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Typical (1st generation)-low weight gain Atypical (2nd generation)-high weight gain
1) Phenotiazines: Clozapine
Chlorpromazine Risperidone
Fluphenazine Olanzapine
Trifluoperazine Quetiapine
Thiordazine
2) Thioxanthenes :
Cholrprothixene
Thiothixene
3) Butyrophenones :
Haloperidol
Droperidol
4) diphenylbutyrylpiperidine
pimozide
5) dibenzoxazepine
Loxapine
6) Dihydroidolon
Molindone, Domperidone
Drug Mechanism Thera.use Side-effects Drug –drug Contraindication&
interaction monitoring
First generation Block dopamine antipsychotics EPS-parkinsonism
receptors in Sexual dysfunction
cortical and limbic Anticholinergic side
Advantage; -
areas of brain effects
Low weight gain
Mainly binds at D2 Tardive dyskinesia
Sedation
Hyperprolactinemia,
Risperidone Blocks D2 & 5HT NO WBC IS
EPS MONITORED
Hyperlipidemia
Quetiapine
↑TG
↑ cholesterol
hypothyroidism
akathisia
SYMPTOMS; -
The schizophrenic individual- out of touch with reality, hallucinates, hears voices & exhibit bizarre
behavior. The symptoms are only one aspect of schizophrenia – other symptoms are ;- social
withdrawal, and an inability to communicate or to concentrate
Auditory Avolation/apathy
Olfactory Lack of interest in activities
Somatic No motivation
Visual Social withdrawal
Poor hygiene
Disorganizations
Disorganized speech
Incoherent speech Anhedonia
Tangentially
Loose association Loss of pleasure
Few recreational activities
Disorganized behavior
Attentional impairment
Agitation
Hostility
Assaultiveness Lack of ability to concentrate on tasks or
Uncooperativeness conversations
Inappropriate sexual/social behavior
Inappropriate dress
Catatonia