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Kostyuk I. A., candidate of agricultural science
Zhukova I.A., doctor of veterinary science
Kharkiv state zooveterinary academy, Kharkiv, Ukraine

THE USE OF SUCCINATE AS AN ENERGETIC SUBSTRATE OF

TISSUE RESPIRATION WHEN VITAMIN A IS ACCUMULATED IN LIVER
OF POULTRY

The study of the peculiarities of the use of succinate as an energetic substrate of

the tissue respiration is actual in connection with the use of the above acid
(succinate) in the ration of animals and in veterinary medicine as one of the factors of
metabolic correction. The investigation of the effect of membranotropic substances,
namely vitamin A, on the oxidation of succinate by liver metochondria is important
for the effective use of metabolic correction. The stimulation of oxidation of succinate
in liver mitochondria under the influence of high doses of vitamin in the ration of
hens has been shown. At the application (40–60 days) of the increased doses of
vitamin A in the rations of hens it is necessary to take destructive changes in the cells
of liver and violation of biological oxidation in chikens.
At the age of chickens daily negative effect of high doses of vitamin A on the
functional state of liver mitochondria is much more pronounced than in chickens from
which the resulting offspring. In the case of chickens in the diet of vitamin A in a dose
of 400 thousand IU / kg of growing free oxidation of succinate, dissociation reactions
of respiration and phosphorylation in liver mitochondria of chickens. A single oral
administration of day-old chicks 10 times the dose of vitamin A leads to activation of
succinate oxidation in mitochondria disconnected state.
Key words: biological oxidation, hens, liver, mitochondria, oxidative
phosphorylation, tissues respiration, succinate, vitamin A.

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Linus Pauling Institute, Oregon State University, Micronutrient Information Center.
— Copyright 2000-2014. — Mode of access : URL :
http://lpi.oregonstate.edu/infocenter/vitamins/vitaminA/. – Title from the screen
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