ABSTRAK

FARAH MEUTIA. Aktivitas Hepatoprotektor Ekstrak Metanol Daun Kari

(Muraya koenigii. L.) Pada Tikus Putih Sprague dawley. Dibimbing oleh HASIM
dan SYAMSUL FALAH.

Daun kari diduga memiliki aktivitas hepatoprotektor terhadap kerusakan hati

yang disebabkan oleh agen hepatotoksik. Penelitian ini menguji ekstrak daun kari
terhadap peningkatan aktivitas alanin aminotransferase (ALT) dan aspartat
aminotransferase (AST) serum darah tikus yang dicekok parasetamol dosis tinggi.
Sebanyak 25 ekor tikus jantan terbagi atas 5 kelompok sebagai berikut: kelompok
kontrol normal (N), kelompok kontrol negatif (KN) (parasetamol dosis 500
mg/Kg BB diberikan selama 21 hari), kelompok kontrol positif (KP) (curliv dosis
42.86 mg/Kg BB diberikan selama 21 hari), kelompok ekstrak dosis 200 mg/Kg
BB (ED200), dan kelompok ekstrak dosis 300 mg/Kg BB (ED300). Pemberian
ekstrak dimulai 7 hari sebelum pemberian parasetamol dan seterusnya hingga
akhir percobaan. Hasil uji fitokimia menunjukkan bahwa daun kari mengandung
senyawa alkaloid, tanin, saponin, dan steroid. Aktivitas ALT dan AST pada
kelompok ekstrak menurun tidak signifikan (p>0.05) dibandingkan kelompok N.
Penurunan aktivitas ALT kelompok ED200 sebesar 16.21% dan AST sebesar
33.82%. Penurunan aktivitas ALT kelompok ED300 sebesar 33.82% dan AST
sebesar 62.60%. Ekstrak metanol daun kari dosis 200 mg/Kg BB dan 300 mg/Kg
BB memiliki efek hepatoprotektor walaupun tidak berbeda nyata.
 ABSTRACT

FARAH MEUTIA. Activity of Curry Leaf (Muraya koenigii. L.) Methanol

Extract as Hepatoprotector in Sprague dawley Rats. Under the direction of
HASIM and SYAMSUL FALAH.

Curry leaf is being thought as hepatoprotector againts liver damage caused by

hepatotoxic agent such as paracetamol. This study was assesing the activity of
curry leaf extract in reducing the activity of ALT (alanine aminotransferase) and
AST (aspartate aminotransferase) in rats were given high dose paracetamol. Total
of 25 rats were used in this research which were divided into 5 experimental
groups as follows: normal control group (N), negative control group (KN)
(paracetamol dose 500 mg/Kg BW were given 21 days), positive control group
(KP) (curliv dose 42.86 mg/Kg BW were given 21 days), dose 200 mg/Kg BW
extract group (ED200), and dose 300 mg/Kg BW extract group (ED300). Extracts
were given 7 days before paracetamol treatment and continous until end of
experiment. Pytochemistry test results showed that curry leaf methanol extract
contain alcaloids, tannins, saponins, and steroids. Extract group had not
significantly reduced ALT and AST activity (p>0.05) compared to N group.
Decreasing ALT and AST activity in ED200 group is 16.21% and 33.82%.
Decreasing ALT and AST activity in ED300 group is 33.82% dan 62.60%.
Methanol extract curry leaf had hepatoprotector activity although not significantly
differences.