DR Matthias Rath Victory Over Cancer Ebook PDF (Pauling-Rath Therapy Protocol: Vitamin C / Lysine)

Victory
Victory Over Cancer!

Part 1 – Making the Unthinkable Possible Over Cancer!
First Edition
© 2012 by Dr. Matthias Rath and Dr. Aleksandra Niedzwiecki.
ISBN 978-90-76332-76-5 – Part 1 –

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Unthinkable Possible
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Dr. Matthias Rath

All rights reserved. Distributed by Dr. Rath Health Foundation, Santa Clara, CA 95050
Individual pages or small portions of this book may be used for private and non-profit
educational purposes only. Dr. Aleksandra Niedzwiecki
Disclaimer:
This book is not intended as a substitute for the medical advice of a physician.
The reader should regularly consult a physician in matters relating to his or her health and
particularly in respect to any symptoms that may require diagnosis or medical attention.
The author and publisher disclaim responsibility for any adverse effects resulting directly
or indirectly from the information contained in this book.
4 5
Contents
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Chapter I . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Facts No One Can Ignore Any Longer
Chapter II . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
The Medical Breakthrough Towards
the Natural Control of Cancer
Chapter III . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109

Scientific Facts That Make
this Breakthrough Irreversible
“We will live to see a time when we no longer

have to look over our shoulder like a criminal
when we say: two and two makes four.” Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177
Bertolt Brecht, “Life of Galilee“ Important documentation
6 7
Victory Over Cancer – Part One: Making the Unthinkable Possible Introduction
Introduction
Only once in the history of mankind is the discovery being made that
will lead to the natural control of cancer.
This book documents this discovery.
A breakthrough of this nature leads the pioneering scientists on a

path from the discovery of the underlying cellular mechanisms to
the confirmation of new therapeutic approaches at the level of
basic research and ultimately to the clinical proof in patients suf-
Dr. Matthias Rath Dr. Aleksandra Niedzwiecki fering from cancer.
This book is the report of the pioneering scientists.
One author, Dr. Matthias Rath, was privileged to contribute the

discovery of new natural ways to control cancer. Dr. Aleksandra
Niedzwiecki coordinated the scientific proof of this medical
breakthrough.
‘Victory Over Cancer’ is not an achievement that is given to us,

the people, voluntarily. Mankind has to earn the right to live in a
world without fear of cancer. The battle for that fundamental right
to become reality is being fought once.
This time is now.

Significantly, for mankind to achieve ‘Victory Over Cancer’ it was
not necessary to invent new, hi-tech approaches to control this
disease. The decisive breakthrough towards the effective preven-
tion, control and ultimately the elimination of cancer is based on
our new understanding of the critical role of micronutrients.
8 9
The fact that the essential role of micronutrients in controlling

cancer thus far has not been understood – let alone applied
towards the control of the cancer epidemic – is no coincidence. It
has been deliberately neglected and withheld in the interest of the
pharmaceutical investment business.
Diseases in general have been exploited by the pharmaceutical

business interests as markets for their patented drugs. In cancer an
additional, particularly appalling, aspect deserves consideration.
The diagnosis ‘cancer’ has been kept as a ‘death verdict’ in the As the authors of this book, our gratitude goes first and foremost to the
perception of people. That was not a coincidence. This fear of team of researchers at our Institute – in particular to the head of our can-
cer research group, Dr. Waheed Roomi (second from left).
death made millions of cancer patients accept literally any proce-
dure – as questionable as it may be – including highly toxic
chemotherapy. The key discoveries towards ‘Victory over Cancer‘ were made
already two decades ago. Our efforts at that time to convince large
This report will end this fallacy and, thereby, help to liberate pharmaceutical companies to commit to the elimination of cancer
mankind from the fateful dependency upon the pharmaceutical were futile. In retrospect, this was no surprise: This discovery
‘business with disease’. threatened their multi-billion dollar market with chemotherapy
drugs.
The victory over cancer ranks among the great advances in medi-
cine. One hundred and fifty years ago Louis Pasteur discovered However, we did not give up, but it took us about one decade to
that microorganisms are the cause of infectious diseases and start our own research institute in California and to launch a com-
thereby paved the way for the control of many epidemics that had prehensive cancer research project in 1999.
haunted mankind for millennia. It was more than a quarter centu-
ry later that his theories were finally accepted. By the end of 2001 we had obtained the first research confirma-
tion that key steps of the cancer disease can be controlled natural-
As the philosopher Arthur Schopenhauer already noted: “Every ly. We decided to share this life-saving information with the world.
truth passes through three stages before it is recognised. In the On March 8, 2002, we announced this medical breakthrough on
first it is ridiculed, in the second it is opposed, in the third it is a full page in USA Today – the world’s largest newspaper.
regarded as self-evident.”
10 11
The significance of this breakthrough for human health can per-

haps best be judged from the fierce reactions by the status quo.
Over the past ten years the pharmaceutical lobby filed more than
100 legal attacks against this breakthrough, to no avail. The publi-
cation of this book now documents that we are right.
This book will empower millions of people to take actions toward

ending the devastating dependency upon the economic interests
who have been putting profits over life for an entire century.
This book will break mankind’s psychological dependency on the

‘investment business with the cancer epidemic’. It will inspire
similar breakthroughs in the fight against other diseases and con-
tribute to a new, independent, global health care in the interest
of billions of people living today and of future generations.
Santa Clara, California,

Autumn 2011
Matthias Rath and Aleksandra Niedzwiecki
Above: A copy of our announcement about the breakthrough in the

natural control of cancer in USA Today, on March 8, 2002. By present-
ing this information directly to the public we wanted to make sure the
whole world learned about it.
12 13
Do Stars ‘Science as Art’’ is an idea by August Kowalczyk.
Shine in Red? ‘Do Stars Shine in Red’ is a microscopic picture of cervical
cancer cells undergoing natural death (suicide).
The picture was taken at the Dr. Rath Research Institute.
Visit the entire art gallery at
www.dr-rath-humanities-foundation.org/exhibition/index.html.
I. Facts No One Can
Ignore Any Longer
Victory Over Cancer – Part One: Making the Unthinkable Possible Chapter I − Facts No One Can Ignore Any Longer
Fact #1:
The Sobering Cancer Death Statistics
Cancer Is the Third Largest Cause of Death in of the World Health Organization (WHO)
The Industrialised World
• At the beginning of the 21st Century, the cancer epidemic Infections Cardiovascular
remains one of the largest killers on our planet. Disease
• According to the World Health Organization, 7.5 million peo- Other
ple worldwide die each year from cancer. This number is only Diseases
slightly behind the number of deaths from infectious diseases.
Cancer
• In the US, Canada and Europe, the numbers are even more
staggering – 5.6 million people die here from cancer each year.
This means that every third man and woman in the communi-
ties across North America and Europe dies from this disease. A. Worldwide 7.5 million people die each year
from the ongoing cancer epidemic
Infections
Most importantly,
every number in these statistics Cardiovascular
means a human life lost. Other Disease
Diseases
Cancer
B. In North America and Europe, 5.6 million people

die each year from the ongoing cancer epidemic
Reference: WHO Mortality Statistics for 2008
18 19
The Dimension of the Cancer Epidemic Visualising the Dimension:

At the beginning of the 21st Century, cancer remains one of the
largest epidemics of mankind. It is almost impossible to demon-
New York Tokyo
strate the entire magnitude of this epidemic. What we can do to
visualise its dimension is to take the number of cancer patients
who die each year – and compare it to the population of the
world’s largest cities.
Every year the cancer epidemic takes the lives of 7.5 million
patients worldwide. In comparison, here are the current popula- London Rio de Janeiro
tion numbers for some of the world’s largest metropoles: Tokyo 8.9
million, Mexico City 8.9 million, New York City 8.4 million, Lagos
(Nigeria) 8 million, London 7.8 million, Lima (Peru) 7.6 million,
Hong Kong 7 million, Bangkok (Thailand) 7 million, Cairo (Egypt)
6.8 million and Rio de Janeiro (Brazil) 6.3 million.
Imagine you are living in one of these giant cities. You have to dri-
ve for hours to get from one end of the city to the other. And all
those people living in every street of this city disappear each year
as the result of this unconquered epidemic. Over the past half
century more than 300 million people have died from cancer –
this translates to the eradication of the entire population of the
United States of America.
USA
Besides the unimaginable cost of human life there is a strangulat- Population above 300 million
ing economic burden associated with this disease for every
patient, community and country. The global costs for oncology
drugs in 2010 alone was 56 billion US dollars. The economic
impact of the cancer epidemic – excluding all medical costs – was
even more staggering: With 895 billion US dollars, cancer had by
far the greatest economic toll among all diseases. We will provide
more details in part 2 of this book, chapter IV. Every year the cancer epidemic takes the lives of cancer patients
in numbers corresponding to the inhabitants of some of the
world’s largest cities. Over the past half century – during the age
of ‘chemotherapy’ – the number of patients killed from the can-
cer epidemic equals the entire population of the United States of
America.
20 21
Translating the Global Scope of the

Cancer Epidemic to Your Home Town
Number of worldwide
cancer deaths each year Compared to cities in the UK
7.5 M
Imagine
how many
• Nottingham + Leicester + Sunderland + 24 other cities of this size

lives can
• Stoke-on-Trent + Wolverhampton + 29 other cities of this size

• Liverpool + Manchester + Bristol + 15 other cities of this size
• Belfast + Newcastle upon Tyne + 26 other cities of this size

• Wakefield + Cardiff + Coventry + 21 other cities of this size
be saved
• Brighton + Hull + Plymouth + 28 other cities of this size

5M • Bradford + Edinburgh + 14 other cities of this size if an
• Glasgow + Sheffield + 12 other cities of this size
effective
cure for
• Birmingham + 7 other cities of this size
cancer is
found!
• Leeds + 9 other cities of this size
2.5 M
• London
On the previous pages we compared the scope of the global ing your hometown. In the above graph every column totals to
cancer epidemic to large cities. But cancer happens where you the approximate number of people who die each year from can-
live – in every community in the country. On this page, we there- cer. We created this chart not only to emphasise the dimension
fore compare the number of people dying each year from cancer of this disease but – above all – to underscore the urgency to find
globally to the population of major UK cities – possibly includ- a solution to it!
22 23
Fact # 2:
The Cancer Epidemic Is Still Expanding – Increase in Cancer Deaths (Mortality)
From 1970 to 2000 in Different Age Groups
Despite All Media Hype About Medical
‘Breakthroughs’
Cancer Patient
Age 70 - 79
What does this mean?
• If a disease still increases, it means that the mechanisms for its

control have not yet been discovered or they are not being
applied in the medical practice.
• Conventional approaches like chemotherapy and radiation –
that have been used on cancer patients for over half a century –
have obviously failed to curb the cancer epidemic.
• Thus, chemotherapy and radiation can no longer be considered Cancer Patient Age 60 - 69
a credible answer to the cancer epidemic.
• Therefore, there is an urgent need for new, effective approaches
to control the cancer epidemic!
Cancer Patient Age 50 - 59
6 September, 2008
1970 2000
Statistics for USA; data for developed countries are comparable.

Source: Journal of the American Medical Association, 2005.
24 25
Fact # 3:
The Therapeutic Goal of Chemotherapy And Deadlocks of Conventional Cancer Therapies
Radiation Is to Kill Cancer Cells by Intoxicat-
ing the Entire Body
Radiation and chemotherapy – which have been used by conven-
tional medicine for more than half a century to fight cancer, have
one common ‘therapeutic’ effect: they kill cancer cells and bil-
lions of healthy cells alike. These highly toxic procedures indis-
criminately damage all cells in the body of patients and have,
therefore, been compared to a ‘shotgun’ approach.
To make things worse, chemotherapy affects particularly those

healthy cells in our body that are multiplying rapidly, such as the Radiation Chemotherapy
white blood cells of the immune system. Thus, when the body of a
cancer patient has the greatest need for effective defence, the
immune cells are being systematically destroyed by highly toxic
procedures.
Even a lay person can understand that if medicine has to resort to

‘shotgun’ approaches, this means only one thing: the causes and
pathways of the disease are not properly understood so that effec-
tive therapies could not be developed that specifically target Cancer Cell
abnormal cells, e.g., cancer cells.
Any ‘shotgun’ approach to a disease reflects the desperation on

the part of medicine itself. To deceive the patients and provide
false hope, conventional medicine uses the terms chemo-’therapy’
and radio-’therapy’ – when actually no effective ‘therapy’ is avail-
able. The past half century of conventional cancer therapy can
only be described as a failure. Healthy Cell
Both radiation and chemotherapy kill cancer cells and – at

the same time – healthy cells in the body of cancer
patients.
26 27
Fact # 4:
The Horrific Toxicity of Chemotherapy
Chemotherapy Is Extremely Toxic
A whole array of highly toxic chemicals are being applied to mil-
lions of cancer patients around the world with the alleged promise
to cure cancer, hence the term ‘Chemo-Therapy’. Among these
substances are some of the most toxic chemicals known to man.
The first chemotherapy drug was directly derived from ‘mustard
gas’, a chemical warfare agent used in World War I as a weapon!
Derivatives of this deadly gas are still being used today in cancer Mustard gas molecule. About one third of the soldiers exposed to
patients as mechlorethamine, cyclophosphamide, chlorambucil it in WWI died.
and ifosfamide.
Besides these derivatives of mustard gas, there are several other

groups of highly toxic chemicals applied to cancer patients. The
common denominator of all these chemicals is that they damage
the molecules of inheritance (DNA) in the cell core and interrupt
other essential biological processes in every cell of the body.
The toxicity of chemotherapy is also reflected in the ‘safety pre-

Health professionals handling chemotherapy must wear extremely
cautions’ for cancer patients published by the ‘American Cancer thick gloves to protect themselves from toxic damage (left). The
Society’. Even health professionals are being reminded about the picture on the right shows damage caused by chemotherapy sub-
health risks they are exposed to while handling chemotherapy stance spilled on an unprotected hand.
drugs. These risks include damage to their DNA, birth defects,
development of new cancers and organ damage. Thus, health pro-
fessionals have to “wear special gloves, goggles, and gowns when
preparing and giving chemotherapy” (www.cancer.org).
These chemicals are toxic and dangerous to others even after they
are excreted through the skin, urine, stool, even tears, semen and
vaginal fluid. The people at particular risk include family mem-
bers, caregivers and literally anyone touching a chemotherapy
patient.
Entire companies flourish on the sales of protective gear and

waste disposal devices for the chemotherapy business.
28 29
Damaging Side Effects of Chemotherapy

Introducing the ‘Hickman’-Catheter
Most other infusion drugs are being applied to the patient via the
arm veins. However, this application mode is not possible for most
chemotherapy drugs because the chemicals would instantly ‘burn’
the blood vessel walls, leading to severe tissue damage and
inflammation.
To apply these substances to the cancer patient, nevertheless, a

special infusion device has to be used, the ‘Hickman Catheter.’
This special catheter is inserted directly into the superior vena
cava, one of the largest veins of the body, that is located close to
the right heart atrium. Because of the large diameter of this vein
(about 1 inch), the highly concentrated chemical substance does
not get into direct contact with the blood vessel wall and is being
diluted with the blood stream directly into the right heart ventricle.
With these toxic substances circulating in the body for many hours,
even days, with the destruction of cells being the desired therapeu-
tic target of these chemicals, it is no wonder that ‘chemotherapy’
causes severe side effects in the patients, including:
• Destruction of the bone - Vision and hearing impairment

marrow, the site of blood cell for- - Damage to the entire digestive
mation, resulting in system, ulcers in mouth, vomit-
- Impaired immune system ing, diarrhea
- Increased rate of infections - Infertility
- Anemia - Weight loss, anorexia
Hickman Catheter:
- Excessive bleeding - Hair loss
• Organ damage • Triggering the growth of new can-

Most chemotherapy
- Heart damage, shortness of cers anywhere in the body drugs are so toxic that
breath, edema, arrhythmia they need this special
- Lung damage, breathing • Death device to be delivered
problems, fever into the patient’s body.
- Liver damage and failure
- Kidney damage and failure
- Damage to brain, memory loss,
decreased mental
function, depression
30 31
Why Cancer Patients Voluntarily Subject The Psychological War

