRUG
5-Fluorouracil
ACE Inhibitors (angiotensin
converting enzyme inhibitor)
Acute M.I. (to prevent cardiac
CLASS / INDICATION
Colon CA Stage III
Pancreatic CA
Left Ventricular failure,
remodeling, not as anti-
hypertensive)
7
EFFECTS/side effects/notes
This chemotherapeutic agent inhibits
thymidylate synthetase
Bradykinin-induced cough
Fetal renal agenesis
oligohydramnios
To be avoided in patients with renal
stenosis (Px with hypertension and
abdominal bruit)
 8

Acetazolamide Glaucoma A carbonic anyhydrase inhibitor

nd
(as 2 line drug)
st
(1 Line: Pilocarpine) Can cause hypochloremic, metabolic
acidosis: “acidazolamide”

ACTH Infantile spasm W est syndrome

Acyclovir Herpes infection

Allopurinol Chronic Gout Can cause Steven-Johnson’s

syndrome

Inhibits Xanthine oxidase

Alphaprodine Potent pain reliever/Analgesic Sinusoidal Fetal heart rate: Pattern

Alphaprodine (Nisentil) doses of 1
mg/kg has been found to reduce
both the respiratory rate and
minute volume
that occurs with maternal use of this
drug  indicates fetal compromise;
an ominous sign
a regular, smooth, undulating form typical
of a sine wave that occurs with a
frequency of two to five cycles per minute
and an amplitude range of five to 15
bpm. It is also characterized by a stable
baseline heart rate of 120 to 160 bpm
and absent beat-to-beat variability

Aluminum hydroxide antacid “ayaw lumabas”: constipation

Amiodarone Class I & III anti-arrhythmic can cause

For ventricular tachycardia
Pulmonary Fibrosis (also
Bleom ycin & Busulfan:
antineoplastics for leukemia),
Hypo/Hyperthyroidism,
Hepatotoxicity

Blocks Na and K channels

Aminoglycosides Ototoxicity
Nephrotoxicity

Anesthetic induction agents Propofol

Midazolam
Sodium thiopental

Anti-helminthics Albendazole Echinococcus granulosus

Strongyloides stercoralis

Bithionol Fasciola hepatica

Iodoquinol Balantidium coli

Metronidazole Entamoeba hystolytica – amoebiasis

Giardia lamblia - giardiasis
Trichomonas vaginalis-
trichomoniasis
Clostridium difficile overgrowth
(clindam ycin side effect)-
pseudomembranous colitis
Gardnerella vaginalis- bacterial
vaginosis
Helicobacter pylori - PUD
 9

Mebendazole/Pyrantel pamoate Enterobius vermicularis

Ascaris lumbricoides
Ancylostoma duodenale
Necator americanus

Niclosamide (very old drug) Tapeworms

Praziquantel (newer) Tapeworms

Quinacrine best drug for Giardia lamblia; also for

tapeworms

Sodium stibogluconate Leishmania donovani, Sandflies

Thiabendazole Trichinella spiralis

Anti-TB drugs Dapsone Hemolytic anemia

A PABA antagonist

Ethambutol Barrel vision

Optic neuritis
Red-Green blindness
st
(1 Line)

INH Drug-induced Hepatitis

(Isonicotinic Hydrazine)
(even for pregnant patient)
Peripheral neuropathy: numbness
Blocks Pyridoxine/Vit.B6
SLE-like syndrome/ drug-induced
lupus
Metabolite: Acetylhydrazine
Antacids impair the absorption of
INH
st
(1 line)

Pyrazinamide Hyperuricemia

Rifampicin Orange colored body fluids

Prophylaxis for: Meningococcemia
(alt: Ciprofloxacin)
Blocks RNA Polymerase
st
(1 Line)
nd
Streptom ycin 2nd line anti-TB
Ototoxicity, Nephrotoxicity

APLASTIC Chloramphenicol
Phenytoin
ANEMIA Quinine
Carbamazepine
Felbamate
Phenylbutazone
PTU
Benzene

