Tabel 1.

Karakteristik dan hasil penelitian hubungan preeklampsia berulang dengan hipertensi

Penulis Negara Desain Paparan Definisi Preeklamsi Hasil Peserta Waktu Follow Hasil**
Tahun SBP, Proteinuria follow up usia
DBP up (median,
(mmHg) (median, range)
range) (tahun)
(tahun)
Singh, UK, NS RCS PE berat NS NS Mean BP 147 17.8 40 sPE 137
1974 (mmHg) (1.9)/87
(1.2)
rPE 152
(3.9)/92
(2.8)
Sibai, USA, RCS PE berat > 160, > 1 g/24 Obat anti 815 6.6 30.9 OR 7.4
1986 NS >110 jam hipertensi (NS)
Sibai, USA, RCS PE berat NS NS Obat anti 125 5.4 NS OR 10.7
1991 NS (trimester hipertensi (NS)
2)
Nisell, Sweden RCS PIH/PE >140, >90 >0.3 g/24 Obat anti 138 7 NS Insiden
1995 986 jam hipertensi OR sPE 21%
dua rPE 25%
pengukuran
DBP ≥90
mmHg
dengan selang
15 menit
Gaugler The CCS PE berat NS, >110 2+ (1 g/l) > 140 dan / 40 5.5 38.8 NS
Senden, Netherla /E/ >140,>90 atau > 90
2008 nds HELLP mmHg, dan /
1993– (GA < 24 atau
2003 minggu) penggunaan
anti hipertensi
Tabel 1. (Berikutnya)

Penulis Negara Desain Paparan Definisi Preeklamsi Hasil Peserta Waktu Usia Hasil**
Tahun SBP, Proteinuria follow- follow
DBP up up
(mmHg) (median, usia
range) (median,
(tahun) range)
(tahun)
Lykke, Denmark RCS PE/E/HE Kriteria ICD- 536.419 12.9 42.6 sPE HR 2.7
2009 1978– LLP ACOG 8/ICD-10: (2.5–2.9)*
2007 DI10–13, rPE HR 6.0
DI15, (5.4–6.7)*
400–404
Magnus Norway PCS PE >140, >90 >0.3 g/24 Mean BP 15.065 16.5 40.1 sPE 132.2
sen, 1967– jam (mmHg) (130.7–133.7)
2009 1995 Obat anti Anti hipertensi
hipertensi rPE 136.7
(133.6–139.9)
tata laksana sPE
OR 3.1 (2.2–4.3)
rPE OR 11.6
(7.1–26.3)
Smith, Canada, PCS PE >140, >90 >0.3 g/24 Mean BP 70 1 NS NS
2009 NS jam (mmHg)
≥2 dipstick
Spaan, The RCS PE >140, >90 >0.3 g/24 Obat anti 339 6 NS HR 4.3 (1.6–
2012 Netherla jam hipertensi 11.5)
nds
1996–
2010
RCS PIH/PE/H >140, >90 >0.3 g/24 189 8.5 NS RR 2.4 (1.0–
ELLP jam 5.4)***
preterm
Tabel 1. (Berikutnya)

Penulis Negara Desain Paparan Definisi Preeklamsi Hasil Peserta Waktu Follow Hasil**
Tahun SBP, Proteinuria follow- up usia
DBP up (median,
(mmHg) (median, range)
range) (tahun)
(tahun)
Van The Hipertensi
Oostwa Netherla kronik
ard, nds
2012 2000–
2002
Ghosein The NCCS PE >140, >90 >0.3 g/24 BP ≥ 28 14 43 Insiden
Doha, Netherla jam 140/90 sPE 22%
2014 nds, mmHg rPE 86%
1996–
1999
Van The RCS PIH/PE/ >140, >90 >0.3 g/24 Hipertensi 120 11 NS RR 1.8 (1.1–
Oostwa Netherla HELLP jam kronik 3.0)***
ard, nds term
2014 2000–
2002
Engelad Norway PCS PE/E/ >140, >90 >0.3 g/24 Obat anti 978.493 46 NS sPE HR 2.0
2015 1967– HELLP jam hipertensi (2.0–2.0)*
2012 rPE HR 2.8
(2.7–3.0)*
Scholte, The PCS PE >140, >90 >0.3 g/24 BP ≥ 104 4.6 36 Insiden sPE
2015 Netherla jam 140/90 15.9%
nds mmHg rPE 27.8%
2008–
2010
Tabel 1. (Berikutnya)