Themselves to Such Toxic Procedures With the Cancer Epidemic
While reading the previous pages, you, our readers, may have
asked yourself the question: how is it possible that 1. The fear of death from cancer is a
anyone would voluntarily allow such toxic chemicals to be inject- precondition for the acceptance of
ed or infused into the body? potentially deadly treatments like
chemotherapy.
Even more, how can it be that mankind as a whole could allow
the intoxication of the human body to become the universal stan- 2. As long as cancer remains essentially a
dard ‘therapy’ for cancer for more than half a century. ‘death sentence’ the investment business
with toxic chemotherapies will continue.
The answer to this question is sobering: A patient who associates
the diagnosis ‘cancer’ with the worst outcome – death – is instant-
ly put into a psychological state of fear and despair. This, in turn, 3. Any medical breakthrough that will turn
renders this patient susceptible to accept any ‘therapy’ – even if cancer into a manageable disease will,
that treatment itself is potentially deadly – as long as the threat of inevitably, remove the ‘death sentence’
certain death is being delayed for only a short time. associated with this disease – and thereby
destroy the fatal dependency of millions of
What makes things worse is the fact that for many types of cancer patients on toxic chemotherapy.
it is already established that chemotherapy does not prolong the
life of cancer patients at all. This includes prostate cancer, skin 4. Considering the fact that cancer has
cancer (melanoma), bladder cancer, kidney cancer, pancreatic
remained a ‘death sentence’ for more than
cancer and others. Patients with these types of cancer who
half a century, there exists an objective and
received chemotherapy have the same limited life expectancy as
those who don’t.* immediate need for new scientific direc-
tions that will also end the ‘psychological
war’ with the cancer epidemic.
* www.ncbi.nlm.nih.gov/pubmed/15630849
32 33
{
Fact # 5: New Cancer Drug Markets for a
Toxic Chemotherapy Drugs Boost Multitude of ‘Side Effect Diseases’
Multi-Billion Dollar Sales of Other Drugs
The toxicity of chemotherapy agents damages not only a few
organs in our body, but all organs and cell systems. For most • Painkillers
patients, every cycle of chemotherapy is associated not only with
severe pain, but with a multitude of new health problems. Some • Steroids/Cortisone
of these ‘side effect diseases’ continue for their entire lives – e.g.,
The Toxicity of • Other Anti-Inflam-
irreversible organ damage.
Chemotherapy matory Drugs
To cope with these side effects of chemotherapy, a series of drugs Creates the • Antibiotics
are being prescribed in order to alleviate the symptoms of these Need for Even
‘side-effect diseases.’ The most frequent categories of prescription
More Drugs • Blood Transfusions
drugs applied to cancer patients during and after chemotherapy
include:
• Antidepressants
• Different types of antibiotics prescribed against frequent infec- • Many Other Drugs
tions resulting from the damaged immune system.
• Painkillers, including morphine, to alleviate the unbearable
pain often associated with the chemical intoxication of the
human body.
• Steroids and all other inflammatory drugs to alleviate systemat- The toxicity of chemotherapy
ic inflammation of joints and other organs from toxic triggers a myriad of ‘side effect
chemotherapy. diseases’ which are treated with
a multitude of prescription
• Antidepressants and other psychiatric drugs prescribed to help
drugs and intensive medical
patients cope with the traumatic physical and psychological
procedures.
consequences of chemotherapy.
Right: Over the past decades,
Moreover, countless medical procedures are being performed on several handbooks were
cancer patients in an attempt to repair the severe damage caused published for patients and
by chemotherapy drugs. Among them are transplants of bone mar- nurses about managing the
row, liver, kidneys and other organs. side effects of chemotherapy
and radiation therapy.
34 35
Fact # 6: Many Widely Used Prescription

Many Pharmaceutical Prescription Drugs Drugs Can Cause Cancer
Can Cause Cancer
US Government Report:
We have just learned that the toxic side effects of chemotherapy
require even more prescription drugs to alleviate the so-called
A multitude of widely used prescription drugs account for
‘side effect diseases’. What you should also know is that almost more than 40% of all chemical substances that can cause
half of all the substances listed by the US government as ‘carcino- cancer in humans.
genic’ – i.e., cancer causing – are pharmaceutical drugs pre-
scribed for various diseases. Different classes of prescription drugs can cause new
cancers to a varying degree:
The reason for this is that pharmaceutical drugs are synthetic –
i.e., artificial – compounds, not natural substances. Thus, the
human body cannot recognise them and they cannot easily be • 87% of anti-cancer drugs can cause new cancers
neutralised and eliminated. Most of these drugs cause damage to
• 50% of all antibiotics can cause cancer
the DNA of cells, thereby inducing the cancer process.
• 60% of drugs prescribed against depression and mental
The reason why most prescription drugs are not natural com- disorders are potentially carcinogenic
pounds but synthetic in nature is their patentability. The pharma- • Almost all immunosuppressants facilitate the develop-
ceutical business is based on profiting from the huge patent fees of ment of cancer
newly synthesised chemical compounds. Thus, the ongoing can- • Many other drugs are listed as cancerogenic, including
cer epidemic is also the result of this business principle. We will anti-ulcer drugs, anti-allergy drugs and others
talk more about that in chapter V.
The fact that many prescription drugs can cause cancer is widely
Sources:
known and is documented in many clinical studies and even gov- • National Institutes of Health, 9th
ernment reports. On the facing page is a list of some of the pre- Report on Carcinogens, 2001
scription drug classes that are known to pose the highest risk for • National Institutes of Health, NIH
12th Report on Carcinogens, 2011
developing cancer. Other powerful carcinogenic substances • US Department of Health and
include hormones such as estrogen, present in anti-contraceptive Human Services, 7th Annual
pills and prescribed to millions of menopausal women as ‘hor- Report on Carcinogens, 1995
mone replacement therapy.’
36 37
Fact # 7: Biological Regulation Instead of

The Indiscriminate Killing of Cells as Chemical and Radioactive Intoxication
Failed ‘Therapy’ for Cancer Will Be
Replaced by the Modern Approach of
‘Cellular Regulation’ Toxic Chemicals
The 20th Century will go into history as a deadlock in the

‘war against cancer’. Despite countless media reports about
alleged breakthroughs of cancer ‘cures’, the Cancer epi- Radioactive Agents
demic is still spreading on a global level.
The prevailing therapeutic approaches to this disease by

conventional medicine – chemotherapy and radiation –
were based on the indiscriminate damaging and killing of
billions of body cells in the hope to eliminate cancer.
The statistics prove that this approach of ‘intoxication’ was a

failure. For many types of cancer, chemotherapy and radia- Natural Regulation of
tion therapy had no advantage at all, for other types the
• Inhibition of
effects were minimal, short-term – and they were achieved Tumour Growth
at the expense of suffering and a dramatic decline in the
• Inhibition of
quality of life for the patient. Metastasis
• Encapsulation of
Thus, there exists an objective need for a completely new Tumour
direction in cancer therapy. This new approach has to be
• Selective Elimination
based on a new understanding about the natural regulation of Cancer Cells
of cancer cells. The keys to the effective control of cancer
are natural therapeutics that can interfere with and regulate
the malfunction of the biological software of cancer cells –
without affecting healthy cells.
Once that is accomplished, cancer can largely be eliminat-

ed as a cause of death and disability among humans.
Key to Victory Over Cancer:
Regulation Instead of Intoxication
38 39
“Doctor, how long?”
At the beginning of the 21st Century, the same bizarre ritual con- The hand of a doctor pats the patient’s leg in a mixture of conso-
tinues in doctors’ offices and hospitals around the world: Patients lation, reassurance and offering hope. Of course, there is no basis
are being diagnosed with ‘cancer’. Their wrenching hands for any of these delusive messages communicated by the doctor’s
express their minds that switch between helplessness and desper- hand – cancer is still largely what it was a century ago: a death
ation. In parallel, a second ghostly ritual takes place. verdict. It’s time for change!
40 41
In the next chapters

we will take you on
a remarkable health journey.
You will realise that

the biological tools to achieve
‘Victory Over Cancer’
are available right now!
42 43
Purple Coast ‘Science as Art’ is an idea by August Kowalczyk.
‘Purple Coast’ is a microscopic picture of kidney tissue
with the collagen stained pink.

www.dr-rath-humanities-foundation.org/exhibition/index.html
II. The Medical Breakthrough
Towards the Natural Control
of Cancer
Victory Over Cancer Part One: Making the Unthinkable Possible Chapter II – The Medical Breakthrough Towards the Natural Control of Cancer
Chapter Introduction by Dr. Rath

The discoveries reported in the following chapter were made
more than two decades ago. The facing page shows a page from
my manuscript published under the title of “Plasmin-Induced Pro-
teolysis” in early 1992. It described for the first time that the key
mechanism of cancer spread, collagen-digestion, can be blocked
by natural substances. Nobel Laureate Linus Pauling supported
the far-reaching conclusions of this publication: The implementa-
tion of these discoveries into medicine will lead to the natural
control of cancer!
Immediately after this publication, ‘collagen-digestion’ took a

centre stage at many scientific conferences. Moreover, it triggered
a race among drug companies to find synthetic blockers of this
mechanism – which they could patent. Ten years later, on May
12, 2002, the San Francisco Chronicle published a report of this
dramatic race with the title, ‘Misdiagnosis’. Without referring to
the original work, they described the race of drug companies to
find, what the newspaper called, the ‘holy grail of medicine’ – the
solution to the cancer epidemic.
The race failed – or so they say. It is easy for drug companies to

abandon a race if, at the end of it, they would lose hundreds of
billions of dollars. For decades, the cancer epidemic had been
one of the pharmaceutical industry's most lucrative markets. Thus,
the end of the cancer epidemic would have been a debilitating
disaster. So abandoning the search for the ‘holy grail of medicine’
at that time was an easy decision for the pharmaceutical invest-
ment ‘business with disease’.
Plasmin-Induced Proteolysis
But the ‘Genie’ was out of the bottle. In an effort to ‘solve’ this
and the Role of Apoprotein(a),
problem, the drug lobbyists decided to spend the next decade
fighting the pioneers of this breakthrough (see also chapter IV). Lysine, and Synthetic Lysine Analogs
But their efforts were in vain. This book offers the ‘holy grail of Matthias Rath and Linus Pauling
Journal of Orthomolecular Medicine, 1992, 7, 17-22
medicine’ to all mankind.
For full text, see Appendix
50 51
What you will learn in this chapter • Thus, cancer cells mimic and abuse natural mechanisms,
already used by our body under normal conditions. But, as
opposed to normal conditions, where the production of colla-
• Cancer is no longer a mysterious disease. Its key mechanisms
gen-digesting enzymes is tightly controlled, cancer cells pro-
of development and control can be understood by everyone,
duce these biological scissors out of control and forever.
without any special medical education.
• This biological deception, the mimicking of normal biological
• Cancer can be caused by many factors, but there is one com-
mechanisms by cancer cells, is the reason why cancer cells are
mon pathway via which all types of cancer cells spread: the
easily evading the defence system of our body – and why can-
digestion of connective tissue around the cancer cell.
cer is such an aggressive disease.
• Overcoming the confinement by the surrounding connective
• Most importantly, we will learn that there are certain natural
tissue (e.g., collagen) is a pre-condition for cancer cells to
dietary molecules – micronutrients – which are able to block
grow, metastasise and to develop into a life-threatening dis-
the biological scissor enzymes. Taken in optimum amounts
ease.
these micronutrients are able to inhibit uncontrolled connec-
tive tissue digestion and the spread of cancer cells.
• The mechanism by which cancer cells break this barrier is by
producing uncontrolled amounts of enzymes, or biocatalysts.
These small proteins function as ‘biological scissors’ paving the
way for cancer cells to move through the body.
The information
provided in this
• All cancer cells, irrespective of the organ where they originate, book is so basic and
use the same collagen-digesting enzymes. easy to understand
that it will soon be
• The more of these ‘biological scissors’ a cancer cell produces, part of biology
the more aggressive and malignant it is, the faster it spreads classes in schools
and, generally, the shorter is the life expectancy of the patient. around the world.
• These ‘biological scissor’ enzymes are not confined to cancer

cells. Already under normal (physiological) conditions cells
use these enzymes to migrate through the body, including
white blood cells (leucocytes), while defending our body
against infections, and egg cells during the process of ovula-
tion in the female menstrual cycle.
52 53
Let’s have a first look at a cancer cell ‘Biological Scissors’ Enzymes

Normally, the cells of our body are embedded in a network of col- Are Produced By All Cancer Cells
lagen and other connective tissue molecules which keep them in
place. For cancer cells to grow into a tumour and to spread
throughout the body, they need to overcome this connective tissue
confinement. In order to do so, every cancer cell produces ‘bio-
logical scissors,’ enzymes (or biocatalysts) that are able to digest
the connective tissue surrounding the cancer cells.
Cancer cells do not produce these destructive enzymes just for a

short period of time, but as long as they live. Since cancer cells are
by their very nature immortal, a growing cancer could be
described as a disease that gradually digests the body from within.
The facing page shows the picture of a real cancer cell taken with
an electron microscope, which magnifies this cell to 6500 times of
its normal size. This type of cell is called a carcinoma cell, which
means that it derives from epithelial cells, the type of cell that
lines both the inner (i.e., lung, bowel) and outer (skin) surfaces of
the body.
Under this high magnification we can clearly identify some of the

characteristic features of all cancer cells: a) The huge, unusually
shaped cell core (nucleus) reflecting a high multiplication rate of
the cancer cells and b) the uneven, complex cell surface structure,
reflecting a high activity of secretion of substances produced by
cancer cells.
One of the most important molecules secreted by cancer cells in

huge amounts are the collagen digesting ‘scissor’ enzymes. They
are graphically added to this picture in the form of red ‘pacman’-
like structures.
54 55
Collagen-Digesting Enzymes
Function as Biological Scissors
Plasminogen Activator Plasminogen Metalloproteinases (MMPs)

(Urokinase)
The purpose of this

biological cascade is to
digest the connective
tissue of our body
Connective Tissue
Biological ‘chain reaction’ for connective tissue digestion (Collagen) Digestion
Of course, these ‘pacman’ structures in real life are biological of them, such as Plasminogen/Plasmin and Metalloproteinases
molecules, proteins, that have the unique ability to chop up colla- (coloured three-dimensional structures). To enhance their destruc-
gen fibers and other connective tissue molecules. The above pic- tive effect, they can activate each other in the form of a biological
ture shows that there is not just one type of ‘pacman’, but several ‘chain reaction’.
56 57
How Cells Move Through the Body

Cells Move Through the Tissue
If we want to understand how diseases spread, we must look at and Organs of Our Body
the way healthy cells move through the body. This is easy to
explain in the case of red blood cells; they are just carried along in
the blood stream. However, it is more difficult to imagine how Cell nucleus initiates the production of
collagen digesting enzymes
cells from other organs can move through our body and overcome
the barriers formed by the connective tissue.
In order to move through the connective tissue, a cell has to be A

capable of temporarily dissolving the surrounding tissue – the col- Production of
lagen and elastic fibers – so it can make its way through. Cellular these enzymes
migration through dense tissue requires that these cells secrete inside the cell
and secretion to
enzymes – ‘biological scissors’ – that can dissolve the surrounding the outside
collagen. This is why these protein molecules are known as con-
nective tissue dissolving enzymes, or in short: collagen-digesting
enzymes. Enzymes attack
collagen and
For easy understanding, we will continue to symbolise collagen- other connective
tissue
digesting enzymes as red circles or as a ‘pacman’ throughout the
book.
On the facing page you see the production of collagen-digesting

enzymes inside a cell (picture A). These enzymes are then secreted B The enzymes
into the environment of this cell where they ‘attack’ and digest the temporarily
digest the con-
surrounding collagen fibers. This process allows this cell to create nective tissue
‘loop holes’ within the dense network of connective tissue and surrounding the
pass through it (picture B). cell, thereby
paving the way
for it to migrate
On the following pages we will provide you with some examples through the body
of how this interesting biological mechanism is being used in our
body under normal (physiological) conditions.
58 59
Collagen Digestion During Ovulation

The Cellular Mechanism of Ovulation
The process of ovulation in the female body is one of the most fas-
cinating functions in which the body uses a collagen-dissolving
mechanism. Monthly hormonal changes in the female cycle stim- Womb
ulate certain cell types (granulocytes) surrounding the ripening (Uterus) Fallopian Tube
egg cell (follicle) inside the ovary.
Under hormonal influence (e.g., estrogen) these cells start produc-

ing large amounts of fluid rich in these collagen-dissolving
enzymes. In the middle of the female cycle, the surrounding of the Ovary
mature egg cell is so rich in collagen-dissolving enzymes that the
collagen tissue of the ovarian wall loosens and forms a hole. This
opening is just big enough for allowing the egg cell to move from
the ovary through the small connecting channel (fallopian tube)
into the womb (uterus). View inside the ovary:
Ovulation:
Mature egg pass-
It is clear that this mechanism needs to be precisely timed and to es through the
be confined to this specific location. This mechanism must let only ovary wall and
one egg per menstrual cycle pass through and start its journey to begins its passage
the womb. Therefore, it is absolutely necessary that collagen-dis- View inside
to the womb
solving enzymes remain in a timely and physiological balance the wall of
with the mechanism that blocks these enzymes and initiates self- the ovary:
healing of the tissue.
Immediately after the egg cell has left the ovary, the activity of col-
lagen-dissolving enzymes is stopped by the body’s own enzymatic
blocks. This shifts the balance toward collagen-producing mecha-
nisms, which dominate over the collagen-dissolving process.
Using this mechanism the tissue of the ovary wall can quickly heal
and close itself. Four weeks later, the whole process repeats.
Triggered by hormones, a temporary peak in the production of collagen-
digesting enzymes ‘opens’ the ovary tissue for a few seconds – just
enough time for the mature egg to leave the ovary and start its journey to
the womb.
60 61
A Closer Look at This Mechanism

Collagen Dissolving During Ovulation
We are aware that the comprehensive health information of this
book may be a challenge. However, in order to understand the
origin of diseases and how we can prevent them it is absolutely
necessary to learn to ‘think’ at the level of cells.
For health professionals this may be easier because they are

already familiar with processes occurring at the microscopic level.
For lay persons this may be more difficult.
Uterus Ovary
Since we want the information of this book to reach every person
on this planet we will make a particular effort to illustrate and
visualise this cellular level to our readers in an easy-to-understand
manner. Throughout this book we will take you on a fantastic jour-
ney through the human body. A
On the facing pages we start this journey by looking at microscop-
ic pictures of the fascinating process of ovulation.
Picture A catches the moment when the mature egg cell leaves the
ovary through a small hole biologically created in the wall of this
organ. The collagen digesting enzymes (red pacmen) are added to
illustrate this biological process.
Picture B shows an egg cell (centre) under a highly magnifying B

microscope. The small bumps surrounding this large cell are the
cells (granulocytes) specialised in producing the large amounts of
collagen digesting enzymes needed for ovulation.
Follicle Cell
Granulocytes
62 63
Collagen Digestion During Infections