Asparaginase ALLeukemia

Aspirin (Salicylates)  Acute M.I. “Irreversibly” binds COX-1and

 Colon Ca modifies enzymatic activity of COX2
Inhibits platelet aggregation 
Thromboxane A2
Can cause gastric irritation  PUD

 Coronary Artery Disease Reye’s syndrome (if given to children

in Kawasaki disease with a viral disease, e.g. chicken
pox)
 10

ARB Diabetes with proteinuria No bradykinin-induced cough as

(Angiotensin II Receptor side effect
Blocker)

Atropine (Pralidoxime) Anticholinergic (alkaloid) Can ↑ heart rate

Organophosphate poisoning
(pesticide/malathion)

Barbiturates Drug contraindicated in patient with

acute intermittent porphyria

Bepridil Anti-arrythmics Torsade de Pointes

and Sotalol

Betamethasone/Dexametha to induce Fetal Lung Maturity Given antenatally; most effective if

sone delivery occurs at least 24 hours
also reduce intraventricular after the first dose
hemorrhage
and neonatal mortality two doses of 12 mg bethamethasone
given 24 hours apart
Normal lecithin-sphingom yelin
ratio 2:1 or four doses of 6 mg
dexamethasone given 12 hours apart

during premature labor, infants

between 24 and 34 weeks gestation

Bismuth sulfate H.pylori infection Can cause black stool which

(used to be) makes it difficult to distinguish from
melena

Bromocriptine Prolactinoma To reduce the size of adenoma and

prolactin secretion

A dopamine agonist

Bupivacaine Bupivacaine (Marcaine): local and Cardiac dysrhythmia fatal

regional anesthetic refractory dysrhythmia

The most cardiotoxic of all

local aesthesia

Cabergoline Prolactinoma Inhibits prolactin release

A dopamine agonist
Also used by a female when she
wants to cease breastfeeding

Carbamazepine Tic Doloreux/Trigeminal

Neuralgia
Partial seizures

Cefazoline Pre-operative prophylactic

antibiotic in abdominal surgery

Ceftriaxone DOC: Typhoid fever A Cephalosporin

(alternative: Chloramphenicol)

Celecoxib Arthritis with history of PUD Cox1 and Cox 2 inhibitors

 11

Chlorambucil CLL Least toxic & the slowest acting

among the alk ylating agents

Chloramphenicol Alternative drug for Typhoid fever Gray baby syndrome: because
of lack of glucuronyl transferase
Aplastic anemia (hypoplastic
bone marrow filled with fat)
Optic neuritis
Bone marrow suppression
Blocks the 50s ribosomal subunit

Cholestyramine Drug that will inhibit enterohepatic

circulation of bile acids and salts

Cilastatin Imipenem and cilastatin is used Inhibits renal

to treat severe infections of the
lower respiratory tract, skin,
stomach, female reproductive
organs, and other body s ystems.
dihydropeptidase
Imipenem is an antibiotic that fights
serious infections caused by
bacteria.

Cilastatin helps imipenem work more

effectively by preventing the
breakdown of the antibiotic in the
kidneys.

Cimetidine Prototype of H2 blockers Cytochrome p-450 inducer

Grapefruit can increase its
bioavailability
Gynecomastia

Cisplatin Platinum-based chemotherapeutic Ototoxicity

agent

Nasopharyngeal CA Cisplatin + 5-FU (mainstay Tx)

Bronchogenic CA Cisplatin + Cyclophosphamide +

Etoposide

Clomiphene Fertility drug A selective estrogen receptor

(induces ovulation) modulator (SERM) that
increases production of
gonadotropins by
inhibiting negative
feedback on the hypothalamus
Can cause multiple pregnancy

Cocaine, D.O.C. BY DRUG USERS!!! Dilated cardiomyopathy

Metamphetamine

Colchicine Acute Gouty Arthritis A mitotic spindle inhibitor:

Mediterranean Fever inhibits tubulin
Can cause diarrhea

Cox-Inhibitor Arthritis with history of PUD

 12

Cromolyn sodium Prototype of mast cell stabilizers used to treat the s ymptoms of a
condition called mastocytosis, which
can cause diarrhea, nausea,
vomiting, headaches, stomach pain,
itchy skin, and flushing (warmth or
redness under the skin)

