Antiphospholipids

Cardiolipin antibodies are the most common antiphospholipid antibody, a group of

autoantibodies associated with excessive clotting and autoimmune diseases, such
as lupus. They are frequently detected with other antiphospholipid antibodies, such
as lupus anticoagulant and anti-beta-2 glycoprotein 1. They may also be detected
temporarily in people with acute infections, HIV/AIDS, some cancers, with drug
treatments (such as phenytoin, penicillin, and procainamide), and in the elderly.

- are associated with an increased risk of developing recurrent inappropriate blood

clots (thrombi) in veins and arteries, such as the deep veins of the legs (DVT) or
the lungs (pulmonary embolism, PE).
- Also associated with a low platelet count (thrombocytopenia), recurrent
miscarriages (especially in the second and third trimester), and with premature
labor and pre-eclampsia