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    0 views21 pages

    Asma Anak Nelson 20th Ed

    Uploaded by

    MikhaelLoho

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF or read online from Scribd
    Flag for inappropriate content
    of 21
    ry ei liters PE) Asthma isa chronic intamnmatory condition of the hang airway esl ing in epee ecflow bsroction, This chronic inflammation bight fens the twfchiesr of the sways—airways hyperesponsiveness (IIR) to provocative exposures. Asthma management aimed at ‘edicngsiraystfarmation by iniesing prnlamaacory en ‘onmentalexporares using dail controler aninflamtory medics ‘ions and contralling comorbid conditions that can worsen asthma {es ilcamation typically eds better athns coat, with fewer cacethations and decreased need for quiskeelieverasthina medica ‘ons. Nevethelas, excerbations can all orenrEary intervention with systemic corticosteroids greatly reduces the severity of such ep Soves Advances in asthina management and especialy, pharmaco ‘herapyenableallbu the uncommon child with dificult asthma to ive pormaly ETIOLOGY “Although the cause of cihod ant has not been determined 2 ‘combination of environmental exposures and inherent biologic and text susceptibilities fas been implicated (Fig 141). Inthe suscep {ble host, Immune responses to common airways exposures (68, respiratory viruses, allergens, tobacco smoke. alr pollutants) an Stimulate protonged, pathogenic inflammation and aberrant pat of {injured airways issues. Lung dysfunction (AHR, reduced alow) and alrway remodeling develo. Tes pathogenic processes nthe growing Tung during erly fe adversely aflac airways growth and diferent ton leading to altered aways at mature ages Once asthma has deve oped, ongoing inflammatory exposures sppeat fo worsen i deiing

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