Cyanide, Carbon monoxide Inhibits c ytochrome oxidase of the

ETC (level IV)

Cyclophosphamide Bronchogenic CA Hemorrhagic cystitis

(Ifosphamide) Antidote: N-acetylcysteine

Cytarabine Acute Myelogenous Leukemia Drug of choice

Danazole (Mestranol) Endometriosis

Dantrolene Malignant hyperthermia

Daunorubicin/Doxorubicin Antibiotic with Antineoplastic Cardiac toxicity

actions

Chemotherapy: leukemia,
hodgkin’s lymphoma, bladder
cancer

DEC W uchereria bancrofti Mazzotti reaction

(Diethylcarbamazepine)

DES Clear cell adenocarcinoma of the

(Diethylstilbestrol) vagina
(if exposed in utero): Butryoides

Deferoxamine/desferrioxami Iron toxicity A chelating agent used to remove

ne B excess iron from the body
Iron toxicity usually occurs is
Hemochromatosis, Hemosiderosis
and multiple blood transfusion

Desmopressin Diabetes Insipidus Drug of choice; long acting

Alt: Vasopressin (exogenous)

Diazepam Status epilepticus Drug of choice (in the book)

Digitalis / Digoxin Heart Failure From fox-glove plant

Hypokalemia triggers digitalis
toxicity
Antidote: Digibind/Fab fragments

DIHYDROFOLATE Methotrexate
Trimethoprim
REDUCTASE Pyrimethamine
INHIBITOR Proguanil
Sulfasalazine
JPC-2056 (an experimental
antimalarial)
 13

DISULFIRAM-LIKE Metronidazole
st
Tolbutamide (1 gen sulfonylurea)
REACTION Cefoperazone
Cefotetan
Griseofulvin
Temposil

Doxycycline Leptospirosis The tetracycline with the longest half

(prophylaxis and treatment in life (36 hours)
adults)
Not to be given in children!!!
DOC: STD, PID

Drugs for Alzheimer’s Donepezil Acetylcholineserase inhibitor

disease
Memantine Memantine is used to treat moderate
to severe dementia of the
Alzheimer's type.

Tacrine (a very old drug already)

improves the function of nerve cells
in the brain

works by preventing the breakdown

of a chemical called acetylcholine

People with dementia usually have

lower levels of Ach, which is
important for the processes of
memory, thinking, and reasoning.

Tacrine is used to treat mild to

moderate dementia caused by
Alzheimer's disease.

Echothiophate Acetylcholinesterase An ocular anti-hypertensive

Chronic Glaucoma

EDTA Lead poisoning Patient will present with a wrist drop

Dimercaprol

Epinephrine DOC: Anaphylactic shock

Ergotamine Migraine Drug of choice

Ethosuximide/Valproic acid Absence seizure

Etoposide Bronchogenic CA given with

Cisplatin/Cyclophosphamide

Fenofibrates DOC: Hypertriglyceridemia Do not give HMGCoA reductase right

away if the patient’s problem is only
the triglycerides

Fentanyl Very potent narcotic

MC drug of abuse by
anesthesiologists

Finasteride BPH 5-α reductase inhibitor

 14

Alopecia

Flumazenil W arfarin toxicity Used to reverse benzodiazepines

Furosemide Loop diuretic Inhibits the NaKATPase pump in the

DOC: Pulmonary edema thick ascending loop of Henle
(Px with CHF and frothy oral
secretions) Causes Ototoxicity and
hypokalemia

Gangcyclovir Cytomegalovirus

Glucocorticoids Glucocorticoids e.g. cortisol and Inhibits phospholipase A2 will

(methylprednisolone, cortisone, are essential for the ↓↓↓arachidonic acid
prednisolone, triamcinolone, utilization of carbohydrate, fat and
hydrocortisone, protein by the body and for normal Inhibits leukotrienes, the Slow
betamethasone, response to stress. Reacting Substance of Anaphylaxis -
dexamethasone) SRSA (Montelukast)
Naturally occurring and synthetic
glucocorticoids have very powerful
anti-inflammatory effects and are
used to treat conditions that
involve inflammation.