How White Blood Cells Migrate
Another mechanism where collagen digestion playes a role is Through Our Body
infection. The body’s basic protection against invaders (microbes)
is secured by the white blood cells. Several subgroups of white For example: Lung Infection
blood cells perform specific functions in the immune system, a
sort of ‘police cell’.
Especially important are the macrophages, which can ‘eat’ and

digest invaders. Immature forms of these cells, called monocytes,
White blood cells
can reach every part of the body through the blood stream. If an
(“police cells”)
infection takes place in the lungs, the body releases ‘alarm sub-
leave a small lung
stances’ that attract monocytes to the site of infection. blood vessel and
move toward the
In case of a lung infection, the white blood cells, arriving with the area of infection
blood stream, traverse the blood vessel wall of the small lung cap- with the help of
illaries and move into the lung tissue with the help of collagen-dis- collagen-digesting
solving enzymes. To reach the site of infection in the lung, (e.g., by enzymes.
bacteria or viruses), the white blood cells must be able to migrate
through the lung tissue. In order to do so, they use the same colla-
gen-dissolving mechanism, loosening the dense surrounding con-
nective tissue and moving through the tissue much like an expedi-
tion that cuts its way through the jungle with the help of machetes.
Just as we have seen in ovulation, the connective tissue will close

again right after the cells have passed through, using the enzyme-
neutralising and tissue-repairing mechanisms. Bacteria
This repair is assured by the optimal availability of ‘pac men’

After the white blood cells have passed through,
−neutralising factors and of production of new collagen molecules.
the collagen-digestion stops and the tissue repairs itself.
White blood cells use the mechanism of collagen

digestion already under normal (physiological) condi-
tions in a controlled and precisely timed process.
64 65
Take a Microscopic View

of How a White Blood Cell Migrates
a) A white blood cell c) The white blood
A from the blood stream C cell now has entire-
(white area) attaches ly left the blood
to the cell lining stream, the blood
(endothelial cell) of vessel wall has
the blood vessel wall. closed behind it.
b) The white d) The white blood

blood cell leaves B cell has started its D
the blood stream migration through
and – with the the connective tissue
help of collagen- and is completely
digesting enzymes surrounded by it.
– it ‘squeezes’ its
way inside the
blood vessel wall.
Copyright Dr. A. Loesch,

printed with permission
66 67
Collagen Digestion in Tissue Remodelling

Collagen Digestion in the Breast
Another process where collagen-digesting enzymes are used
under normal conditions are all forms of tissue remodelling
processes. One such example is the preparation of the female
breast for lactation, (i.e., breastfeeding). A. Milk Duct (Closed) in Normal Breast Tissue
At the end of pregnancy, and in preparation for breastfeeding for

the newborn, hormonal signals ‘tell’ the cells of the breast to
‘switch on’ the production of collagen digesting enzymes. Just like
a ‘demolition team’ in real life their job is to tear down the existing
architecture of breast tissue in order to allow the reconstruction of
the ‘lactating breast’ – and its adaptation for milk production.
On the facing page you can see under the microscope the dramat-
ic architectural changes the female breast tissue undergoes from
normal stage to lactating phase.
In picture A you can see the tissue architecture of a non-lactating

breast, characterised by the dense structure of connective tissue
surrounding a largely closed milk duct in the center of the picture.
In sharp contrast, picture B shows the cellular (histological) struc-

ture of a lactating breast, characterised by loosened connective tis-
sue, the presence of prominent gland cells required for the pro-
duction of milk (small white circles) as well as the widely open
milk duct (centre of the picture).
Imagine the amount of collagen digesting enzymes required for

initiating this process and the fascinating architectural blueprint to B. Milk Duct (Open) During Lactation
rebuild the breast tissue for each of these stages.
A. Microscopic picture of a milk duct which is closed in
Other processes of tissue remodelling involving collagen-diges- non-lactating women.
tion include wound healing as well as body and organ growth. B. For lactation the breast tissue is restructured.
The open milk ducts allow the flow of milk.
68 69
Unravelling the
Secrets of Cancer
70 71
Unsolved Question No. 1:

Cancer Cells Abuse
Why is Cancer Such an Aggressive Disease?
Natural Mechanisms of Our Body
Despite the elucidation of some selected aspects, the fundamental
nature of cancer has remained a mystery. Moreover, as long as the
A
most basic questions in connection with cancer remain unan- Health (Physiological Conditions)
swered, there can be no effective cure.
This book provides answers to the most basic questions:
1. Why is cancer a particularly aggressive disease.

2. Why some organs in our body are more affected Tightly Controlled
by cancer than others. White Blood Cell (Leukocyte) Connective Tissue
Digestion
The facing page summarises the answer to the first question in
graphical form. If a disease mechanism is being used already under
normal, healthy conditions, the body simply has not developed
any effective defences to counteract these disease mechanisms.
Since white blood cells, ovary cells and many other body cells
already use the mechanism of producing collagen digesting Egg Cell (Ovary Cell)
enzymes under normal (physiological) conditions (A), cancer can
spread in an uncontrolled fashion and uninterfered with by the
body’s defences (B). The trick is simple: Cancer cells hijack the
very same mechanism that healthy cells use – but in an uncon- B
trolled manner.
Disease, e.g., Cancer (Pathological Conditions)
For the first time, we can now explain the aggressive nature of
cancer. This new understanding points at the significance of spe-
cific disease mechanisms and, thereby, will lead towards an effec-
tive, natural control of cancer.
Uncontrolled
Connective Tissue
Digestion
72 73
Unsolved Question No. 2:

Cancer in Reproductive Organs
Why are Some Forms of Cancer
More Frequent Than Others?
The second question that has remained unanswered by cancer Collagen Digestive
researchers and specialists (oncologists) until today is ‘Why are Enzymes Used Under
some forms of cancer more frequent than others?’ Normal Conditions
Our research has provided the answer to this key question too.
Cancer develops particularly often in organs that use collagen
digestion already under normal or physiological conditions. The Breast Lactation
first group of organs affected are reproductive organs. In particular
female reproductive organs undergo dramatic and repeated func-
tional (hormonal) and structural changes during their lifetime.
Ovary Ovulation
Earlier in this chapter we already discussed the profound changes Uterus Pregnancy
in the female body during ovulation and lactation. In a similar
way, the womb (uterus) and the cervix undergo tissue restructuring
in connection with the monthly cycle and pregnancy that all Cervix Conception
require a high activity of collagen digesting enzymes. Not surpris-
ingly, these organs are the most susceptible to connective tissue Testes Sperm Production
digestion going out of control – and, therefore, most prone to can-
cer.
Prostate Sperm Fluid Production
For the very same reasons, the reproductive organs of men, the
prostate and testes, are also frequent sites of cancer development.
Another factor is of particular significance: Both female and male

reproductive hormones are known to stimulate the production of
collagen digestion enzymes in reproductive organs. Elevated lev-
els of these hormones – either by increased production in the
body or from hormonal drugs (contraception, hormone replace-
ment) increase the risk for reproductive cancers.
74 75
Why Some Forms of Cancer Are More

Frequent Than Others: Bone Cancer Bone Cancer in Children
Another organ that often develops cancer is our skele-

tal system. Noteworthy is the fact that bone cancer Joint
occurs particularly frequently in children and adoles-
cents.
Area of
This phenomenon, too, can now be explained. The Bone Growth
bones are among those organs that undergo the most (Epyphysis)
dramatic architectural changes during the growth
phase from childhood to adult age. Bone growth
requires a high activity of collagen digestive enzymes.
The extension of bone length is not a uniform process

that occurs evenly across the entire length of a bone.
It is concentrated at distinct areas towards the end of
X-ray of bone cancer.
a bone – near the joint.
Note the cancer development in the bone ‘growth area’
near the joint.
Not surprisingly, it is in this area, called the epiphysis,
where most forms of primary bone cancers originate.
76 77
Why Some Forms of Cancer Are More

Blood Cancer
Frequent Than Others: Leukemia
(Leukemia)
Earlier in this chapter we described the white blood
cells' (leucocytes) unique ability to migrate through
body tissue with the help of collagen digestion
enzymes.
Imagine if this process goes awry in some white blood

cells. Then it would destroy the connective tissue with-
out stopping.
Precisely that happens in cancer of white blood cells,

also known as leukemia.
The innate ability of white blood cells to produce

large quantities of collagen digesting enzymes render
these leukocytes particularly prone to cancer.
Now we also understand why leukemia is one of the

most frequent forms of cancer.
Leukemia cell under a highly magnifying electron micro-

scope. The continuous secretion of collagen-digesting
enzymes is illustrated by red ‘pacmen’.
78 79
A Closer Look at Leukemia

Leukemia Under the Microscope
Once cancer cells produce the biological ‘scissor’ enzymes they
no longer know any barriers and can invade and slowly ‘digest’
the structure of any organ of the body.
This is also true for leukemia cells. One of the phenomena associ-
ated with this form of blood cancer is the fact that leukemia
patients do not primarily die from an overproduction of leukocytes
and from these cells clogging the blood circulation.
In many cases leukemia patients die from the failure of various

organs, in particular the ‘filter organs’ - the liver and spleen. Mil-
lions of white blood cells invade these organs from the blood
stream. But they don’t just pass through like healthy white blood
cells would do. These cancerous white blood cells produce
immense amounts of collagen digesting enzymes, literally digest-
ing these organs from within.
The picture on the facing page shows a microscopic cross section

through the liver of a patient with ‘lymphatic leukemia’. Each of
the small purple dots in the picture is a white blood cell (in this
case lymphocyte) that has invaded the liver tissue (pink areas).
Considering the massive number of these purple dots and how

many collagen digesting enzymes each of them produces, it is
easy to imagine the amount of connective tissue destruction and
organ damage done by this type of cancer.
Leukemia is a good example of how the understanding of cellular

mechanisms – the production of collagen digesting enzymes by
white blood cells – guides us towards effective therapies. Microscopic picture of lymphatic leukemia.
Cancerous white blood cells (lymphocytes) invaded the liver.

The massive amounts of collagen digesting enzymes they pro-
duce destroy the organ, eventually leading to organ failure.
80 81
Collagen Dissolving in Cancer

How Tumours Develop
The collagen digesting mechanism we just learned about is being
abused by all forms of cancers irrespective of their origin. The
illustration on the facing pages shows an example of this process: Liver Tumour
The development of liver cancer.
The liver is the body’s central metabolic organ, among others, it is Liver cells:
responsible for neutralising and removing toxins from the body. • Healthy cells
Toxins such as pesticides, preservatives as well as many synthetic (brown)
• Cancer cells
pharmaceutal drugs are the most common causes of liver cancer. (green)
Liver cells that are exposed to these poisonous substances can be
permanently damaged or destroyed. The most frequent form of
damage leads to a permanently false ‘programming’ of the cell’s
genetic material (DNA). In cancer cells, the
software in the cell
Such a malignant alteration of the cell’s software marks the begin- core is reprogrammed
ning of the cancer process by activating a cascade of biological turning cancer cells
immortal.
steps that eventually lead to full-blown cancer. Some of these
steps are essential for the growth and spread of cancer:
Cancer cells
continuously
1. Uncontrolled cell multiplication. The software of a cancer cell • multiply and
is altered in such a way that it renders this cell ‘immortal’ and • produce
causes it to multiply indefinitely. collagen-digesting
enzymes
2. Mass production of collagen-dissolving enzymes. The software
of a cancer cell is altered in such a way that it renders this cell Here individual cancer cells from a liver tumour use collagen-digesting
‘immortal’ and causes it to multiply indefinitely. enzymes to break their way through the surrounding connective tissue
tissue and spread.
The more collagen digesting enzymes a cancer cell produces, the
more aggressive the cancer, the faster the cancer spreads through
the body, and the shorter the life expectancy of the patient if the
mechanism is not stopped. The production of collagen-digesting enzymes is a pre-
condition for any type of cancer to grow and spread –
irrespective of the organ it originates from.
82 83
How Cancer Cells Spread

And Invade Other Organs (Metastasis) How Cancer Cells Metastasise
The collagen-dissolving mechanism also plays a major role when

cancer cells migrate to form secondary tumour in other organs or
parts of the body. This secondary tumour is called metastasis. The Liver Tumour
illustration on the facing page shows the process of a liver tumour (Primary Tumour)
metastasising to the lungs.
Every tumour is surrounded by a network of small blood vessels

(capillaries). With the help of collagen-dissolving enzymes, indi- Cancer cells enter
the blood stream
vidual cancer cells can ‘puncture’ the wall of these capillaries and with the help of
enter the blood stream. Once inside the blood vessel, cancer cells collagen-digesting
are being swept away with the blood flow, just like red or white enzymes
blood cells, and reach other organs.
Through the
blood stream
The lung is a particularly frequent organ for the formation of Liver cancer cells can
metastasis because the blood circulation in the lung branches out Blood Vessel reach other
into billions of tiny capillaries that facilitate optimum blood oxy- organs
genation. The diameter of these lung capillaries is even smaller
than a hair which allows for an easy adherence of cancer cells to Cancer cells leave the
the wall of these blood vessels. blood stream using
collagen-digesting
Since these cancer cells are still producing large amounts of colla- enzymes to form
metastatic tumours
gen digesting enzymes, they now are able to leave the blood
(here in the lung)
stream again and penetrate the lung tissue. There the cancer cells
continue to multiply and develop into a secondary tumour, a Metastasis
metastasis. (Secondary Tumour)
The more collagen-dissolving enzymes a specific type of cancer

cell can produce, the more easily it develops metastases.
All types of cancer – irrespective of the organ where the pri-
mary tumour is located – use collagen-digesting enzymes to
reach other organs in the body in order to metastasise.
84 85
Our Journey Through the Body Continues ...
The process of metastasis is no longer a mystery.
The picture on the facing page shows an actual can-

cer cell under a highly magnifying microscope.
The body of this migrating cancer cell expands in the

direction of its movement in the tissue. It can form
little ‘arm’-like structures that drag the cancer cell
along the surface, in this case, of a blood vessel.
The collagen digesting enzymes are added to illustrate

the process by which any obstruction on the path of
this cancer cell is being overcome.
86 87
Our Journey Through the Body Continues ...
Cancer metastasis is a unique process where the can-

cer cells of one organ nestle in a remote organ and
begin to multiply there.
This unique mechanism leads to phenomena like the

one shown on the facing page: A cluster of breast can-
cer cells is caught inside the portal vein of the liver.
Once these cells invade the liver tissue, a ‘breast

tumour’ will start growing inside another organ, in
this case the liver.
Microscopic picture of breast cancer cells (brown cell

cluster in the centre) that have metastasised to the liver
(blue areas). The cluster of breast cancer cells is shown
within a liver blood vessel (portal vein).
88 89
Now That We Understand the

Key Mechanism of
How All Cancer Cells Spread,
We Need to Find a Way
to Block This Destructive Process –
Naturally!
90 91
Lysine as a Natural Enzyme Block

Lysine Is the Most Effective Natural Way to
In previous chapters we have learned about the role of collagen Block Collagen-Dissolving Enzymes
digestion in facilitating the spread of diseases through the body.
The uncontrolled activation of this collagen-dissolving mechanism Lysine, a natural blocker of collagen-digesting enzymes,
leads to the development of aggressive diseases such as cancer. must be supplied from the diet.
Every therapeutic approach that will halt uncontrolled connective

tissue digestion or even slow it down will therefore be a momen-
tous success in the field of medicine. Because of its universal
importance in fighting all types of cancer, this therapeutic goal has
been designated the ‘holy grail of medicine’.
Interestingly, Nature itself provides us with two large groups of

molecules that can block the collagen dissolving mechanism. The
first group is the body’s intrinsic enzymatic block that can stop the
action of collagen-digesting enzymes in a few moments. The sec-
ond group is the enzyme-blocking substances that come from our
diet or as dietary supplements. The most important micronutrient
is the natural amino acid L-lysine. When a sufficient amount of
lysine is supplied as a dietary supplement, it can block the anchor
sites by which collagen dissolving enzymes bind to connective tis-
sue molecules. Lysine thus prevents these enzymes from uncon-
trollably dissolving connective tissue.
Lysine occupies the ‘anchor sites’ by which the collagen-digest-
The facing page illustrates that lysine can inhibit the collagen ing enzymes would normally bind to the connective tisue mole-
digesting enzymes, the uncontrolled degradation of collagen and, cules in order to digest them. Once lysine occupies these
‘anchor sites’, there is less binding of collagen-digesting
thereby, impede the spread of cancer.
enzymes to the collagen fibers and less tissue degradation.
The essential amino acid lysine can inhibit the uncontrolled

digestion of connective tissue by cancer cells, thereby
inhibiting cancer cell spread and metastasis.
92 93
The Remarkable Value of Lysine

