Professional Documents
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1. Which of the following is the correct definition for ‘The concentration of drug
that produces 50% of maximal effect’
a) ED50
b) EC50
c) AD50
d) TD50
e) LD50
3. Choose the one that describes the first pass effect the best
a) Presence of the drug in higher concentrations in the organs that
receive high blood flow
b) Achieving high concentrations of blood drug concentrations after an
intravenous bolus injection
c) Elimination of the majority of the drugs after their first pass from the
kidneys
d) Starting producing the effect according to the intestinal absorption
e) Hepatic inactivation of an orally taken drug after its first pass and
reduction in its effect
4. How many elimination half-lives are required for a drug to reach its steady-
state concentration when it is used in repeated doses?
a) One b) Two c) Three
d) Four e) Six
8. Which of the following is incorrect for peptide systems that are used for cell-to-
cell communication?
a) Renin catalyzes the release of Angiotensin I from Angiotensinogen
b) Angiotensin II is a very potent pressor agent
c) Captopril is an orally active converting enzyme (ACE ) inhibitor
d) Losartan is superior to other ACE inhibitors since it does not cause
dry cough
e) Enalapril and losartan are peptides in structure
10. Suppose that two groups of mice are injected with phenobarbital (E) and
serum physiologic (C) respectively for three days, after that both groups are
injected with nembutal; Find the correct answer.
a) It takes longer for group E to fall asleep and their sleep duration is
longer compared to group C
b) It takes shorter for group E to fall asleep and their sleep duration is
longer compared to group C
c) There are no differances between these two groups
d) It takes longer for group E to fall asleep and their sleep duration is
shorter compared to group C
e) It takes shorter for group E to fall asleep and their sleep duration is
shorter compared to group C
11. Calculate the dosing rate for a drug whose clearance is 1.5L/h/70kg, when
the target plasma concentration is 10 mg/L.
a) 150 mg/h b) 15 mg/h c) 0.66 mg/h
d) 15g/h e) 15μg/h
CORRECT ANSWERS
1. b 2. b 3. e 4. d 5. d 6. e 7. c
8. e 9. d 10. d 11. b