Halothane Anesthetic Hepatitis/liver toxicity

Also causes malignant hyperthermia,
like Succinylcholine

HEMOLYTIC Sulfonamides CONTRAINDICATED in:

Anti-malarial drugs
ANEMIA Dapsone G6 P D
Penicillin Sickle cell disease
Methyldopa
Mycoplasma pneumoniae

HMGCoA Reductase Increase the liver's ability to collect “Statins”

inhibitor and get rid of LDLcholesterol
("bad" cholesterol)
Increase HDL cholesterol
("good" cholesterol)
Decrease triglycerides
Atorvastatin
Rosuvastatin
Fluvastatin
Lovastatin
Grapefruit interfere with this enzyme;
much more medication than intended
reaches the bloodstream; grapefruit
juice can significantly increase the
levels of some statins in the blood

SE: Myositis (muscle pain)

Hydrocortisone DOC for Addison’s disease ↓aldosterone, ↓sex steroids, ↓cortisol

(primary chronic adrenocortical due to destruction of 90% of adrenal
insufficiency) cortex

Hydrox yurea Hemoglobin S disease  Reduces pain crisis

(sickle cell)  ↑ in the concentration of HbF
 Anti-inflammatory agent ↓
production of white cells
 ↑ in the mean red cell
volume
 Oxidized by the heme
groups to produce Nitric
 15

Oxide

Isoflurane Inhalational anesthesia that

is least toxic

IV Immunoglobulins DOC: Kawasaki disease Aspirin is also given for coronary

DOC: Guillain-Barre involvement in Kawasaki

Ketamine anesthetic Blocks glutamine, a neuroexcitatory

amino acid (same as Felbamate)
Dissociative anesthesia

Lactulose Hepatic encephalopathy Given to acidify the urine

Lamivudine Hepatitis B

Leuprolide/Flutamide DOC: Prostate cancer Leuprolide is also used for Tx of

gonadotropin-independent
precocious puberty: McCune
Albright syndrome

Levothyroxine Hypothyroidism acts like the endogenous

(by acting as a replacement for
natural thyroxine, s ymptoms of
thyroxine deficiency are relieved)
thyroid hormone thyroxine
(T4, a tetra-iodinated tyrosine
derivative)
In the liver and kidney, T4 is
converted to T3, the active
metabolite.
In order to increase solubility, the
thyroid hormones attach to thyroid
hormone binding proteins, thyroxin-
binding globulin, and thyroxin-binding
prealbumin (transthyretin).
Transport and binding to thyroid
hormone receptors in the cytoplasm
and nucleus then takes place.

Lidocaine Local and regional anesthetic
Lidocaine + Epinephrine:
For vasoconstriction ↓bleeding,
↓washing out of lidocaine ↑effect
It is acidic; therefore, does not work
in an acidic environment (e.g.
abscess)
Lidocaine duration of action: 30-60
minutes
w/ Epinephrine: up to 4 hours

Liothyronine Myxedema coma acts on the body to increase the

basal metabolic rate, affect protein
synthesis and increase the body's
sensitivity to catecholamines (such
as adrenaline)

The major form of thyroid hormone in

the blood is thyroxine (T4). This is
converted to the more active
liothyronine form (T3) by
deiodinases in peripheral tissues.

Lithium salts DOC: Bipolar disorder Diabetes insipidus

(DOC: Vasopressin/Desmopressin)
 16

Lugol’s iodine Pre-operative drug: thyroidectom y To decrease the gland vascularity

prior to surgery
Iodine’s effect on thyroid gland
vascularity and friability was
hypothesized to occur as a result of
increased colloid formation,
which would in turn lead to thyroid
enlargement and compression of
local thyroid vasculature and
lymphatics

Magnesium hydroxide antacid Can cause diarrhea: “Magtatae…”

Magnesium sulfate Pregnant ecclamptic Hydralazine for the BP

Mannitol For increased intracranial pressure Osmotic diuresis

Mebendazole Enterobius vermicularis

(pinworms)