All metabolic functions in the human body are controlled by bio- The Natural Amino Acid Lysine
logical language. Some twenty known amino acids compose all
Nitrogen Oxygen
the proteins in our bodies. These building blocks of life function atoms
atoms
like the letters of the alphabet. Our bodies use various combina-
Hydrogen
tions of amino acids to create innumerable biological words (pep- atoms
tides) and sentences (proteins). Separate amino acids (letters) also
have important individual metabolic functions, and lysine is a
prime example.
The cells of the body can produce most amino acids themselves.
These amino acids are called ‘non-essential’. However, there are 1 nm = 1 Millionth of a Millimeter
nine known amino acids that our body cannot produce, so they (10,000 times smaller than a cell)
have to be supplied through the diet. These amino acids are called
‘essential’.
Lysine plays a similarly important role within the group of essen-

tial amino acids as does vitamin C within the vitamin group. The How much lysine can our bodies handle?
daily requirement for lysine surpasses that of all other amino
acids. Among its many functions, lysine is also the basic building • A human body weighing about 155 lbs. contains
block of the amino acid carnitine, which is important for energy about 22 lbs. of proteins.
metabolism in every cell. • 50% of this protein mass is present as the connec-
tive tissue proteins, collagen and elastin.
The fact that the human body can store a large amount of this
amino acid proves its importance for our health. About 25 percent • The amino acid lysine forms about 12 percent of
the collagen and elastin mass, or about 1.3 lbs.
of collagen, the most abundant and important structural molecule
of bones, skin, blood vessel walls, and all other organs, consists of • Therefore, a human body weighing 155 lbs. con-
two amino acids: lysine and proline. Thus, taking large quantities of tains approximately 1.3 lbs. of lysine.
lysine will not cause adverse effects since our body is familiar with
this molecule and will simply excrete any amount not needed. Since our bodies are accustomed to such large
amounts of lysine, taking 0.4 ounces (11.3g) of lysine
daily as a dietary supplement, e.g., by cancer patients,
should not be considered excessive.
94 95
The Role of Lysine in Balancing

Sustained Imbalance of Collagen-Digesting
Collagen-Digestion and Repair
Enzymes Triggers Disease
We have just learned that activity of the collagen digesting
enzymes can be blocked in two ways: with the body’s own inhibit-
ing molecules (enzymatic proteins) and with natural inhibitors Collagen Block (produced by the body)
supplied in the diet, such as lysine. Dissolving
Enzyme
Block from the diet (Lysine)
The body’s internal inhibitors form the first line of defence that
assures the balance between the degradation and new formation
of collagen and connective tissue. In the illustration on the facing Health:
page, the enzyme ‘blockers’ produced by the body are represent-
Balance
ed by blue triangles. or
Lysine molecules, shown in green, have the same goal. They form
the second line of defence, ready to step in when the body’s own Temporary
systems are insufficient. The dietary ‘blockers’ cannot overshoot Imbalance
their goal, even when taken in high amounts.
A second important fact shown in the facing illustration is the bal-

Immediately
ance between the collagen-dissolving mechanism (red) and its Restored
blocking mechanisms (blue and green) during health and disease.
For instance, when fighting infections, white blood cells migrate
through the body creating a momentary imbalance in favor of col-
lagen degradation – just long enough to allow the leucocytes to
pass through towards the site of infection. Once this cell has Disease:
passed, the healthy body restores the balance within moments. Long term
imbalance
In cancer this balance is permanently shifted towards collagen
degradation, and the internal ‘blockers’ are not sufficient to stop
Prevention and
connective tissue destruction. In this situation, high nutritional Correction:
intake of lysine and other dietary ‘blockers’ is the most effective
way to restore the balance of connective tissue degradation and Supply of high
repair. dose of lysine and
other natural
dietary blockers
96 97
Vitamin C and Lysine:

Key Molecules for Health Encapsulation of Tumours by Natural Means
The stability of our connective tissue – and therefore our body’s
strength – is determined by two main factors: first, an optimum pro-
Lysine Vitamin C
duction of collagen and other connective tissue stability molecules, Molecule Molecule
and second, the prevention of uncontrolled tissue degradation.
Besides lysine, vitamin C (ascorbic acid) is another essential

micronutrient for our body. The role of these two micronutrients in
providing connective tissue stability and, therfore, in helping to
control cancer and other diseases can be summarised as follows:
1. Lysine inhibits the destruction of connective tissue by preventing

enzymatic digestion of collagen molecules. At the same time this
amino acid is an essential building block of collagen in the body.
2. Vitamin C stimulates the production of collagen and other con-

nective tissue molecules and is essential for their optimal struc-
ture. As we know from the sailor’s disease scurvy, deficiency of vit-
amin C weakens the connective tissue of our body. Vice versa, an
optimal supply of vitamin C assures optimal production of colla-
gen and elastin fibers and contributes to strong connective tissue.
What makes things worse is that the human body neither pro-
duces lysine nor vitamin C, and our modern diet does not contain
sufficient amounts of them. As a result, almost every person suffers
from long-term insufficiency of these essential micronutrients. Lysine
Vitamin C
blocks collagen-digesting stimulates the production of
This knowledge now allows us to formulate effective strategies enzymes and uncontrolled new collagen molecules and
towards the control of cancer. Optimum production of connective destruction of connective tissue strengthens connective tissue
tissue promotes the encapsulation, the biological confinement, of
tumours.
98 99
Healthy Collagen —
Amino Acids Proline and Lysine
Key to Disease Prevention and Control
Are Building Blocks of Collagen
Optimal production of collagen molecules is critical for healthy
connective tissue and it forms the basis for effective control of
cancer and other diseases. The picture on the facing page illus- Vitamin C Proline Lysine
trates the important steps of collagen production inside a cell and Controls produc- Component of col- Component of colla-
describes the essential role of certain micronutrients in this tion of collagen lagen, often insuffi- gen, exclusively sup-
process. in the nucleus ciently produced in plied from the diet
the body
Optimal production and structure of collagen critically depends
on three micronutrients:
• Vitamin C controls collagen production at the level of the cell

nucleus. In addition, newly formed collagen strands, which
wind around each other like a twisted rope, need this vitamin
to attain the optimum stability of collagen. Towards this end,
vitamin C catalyses the formation of chemical ‘bridges’
between separate collagen fibers, which stabilise the entire
structure.
• Lysine is an important building block of the amino acid chain

that forms the collagen protein molecule. Since our body can-
not produce its own lysine, every single lysine molecule must
be supplied from the diet or from dietary supplements.
Collagen
• Proline is an amino acid and also an important building block molecule
of collagen. In contrast to lysine, proline can be produced by
our body, but only in limited amounts. If a person suffers from a
chronic disease – associated with long-term enzymatic degra- Vitamin C
dation of collagen – the body’s capacity to produce proline can
Forms OH (Hydroxyl Groups)
be exhausted. This often leads to relative proline deficiency needed for linking collagen
with the known consequences of tissue weakness, which, in strands stabilising collagen
turn, facilitates disease progression.
100 101
Tumour Encapsulation: The Proof

Scientific Proof: The Natural
Now we owe our readers a first scientific proof. We choose to doc-
Encapsulation of Tumours is Possible
ument the decisive role of vitamin C for the encapsulation – the
connective tissue ‘confinement’ – of tumours.
It is a remarkable fact that, unlike humans, most animals can pro-
duce their own vitamin C. Even more surprising is the fact that can-
cers are rare in the animal world - whereas they kill every fourth
A
man and woman.
We wanted to study the intriguing question of whether it is possible
that one factor alone, the presence of vitamin C in optimum
amounts, can decide about the inhibition of tumour development.
To answer this question we developed a mouse model that was
unable to produce vitamin C in its body. By this genetic variation
we mimicked exactly the ‘genetic defect’ that affects all humans
today. A. Cancerous tumour developed in a mouse, unable to pro-
duce its own vitamin C and kept on a vitamin C deficient
For the subsequent experiment we divided the animals unable to diet.
produce their on vitamin C into two groups. Then the animals of Note the diffuse border of the tumour (arrow) with cancer
both groups were challenged with skin cancer (melanoma) cells. cells easily invading the surronding tissue.
Subsequently, we placed one group of these animals on a diet con-
taining optimum amounts of vitamin C, while the other group
received a diet deficient in this essential nutrient. B
The facing page shows the dramatic results documented for the first
time in this experiment. The animals with dietary vitamin C defi-
ciency developed large tumours, which were growing diffusely into
the neighboring tissue (picture A). In contrast, the animals supple-
mented with vitamin C developed fewer and smaller tumours.
Most remarkably, optimum vitamin C in the diet led to the forma-
tion of connective tissue confinement (encapsulations) of the
tumours in this group (picture B). This experiment shows that the
presence or absence of vitamin C is a decisive factor stimulating B. With vitamin C supplementation, the mice in the same
the body’s defence against cancer tumours. experiment formed a strong barrier of connective tissue
arround the tumour, confining it to its original location.
It is evident from this picture that encapsulated tumours
are unlikely to invade the surrounding tissue and to metas-
tasise.
102 103
Victory Over Breast Cancer Meet Baerbel Saliger
My name is Baerbel Saliger. Three months after I began to supplement my diet with micronu-
trients, the pain in my body subsided. I explained to my doctor
At age 48 I was diagnosed with breast that I no longer wanted to take the cortisol. She objected. Against
cancer, a moment that changed my her advice I decided to discontinue the cortisol. Four weeks later
life. I underwent surgery and had my my blood tests showed good results. My doctor explained to me,
left breast removed. The subsequent that this was the result of the cortisol treatment. I smiled by myself
14 cycles of agressive chemotherapy but did not say anything.
made my beautiful hair fall out. For
my partner I was no longer the Half a year after starting to supplement my diet with micronutri-
woman he had loved. When he left ents I was able to walk again - and also to laugh again. I was con-
me for good, my last spark of hope vinced that pretty soon I would also be able to love again. When I
left with him. I did not want to live sent the bills for the micronutrients to my insurance company,
any longer. they denied the coverage - despite the fact that they had helped
me.
My 18-year-old daughter and my When I look back today, the cancer diagnosis happened 12 years
parents took great care of me, but ago and the supplementation of my diet with micronutrients start-
also relatives and friends called me ed exactly ten years ago.
and encouraged me. One year after
undergoing chemotherapy, I was In January, my daughter gave me a big bouquet of flowers and
diagnosed with ‘osteoporosis in the told me how happy she is that I am alive. If I look into the mirror
final stage’, which put me down today, the memories of the past sometimes come back, but only
even further. I was desperate but I for a short time. Today a happy woman is smiling at me from the
did not give up. mirror.
I could no longer walk and my Dancing has become my favorite hobby again – and in a few
hands were merely able to turn months I will become a grandmother. I couldn’t be happier.
pages, but I could at least read. The
cortisol I received made my body
look puffy like a bowl of rising yeast dough, and a wheelchair had Halle, August 2011,
to substitute for my inability to walk.
Baerbel Saliger
It was at this point that I received information about micronutri-
ents in the fight against cancer. I said to myself: “It can’t get any
way worse - from now on there is only one way, upwards.”
104 105
What Did We Do to Spread This Message Increase in the Number of Annual Research Publications In
the Field of ‘Vitamins and Canccer’
When you read the testimonial of Mrs. Saliger on the previous
pages you may have asked yourself some of the following ques-
tions: Have such cases occurred only in other parts of the world? 5000
Why are not more cancer patients worldwide taking advantage of
this knowledge? Why aren’t the media talking about it? What did
you, as the pioneering researchers, do to spread this information?
3000
These questions are all legitimate. We will provide detailed
answers in Part 2 of this book. Here, we would like address only
some immediate aspects.
1000
Currently, we have information about several thousands of cancer
patients, many of whom shared their records with us. Many of
them are still alive after 10 years and longer of continuous 2001 2003 2005 2007 2009
micronutrients supplementation. Throughout this book we will
share some of these reports with you. Source: www.ncbi.nlm.nih.gov/
In 2001, we obtained the first confirmation about this breakthrough

in the fight against cancer at our research Institute. Subsequently,
we did everything to inform the world about it. One of the first chemotherapy’ our findings posed a fundamental threat. Not sur-
steps was the publication of this medical breakthrough in the prisingly, it was met from that side with indifference and even
world’s largest newspaper, USA Today, on March 8, 2002 (see resistance.
chapter introduction).
Over the years, however, this resistance was decisively weakened
In the following years we gave a multitude of lectures in the United by the large amount of research data published by our institute –
States and many European countries. We went to universities with and by an ‘explosion’ of research studies worldwide that followed
a focus on oncology and invited the medical profession there to our initial public announcement in USA Today in 2002 (see graph).
join in an international research effort to save millions of lives.
The next chapter will provide you with an overview of our com-
In parallel, our research Institute became a leading independent pelling research that cracked the half-century old fortress of the
research institution in science-based natural health. We are not pharmaceutical monopoly with chemotherapy and radiation in
aware of any other research institution that has published more sci- cancer.
entific data about the natural control of cancer and documented it
online (www.drrathresearch.org).
Our message about the ‘Victory over Cancer’ through natural,
non-patentable means was welcomed by the general public and
open minded health professionals everywhere. However, for phar-
maceutical-oriented medicine and for the ‘business with
106 107
Your Personal Summary of This Chapter
When writing this chapter we had important goals in

mind about the changes this information would make in
the understanding of cancer by our readers. On this page
we give you the possibility to check the most important
of these goals.
Do you know now that: Yes No
Cancer cells mimic natural mechanisms

used by our body under normal conditions?
This biological ‘deception’ is the reason

why cancer can evade the defence system
of our body?
Every type of cancer cells uses aggressive

enzymes that are able to destroy the sur-
rounding connective tissue in order to If you think that what you just learned is
spread and invade other organs? important for your fellow students, take this
book with you to school or college and
By understanding the cellular mechanisms
introduce it to them and to your teachers
of invasion, we can identify key mecha-
nisms and develop specific targets for the
effective and natural control of this dis-
ease?
The amino acid lysine and vitamin C are

the first two natural substances essential
for stabilising the connective tissue around
tumours – a key mechanism for the ulti-
mate control of the cancer epidemic?
108 109
The Goal of This Book:
Ending the Age of Fear!
110 111
Martian Storm ‘Science as Art’ is an idea by August Kowalczyk.
‘Martian Storm’ is a microscopic picture of a melanoma
tumour taken at the Dr. Rath Research Institute.
III. Scientific Facts That
Make This Breakthrough
Irreversible
Victory Over Cancer Part One: Making the Unthinkable Possible Chapter III − Scientific Facts That Make This Breakthrough Irreversible
Chapter Introduction by Dr. Niedzwiecki In 1999 when we started our own

research Institute and Dr. Rath invited me
to direct it, I asked some of my former
Cancer is one of the most challenging projects for a scientist – it
colleagues to join us. Thanks to the first
has been marked by many decades of unfulfilled hopes and dead
pioneers of our cancer research, Dr. Shri-
end ideas. However, the cancer research based on the new con-
rang Netke and later, Dr. Waheed Roomi,
cept by Dr. Rath has been one of the most rewarding projects in
we could advance research in this area
my scientific life.
very fast. Already in 2001 we knew that
the direction outlined in Dr. Rath’s con-
Before joining Dr. Rath, I worked on unravelling many biological
cept was right. Our first challenge was to
aspects that make our body so unique. Among them I studied how
identify the most effective group of natur-
the nuclear ‘software’ of the cell is built, how cells multiply and
al substances in curbing the invasion of
what happens when they become old. I was fortunate to research
cancer cells in the body.
many of these aspects in famous research institutions in the US
and Canada, and cooperated with two Nobel Laureates.
Until today we have published more than 60 publications on this
topic, participated in and given presentations at many scientific
However, my most remarkable scientific journey began when I
conferences in the US and other countries, written book chapters
met Dr. Rath and we started working together more than two
and cooperated with other scientific groups on cancer and other
decades ago. It was clear to me from the beginning that he had a
projects.
special way of looking at the same things everyone did, but seeing
what no one could see.
We are proud that many students who participated in the research
projects at our laboratories could see for themselves the powerful
His ideas were challenging but at the same time simple in explain-
effects of micronutrients in various aspects of cancer. Many of
ing complex processes.
these young people continue their studies at medical schools,
including the Medical Schools of Yale and other acclaimed univer-
sities. They form a new generation of doctors who will take an
unbiased look at science-based natural approaches in helping
their patients.
As a research team, we are propelled by great ideas and a desire

to make the results of our work benefit all humanity.
Together with Dr. Rath during the ‘early days’ of our research in 1991
118 119
What You Will Learn in This Chapter

In this chapter, we will share with you many more exciting facts
about the breathtaking possibility to finally achieve victory over
cancer. We will learn that:
Knowledge of these
• Besides the mechanism of cancer cell invasion, there are other
facts opens the door to
key cellular processes that determine the course of the cancer
a world without cancer
disease;
for future generations.
• In addition to vitamin C and lysine, there are certain other
important micronutrients that are able to block these disease
mechanisms naturally;
• All these micronutrients work together in synergy, i.e., as a

team, thereby mutually increasing their effectiveness in control-
ling cancer.
Most importantly, on the following pages we will take you through

the huge amount of scientific proof about the possibility to control
cancer naturally.
120 121
The Science of Cancer Made Easy

