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cantly increase or decrease myocardial perfusion or aortic stiffness and was con- respiratory disease and orthopaedic problems and 45% of patients had more than
sidered safe up to 180 days following the infusion. two comorbidities.
Acknowledgement/Funding: This study was funded by Novartis Pharma AG, Conclusions: In our center, HFC allowed to significantly reduce the rehospitali-
Basel, Switzerland sation rate in a paediatric population.
Results: Basic characteristics of the groups at baseline were similar. There was a collected from August to December 2016 worldwide with more than 90% of users
drop out of 4 patients in the CG (13%), 2 in the HB group (7%). After 12 weeks of from US, Canada, Europe, Japan, and China. To identify users that had reduced
intervention, there was a significant increase in exercise capacity in the CB group their PWV we calculated the percent change in PWV between August and De-
of 1.3mL·kg–1 ·min–1 (95% CI -0.09, 2.49; P=0.034), and of 1.1mL·kg–1 ·min–1 cember averages and set a threshold of -10%. We used a Welch’s t-test for eval-
(95% CI -0.04, 2.51; P=0.043) in the HB group, whereas in the CG the exercise uating whether there was a difference in the levels of self-measurement and ac-
capacity decreased 0.20mL·kg–1 ·min–1 (95% CI -2.01, 0.59; P=0.28). No signifi- tivity between users who reduced their PWV and other users. To evaluate the dif-
cant differences were found for the secondary outcomes. ference in weight change from August to December between users who reduced
Conclusion: After completion of a phase II program, a HB is equally effective as their PWV and other users we performed a linear regression for each group and
a CB CR program to further increase exercise capacity. compared the slopes with a Student t-test.
Acknowledgement/Funding: The Joint Doctorate Program “MOVE-AGE”, is Results: 960 users had reduced their PWV by more than 10% from August to
funded by the European Commission as part of the Erasmus Mundus program December. These users measured themselves 25.7 times per month on average,
which is significantly more often than others at 18.1 times per month with a p-
value less than 10–10 . The activity level of users who reduced their PWV was
P2476 | BEDSIDE significantly higher than that of others at an average of 6065 daily steps versus
Assessment and control of physical activity by step counters and 5763 respectively with a p-value of 1.6x10-6 . Users who reduced their PWV also
online documentation in secondary prevention after myocardial reduced their weight by 0.31 kg/month while other users gained weight during
infarction the 4-month year-end period at a rate of 0.22 kg/month, a difference which is
statistically significant with a p-value less than 10–10 .
H. Wienbergen 1 , T. Backhaus 1 , S. Michel 1 , J. Stehmeier 1 , K. Kraemer 1 ,
Conclusions: This study suggests that a reduction in PWV and thereby an im-
J. Schmucker 1 , S. Meyer 2 , J. Meyer 3 , H. Haase 4 , A. Elsaesser 2 , R. Hambrecht 1 .
1 proved cardiovascular health can be brought about over the course of 4 months
Klinikum Links der Weser, Bremer Institut für Herz- und Kreislaufforschung, Bre-
through frequent self-measurement, an increased activity level, and weight reduc-
men, Germany; 2 Oldenburg Hospital, Oldenburg, Germany; 3 OFFIS - institute for
tion. The results can form the basis of recommendations used in medical practice
information technology, Oldenburg, Germany; 4 RehaZentrum, Bremen, Germany
to improve cardiovascular health. This study further demonstrates the value of au-
Background: Physical inactivity is an important modifiable risk factor in sec- tomatically collected self-measurement PWV data, enabled by connected scales.
ondary prevention. It was the purpose of this study to investigate feasibility and
effects of step counters and online documentation of steps to prevent physical
inactivity after myocardial infarctions. P2478 | BEDSIDE
Methods: The randomized IPP study investigates the effects of an intensive Intermittent hypoxia-hyperoxic training as a new method of
longterm prevention program (IPP) compared with usual care (UC) after acute cardioprotection during coronary artery bypass surgery
myocardial infarctions. As part of the prevention program step counters were of-
D. Tuter, P. Kopylov. I.M. Sechenov First Moscow State Medical University,
fered to all patients of the IPP group. The patients were requested to document
Moscow, Russian Federation
the number of steps in a study online portal, feedback was given by the study
center. Introduction: The rate of complications during coronary artery bypass surgery,
Results: 103 patients (81.1%) of the 127 patients in the IPP group documented particularly in cases of using of heart-lung machine, is still high. An impor-
steps, 91 patients (71.7%) for >6 months. tant task is to find new methods of heart protection from damaging effects
The mean number of daily steps increased with growing time interval from my- of ischemia/reperfusion during surgery. Proposed technique of cadioprotection
ocardial infarction (Table). involves achieving of myocardial preconditioning effect using short alternating
In patients that increased the number of daily steps >30% during 6 months, an episodes of hypoxia (O2 concentration of 12%) and hyperoxia (O2 concentration
improvement of the clinical parameters body mass index (BMI) [-1.1±1.7 kg/m2 of 35%). Total time of breathing with hypoxic gas mixture during one procedure is
(-3.9%), p<0.01], blood pressure [-6.7±13 mmHg (-4.9%), p 0.01] and LDL- 20–30 minutes, total time of one procedure is 40–50 minutes. The final training -
cholesterol [-3.5±22 mg/dl (-4.9%), p 0.39] was observed. on the day before surgery.
