DRUG STUDY

Brand Name: Iterax

Generic Name: Hydroxyzine diHCl
Indication: Symptomatic treatment of anxiety, pruritus of allergic origin; premed
to general anesth.
Dosage: Tab/Syr Adult Anxiety 25 mg bid-qid, or 50-100 mg at night. Premed to
general anesth 100-200 mg the night before surgery. Symptomatic treatment of
pruritus of allergic origin 30-100 mg/day. Childn 30 mth-15 yr 1 mg/kg/day in
divided doses.
Over dosage: View Iterax over dosage for action to be taken in the event of an
overdose.
Administration: May be taken with or without food.
Contraindications: Hypersensitivity to cetirizine & other piperazine derivatives.
Intermittent acute porphyria. Pregnancy & lactation.
Special precautions: Glaucoma, prostatic hypertrophy, intestinal or urinary
obstruction, myasthenia, dementia, convulsions. Predisposition to cardiac
arrhythmia. May impair ability to drive or operate machinery.
Adverse drug reaction: Dry mouth, fatigue, headache, sedation. Somnolence.
Drug interaction: CNS depressants eg narcotics, non-narcotic analgesics,
barbiturates & alcohol. Phenytoin, epinephrine.
View more drug interactions with Iterax.
Nursing responsibilities: Assess client for dizziness and drowsiness, Assess client
with kidney disease, Assess clients for allergic reactions.

Generic name: chlorpromazine

Brand name: Thorazine
Preparations: PO 10-25mg 2=4 times daily; may increase every 3-4 days (usual dose
is 200ng/day; up to 1g/day)
CLASSIFI-CATION: Antipsychotics
ACTION: Block dopamine receptors in the brain; also alter dopamine release and
turnover, Prevention of seizures
INDICATION / USES:
•Acute and chronic psychoses, particularly when accompanied by increased
psychomotor activity. Nausea and vomiting.
• Also used in the treatment of intractable hiccups.
COMMON ADVERSE EFFECTS:
•CNS: neuroleptic malignant syndrome, sedation, extrapyramidal reactions, tardive
dyskinesia
•CV: hypotension (increased with IM, IV)
•EENT: blurred vision, dry eyes, lens opacities
• GI: constipation, dry mouth, anorexia, hepatitis, ileus
• GU: urinary retention
• Hematologic: agranulocytosis, leukopenia
• Skin: photosensitivity, pigment changes, rashes
CONTRA-INDICATIONS:
• Hypersensitivity.
•Cross-sensitivity may exist among phenothiazines. Should not be used in narrow-
angle glaucoma.
•Should not be used in patients who have CNS depression.
NURSING CONSIDERATIONS:
• Assess mental status prior to and periodically during therapy.
• Monitor BP and pulse prior to and frequently during the period of dosage
adjustment. May cause QT interval changes on ECG.
• Observe patient carefully when administering medication, to ensure that
medication is actually taken and not hoarded.
•Monitor I&O ratios and daily eight. Assess patient for signs and symptoms of
dehydration.
• Monitor for development of neuroleptic malignant syndrome (fever, respiratory
distress, tachycardia, seizures, diaphoresis, hypertension or hypotension, pallor,
tiredness, severe muscle stiffness, loss of bladder control. Report symptoms
immediately. May also cause leukocytosis, elevated liver function tests, elevated
CPK.
• Advise patient to take medication as directed. Take missed doses as soon as
remembered, witih remaining doses evenly spaced through out the day. May require
several weeks to obtain desired effects. Do not increase dose or discontinue
medication without consulting health care professional. Abrupt withdrawal may
cause dizziness, nausea, vomiting, GI upset, trembling, or uncontrolled movements
of mouth, tongue or jaw.

Generic name: haloperidol

Brand name: Haldol
Preparations: Tablets: 0.5mg, 1mg, 2mg, 5mg, 10mg
CLASSIFICATION: Antipsychotics
ACTION:Alters the effects of dopamine in the CNS, Also has anticholinergic and
alpha-adrenergic blocking activity, Diminished signs and symptoms of psychoses
INDICATION / USES:
•Organic Psychoses
• acute psychotic symptoms
• Relieve hallucinations, delusions, disorganized thinking
• severe anxiety
• seizures
COMMON ADVERSE EFFECTS:
•CNS: extrapyramidal symptom such as muscle rigidity or spasm, shuffling gait,
posture leaning forward, drooling, masklike facial appearance, dysphagia, akathisia,
tardive dyskinesia, headache, seizures.
•CV: tachycardia, arrhythmias, hypertension, orthostatic hypertension.
•EENT: blurred vision, glaucoma
• GI: dry mouth, anorexia, nausea, vomiting, constipation, diarrhea, weight gain.
• GU: urinary frequency, urine retention, impotence, enuresis, amenorrhea,
gynecomastia
• Hematologic: anemia, leucopenia, agranulocytosis
• Skin: rash, dermatitis, phtosensitivity
CONTRA-INDICATIONS: seizure disorder, glaucoma, elderly clients.
NURSING CONSIDERATIONS:
• Assess mental status prior to and periodically during therapy.
• Monitor BP and pulse prior to and frequently during the period of dosage
adjustment. May cause QT interval changes on ECG.
• Observe patient carefully when administering medication, to ensure that
medication is actually taken and not hoarded.
•Monitor I&O ratios and daily eight. Assess patient for signs and symptoms of
dehydration.
• Monitor for development of neuroleptic malignant syndrome (fever, respiratory
distress, tachycardia, seizures, diaphoresis, hypertension or hypotension, pallor,
tiredness, severe muscle stiffness, loss of bladder control. Report symptoms
immediately. May also cause leukocytosis, elevated liver function tests, elevated
CPK.
• Advise patient to take medication as directed. Take missed doses as soon as
remembered, witih remaining doses evenly spaced through out the day. May require
several weeks to obtain desired effects. Do not increase dose or discontinue
medication without consulting health care professional. Abrupt withdrawal may
cause dizziness, nausea, vomiting, GI upset, trembling, or uncontrolled movements
of mouth, tongue or jaw.