This chapter is about science – the science of disease and the sci-
Three Steps of Scientific Confirmation
ence of life. You may say: I am not a scientist, why bother reading
this chapter and making efforts to understand its contents.
We have to tell you that this understanding by you, your family –

even your children – and millions of people is a precondition for
the control of cancer.
This understanding of the basis for the natural control of cancer is

important for every person in order to make informed decisions
about their own health. This is critical not only in case you are
affected by this disease – but also if you want to prevent it in the
first place.
Moreover, this new understanding will protect you from falling

prey to the economic interests that thrive on the continuation of
the cancer epidemic as a global market for their patented
chemotherapy drugs.
It was clear to us already two decades ago that the discovery we

shared with you in the previous chapter, if confirmed, would
mean victory over the cancer epidemic – and thereby a significant
advance for all of mankind.
On the following pages, we will now share with you a few exam-
ples of the comprehensive rigorous scientific testing conducted at
our research institute over the past decade.
With each of the experiments described here, you will find a refer-
ence to the original scientific publication with additional online
links at the end of this chapter.
122 123
Key Mechanisms of Cancer Disease

Key Cellular Targets
Cancer cells use various mechanisms to grow, spread and ulti- for the Effective Control of Cancer
mately overpower the body:
1. Cancer cell invasion and metastasis. The most critical mecha-

nism is the ability of cancer cells to digest the connective tissue
surrounding them and thereby pave the way for invasive growth
and metastasis to other organs.
2
2. Cancer cell multiplication and tumour growth. A characteris-
tic feature of cancer cells is a change in the biological ‘soft- 4
ware’ in the cell core (nucleus) that renders them immortal. This
explains why cancer cells multiply indefinitely – thereby gradu-
ally increasing tumour size and ultimately overwhelming the
3
body.
3. Formation of new blood vessels that feed the tumour (Angio-
genesis). If the tumour surpasses a certain size, normally 1/20
of an inch, the tumour cells can no longer be nourished from
within. Therefore, growing tumours induce the formation of
1
new blood vessels that supply oxygen and nutrients for further
growth. This formation of new blood vessels is called ‘angio-
genesis’. The blocking of angiogenesis has become an impor-
tant target of international anti-cancer research.
4. Inducing the natural death of cancer cells (Apoptosis). We
already know cancer cells never die. The immortality of cancer 1. Cancer cell invasion and metastasis
cells is due to a genetic ‘switch’ in the cell core. Correcting this
abnormality and reversing this ‘switch’ induces natural cell 2. Cancer cell multiplication / tumour growth
death. This is a precondition for stopping the continuous multi-
3. Growth of new tumour blood vessels (Angiogenesis)
plication of cancer cells and ultimately leading to the shrinkage
and disappearance of tumours. 4. Triggering death of cancer cells (Apoptosis)
Effectively blocking even one of these mechanisms can be suffi-
cient to control cancer.
124 125
Key Micronutrients for the Natural

Micronutrient ‘Team’
Control of Cancer
Tested in Cancer
In the previous chapter we already learned about the key role of
vitamin C and lysine in blocking the spread of cancer cells.
Our research over the past decade has shown that other specific Vitamins
micronutrients can enhance the effectiveness of these two natural
compounds in controlling cancer. • Vitamin C
This ‘team’ of micronutrients can be subdivided according to spe- Amino Acids

cific mechanisms of cancer control. For example:
• L-Lysine
• Support of connective tissue production and maintaining its • L-Proline
integrity and stability: vitamin C, lysine, proline, copper, man- • L-Arginine
ganese.
• N-Acetyl L-Cysteine (NAC)
• Inhibitors of connective tissue digestion: lysine, proline, vitamin
C, N-acetyl-cysteine (NAC), green tea, selenium. Polyphenols
• Inhibitors of new blood vessel formation (Angiogenesis): green • Green Tea Extracts (EGCG)
tea, NAC. • Quercetin*
• Inducers of cancer cell death (Apoptosis): vitamin C, green tea,
NAC, selenium, arginine, proline. Minerals
• Selenium
• Copper
• Manganese
* Quercetin is proven to be an essential part of nutrient syn-

ergy. It has therefore been included in all our current
experiments.
126 127
Increased Biological Effectiveness by a ‘Team

The Principle of Synergy
Effort’ of Micronutrients (Nutrient Synergy)
Over the past decades, anti-cancer research has been conducted
involving individual micronutrients (e.g., vitamin C, which was
applied in high doses), in approaches referred to as so-called
'megadoses'.
Our research over more than a decade has created a modern Vitamin C + Polyphenols
understanding about how to maximise the biological effectiveness
of micronutrients.
The key principle is ‘Synergy’. This principle is so important that

we have to highlight some of its characteristics:
1. Synergy is a principle of life. Many biological components

work together within cells to achieve a desired biological result.
2. Synergy means that the effectiveness of this group of biological Synergy

components working together is greater than the sum of its indi- Benefit
vidual parts.
3. Applied to the anti-cancer properties of micronutrients, this

‘Synergy’ principle means that high amounts of an individual
vitamin are less effective than the combination of moderate
amounts of selected micronutrients.
Synergy is more than
This principle is illustrated on the facing page and we will revisit it the sum of its individual components.
throughout this chapter.
128 129
How We Proved that Micronutrient Synergy

Prevents Destruction of Connective Tissue –
A Necessary Step to Halt the Spread of Cancer
Biological
Scissor
Biological Biological
Scissor Scissor
Cancer Cell Plasminogen Activator Metalloproteinases Connective Tissue

(Urokinase) (MMPs) (Collagen) Digestion
FIRST PROOF SECOND PROOF

Effect of micronutrients in blocking the Effect of micronutrients in blocking
secretion of ‘Plasminogen Activator the secretion of Metalloproteinases For further information
produced by cancer cells. (MMPs) produced by cancer cells. about this illustration,
please revisit Chapter II.
We already know that the aggressiveness (malignancy) of any type We tested the effect of micronutrient synergy on the two most
of cancer depends on the amount of ‘biological scissors’ produced important types of enzymes used by cancer cells. Our goal was to
by this type of cancer. prove that micronutrient synergy can inhibit both of them.
Thus, any successful approach to block cancer has to aim at The first key enzyme is called ‘Urokinase Plasminogen Activator
inhibiting the excessive, uncontrolled production of these colla- (uPA)’, the second is the group of ‘Metalloproteinases’ (MMP2 and
gen-digesting enzymes (see Chapter II). MMP9). The following pages show the results.
130 131
Scientific Proof:
Micronutrients Inhibit the Secretion of
Blocking the Secretion of Plasminogen
‘Biological Scissors’ by Cancer Cells
Activator (Urokinase) Produced by
Human Cancer Cells
In this experiment, we tested whether our micronutrient team is

able to inhibit the secretion of the ‘biological scissor’ enzyme
Urokinase, produced by human prostate cancer cells.
For this purpose, six test sets containing equal numbers of prostate
cancer cells were used. The first set did not contain additional
Secretion of the ‘Biological Scissor’

Plasminogen Activator Urokinase
micronutrients and served as the control. The other five sets of
cells were placed (incubated) with increasing amounts of
micronutrients.
The next day we measured the amounts of Urokinase collagen-

digesting enzymes that were secreted by each set of cells exposed
to different levels of micronutrients.
We found that the higher the concentration of micronutrients, the

lower the production of the ‘biological scissor’ Urokinase by
prostate cancer cells.
In the meantime we could confirm this effect of micronutrients in Control 50 100 250 500 1000
many other types of human cancer. Micronutrient Concentration
(micrograms/mililiter)
This means that – by inhibiting the secretion of Urokinase –

micronutrients are able to reduce the ability of many types of can-
cer cells to grow, spread and metastasise to other organs.
The higher the micronutrient concentration, the less
Other scientists have confirmed these research results in the
cancer cell enzymes can digest the surrounding collagen.
meantime. They demonstrated that cancer metastasis can be
inhibited in mice lacking the enzyme urokinase, thereby under-
scoring the significance of this enzyme in cancer.
Read the complete study results online at
http://www.drrathresearch.org/pub/voc/121
132 133
Scientific Proof:
Micronutrients Inhibit the Secretion
Blocking the Secretion of Collagen Digesting
of ‘Biological Scissors’ (MMPs)
Enzymes (MMPs) Produced by Human
by Human Cancer Cells
Cancer Cells
As we already know, the second key group of collagen digesting

enzymes produced by cancer cells is called matrix metallopro-
teinases (MMPs) – two of them, MMP-2 and MMP-9, are most crit-
ical in cancer. MMP-2
Amount of MMP Enzymes Secreted

We wanted to prove that the defined team of micronutrients is also MMP-9
able to inhibit the production and secretion of the ‘biological scis-
sors’ MMP-2 and MMP-9 by cancer cells.
For this purpose, five test sets containing equal numbers of cells
were used, this time from human bladder cancer. The first set did
not contain additional micronutrients and served as the control.
The other four sets of cells were placed (incubated) in the pres-
ence of increasing amounts of micronutrients.
On the following day, we measured the amounts of MMP-2 and

MMP-9 enzymes that were secreted by each set of cells, which
had been exposed to different levels of micronutrients. The results
are shown on the facing page. Control 10 50 100 500
Micronutrient Concentration
As in the previous experiment with Urokinase, we found that (micrograms/milliliter)
micronutrients can also inhibit the secretion of MMP ‘scissor’

enzymes. It is important to note that in this case, micronutrients in
moderate and higher concentrations were able to completely stop The higher the micronutrient concentration, the less cancer
the secretion of both MMP enzymes by these cancer cells. cell enzymes can destroy the surrounding collagen.
In the meantime we could confirm this effect of micronutrients in

more than 40 types of human cancer. Read the complete study results online at
• http://www.drrathresearch.org/pub/voc/123
• http://www.drrathresearch.org/pub/voc/124
134 135
Testing the Ability of Micronutrients to

Testing the Invasion of Cancer Cells
Inhibit the Invasion of Cancer Cells
The next question was whether the micronutrient team would not
only block these ‘scissor’ enzymes but actually prevent the cancer
cells from cutting through the connective tissue to invade other
organs.
To study this decisive question without ambiguity, we set up a test-

ing system that mimics the situation in the human body with
respect to its components (shown on the facing page):
• The test vials were filled with a liquid solution mimicking

human body fluid.
• The top and bottom portion of the vial were separated by a STOP
membrane of connective tissue called Matrigel.
• The top portions of the vials contained equal numbers of

human cancer cells.
The only difference between vial A and vial B was the presence of
micronutrients, which were added only to vial B.
From earlier experiments, we knew that the cancer cells are easily
able to cut through the separating connective tissue membrane A B
and can be found – and counted – on the other side of the mem-
brane. Generally, the more aggressive the cancer type is, the more
cancer cells are found on the other side of the membrane. Micronutrients prevent cancer cells
from migrating through connective tissue.
In an extensive series of experiments, we could show that the
team of micronutrients was able to block all tested types of cancer
from breaking through the connective tissue.
The following pages will show some of these research results in

more detail.
136 137
Scientific Proof:
Micronutrients Inhibit the Invasion of
Micronutrients Inhibit
Connective Tissue Cancer (Fibrosarcoma)
the Invasion of Human Cancer Cells
A. Control B. 10 mcg/ml
Fibrosarcoma is a frequent form of cancer of the connective tissue.

This cancer develops when the software of human fibroblast cells
is modified to become carcinogenic.
We tested the inhibitory effect of micronutrients on the invasion

of these fibrosarcoma cells in the test system described on the
previous pages. The four images in the upper half of the facing
C. 100 mcg/ml D. 1000 mcg/ml
page show microscopic pictures of fibrosarcoma cells (dark
brown structures) that had cut through the connective tissue
membrane.
• Picture A, designated ‘Control’, was taken in the absence of the

micronutrients. Most of fibrosarcoma cells had cut their way
through the membrane.
100% Blockage
• The pictures designated B, C and D from the same test system of Cancer Cells
Inhibition of Cancer Invasion (%)

Invasion
show decreasing numbers of migrating cancer cells when
exposed to increasing amounts of micronutrients.
You can clearly see that at the highest concentration of micronutri-

ents (picture D), no cancer cells were detected because they were
blocked in their attempt to break through the connective tissue.
The small dark spots in the pictures are not cells, but membrane A B C D
All Cells
background. Invade
Control 10 100 1000
The lower portion of the page shows the quantitative results of Micronutrient Concentrations
these experiments: The higher the columns, the greater the effect (micrograms / mililiter)
of micronutrients in inhibiting the invasion by cancer cells. At the

highest concentration of micronutrients, no cancer cells could cut Micronutrients are inhibitors of cancer cell invasion.
through the connective tissue any more (column D).

138 139
Scientific Proof: Micronutrients Inhibit the Invasion

Micronutrients Inhibit of Breast Cancer Cells
the Invasion of Breast Cancer Cells
Estrogen Independent Breast Cancer

We were particularly interested to study the effectiveness of 100% Blockage
of Cancer Cells
micronutrients in controlling the most frequent forms of cancer. Invasion
The most frequent form of malignancies in women is breast can-

cer. These cancers are categorised in two main groups. Since the
invasive potential of one type of breast cancer is dependent on the
hormone estrogen, these cells are categorised as ‘estrogen depen-
Control 10 50 100
dent’. The second type of breast cancer grows independently of
this hormone and is called ‘estrogen independent’.
We studied whether our team of micronutrients is able to halt the Estrogen Dependent Breast Cancer

invasiveness of both types of human breast cancer cells. To answer 100% Blockage
this question, we used the same experimental setting as described of Cancer Cells
Invasion
on the previous pages.
With breast cancer, we could also observe that the invasive poten-
tial of this type of cancer decreases with increasing amounts of
micronutrients. At the highest concentration of micronutrients, no 100
Control 10 50
breast cancer cells were able to cross the connective tissue barrier
anymore.
The same encouraging results were obtained for both ‘estrogen http://www.drrathresearch.org/pub/voc/129
dependent’ and ‘estrogen independent’ types of breast cancer, as
shown in the two graphs on the facing page.
The microscopic picture at the bottom of this page shows a specif-

ic type of breast cancer, called Adenocarcinoma, which derives
from the glandular cells that line the milk ducts in the breast. This
is one of the most frequent forms of malignancy in women.
Microscopy Picture of Human Breast Cancer (Adenocarcinoma)
140 141
Scientific Proof:
Micronutrients Inhibit the Invasion
Micronutrients Inhibit the Invasion
of Prostate Cancer Cells
of Prostate Cancer Cells
Hormone Independent Prostate Cancer

One of the most frequent forms of cancer in men is prostate can- 100% Blockage
of Cancer Cells
cer. Similar to breast cancer in women, prostate cancer, too, can Invasion
be hormone dependent. In this case its growth can be regulated
by male hormones called androgens, which include testosterone.
We studied whether our team of micronutrients is able to halt

the invasiveness of both types of human prostate cancer cells. As
in the previous experiments, we used the experimental design Control 10 50 100 1000
Micronutrient Concentrations
described before to answer this question.
Similar to fibrosarcoma and breast cancer, we observed that the Hormone Dependent Prostate Cancer

invasion of prostate cancer cells decreases with increasing 100% Blockage
of Cancer Cells
amounts of micronutrients. Again, at the highest concentration Invasion
of micronutrients, no prostate cancer cells were able to cross the
connective tissue barrier any more.
The same encouraging results were obtained for both hormone

dependent and independent types of prostate cancer. The graphs
Control 10 50 100 1000
on the facing page summarise these results.
Micronutrient Concentrations
The microscopic picture at the bottom of this page shows an Read the complete study results online at
adenocarcinoma of the human prostate. We already know that http://www.drrathresearch.org/pub/voc/131
this form of cancer derives from glandular cells that produce

hormones.
This highly magnified picture is taken with a Scanning Electron

Microscope (SEM) and shows the ducts of the prostate complete-
ly covered with carcinoma cells (blue/grey structures).
Microscopy Picture of a Human Prostate Cancer (Adenocarcinoma)
142 143
Micronutrients Inhibit the Invasion of

Blocking Cancer Invasion Naturally –
More Than 40 Human Types of Cancer
Examples of Human Cancer Types
When you read through the previous pages, you may have felt like
we did as researchers when we conducted these experiments: Can Complete Block at Low Nutrient Concentration
the solution to the cancer epidemic be so simple and universal? To • Breast Cancer
answer this question we studied the effectiveness of the micronu- • Hodgkin’s Lymphoma
trient team on the invasion of all available human cancer types.
Altogether, we tested the effect of micronutrient synergy on more Complete Block at Moderate Nutrient Concentration
than 40 different types of human cancer. Among the cancer cell • Lung Cancer
types tested are some of the most frequent forms of cancer that • Colon Cancer
affect the lives of millions of people, including cancer of the lung, • Cervical Cancer
colon, pancreas, brain, blood, skin, ovaries, and many others (see • Skin Cancer (Melanoma)
facing page).
• Bone Cancer (Osteosarcoma)
• Testicular Cancer
While studying this large number of human cancer types we
established that micronutrient synergy was able to completely • Blood Cancer (Non-Hodgkin’s Lymphoma)
block the invasiveness of all human cancer cell lines tested. The • Pancreatic Cancer
only difference was the amount of micronutrients needed to
achieve this goal. Complete Block at High Nutrient Concentration
• Liver Cancer
Some chemotherapy proponents may argue that the solution to
• Bladder Cancer
cancer cannot be that simple. But it can – and we know why: All
cancer cells use the same mechanism to invade the surrounding • Kidney Cancer
tissue and metastasise. Since micronutrients are capable of block- • Ovarian Cancer
ing this universal cellular mechanism, they can inhibit the inva- • Prostate Cancer
sion of any type of cancer cells irrespective of their origin. • Brain Cancer (Glioblastoma)
• Blood Cancer (Leukemia, PML)
Of course, this does not mean that cancers at any stage can be
halted by micronutrients. This is particularly true for patients with
advanced stages of cancer, as well as in cases where the immune Micronutrients are capable of inhibiting the
system – and thereby the body’s capability to fight cancer – had invasiveness of all types of cancer cells we tested.
been destroyed by chemotherapy.
Read the complete studies results online at