In patients that did not increase the number of daily steps >30%, no improve- Objective: Development of new methods of heart protection, decreasing of com-
ment of the clinical parameters was found [BMI: ±0.0±3.9 kg/m2 (±0.0%), p 0.98, plication rates in coronary artery bypass surgery.
blood pressure: +2.0±15 mmHg (+1.5%), p 0.31, LDL-cholesterol: +1.2±26 mg/dl Research methods: 80 patients, who underwent aorto- and/or internal mam-
(+1.6%), p 0.24]. mary coronary artery bypass surgery, were included in the study, of them 40
patients were included in the main group and 40 in the control group (groups
Table 1 were matched by sex, age, extent of coronary artery disease and number of co-
Study start (n=91) 3 months (n=91) 6 months (n=91) P morbidities). Patients of the main group had 4-day course of intermittent hypoxia-
Number of steps/day (MV ± SD) 8015±3834 8826±4102 9480±3627 <0.01 hyperoxic training (IHHT) before surgery, patients of the control group 4-day train-
ing course simulating IHHT (supplied air contained usual oxygen level). Opera-
Conclusions: Acceptance of step counters and online documentation as part tions were carried out in conditions of cardiopulmonary bypass and cold cardio-
of a longterm prevention program was good and the number of steps increased plegia. Monitoring of Troponin I and lactate levels was performed for all patients
significantly during study course. Patients with an increase of steps >30% dur- immediately before surgery, 2 and 24 hours later.
ing 6 months improved the clinical parameters BMI, blood pressure and LDL- Results: Statistically significant decreased mean level of Troponin I were seen
cholesterol, while patients without increased steps did not. in the IHHT group on the day after surgery in comparison with the control group
The data underline the value of step counters and online documentation as a (2.16 ng/mL and 3.44 ng/mL, respectively; p=0.012). Difference between values
strategy to prevent physical inactivity after myocardial infarctions. of Troponin I before surgery and two hours later was not statistically significant.
Acknowledgement/Funding: Deutsche Herzstiftung e.V., Stiftung Versorgungs- Also values of lactate are significantly different after surgery (1.96 mmol/L in the
forschung der ALKK e.V., Handelskrankenkasse Bremen, Stiftung Bremer Wert- IHHT group and 2.35 mmol/L in the control group, p=0.04). Lactate levels before
papierbörse surgery are the same in both groups. By the number of complications downward
trend in the number of paroxysmal atrial fibrillation in the perioperative period
was noticed in the IHHT group compared with the control group (8 (20%) and 12
P2477 | BEDSIDE (30%) episodes, respectively). In addition, 2 cases of ventricular fibrillation (5%)
Assessing self-measurement, activity, and weight change behaviors of were seen in the control group only, one of which occurred on the background of
connected scale users who reduced their pulse wave velocity over 4 intraoperative myocardial infarction with transition to asystole, which caused the
months death of the patient. Rate of other complications was the same in both groups.
Conclusions: Although rate of complications between two groups did not reach
E. Roitmann, A. Chieh. Withings, Paris, France
tests of significance (that can be attributed to a small number of patients included
Introduction: Pulse wave velocity (PWV) is widely known as a marker of cardio- in the study), lower levels of Troponin I and lactate in the IHHT group after coro-
vascular risk. As a preventive measure against cardiovascular events it is desir- nary artery bypass surgery indicates the increased resistance of the myocardium
able to reduce the PWV. While there are many cross-sectional analyses describ- to the damaging effects of ischemia/reperfusion in the course of operation.
ing the association between cardiovascular risk and PWV, little research has eval-
uated longitudinal changes and the behaviors associated with a PWV reduction.
PWV measurements have until recently been limited mostly to research and med- P2479 | BEDSIDE
ical centers because measurements required the use of expensive and complex Behaviours of French amateur rugby players, lifestyle of the younger
devices. The new connected scales that permit self-measurement of the PWV at higher risk for their heart?
makes it possible to analyze the PWV of large cohorts with a high measurement
F. Chague 1 , M. Zeller 2 , J. Petit 3 , C. Guenancia 1 , P. Aviat 4 , Y. Laurent 3 ,
frequency.
A. Gudjoncik 1 , J.C. Perrin 4 , J.P. Hager 4 , V. Gremeaux 3 , Y. Cottin 1 . 1 University
Purpose: The study aims to leverage the availability of high-frequency PWV self-
Hospital of Dijon, Cardiology department, Dijon, France; 2 University of Bour-
measurements of a large number of connected scale users to determine the be-
gogne Franche-Comté, Laboratory PEC 2, Dijon, France; 3 University Hospital
haviors of users who reduce their pulse wave velocity over the course of 4 months.
of Dijon, Rehabilitation department, Dijon, France; 4 French Rugby Federation,
Methods: The study was conducted on anonymous data from a pool of 99,327
Marcoussis, France
users of connected scales that measure both weight and PWV. 59,497 of these
users also track their daily steps with wearable activity trackers. The data was Background: Sudden cardiac death during sport remains a major problem. In