Mercaptopurine Cell -cycle specific agent

Methotrexate Choriocarcinoma Inhibits tetrahydroflate reductase

Methoxyflurane Most potent inhalational anesthesia

Methyldopa Hypertension in Pregnanc y SLE-like syndrome

(not pre-ecclamptic) (also: INH, Hydralazine and
Procainamide)
Can cause a (+) Coomb’s test

Misoprostol (Cytotec) PUD PGE1 analog protects the gastric

mucosa
Abortifacient can cause
uterine contractions
The MC abortifacient in the
Philippines

Naloxone Opioid toxicity An opioid antagonist that binds to the

(Narcan IV) from morphine, opium poppy “mu receptors”

Pinpoint pupils: think of a

pontine bleed or opioid toxicity

Patient will have a shallow

respiration

Common in cancer patients on

palliative care (on morphine drip)

Nimodipine Subarachnoid Hemorrhage Nimodipine prevents

vasospasm
Alt: Papavirine

Nitrates/nitroglycerine Angina/chest pain Sublingual route to avoid the

 17

(not “Vagina Pectoris”) first pass effect

Decreases peripheral vascular
resistance by causing
venodilation

Nitrous oxide Anesthetic Diffusion anoxia

“laughing gas”
CONTRAINDICATIONS:
Pneumothorax
Small bowel obstruction
Middle ear occlusion

Ocreotide Acromegaly

OTOTOXICITY Aminoglycosides
Furosemide
Cisplatin
Streptom ycin

Penicillin Diptheria Hemolytic anemia

Leptospirosis (in children)
Syphillis

Pentostatin treatment of many A potent inhibitor of adenosine

lymphoproliferative malignancies, deaminase. (recall SCID and
particularly hairy-cell Diamond-Blackfan disease)
leukemia

Phenobarbital DOC: Seizure/ Epilepsy Absolutely contraindicated in

(not “Phenobarbiedoll”) (even in pregnanc y) Porphyria
DOC: Febrile seizure in children Induces Cytochrome p450
Generalized Tonic-Clonic seizure Blocks Na Channels

Phenoxybenzamine, Pheochromocytoma Alpha-blockers

Phentolamine

Phenytoin Class I anti-arrhythmic Fetal hydantoin syndrome: do

(Blocks the Na channels) not give to pregnant woman
Gingival hyperplasia
Pro-arrythmic effect (ironical)
Purple glove syndrome: phlebitis

Prazosin/Terazosin DOC: BPH An α-1 blocker

Can cause orthostatic/first
dose hypotension

Probenecid Gout A uricosuric drug ↑urine excretion

Hyperuricemia of uric acid

Propranolol  ß-Adrenergic symptoms of Anti- anginal drug which causes

Grave’s disease impotence


st
1st line drug for Migraine also Ergotamine or Sumatripan

Propylthiouracil (PTU) Hyperthyroidism

Grave’s disease
Thyroid storm
 18

Protamine sulfate Heparin toxicity

Pyridostigmine Myasthenia Gravis inhibits acetylcholinesterase

(Mesthinone)
MG: Decreased neuromuscular
transmission due to antibodies
against the Nicotinic receptors
in the synaptic cleft by competing
with acetylcholine for attachment to
acetylcholinesterase, thus slowing
down the hydrolysis of
acetylcholine, and thereby
increases efficiency of
cholinergic transmission in
the neuromuscular junction and
prolongs the effects of
acetylcholine

Alt: Neostigmine (shorter duration of

action than pyridostigmine)

Pyrimethamine Sulfadoxine Toxoplasmosis A dihydrofolate reductase inhibitor

(Fansidar) (just like methotrexate)
also for Chloroquine-resistant
malaria spp.