144 145
Scientific Proof:
Micronutrients Inhibit Metastasis
Micronutrients Inhibit Cancer Metastasis
of Melanoma Cells to the Lung
in Living Organisms (I)
Metastases
After confirming the benefits of micronutrients in blocking the in Lung
invasion of cancer cells in a laboratory setting (in vitro), we (black spots)
wanted to establish the scientific proof also at the next level – in
a living organism (in vivo).
After careful evaluation and approval by an animal care commit-

tee, we conducted these important experiments in mice. These
Number of Lung Metastases

50
experiments were justified considering the fact that more than 4
million people will continue to die from cancer each year – if no
cure is found.
In order to spare animal life, we immediately addressed the most

challenging question in cancer, which is the prevention of metas-
tasis. After all, 9 out of 10 patients die of metastasising cancer, not 10
of a tumour confined to one organ.
We tested the ability of micronutrients to inhibit the metastasis of

No In Diet Intravenous
cancers in the following way: A group of mice was injected with
Micronutrients
an equal number of skin cancer (melanoma) cells. Thereafter, the Supplementation
Micronutrient Supplementation
mice were divided into three groups: a) a control group without
micronutrient supplementation, b) a group receiving micronutri- Read the complete studies results online at
ent supplements in the diet and c) a group receiving micronutri-
ents directly into the blood stream (intravenously).
Micronutrients can reduce cancer metastasis in vivo.
When the lungs were later analysed for the numbers of metas-
tases, we found that micronutrient supplementation in the diet
reduced the number of metastases in the lungs by more than 60%.
In the group that had received the micronutrients directly into When Animal Experiments Are Justified
the blood, the results were even better: The metastases were Our position on this important topic is clear. Life in general needs to be protected and
animal experiments have to be avoided whenever possible. They should be considered
reduced by more than 80% compared to the control group only in those cases when the results of these experiments directly affect human life and
without micronutrient supplementation. if there are no alternatives available. In the case of cancer, where millions of lives each
year are at stake, we are convinced that the experiments documented here will help
greatly reduce human suffering and death.
146 147
Scientific Proof:
Micronutrients Inhibit Cancer
Micronutrients Inhibit Cancer Metastasis
Metastasis from Organ to Organ
in Living Organisms (II)
In the previous experiments we showed that micronutrient supple- A Primary Tumour in Spleen
mentation can prevent cancer cells – injected directly into the
bloodstream – from metastasising into the lungs.
This was an important step; however, it does not exactly reflect the
development of the cancer disease in people. Normally, a cancer
starts with a ‘primary tumour’ in one organ. From there, the cancer
cells metastasise to other organs in the patient’s body. Thus, it is
important to know whether micronutrients can reduce the
spread of cancer from the primary organ to another organ.
No added micronutrients With added micronutrients
To establish this important fact, we injected melanoma cells The tumour (black areas) The tumour is significantly
has massively enlarged reduced. No organ
directly into the spleen of mice. Then one group of animals was
the entire organ. enlargement.
placed on a normal diet, without additional micronutrients (con-
trol). The other group received daily supplementation of micronu-
trients in their diet. Subsequently, the organs were analysed for the
growth of the primary tumour in the spleen (picture A) and the
B Metastases in the Liver
presence of metastases in the liver, a primary organ of metastasis
for melanoma cancer (picture B).
Our findings in these studies were as equally significant as the

results from the previous experiments. We established that ani-
mals which received micronutrient supplementation had signifi-
cantly less growth of the primary tumour. The metastases from
the primary organ (spleen) to the liver were reduced almost by
No added micronutrients With added micronutrients
half.
The enlarged liver The number of metastases
contains numerous in the liver is greatly reduced.
Additional studies will establish whether increased amounts of
metastases (black areas). No organ enlargement.
micronutrients in the diet can further reduce or even completely
block metastasis to secondary organs.
Micronutrients can reduce cancer metastasis
from one organ to another.

148 149
As the authors of this book we undertook great efforts to present We are, of course, also aware of the effort you and every new
this complex but life-saving medical and scientific knowledge in a reader of this book have to undertake to work through this excit-
way that can be understood by everyone. ing, but new, information.
From the response of our readers we know that we accomplished Great that you made it to this point! Now it’s time for a little
that to a large degree. break.
To relax your mind for a moment, before you go on, we would

like to share with you the view we enjoyed during the time of
writing this book.
150 151
Micronutrients in Blocking Tumour Growth

Cancer Cells Constantly Divide
Up to now we presented the results of our research in connection
to Form a Tumour
with invasion and metastasis, the most important mechanisms of
Picture of multiplicating tumour cell (schematic)
cancer disease.
In the course of our decade-long research we, of course, also

wanted to know whether micronutrients are able to affect – or
even block – other important mechanisms of cancer development.
Thus, another important mechanism we looked at was tumour
growth, i.e., the uncontrolled multiplication of cells making up a
tumour.
Growth of normal cells is strictly regulated. Some cells in our

body grow and reproduce frequently, i.e., blood cells (erythro-
2
cytes, leukocytes), the cells lining our intestines and skin cells.
Most cells multiply less frequently and a few cell types reproduce
rarely, like bone cells or nerve cells.
In contrast, cancer cells have lost the ability to regulate their own
growth and they constantly multiply. Moreover, by definition, can-
Dividing Bone Cancer Cell (Ewing Sarcoma)
cer cells have become immortal and never die. Both mechanisms – Electron Microscopy Picture –
together have deleterious consequences for the organ where can-
cer develops. Sooner or later the tumour is taking over major parts
or the entire organ.
The microscopic picture at the bottom of the facing page shows a

dividing cancer cell from an aggressive bone cancer (Ewing Sarco-
ma). The two cell cores (nuclei), shown here as blue structures,
have already completely separated. The remaining cell bodies will
follow soon.
152 153
Scientific Proof:
Micronutrients Block Tumour Growth Micronutrients Block Tumour Growth
To test the effect of micronutrients on the multiplication of tumour

cells, we set up the following experiment: Bone Cancer (Osteosarcoma) Growing in Mice
We injected equal numbers of bone cancer cells (osteosarcoma)

into two groups of mice. One group did not receive any dietary A B
micronutrient supplementation after the cancer cells were applied,
the other group did receive a micronutrient supplemented diet.
As documented on the facing page, the results were amazing.

Picture A shows a huge tumour that had developed in an animal
that did not receive micronutrient supplementation. In contrast,
picture B shows a tumour from an animal receiving high amounts
of micronutrients in the diet. The difference is clearly visible.
These results were confirmed when the tumours were analysed

Without With
under the microscope. The bottom part of the facing page shows
Micronutrient Micronutrient
tissue cross sections of the tumours under high magnification. The Supplementation Supplementation
individual tumour cells in both pictures are visible. However, the
picture on the left side – without micronutrient supplementation –
shows many more dividing cells (brown colour) than the picture
on the right side – with micronutrient supplementation.
The growth of all types of human tumours investigated by

us could be inhibited by micronutrients to a varying degree:
Microscopy pictures of the tumours from A and B. The brown colour indicates
Breast Cancer 78% Osteosarcoma 53% cancer cells that are multiplying at this moment. Note the high number of
cancer cell divisions in A – without dietary micronutrients.
Pancreatic Cancer 64% Prostate Cancer 47%
Colon Cancer 63% Lung Cancer 44% Micronutrients are able to inhibit
Fibrosarcoma 59% Synovial Cancer 44% the multiplication of cancer cells.
Melanoma 57% Liver Cancer 36%
154 155
Micronutrients and the Formation of New

Formation of New Blood Vessels
Blood Vessels in Tumours (Angiogenesis)
That Feed the Tumour
Another key mechanism of cancer development is the formation of
Picture of tumour blood vessel formation (schematic)
new blood vessels that feed the tumour. Every tumour needs a con-
tinuous supply of nutrients in order to grow and expand. Tumours
as small as 1 mm (1/25th of an inch) in size cannot grow without
generating new blood vessels to provide their own blood supply.
To induce the formation of these new blood vessels, called angio-

genesis, cancer cells produce various signal molecules that are
being sent out to the nearby blood vessels in order for these ves-
sels or capillaries to sprout. Under the effect of these signal mole-
cules the endothelial cells, i.e., the cells that form the lining of
blood vessels, separate from the ‘mother vessel’ and migrate
3
towards the tumour. The pictures on the adjacent page illustrate
this important process.
On the upper picture, the new blood vessel that has formed from
the original one – and is now supplying blood to the tumour – is
circled. In the bottom picture a microscopic image is shown that
Picture of tumour blood vessel formation
illustrates the formation of a whole branching system of blood ves- under the microscope
sels reaching deep inside a tumour (black area). The unique form of
these structures, which resemble the roots of plants, is clearly visi-
ble.
The growth of new blood vessels through a tissue requires the

restructuring of this entire area. Any restructuring in the human
body, in turn, requires the breaking down of collagen and other
connective tissue molecules with the help of collagen-digesting
enzymes.
Based on a detailed understanding of these mechanisms, we were

confident that micronutrients would also be able to block angio-
genesis, as another key mechanism of cancer.
156 157
Scientific Proof:
Scientific Proof:
Micronutrients Inhibit the Formation
Micronutrients Inhibit Angiogenesis
of New Blood Vessels in Tumours
To test the effectiveness of micronutrients in inhibiting the forma-
tion of new blood vessels during cancer growth, we used the same
experimental model as described in the previous 4 pages.
A
As mentioned before, the two groups of animals received equal No
numbers of bone cancer (osteosarcoma) cells. From the previous Micronutrients
experiment we already know that animals receiving micronutrient in Diet
supplementation had significantly smaller tumours.
In this set of experiments we were particularly interested in

whether the micronutrient supplementation would also be able to
decrease the formation of new tumour blood vessels. By looking
at the tumour from the outside (facing page A) the network of
blood vessels can be clearly seen in the tumour formed in mice
B
deprived of micronutrient supplementation. With
Micronutrients
The microscopic pictures (to the right of the facing page) con- in Diet
firmed this observation. The cross-section view of the tumours of
animals not receiving micronutrient supplementation show that
the tumour had developed a large number of new blood vessels
(red structures).
In contrast, the microscopic cross-section of the tumours of ani-

mals that received high amounts of micronutrients in the diet Micronutrients help to decrease tumour growth
showed little or no formation of new blood vessels. also by inhibiting the formation of new blood
vessels that feed tumours.
Moreover, we also determined an important reason why micronu-
trients had this dramatic effect: Many signal factors produced by
tumour cells to stimulate blood vessel growth were significantly
decreased in animals receiving a micronutrient supplemented
diet. These factors include the vascular endothelial growth factor
(VEGF) and others.
158 159
Scientific Proof:
Micronutrients Inhibit the Formation of
Micronutrients Inhibit
Blood Vessels by Human Endothelial Cells
Angiogenesis in a Human Model
This is a model of a small
Considering the fact that the inhibition of angiogenesis is a central blood vessel (capillary).
Its formation can be studied
mechanism for controlling cancer, many drug companies are cur-
in a model using
rently spending hundreds of millions of dollars to find new, synthet- human cells. The dark
ic inhibitors of angiogenesis which they can then patent and market tubes below correspond
as anti-cancer drugs. The global market of angiogenesis inhibitors is to such capillaries.
estimated to reach tens of billions of dollars.
Considering that fact, our research results based on micronutrients
– which are after all natural substances – are of utmost significance A. Control B. 50 mcg/ml
for millions of patients and for the health care systems worldwide.
In light of this fact, we undertook a further step to verify the role of
micronutrients in controlling this important therapeutic mechanism.
We chose a system that would eliminate all potential variables
when studying the effects of micronutrients on the formation of
blood vessels. We used blood vessel lining cells (endothelial cells)
derived from human umbilical cords.
C. 500 mcg/ml D. 1000 mcg/ml
These cells were cultured and exposed to increasing amounts of
micronutrients.
As shown in the pictures on the facing page, the endothelial cells
without micronutrients produced a dense network of capillary
‘pipes’ (Picture A) which are seen as dark lines.
With increasing amounts of micronutrients, the human endothelial
cells produced less of these capillary structures (B to D). At the The pictures B to D show human blood vessel lining cells (endothelial cells) exposed to
highest micronutrient concentration (D), the formation of capillaries increasing amounts of micronutrients. At the highest micronutrient concentration (D) no
blood vessel structures are formed.
was completely blocked.
This study is irrefutable scientific proof that micronutrients are pow-
erful anti-angiogenic agents that can be immediately applied to Micronutrients can inhibit the formation of capillary
help control cancer. blood vessel structures by human endothelial cells,
a relevant mechanism for inhibiting tumour growth.
160 161
Micronutrients and the Induction of

Natural Death of Cancer Cells
Natural Death of Cancer Cells (Apoptosis)
Schematic picture of cancer cells that
A hallmark of every cancer is immortality, which means its ability
had turned mortal again and had subsequently died
to live forever. This malfunction of a normal cell cycle originates
from an error in the software program, the DNA, in the core
(nucleus) of cancer cells.
To turn this ‘biological switch’ back and cause the natural death of
4
cancer cells is a pre-condition to reverse and eliminate cancers.
This mechanism that causes the natural suicide of cancer cells is
called ‘apoptosis’ and is defined as the natural death of cells. It
derives from the Greek word for ‘dropping off’, e.g., like falling
leaves.
As opposed to apoptosis the premature – unnatural – death of

cells and living tissue is called ‘necrosis’, deriving from the Greek
word ‘making dead’, i.e., killing. It is caused by injury from factors
outside the cell or tissue such as highly toxic chemotherapy
agents, high-energy radiation and other harmful agents.
Cancer cell committing ‘suicide’
In the human body each day, between 50 and 70 billion normal by apoptosis (microscopic picture)
cells die through apoptosis. Cancer cells are the exception.
We tested whether micronutrients can induce this natural death in

cancer cells and thereby reverse their immortality. We studied this
process in great detail, identifying genetic and cellular mecha-
nisms involved. The bottom of the facing page shows a cancer cell
that is undergoing natural death from apoptosis. Characteristic are
the rough surface (‘buds’) which contain fragments of the cell
breakdown.
On the following pages we show examples of our research with

micronutrients inducing apoptosis in cancer.
162 163
Scientific Proof: Micronutrients Can

Micronutrients Can Induce
Induce the Natural Death of Cancer Cells
Apoptosis of a Melanoma Cancer Cell
An important step in studying the process of apoptosis of cancer
cells is to visualise the cellular steps involved for evaluation under
the microscope.
Towards this end, certain markers within the cell or the cell core
(nucleus) were defined that allowed us to distinguish those cells
undergoing apoptosis from other living cells.
The facing page shows a single melanoma cancer cell undergoing

apoptosis, a process that was induced by exposing these
melanoma cells to micronutrients. Details of this experiment are
described on the following pages.
In the facing picture, the cell nucleus is outlined by a white circle.

The red colour inside this circle marks the active process of core
breakdown. The darker reddish spots within this red area (under
magnifying glass) represent DNA and related core components Skin cancer cell (melanoma) in the
packed in small, dense bundles. process of commiting suicide (apoptosis).
Apoptosis starts with the activation of special enzymes – inside the

cell – which cause gradual disintegration of all cellular compo- Micronutrients can induce cellular processes that
nents, including the nucleus. lead to the natural death of cancer cells.
At a later stage, the cell develops buds on the surface (see previ-
ous page). Finally, the cell shrinks and becomes fragmented into
small units that are then disposed of by white blood cells (phago-
cytes), which specialise in biological ‘waste removal’.