Penulis Negara Desain Paparan Definisi Preeklamsi Hasil Peserta Waktu Follow Hasil**
Tahun SBP, Proteinuria follow- up usia
DBP up (median,
(mmHg) (median, range)
range) (tahun)
(tahun)
Verbeek The PCS PE/PIH >140, >90 >0.3 g/24 Mean BP 152 2-5 31-34 sPE 124.2
, 2015 Netherla hr (mmHg) (13.2)/81.9
nds ≥2 on (9.4)***
2008– Dipstick rPE 123.7
2010 (18.3)/83.8
(12.6)***
Zhang, China PCS PE/E/ NS NS NS 115 5 NS Incidence
2015 2009– superimp sPE 23.3%
2013 osed rPE 47.5%
PE
Auger, Canada PCS PE ICD-9: 642.3, 642.4, ICD-9: 401– 1.108.581 14.5 NS sPE HR 3.7
2017 1989– O13, 405, (3.5–3.9)*
2013 642.5, 642.6, O14, O15, 416.8, 437.2, rPE HR 7.2
642.7, O11 461.0, ICD- (6.6–7.8)*
10:
I10–I15,
I27.0,
67.4
BP, blood pressure; CCS, case–control study; CH, chronic hypertension; DBP, diastolic blood pressure (mmHg); E, eclampsia; GA, gestational age; HT,
hypertension; HELLP, haemolysis elevated liver enzymes low platelets syndrome; NCCS, nested case–control study; PCS, prospective cohort study; PE,
pre-eclampsia; PIH, pregnancy-induced hypertension; rPE, women with recurrent pre-eclampsia; RCS: retrospective cohort study; SBP, systolic blood
pressure (mmHg); sPE, women with one pregnancy with pre-eclampsia and normal subsequent pregnancy.
NS: data not shown or specified.
* Hazard ratio dibandingkan dengan wanita tanpa preeklamsi.
** Hasil ditentukan dalam odds ratio, hazard ratio dan risk ratio dengan interval kepercayaan 95% atau tekanan darah rata-rata (mmHg) dengan standar
deviasi atau interval kepercayaan 95% disajikan dalam studi yang sesuai.
*** Angka atau data diterima dari penulis
Tabel 2. Karakteristik dan hasil penelitian tentang preeklampsia berulang sehubungan dengan morbiditas dan mortalitas
kardiovaskular
Penulis Negara Desain Paparan Definisi Preeklamsi Hasil Definisi hasil Peserta Waktu Follow Hasil**
Tahun SBP, Proteinuria follow- up usia
DBP up (median,
(mmHg) (median, range)
range) (tahun)
(tahum)
Lykke, Denmark RCS PE/E/ Kriteria >0.3 g/24 IHD ICD-9: 410–414, 536.419 12.9 NS sPE: HR 1.3
2009 1978– HELLP ACOG jam ICD-10: i20–i25 (1.1–1.5)*
2007 ≥2 rPE: HR 2.8
dipstick (2.3–3.4)*
HF ICD-8: 42709– sPE: HR 1.3
42711, (1.0–1.7)*
42719, 42799, rPE: HR 2.4
42899, (1.6–3.5)*
42900, 42908,
42909,
ICD-10: i50, i513,
i519,
TE ICD-9: 444, 450, sPE: HR 1.3
451, (1.1–1.6)*
ICD-10: i26, i74, rPE: HR 1.8
i82. (1.3–2.5)*
CVA ICD-10: i60–i67, sPE: HR 1.2
g45. (1.1–1.4)*
ICD-8: 430–438 rPE: HR 1.5
(1.2–1.9)*
Skjaer Norway PCS PE >140, >0.3 g/24 CVD ICD-8/9: 390–459, 700.400 7–42 NS sPE: HR 1.5
ven, 1967– >90 jam death 410–414, 430–438 (1.2–1.9)*
2012 2002 ICD-10 i00–i99, rPE: HR 2.3
i20–i25, i60–69. (1.5–3.6)*
Tabel 2. (Selanjutnya)
Penulis Negara Desain Paparan Definisi Preeklamsi Hasil Definisi hasil Pesert Waktu Follow Hasil**
Tahun SBP, Proteinuria a follow- up usia
DBP up (median,
(mmHg) (median, range)
range) (tahun)
(tahun)
Akhter Sweden, CCS PE >140, >0.3 g/24 Aterosklerosis Pengukuran 42 NS 40-50 NS
, NS >90 jam ketebalan
2014 ≥2 intima-media
dipstick arteri karotis
menggunakan
ultrasografi