Quinidine/Quinine Malaria A class I anti-arryhtmic

Can cause cinchonism

Reserpine Anti-hypertensive Sensorial changes

Sympathetic nerve terminals Suicidal ideations
(blocks NE uptake) Mental depression

Scopolamine Anticholinergic (alkaloid) Twilight sleep

Depresses the CNS  fatigue,
For anti-motion sickness hypnosis, amnesia

SLE-LIKE INH
Methyldopa
SYNDROME Hydralazine
Procainamide

Sodium nitroprusside DOC: Hypertensive Cyanide and Thiocyanate

emergency toxicity (Antidote: Na Thiosulfate
in order to induce Methemoglobin)

Dilates both venules and arterioles

sudden drop of BP

Sodium pentothal Lethal injection A barbiturate

Sodium stibogluconate Leishmania donovani Inhibits Phosphofructokinase

Spironolactone K-sparing diuretic An aldosterone antagonist

Can cause hyperkalemia and
gynecomastia

Statins Myositis
 19

Streptozocin Islet Cell tumors

Succinylcholine  Depolarizing  Block nicotinic receptors at

neuromuscular blocking
agent
 Used in surgical
procedures, intubation
Can also result in:
Life-threatening hyperkalemia,
increased intraocular pressure
the NMJunction
 No CNS effect
 Malignant
hyperthermia
 Antidote: IV Dantrolene
CONTRAINDICATIONS:
Patients with burns, neuromuscular
disease/paraplegia, eye trauma,
increased ICP

Sucralfate PUD MOA: forms a protective coat over

the ulcer bed; cytoprotector
Safe to use in pregnancy

Sulfonamides Absolutely contraindicated

(Sulfa drugs) in G6PD, PFKD, and
Hemolytic anemias
Also the following:
Nitrofurantoin
Primaquine: anti-malarial
Chloroquine: anti-malarial

The #1 cause of Steven-

Johnson’s syndrome
(there is mucosa/mucous membrane
involvement)
#2: Anti-convulsants
#3: Allopurinol
*withdraw the offending drug

Tamoxifen/Raloxifen Post MRM hormonal therapy Endometrial CA

Also for Breast cancer

Terbutaline (Ritodrine) Premature Uterine

Contractions

Tetracaine Most potent local anesthesia

Tetracycline DOC: Cholera, Rickettsia (Lyme Teeth discoloration

disease) Milk alkali syndrome: if taken
Chlam ydia with antacids
Early closure of the
e.g. Doxycycline epiphyseal plate in children 
short stature
An antibiotic with anti-malarial
properties
Blocks the 30s subunit

Thiazide diuretic Can cause hyperuricemia (like

pyrazinamide anti-TB)

Trimethoprim- Pneumocystis jiroveci pneumonia Alternative for TMP-SMX for

Sulfamethoxazole pneumocystis: Pentamidine
 20

Vancom ycin DOC: Methillin Resistant Red man syndrome

Staph Aureus
Facial flushing (also: Nicotinic acid &
Alternative Tx for Nifedipine)
Pseudomembranous
For MRSA skin infection give
colitis caused by Clindamycin  Chlorhexidine bath
overgrowth of C. deficille
st
(1 line: Metronidazole)

Vinblastine A vinca alkaloid

Can cause bone marrow
suppression

Vincristine Also a vinca alkaloid

Can cause neurotoxicity
Vincas come from periwinkle
plants

Vitamin K or FFP W arfarin toxicity

PHARMACOLOGY
CYCLOPENTANOPERHYDROPHENANTHRENE: the carbon skeleton found in
steroids (uncountable). The steroid nucleus.

The importance of methotrexate in cancer treatment is attributed to its capacity to inhibit

this enzyme in actively dividing cells: dihydrofolate reductase

Pharmacologic management of a patient with a machinery-like murmur (PDA):

Indomethacin therapy

This agent inhibits topoisomerase1 (DNA gyrase): Ciprofloxacin

Antihypertensive that causes hemolytic anemia and a positive Coomb's test:

Methyldopa

The classic triad of isoniazid toxicity includes the following features:

1. Generalized seizures
2. Coma
3. Metabolic acidosis

Which of the following is the drug of choice for complex partial seizures?
Carbamazepine

ORLISTAT - MOA - INHIBiTS LIPOPROTEIN LIPASE

WHAT GOES OUT IN FECES AFTER A PERSON TAKES IN ORLISTAT?
LIPOPROTeins

VITAMINS TERATOGENIC: VIT A

Protective for colon CA: Aspirin

Most frequently used DMARD in RA: Methotrexate

Retrobulbar neuritis – barrel vision – Ethambutol

Most effective drug for AIDS: Zidovudine

 21

Drug contraindicated in patient with acute intermittent porphyria: Barbiturates

Drug that cause Pulmonary Fibrosis: Admiodarone, Busulfan, Bleomycin

Inhalational anesthesia which is least toxic: Isoflurane

Most Cardiotoxic of all local anesthetics: Bupivacane

All are Nitrosoureas except: Ans: Dacarbazine (Note:e.g. Of Nitrosoureas –

Carmustine, Lomustine, & Streptozocin)