164 165
Scientific Proof:
Micronutrients Trigger Natural Death
The Effectiveness of Micronutrients
of Human Melanoma Cells
in Inducing Apoptosis
A. Control B. 500 mcg/ml C. 1000 mcg/ml
On this page we document the results of the investigation of
whether micronutrients are able to reverse already existing
tumours or make them completely disappear.
This is an important question in light of the fact that conventional

medicine has been largely unable to accomplish this goal.
Chemotherapy, by intoxicating cells, may lead to an intermediate
remission of cancers, generally followed by its re-occurrence due
Micronutrients Induce Apoptosis in Melanoma Cells
to the fact that chemotherapy drugs not only attack cancer cells
but also all healthy cells, including the cells of the immune system
required to fight cancer.
In this series of experiments, we exposed skin cancer (melanoma) Alive Cells 100%
of Cells
cells to increasing concentrations of micronutrients. Dying Cells (Early Apoptosis) Die
Dead Cells (Late Apoptosis) Naturally
As markers of these cells we used the same system described on
Percentage of Cells in Group

the previous pages: green represents cells that are alive, yellow
identifies cells at the stage of early apoptosis (beginning cancer
cell suicide) and red means late apoptosis, when the cancer cells
are essentially dead.
We evaluated the cancer cells exposed to the different concentra-

tions of micronutrients under the microscope (upper half of the
facing page) and quantified the percentages of respective cell A. Control B. 500 C. 1000
colours (bottom half of the page). Micronutrient Concentrations (mcg/ml)
The results show that the higher the concentration of micronutri-

ents, the more cancer cells undergo natural death. At the highest
The higher the micronutrient concentration,
concentration (group C), all cancer cells were found in an the more cancer cells are committing suicide.
advanced stage of apoptosis – i.e., they were dying. Thus,
micronutrients are a safe way to not only halt the further develop-
ment of cancer but also to reverse already existing tumours. www.drrathresearch.org
166 167
Victory Over Lung Cancer Meet

Werner Pilniok
My name is Werner Pilniok.
In September 1999, during a routine x-ray exam, I was diagnosed

with a rapidly growing lung tumour. According to the doctor, a
pulmonologist, the size of this lung tumour was 1.5 x 1cm [0.6 x
0.4 inches]. I had to undergo a series of additional tests after
which the doctors recommended surgery and the removal of the
entire section of the lung where the tumour had been located.
Because I was also suffering from heart disease any operation A-1
would have been a great risk for me, so I started to look for alter-
natives. I read about research conducted by Dr. Rath, who was
studying the role of micronutrients in fighting cancer naturally.
I decided to cancel the scheduled surgery and give micronutrients

a chance. From October 1999 onwards I was supplementing my
diet with high amounts of micronutrients. On April 3, 2000, a
control CT-Test was undertaken. The result: the tumour that had
been diagnosed half a year earlier was gone – the doctor could
not believe it! He told me to wait until another X-ray machine
became available because he apparently thought that this X-ray
machine was broken. The repeated control scan showed the same
result: no more tumour.
This was more than a decade ago. In 2011 I celebrated my 80th A-2 B
birthday in good health. Thanks to the micronutrients I take, I
hope to live many more years. A-1: September 1999, CT scan of Mr. Pilniok’s lungs show the presence of
a tumour in the highlighted area.
Werner Pilniok A-2: Magnification of the highlighted area of picture A-1.
B: April 2000, control CT scan of Mr. Pilniok’s lungs. This picture shows
the same area as in A-2. The tumour can no longer be detected.
The fact that no tumour could be detected anymore

means that it had disappeared by natural means –
without surgery, radiation or chemotherapy.
168 169
Have you realised ... Dr. Niedzwiecki,

Directing Research
that by working through this book chapter you have entered at Our Institute
the world of modern medicine and health? This new world of For Over a Decade
health is characterised by ‘knowledge for all’ – and by taking
responsibility for your own health.
Before you take on the next pages of this book, we invite you
to take a glimpse at our Research Institute in California where
everyone is committed to make ‘health for all’ a reality.
Dr. Rath
Research
Institute
Dr. Waheed Roomi,
Head of Our
Cancer Research,
Evaluating a Cancer
Experiment
Key Researchers
Discussing Scientific
View of One Projects at a
of Our Laboratory Bench
Laboratories
170 171
Increased Effectiveness by a ‘Team Effort’ Micronutrient Synergy –

of Micronutrients (Nutrient Synergy) the Basis of Modern Health Care
Some of our readers, including health professionals, may be sur-
prised about the comprehensive benefits of micronutrients in
blocking cancer and even reversing important cellular mecha-
nisms that have gone awry. Vitamins
The scientific reason behind these amazing results is straightfor-
ward: we mimicked nature! By not relying on individual micronu-
trients but taking advantage of the positive and mutually reinforc-
ing interaction of individual micronutrients, we were able to
unleash the full potential of Nature in activating the self-healing
ability of the body.
Over past decades, many researchers have looked at the possibili-

Minerals
ty to control cancer with micronutrients. Unfortunately, most of
them used individual vitamins and other natural compounds try-
ing to accomplish this goal. One of the reasons for this narrow
approach was the regulatory climate.
Regulatory agencies around the world were prohibiting the regis-

tration of combinations of micronutrients for preventive and thera-
peutic purposes. This was the result of false conclusions.
The regulatory bodies were simply imposing the experiences from

pharmaceutical drug interactions to biological substances. Obvi-
ously, the serious and often deadly interactions of pharmaceutical
drugs are a major health concern. Not so, of course, for biological
substances that work together in billions of biochemical interac-
Phytobiologicals
tions in our body every second.
At our Research Institute we have pioneered the new direction of

micronutrient synergy. On the next pages we will document the
superiority of micronutrient synergy compared to individual com-
ponents.
172 173
Scientific Proof: Nutrient Synergy Has Advantage of Nutrient Synergy in

Advantages over Individual Micronutrients Inhibiting the Invasive Potential of
in Inhibiting the Invasive Potential of Cancer
Cancer Cells (Fibrosarcoma)
To study the advantage of a combination of micronutrients and indi-
vidual natural compounds in the fight against cancer, we decided Inhibitory Effect of Green Tea Extract Alone and
in Combination with Other Micronutrients on the Secretion of
on the following set of scientific experiments:
Collagen-Digesting Enzymes (MMP-9) by Human Cancer Cells
Human cancer cells from connective tissue producing cells

1
(fibrosarcoma) were exposed to two different environments: 2
1. Cell culture solution supplemented with Green Tea Extracts

(GTE), rich in bio-active compounds called polyphenols. This Note the Differences
1 Between the Green
compound is represented in the adjacent graphs in green colour. and Red Columns
2. Cell culture solution supplemented with the same GTE solution 2

as in 1) but – in addition – a composition of micronutrients con-
1
taining certain vitamins, minerals and amino acids. For details
of this composition we refer you to the pages on nutrient syner- A. Control B. 50 C. 100 D. 500
gy (NS) at the beginning of this chapter. On the facing page it is Micronutrient Concentrations (mcg/ml)
represented in red colour.
2. Nutrient Synergy (NS)
Tested Compositions: Composition:
The results of these experiments showed that increasing amounts
of green tea extract as well as the nutrient combination were able 1. Green Tea Extract (GTE)
Amino Acids
to gradually inhibit the production of collagen-digesting enzymes 2. Nutrient Synergy (NS)
Minerals
by cancer cells. It is noteworthy, however, that the green tea
extract – when combined with other micronutrients – was much Vitamins
more effective in inhibiting the invasive potential of cancer cells
1. Green Tea Extract (GTE)
than if used alone. rich in polyphenols
Green Tea Extract
* for details see beginning of this chapter
These results were not limited to fibrosarcoma cells. We document-

ed the same advantage of nutrients in human liver cancer cells, A synergy of micronutrients, mimicking the situation
brain cancer cells (Glioblastoma) and other cancer types. in biological systems, is more effective in inhibiting
cancer than individual components alone.

174 175
Scientific Proof: Nutrient Synergy Has Nutrient Synergy is More Effective

Advantages Over Individual Micronutrients Than Green Tea Alone in
in Inhibiting Breast Cancer Growth Inhibiting Growth of Breast Tumours
After we had confirmed the increased effectiveness of micronutri-
ent synergy over individual micronutrients using cancer cells, we
wanted to answer the important question of whether this finding Inhibitory Effect of Green Tea Extract Alone
also applies to a living system. and in Combination with Other Micronutrients
on the Growth of Breast Tumours in vivo
Our assumption was that this should be the case – after all, the
biochemical functions of the body are not dependent on one sin-
4.0
gle micronutrient alone, but rather than on the availability and
‘orchestrated’ interaction of many micronutrients.
We designed a study where we induced breast cancer in three
Average Size of Tumours (in cc)

groups of animals (in this case rats) and allowed the tumours to A. Control Diet
develop for a period of 18 weeks. With this study design, we want-
ed to mimic the situation in patients in whom cancer had already B. Green Tea Diet
developed.
C. Nutrient Synergy Diet
Before receiving any micronutrient supplementation, the sizes of
the tumours in the three groups were measured. The results are
represented as ‘Start’ on the graph of the facing page. While
Start
Group A continued without micronutrient supplementation and 40
served as a control, the diet of group B was supplemented with 60
green tea extract and the diet of group C with green tea extract Study Duration in Days
plus additional micronutrients (nutrient synergy, see previous
page).
The results of this in vivo study are shown on the facing page. In living conditions too, the synergy of micronutrients is
Dietary supplementation was shown to dramatically reduce the more effective in inhibiting tumour growth than individual
size of the breast tumours. It was noteworthy, however, that ani- micronutrient components alone.
mals receiving the micronutrient synergy diet had the greatest
benefit: between 40 and 60 days of the study duration, the tumour
growth was essentially brought to a complete standstill.
www.drrathresearch.org
176 177
Research You Can Trust!

When you hear media reports about ‘breakthroughs’ in the fight
against cancer, be careful. Pharmaceutical companies are experts
in creating media hype to increase the sales of their patented
drugs and boost share value of their business.
Our research institute is independent from the influence of the

pharmaceutical investment business and from any other private
financial interests. For more than a decade now, our research has
been exclusively financed by people whom we have helped with
the results of our scientific research and the health knowledge we
shared.
Moreover, our Research Institute and the entire group of Dr. Rath
companies are 100% owned by non-profit foundations. Thus,
there is no profit motive involved in our presenting you with this
information. The only interest we represent is your health. What
a better way to earn your trust.
Over the years, our Institute has become one of the world’s lead-
ing research institutions in natural health. The research results
have been published in leading scientific journals and presented
at international scientific conferences. All results are also present-
ed on our Institute’s website:
www.wha-www.org/en/library/index.html
w w w. d r r a t h r e s e a r c h . o r g
178 179
What is Your Summary of This Chapter Compelling Perspectives

for Global Health Care
When writing this chapter, we had important goals in mind
about the changes this information would make in the
understanding of cancer by our readers. On this page you From the scientific evidence provided in this chapter there
can check whether these goals were accomplished. are immediate consequences for patients, health profes-
sionals and political decision makers, in fact, for every
reader.
Yes No
Do you know now that:
With the following postulates we would like to inspire a
All types of cancer use the same public discussion – which is long overdue – that will lead to
mechanism to spread through victory over cancer.
the body?
1. With the scientific basis for the natural control of cancer
Micronutrients can control all key presented in this book, victory over cancer is dependent
mechanisms of cancer? on one factor only: How fast will this information spread
worldwide?
Micronutrients working in teams (synergy)
are more effective than acting alone?
2. The implementation of the knowledge presented in this
Micronutrients represent an option to fight book will help to eliminate cancer as yet another disease
cancer effectively and safely, without side that has been haunting mankind in epidemic propor-
effects? tions.
Micronutrients work through regulation of 3. The economic savings from using this book as the basis
cell function – as opposed to chemotherapy for new public health strategies will save billions in
that works by intoxication of cells?
health care costs and reduce the fateful dependency of
Based on this modern understanding of patients and politicians alike from the strangulating grip
cancer origin and control, this disease can of the multi-billion dollar pharmaceutical investment
become largely unknown in our generation? business thriving on the cancer epidemic.
180 181
Do you realise ... Harvard

Medical School,
that by reading this book, you are obtaining information that is Cambridge, MA
currently not being taught at medical schools anywhere in the
world?
On the facing page you see just three of the world’s leading
medical institutions: Harvard Medical School, Sloan Kettering
Center, and Stanford University.
To this day, generations of future doctors are being trained

there without the basic understanding that the aggressiveness
of cancer disease derives from the abuse of natural mecha- Sloan Kettering Center,
nisms in the body – such as ovulation and leukocyte migration New York
– by cancer cells.
Generations of future doctors at medical schools around the

world don’t learn that this abuse of normal cellular mecha-
nisms is the reason why cancer can so easily escape the
body’s defences – and why cancer is such an aggressive dis-
ease.
With the publication of this book, this life-saving information

is made available to health professionals. More importantly,
the straightforwardness of the message of this book will allow
millions of people without any specific training in medicine to
understand that the victory over cancer is now in their hands.
Imagine!
Stanford University
Palo Alto
182 183
Appendix
Important Documentation
Victory Over Cancer Part One: Making the Unthinkable Possible Appendix − Important Documentation
Acknowledgements
Our thanks go to our entire research team who confirmed this Particular thanks go to the thousands of members of our interna-
medical breakthrough with ingenuity and perseverance. First and tional Health Alliance who have supported our research for more
foremost we owe our appreciation to Dr. Waheed Romi, the head than a decade. Without you this breakthrough would not have
of our cancer research department who conducted and supervised been possible.
these important experiments for more than a decade. We also
thank Dr. Shrirang Netke, Dr. Vadim Ivanov, Dr. Raxit Jariwalla, We thank our families for their support and patience.
Nusrath Roomi and Tatiana Kalinovsky for promoting this break-
through research. We also thank Andy and Jamie Kerr for an inspirational environ-
ment when we wrote this book.
Our thanks go to Lisa Smith for assistance in the layout of this
book as well as Cathy Flowers and John Journey for reading cor- Finally, our thanks go to all those who have remained an invaluable
rections. source of motivation to us through their scepticism and opposition.
We are grateful to Betsy Long, Earle Hall, Christian Kammler and

Thomas Wenn, and Paul Anthony Taylor for organisational support.
We also wish to express our gratitude to all members of our inter-

national legal team that has worked for more than a decade to
protect this breakthrough against the legal attacks of the status quo
lobby.
We thank Werner Pilniok, Baerbel Saliger and all other patients

who had the courage to publicly tell their life story.
We pay special reference to those patients, young and old, who

failed in their efforts to fight the disease and who may have had a
chance had they not lost so much time in the deadlocks of con-
ventional medicine.
We are especially grateful to August Kowalczyk, Jerzy Ulatowski