Kesso Israel RCS PE NS Kejadian ICD-9 4149, 1182 0-24 NS Insiden
us, 1988– simple 4292, 4438, sPE 1.6%
20153 2012 cardiovascular 4139, 44389, rPE 2.2%
3 436, 437,
413, 4371,
4118, 41181,
2722, 2724,
402, 411,
414, 4148,
4299, 440,
4402, 4019,
4439
Kejadian ICD 9 codes Insiden
complex 410, 4280, rPE 2.7%
cardiovascular 4281, 4289, rPE 4.6%
4280, 404,
4049, 4275,
415, 4150
Rawat inap NS Insiden
CVD sPE 4.4%
rPE 6.0%
Tabel 2. (Selanjutnya)
Penulis Negara Desain Paparan Definisi Preeklamsi Hasil Definisi hasil Peserta Waktu Follow Hasil**
Tahun SBP, Proteinuria follow- up usia
DBP up (median,
(mmHg) (median, range)
range) (tahun)
(tahun)
Auger, Canada PCS PE ICD-9: 642.3, Semua CVD ICD-9: 401– 606.820 16 NS sPE: HR 2.3
20162 1989– 642.4, O13, 642.5, 445, (2.2–2.4)*
6 2013 642.6, O14, O15, 447–453, rPE: HR 3.9
642.7, O11 ICD-10: i10– (3.6–4.2)
i82
IHD ICD-9: 410– sPE: HR 1.9
414, (1.7–2.2)*
ICD-10: i20– rPE: HR 3.3
i25 (2.6–4.2)*
CVA ICD-9: 433– sPE: HR 1.6
438 ICD-10: (1.4–1.9)*
I63–I66.9, rPE: HR 3.0
I67.2 (2.3–4.1)*
Aterosklerosis ICD-9:414.0, sPE: HR 2.1
414.3, 414.4, (1.8–2.5)*
429.2, 440, rPE: HR 4.0
ICD-10: (3.0–5.3)*
i25.0, i25.1,
i70
DVT ICD-9: 451.1, sPE: HR 1.7
451.83, (1.3–2.1)*
453.4–453.5, rPE: HR 1.3
453.72, (0.7–2.3)*
453.82, ICD-
10: i
80.1–i80.3
Tabel 2. (Selanjutnya)
Penulis Negara Desain Paparan Definisi Preeklamsi Hasil Definisi hasil Peserta Waktu Follow Hasil**
Tahun SBP, Proteinuria follow- up usia
DBP up (median,
(mmHg) (median, range)
range) (tahun)
(tahun)
Pulmonary ICD-9: 415.1, sPE: HR 1.2
embolism ICD-10: I26 (1.0–1.5)*
rPE: HR 1.4
(0.9–2.1)*
HF ICD-9: 428,
ICD-10: i50
sPE: HR 2.0
(1.6–2.5)*
HF ICD-9: 428, rPE: HR 4.2
ICD-10: i50 (2.9–6.1)*
Ghoss The CSC PE >140 >0.3 g/24 HF Ditentukan 107 4-10 36-40 OR 2.0 (0.7–
ein- Netherl >90 hr dengan 5.2)
Doha, ands, cardiac
20172 NS ultrasound
9
Riise, Norway PCS PE >140 >0.3 g/24 IHD ICD-9: 410– 281.069 18 NS sPE: HR 2.8
20172 1980– >90 hr 414, ICD-10: (1.7–4.6)*
3 2002 i20–i25 rPE: HR 4.7
(2.3–9.4)*
ACOG, American college obstetrics and gynecology; CCS, case–control study; CSC, cross-sectional cohort study; CVD, cardiovascular disease; DBP,
diastolic blood pressure (mmHg); DVT, deep venous thrombosis; E, eclampsia; HELLP, haemolysis elevated liver enzymes low platelets syndrome;
HF, heart failure; HF-B, heart failure type B; HR, hazard ratio; ICD, international classification of disease; IHD, ischaemic heart disease; NS, data not
shown/specified; OR, odds ratio; PCS, prospective cohort study; PE, pre-eclampsia; RCS, retrospective cohort study; rPE, women with recurrent pre-
eclampsia; SBP, systolic blood pressure (mmHg); sPE, women with one pregnancy with pre-eclampsia and normal subsequent pregnancy; TE,
thromboembolism. NS: data not shown or specified.
*Hazard ratio dibandingkan dengan wanita tanpa preeklamsi.
** Hasil ditentukan dalam odds ratio, hazard ratio dan risk ratio dengan interval kepercayaan 95% atau tekanan darah rata-rata (mmHg) dengan standar
deviasi atau interval kepercayaan 95% disajikan dalam studi yang sesuai.