Professional Documents
Culture Documents
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:. ASO in case of streptococci & if untreated Aso react W the heart
muscle tissue causing "rheumatic fever"
- Interferon α, B, Ϫ
α,B produced from the infected cells.
Ϫ produced from T-lymphocytes.
.IFN has an antiviral activity.
.IFN is host cell specific but not virus specific as human IFN has only
activity in human but against all viruses.
When the cell is infected with a virus, the cell process the virus into small
protein fragments that move to the surface of the infected cell acting as
antigens these antigens are present in association with MHC which act as
presenters for those antigens so these antigens are well marked and highly
lighted for t-cells.
. ͘ . MHC major histocom patibility cpx
) لكى تتعرف عليها ونقوم بقتلهاTc( ) لviral parts)و هى تعمل مثل الصينيه لتقديم ال
Immunity
Naturally acquired artificially acquired
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Antigen "Ag": - material that induces production of antibodies when
injected Into the body.
Has large M.WT ≥ 10,000 Dalton. Mainly proteins or large
Polysaccharides .
Ag may be the whole bacterial cell, capsule, flagella, viral coats,
Toxins, pollen grains, dust or egg white.
Epitopes is a specific regions on Ags which the Ab recognize it and bind to it.
Ab has a Y shape and the lower parts of the Y shape is the constant
Region "C"
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The end of the two arms of the Y-shape are called variable
Region "V" which is the antigen binding sites.
The real form of Ab is the Y-shape structure in which the amino acid
Forming the chains exist in form of domains.
L has 2 domains VL and CL
H has 4 domains VH and 3 CH
Constant region of heavy chain has many different amino acid sequences
resulting in 5 different classes of Ig (s).
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Humoral immunity (Ab –mediated immunity) :-
Through circulating Abs W are secreted from B-cells.
B-cells activation activated B-cells differentiated into plasma cells Specific
Ab produce + Memory cells
Stem cells
In liver of foetus.
Immature immature
B-cells T-cells
Maturation maturation
Activation by
Ag(s) on pathogen
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Plasma cells +memory cell attack cancer
form cells and
Receptor (Igd, IgM) Which are bound to the surface of B-cell then the B-cell is
activated.
The human body make 100 million lymphocytes each day so an equivalent No. of
other lymphocytes must die otherwise leukemia occur.
Experianent in rabbit.
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Cytokines is the chemical messengers of immune cells.
between leuckocytes.
The cells that introduce the Ag on its surface are called "antigen presenting
cells"APC(s)".
Types of t-cells
Lytic enzymes.
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Ts "suppressor": - regulate the immune response by turning it off when Ag is no
longer present.
Vaccines: -
E.g. hepatitis B.
Hypersensitivity Rx: -
Type 4
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1-type 1 "anaphylactic" IgE produced on the 1ˢᵗ exposure to the allergen and
attach to mast cells or basophiles so on the 2ⁿᵈ Exposure mast cell degradation
and releasing of histamine and leukotrienes and vasodilatation, mucous
secretion B.V permeability and bronchoconstriction.
E.g. pollen grains, eating fish, nuts, strawberry, Hay fever, urtecaria, asthma.
RH factor: -
Father+Rh
mother –Rh
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E.g. allergic contact dermatitis soap,Gloves "latex one" Poison ivy. And
tuberculin Rx by mycobacterial Ag
Autoimmune disease
2- Myasthenia gravis: gradual loss of muscular tone caused by the Ab(s) that
So the muscle controlling the diaphragm don’t receive the Nerve signals
Respiratory death.
And her there are Ab(s) to the intrinsic factor so vit B₁₂ can't bind to the
4- Rheumatoid arthritis: - immune cpx of IgM and IgG are deposited in joints
affect females> male.
6- hashimotoo thyroditis :
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7- IDDM t-cell attack and destroy B-cell of lengerhans.
(GMB) . ͘ . nephritis and these Abs may pass to the Pulmonary capillary
basement membrane causing Pulmonary hemorrhage.
9-Multiple sclerosis (MS): T-cell attack the basic protein myelin Leading to CNS
demylination with sclerotic plaque.
10-sojorin syndrome:
Abs against salivary gland antigens and exocrine glands of the eye,
Autoimmune diseases
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TTT of type 1 hypersensitivity reaction: -
1-H₁ blocker.
2-EPi.
3-cromolyn Na⁺.
4-topical steroids.
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