Tx for patient with Pancreatic CA: 5-Fluorouracil

Most frequent malignancy secondary to Chemotherapy: Acute Myelogenous

Leukemia ( AML)

Shortest acting neuromuscular blocking agent? Succinylcholine

Most potent inhalational Anesthesia? Methoxyflurane

Most potent local Anesthesia? Tetracaine

D.O.C. For Migraine? Ergotamine

Which of the ff. is Cell-cycle specific agent? Mercaptopurine

Which of the following drugs is not used as a treatment for Acute gouty arthritis?
Ans. Allopurinol (is for chronic gout)

tx for Edometrisis: GnRH [Lupron], Danazol, Medroxyprogeterone Acetate & Progestin

G.I.T. Ulcer is a S/E of: Methotrexate

Podophyllotoxin – Etoposide

In a patient with arthritis taking aspirin Tc fo anticoagulant for M.I leads to: no interaction

Effect o the Barbiturates (e.g. Phenobarbital) in patients taking Dicumarol: the

barbiturate may cause your body to process the blood-thinner more quickly; the effect of
the blood-thinner may decrease. There is an increased chance of bleeding.

Intra ___ tx of bladder Ca: Cisplatin, Mitomycin

Second choice for Tx of choriocarcinoma after Methotrexate: Actinomycin D.

Actinomycin D.- can also be used in W ilm’s Tumor in combination with Vincristine

Treatment for Gastroesophageal Reflux: Cisapride, Metoclopromide

Vitamin C is administered with what drug to acidify urine & enhance drug
effect: Methenamine

Excreted in urine except: Cefoperazone

(Ceftriaxone – excreted thru the bile intestine)

Action of Cocaine: Inhibits re-uptake of Neurotransmitter

Shortest-acting anesthetic: Thiopental (Ultrashort)

 22

Advantage of Fentanyl over Morphine: Fentanyl has 80x analgesic potency than
Morphine

Effect of Niacin: decreased VLDL & decreased LDL SYNTHESIS

D.O.C for Oral Candidiasis: Nystatin

Advantage of Meperidine over MORPHINE: less addictive

Treatment of Diabetes Insipidus: Desmopressin (DOC; long acting), Vasopressin

Post-op Px presents with respiratory depression. W hat is the Tx? Naloxone

Prevention of exercise–induced Asthma: Corticosteroids

Methamphetamine is a: stimulant

Treatment for Cervical Ca: Mitomycin

Tx for Testicular Ca: Cisplatin

Requires Folic Acid tx: Methotrexate

Not a cell-specific cancer drug: Busulfan

Function of ACE – Inhibitor: Angiotensin II receptor blocker

Longest -Acting anti-hyper glycemic drugs: Chlorpropamide (36 hrs. half life)

Ultralente: long– acting insulin

Weak anti –inflammatory action: Paracetamol

Shortest duration of ___NSAIDS: Diclofenac (1-1.5 hours)

A GnRh Agonist: Lupron

Most potent agonist at the muscarinic receptor site: Carbachol

This is a phenothiazine antipsychotic agent that acts as a dopamine antagonist that on

prolonged use can cause Parkinson- like syndrome: Chlorpromazine and Haloperidol

This insoluble starch is used in cases of portal HPN and hepatic encephalopathy due to
decrease intestinal absorption of ammonia transformed into ammonium
acidification of urine: Lactulose

This anticancer is also useful in the treatment of rheumatoid arthritis; its adverse effects
can be reversed by administration of leucovorin: methotrexate

A severely preeclamptic woman suddenly develops respiratory depression after the

administration of hydralazine and magnesium sulfate. Respiratory depression is due to:
Magnesium sulfate toxicity