Professional Documents
Culture Documents
Effects:
- Block the mesolimbic and mesocortical pathway - ↓dopamine binds on D2( antipsychotic)
↓agitation
↓ paranoid idea
↓hallucination
↓ anxiety
Mood stabilizer
Side effects:
Dopaminergic system:
Common side-effects:
- Neuroleptic malignant syndrome (eg: muscular rigidity, fever, delirium, dystonia, akinesia, mutism,
diaphoresis, dysphagia, tremor, incontinence, labile blood pressure, leukocytosis and elevated creatine
phosphokinase)
Tx: muscle relaxant. (eg: dantrolene, diazepam)
- Tardive dyskinesis ( repetitive, involuntary facial and limb movement)
*Maintenance monitoring for SDAs- weight, waist circumference, blood pressure, fasting blood glucose, fasting
serum lipid.
*pt started on clozapine – first 18 weeks = FBC weekly; subsequently= FBC monthly.