and other survivors of the Auschwitz concentration camp. They
remain a lasting inspiration to us and our work. We are united
with them in the commitment: ‘Never again!’
190 191
The following scientific publication from 1992 laid the conceptual Introduction
foundation for our research in cancer. It was written by Dr. Rath
and supported by Nobel Laureate Linus Pauling. In recent years the international research community became fascinated
by a unique protein in the human body: apoprotein(a) [apo(a)]. In the
three decades since its discovery apo(a) has been primarily discussed in
Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine,
relation to its deleterious effects on human health, in particular on cardio-
and Synthetic Lysine Analogs vascular disease (CVD). We did not accept that apo(a) should have only
disadvantageous properties. According to the laws of evolution apo(a)
M. Rath, L. Pauling must have beneficial properties that by far outreach its disadvantages.
Journal of Orthomolecular Medicine 1992, 7: 17-23 Consequently, we discovered that under physiological conditions apo(a)
functions as an adhesive protein, mediating organ differentiation and
Summary growth. Under pathophysiological conditions apo(a) primarily substitutes
for ascorbate deficiency and increases tissue stability by compensating for
Most human diseases, independent of their individual genetic or exoge- impaired collagen metabolism, and by promoting tissue repair (1). More-
nous origin, proliferate via similar pathomechanisms. One of these univer- over, we proposed that apo(a) functions as an inhibitor of important patho-
sal pathways is propagated by oxygen free radicals. Here we present mechanisms involved in the proliferation of many diseases. These patho-
another universal pathomechanism: the degradation of the connective tis- mechanisms are favored during ascorbate deficiency. One of these univer-
sue by the protease plasmin. This mechanism had been described for sal pathomechanisms is the damaging effect of oxygen free radicals, which
some diseases but its universal character has still been insufficiently under- is attenuated by the antioxidative function of apo(a) as a proteinthiol (2).
stood. We propose now that the proliferation of cancer, cardiovascular
disease (CVD), and also inflammatory and many other diseases depends to Apo(a) also led us to determine the universal importance of another path-
a varying degree on this pathomechanism. Activated macrophages, but omechanism: the enzymatic degradation of the connective tissue by the
also cancer cells, virally transformed cells, and other pathogenic cells protease plasmin. We recently proposed that apo(a), by virtue of its
secrete considerable amounts of plasminogen activators, which lead to an homology to plasminogen, functions as a competitive inhibitor of plas-
activation of plasminogen to the protease plasmin which activates procol- min- induced proteolysis (3). In this publication we describe the universal
lagenase to collagenase. The resulting degradation of the extracellular character of this mechanism and the role of apo(a) in more detail. Plas-
matrix is a precondition for the proliferation and the clinical manifestation min-induced proteolysis had been described as a pathomechanism for
of any disease. Most acute and chronic diseases make use of this pathome- some diseases, e.g. cancer and certain viral diseases (4,5). In cardiovascu-
chanism. This pathomechanism is the exacerbation of a mechanism used lar disease, however, this mechanism has received little, if any, attention.
under physiological conditions by a variety of cellular systems of the The insufficient understanding of the universal character of this pathome-
human body. The exacerbation under pathological conditions is the result chanism is further underlined by the absence of a broad therapeutic use
of a chronic imbalance between activators and inhibitors of this pathway. of L-lysine and its synthetic analogs, which are exogenous inhibitors of
Apoprotein(a), apo(a), by virtue of its homology to plasminogen is pro- this pathway. The lack of this knowledge continues to have detrimental
posed to be a competitive endogenous inhibitor of plasmin induced prote- consequences for human health and it prevents millions of patients from
olysis and tissue degradation. The essential amino acid L-lysine functions receiving optimum treatment. It is the aim of this publication to close this
as an exogenous inhibitor of this pathway. Therapeutic administration of gap and to provide the rationale for a broad introduction of lysine and its
L-lysine and synthetic lysine analogs, such as tranexamic acid, should lead synthetic analogs into clinical therapy.
to an effective control of plasmin- induced tissue degradation. Compre-
hensive clinical confirmation of this work will particularly improve the
therapeutic options for advanced forms of CVD, cancer, and inflammatory
and infectious diseases, including AIDS.
192 193
Plasmin-Induced Proteolysis Under Physiological Conditions become 'activated'. This activation reflects a particular state of alert that is
characterized by an abundant release of secretory products. These prod-
Plasmin-induced proteolysis is a physiological mechanism that occurs ucts include oxygen metabolites, collagenases, elastases, and a signifi-
ubiquitously in the human body. The main cellular defense systems, cantly increased secretion of plasminogen activators. It is immediately
monocytes, macrophages, and neutrophiles, use this mechanism for their obvious that this mechanism needs to be precisely controlled. Therefore
migration through the body compartments. They secrete plasminogen macrophages also secrete inhibitory products including plasmin
activators, which then activate plasminogen to plasmin. This mechanism inhibitors and a2-macroglobulin which are able to inactivate plasmin and
makes efficient use of high blood and tissue concentrations of the proen- many other proteases. Any imbalance in this control system leads to an
zyme, plasminogen, which represents a huge reservoir of potential prote- exacerbation of this mechanism and to continued tissue degradation.
olytic activity. The activated protease plasmin then converts procollage- Chronic activation of macrophages and an exertion of the control mecha-
nases into collagenases (6), and quite possibly also activates other nisms eventually lead to a sustained degradation of the connective tissue
enzymes, leading to a local degradation of the connective tissue. This and to an accelerated proliferation of the disease. It is, therefore, not
local degradation of the connective tissue paves the way for the migration unreasonable for us to propose that plasmin-induced tissue degradation
of macrophages through the body. The proteolytic effect of plasmin is also contributes, to a varying degree, to the proliferation of all diseases.
involved in increasing vascular permeability (7). This effect facilitates the
infiltration of monocytes and other blood cells from the circulation to the This mechanism is, however, not limited to macrophages and other
tissue sites of increased requirement. Physiological conditions in which defense cells of the human body. In the following sections we shall dis-
plasmin-induced proteolysis occurs include different forms of tissue for- cuss this pathomechanism for the most important diseases in more detail.
mation and reorganization such as neurogenesis, vascularization, and,
quite probably, growth.
Cancer
Of particular importance is plasmin-induced proteolysis during the
remodulation of female reproductive organs. Under hormonal stimulation Malignant transformation of many cells of the human body leads to an
mammary and uterine cells secrete plasminogen activator and thereby uncontrolled secretion of plasminogen activators. In this situation the
initiate the morphologic changes of the organ during pregnancy and lac- secretion of plasminogen activators is not a temporary event, but is rather
tation (4). A particularly striking example for the effectiveness of this a characteristic feature of malignant cells. The magnitude of increase in
mechanism is ovulation. Luteinizing hormone (LH) and follicle cell stimu- plasminogen- activator production, between 10 and 100 fold, renders this
lating hormone (FSH) stimulate the secretion of plasminogen activators enzyme unique among the biochemical changes associated with onco-
from granulosa cells (8). The subsequent degradation of the ovarian con- genic transformation. Moreover, plasminogen-activator secretion occurs
nective tissue is a precondition for ovulation (Figure 1a). Similarly tro- independently of the induction mechanism and can be found as the result
phoblast cells use plasmin-induced proteolysis to invade the wall of the of oncogenic viruses or chemical carcinogens. Most importantly, the
uterus during embryo implantation in early pregnancy. In all these condi- amount of plasminogen activators secreted was, in general, associated
tions enzyme production is transient and is precisely regulated by hor- with the degree of malignancy (4,5). Immunohistological studies showed
mones and other control mechanisms. that the concentration of plasminogen activators in the vicinity of a tumor
is highest at the sites of its invasive growth (9).
Plasmin-Induced Proteolysis Under Physiological Conditions Because of the prominent role of plasmin-induced proteolysis in female
reproductive organs under physiological conditions it is no surprise that
Plasmin-induced tissue degradation contributes to the proliferation of most the exacerbation of this mechanism is particularly frequent in malignan-
diseases. Of particular interest is the fact that similar mechanisms are cies of the female reproductive organs. Cancer cells of the breast, the
induced by attacking pathogens as they are used by the defending host uterus, the ovaries, and other organs continuously secrete increased
cells, e.g. macrophages. In many pathological conditions macrophages amounts of plasminogen activators, destroy the surrounding extracellular
194 195
matrix, and thereby pave the way for infiltrative growth. These mecha- become macrophages. Their activation inside the vascular wall is enhanced
nisms are also involved in the proliferation of prostatic cancer, one of the by oxidatively modified lipoproteins and other challenging mechanisms
most frequent forms of cancer in males. (3,10). Once they are activated a similar cascade of events occurs, as in any
other disease: increased secretion of plasminogen activators, activation of
Plasmin-induced proteolysis is also critical for the metastatic spread of procollagenases by the protease plasmin, and degradation of the connec-
cancer. As discussed above, plasmin induces increased permeability of tive tissue in the vascular wall. Simultaneously, plasmin increases the per-
the blood vessels and thereby facilitates the systemic dissemination of meability of the vascular wall, leading to a further increase in the infiltration
tumor cells. This pathomechanism is, of course, not limited to reproduc- of plasma constituents. The perpetuation of these pathomechanisms leads
tive organs. Plasmin-induced tissue degradation has been reported for to the development of atherosclerotic lesions. This mechanism is particular-
tumors of the ovaries, endometrium, cervix, breast, colon, lung, skin ly effective when the vascular wall is already destabilized by a deficiency in
(melanoma, and many others (4), suggesting that most cancers make use ascorbate. As described recently in detail (3), this instability is primarily
of this mechanism for their proliferation. unmasked at sites of altered hemodynamic conditions, such as the branch-
ing regions of the coronary arteries. It is therefore no surprise that increased
amounts of plasminogen activators were detected in these branching
Infectious and inflammatory diseases. regions of human arteries. Moreover, atherosclerotic lesions in general were
found to contain significantly higher amounts of plasminogen activators
As for transformed cells in malignancies, virally transformed cells were than grossly normal arterial wall (11). It is a remarkable fact that these early
also found to secrete plasminogen activators (4,5). These cells activate observations have not been followed up systematically. This negligence sug-
plasminogen in their vicinity, e.g., the lung tissue, and thereby facilitate gests that the universal character of uncontrolled plasmin-induced proteoly-
the local spread of the infection. Simultaneously, plasmin increases the sis for disease proliferation has not yet been fully understood. It is the aim of
permeability of the local blood vessels and thereby promotes the systemic this paper to close this gap.
spread of the infection.
It is not unreasonable for us to propose that other pathogens may also Apoprotein(a) - An Inhibitor of Plasmin-Induced Proteolysis
make use of this mechanism during the process of infection. Plasminogen
activators play an important role during inflammation in general. Produc- In identifying the universal importance of plasmin-induced proteolysis for
tion of plasminogen activators by macrophages and granulocytes is close- most diseases we were once again guided by apo(a) and its increased
ly correlated to different modulators of inflammation. Secretion of the demand as reflected by the elevated plasma concentrations in many
enzyme is stimulated by asbestos, lymphokines, and interferon and is pathological conditions. As discussed above, apo(a) exerts a multitude of
inhibited by antiinflammatory agents such as glucocorticoids. Plasmin- functions under physiological and pathophysiological conditions. Here
induced proteolysis has been described for patients with a variety of we focus on the role of apo(a) as an endogenous competitive inhibitor of
inflammatory diseases, including chronic rheumatoid arthritis, allergic plasmin-induced proteolysis and tissue degradation.
vasculitis, chronic inflamatory bowel disease, chronic sinusitis, demyeli-
nating disease, and many others (4). Plasmin-induced tissue degradation Apo(a) is a glycoprotein with a unique structure. It is essentially composed
is therefore likely to be an important pathomechanism in chronic inflam- of a repetitive sequence of the kringle structures highly homologous to the
matory diseases. kringle IV of the plasminogen molecule. The gene for apo(a) is located in
the direct vicinity of the plasminogen gene on chromosome 6. It has been
proposed that the apo(a) molecule derives from the plasminogen mole-
Cardiovascular disease. cule or that the two genes share a common ancestral gene (12). As of
today no explanation has been offered as to why among all five kringles of
Activated macrophages play an important role in the pathogenesis of car- plasminogen it is almost exclusively kringle IV that was chosen by nature
diovascular disease. Blood monocytes enter the vascular wall, where they to compose the apo(a) molecule.We do not accept this selective advan-
196 197
tage of kringle IV as a coincidence. We propose that at least one of the In summary, apo(a) is suggested to be an important element in the endoge-
reasons for the repetition of kringle IV in apo(a) is closely related to the nous control system of plasmin-induced proteolysis. Apo(a) may back-up
structure/function of kringle IV in the plasminogen molecule. antiplasmin and other endogenous inhibitors of this pathway particularly
during chronic activation of this mechanism. Beside endogenous
It is not unreasonable for us to propose that apo(a), by virtue of its multiple inhibitors of plasmin-induced tissue degradation there are also exogenous
kringle IV structures, is a competitive inhibitor of plasmin-induced prote- inhibitors. The universal importance of the pathomechanism described
olysis. Apo(a) could be involved in the control of this pathway without here immediately suggests the great value of these exogenous inhibitors in
interfering with critical functions of plasminogen mediated by other the therapy of many diseases.
kringles of the plasminogen molecule. Consequently, the more kringle IV
repeats one apo(a) molecule contains, the more effective this apo(a) iso- The Therapeutic Use of Lysine and Synthetic Lysine Analogs
form would be as an inhibitor. This concept could not only explain the
selective advantage of kringle IV versus the other kringle structures, but it Lysine, an essential amino acid, is the most important naturally- occurring
could also explain the great variation in genetically determined plasma inhibitor of this pathway. As opposed to the competitive inhibition by
Lp(a) concentrations, which largely reflect the inverse relation between apo(a), lysine inhibits plasmin-induced proteolysis in a direct way. Lysine
the number of intramolecular kringle IV repeats and the synthesis rate of attenuates an overshooting activation of plasmin, at least in part, by occu-
apo(a) molecules. pying the lysine binding sites in the plasminogen molecule. Since lysine
is an essential amino acid, its availability is not regulated endogenously.
Supportive evidence for a role of apo(a) in the control of plasmin- induced Insufficient dietary lysine intake invariably leads to a deficiency of this
proteolysis is also provided by a number of observations. Apo(a) has been amino acid and thereby weakens the natural defense against this patho-
shown to attenuate tissue-plasminogen-activator-induced fibrinolysis and mechanism. Moreover, chronic activation of plasminogen by cancer cells,
competitively interfere with plasminogen- and plasmin- induced pathways virally transformed cells, or macrophages leads to an additional relative
(review in 14). Moreover, immunohistological studies in various diseases lysine deficiency and thereby to an acceleration of the underlying dis-
showed a preferential deposition of apo(a) at the site of increased demand ease. The therapeutic value of lysine has been documented for a variety of
for a control of plasmininduced proteolysis. In several hundred vascular diseases, including viral diseases (18), and recently in combination with
specimens representing various degrees of cardiovascular disease apo(a) ascorbate for cardiovascular disease (19).
was found primarily to be located in the subendothelium, quite possibly
counteracting the increased endothelial permeability. In advanced athero- Synthetic lysine analogs such as epsilon-aminocaproic acid, paraamino-
sclerotic lesions apo(a) was preferentially found around the lesion core, methylbenzoic acid and trans-aminocyclohexanoic acid (tranexamic
particularly at the edges of the lesion (15), the main sites of chronic repair acid) are potent inhibitors of plasmin-induced proteolysis. These sub-
processes. In a comprehensive morphological study in different forms of stances, in particular tranexamic acid, have been successfully used in the
cancer apo(a) was found to be deposited in the vicinity of the cancer treatment of a variety of pathological conditions, such as angiohe-
process (Dr. A. Niendorf, personal communication). Both studies were matoma, colitis ulcerosa, and others. Most remarkable results were
conducted with the same monoclonal antibodies not cross-reacting with reported from the treatment of patients with late-stage cancer of the breast
plasminogen. A preliminary report is also available for the deposition of (20) and the ovaries (21) and also for cancer of other origins (22). We
apo(a) in the microvasculature of inflammatory processes (16). We predict have recently suggested the therapeutic use of synthetic lysine analogs for
that apo(a) will also be found to play an important role in the containment the reduction of atherosclerotic plaques (3).
of infectious diseases, including AIDS. The role of apo(a) as a competitive
inhibitor of plasmininduced proteolysis is not limited to pathological con- On the basis of the work presented here, comprehensive clinical studies
ditions. An increased demand of apo(a) was also observed during the peri- should be initiated to establish the critical role of lysine in the prevention
od of uterus transformation in early pregnancy (17). and treatment of various diseases without delay. A daily intake of 5 grams
198 199
of lysine and more (19,23) has been described to be without side effects. Acknowledgements
On the basis of the encouraging therapeutic results with tranexamic acid,
particularly in inhibiting and reducing late-stage cancer, these substances We thank Dr. Alexandra Niedzwiecki for helpful discussions, Rosemary
should now be extensively tested for a broad introduction into clinical Babcock for library services, Jolanta Walechiewicz for graphical assis-
therapy, particularly for advanced forms of cancer, CVD, and AIDS. A tance, Martha Best and Dorothy Munro for secretarial help.
possible explanation of why this has not happened long ago may be the
argument that these substances may induce coagulative complications.
They are, however, protease inhibitors and inhibit not only fibrinolysis but
also coagulation (24). Moreover, tranexamic acid has been given for more
than 10 years without clinical complications (25). We have proposed that
the risk of any hemostatic complication will be further reduced by a com-
bination of these compounds with ascorbate and other vitamins with anti-
coagulative properties (3). This medical consideration is, however, not the
only factor why these compounds are not used much more frequently and
why thousands of patients are still deprived of optimum therapy. There is
also an economic factor. Patent protection is a guiding principle of any
pharmaceutical company in developing or marketing a drug. Lysine, like
many other nutrients, is not patentable and the patents for the clinically
approved synthetic lysine analogs, including tranexamic acid, have
expired. The negligence of these substances may be explainable from the
economic point of view; from the perspective of human health there is no
justification for this delay.
Conclusion
Here we have described plasmin-induced proteolysis as a universal path-

omechanism propagating cancer, and cardiovascular, inflammatory, and
many other diseases. Plasmin-induced tissue degradation under patholog-
ical conditions is an exacerbation of a physiological mechanism. Apo(a)
is suggested to function as a competitive endogenous inhibitor of this
pathway. On the basis of the selective advantage of apo(a) in the evolu-
tion of man it comes as no surprise that apo(a) should lead us on the way
to recognize the universal importance of this pathomechanisms. Further
clinical confirmation of the therapeutic value of lysine and its synthetic
analogs may provide new options for an effective therapy for millions of
people. We predict that the use of lysine and synthetic lysine analogs,
particularly in combination with ascorbate, will lead to a breakthrough in
the control of many forms of cancer and infectious diseases, including
AIDS, as well as many other diseases.
200 201
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This picture shows a copy of the figures

taken from the original publication in 1992.
204 205
PUBLICATIONS OF OUR WORK OVARIAN CANCER

In vitro modulation of MMP-2 and MMP-9 in human cervical and ovarian cancer
cell lines by cytokines, inducers and inhibitors. M.W. Roomi, J.C. Monterrey,
PROSTATE CANCER T. Kalinovsky, M. Rath, A. Niedzwiecki. Oncology Reports 2010; 23(3):605-614
In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline and Green Tea Extract on
Human Prostate PC-3 Xenografts in Nude Mice: Evaluation of Tumor Growth and Inhibition of MMP-2 Secretion and Invasion by Human Ovarian Cancer Cell Line
Immunohistochemistry. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, SKOV-3 with lysine, proline, arginine, ascorbic acid, and Green Tea Extract. M.W.
M. Rath. In Vivo , 2005, 19(1), 179-184. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Journal of Obstetrics and Gynaecology Research 2006; 32(2): 148-154
Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine and Epigallocatechin
Gallate in Prostate Cancer Cell Lines PC-3, NCaP, and DU145. M.W. Roomi,
V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath COLON CANCER
Research Communications in Molecular Pathology and Pharmacology, 2004, 115:1-6 In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline and Green Tea Extract on
Human Colon Cancer Cell HCT 116 Xenografts in Nude Mice: Evaluation of
Tumor Growth and Immunohistochemistry. M.W. Roomi, V. Ivanov, T. Kalinovsky,
TESTICULAR CANCER A. Niedzwiecki, M. Rath. Oncology Reports, 2005, 12 (3), 421-425
Inhibitory Effects of a Nutrient Mixture on Human Testicular Cancer cell Line
NT 2/DT Matrigel Invasion and MMP Activity. M.W. Roomi, V. Ivanov, Synergistic Effect of Combination of Lysine, Proline, Arginine, Ascorbic Acid and
T. Kalinovsky, A. Niedzwiecki, M. Rath. Medical Oncology 2007 24(2): 183-188 Epigallocatechin Gallate on Colon Cancer Cell Line HCT 116. M.W. Roomi,
V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Journal of the American Nutraceutical Association, 2004, 7 (2): 40-43
BREAST CANCER
In Vitro and In Vivo Antitumorigenic Activity of a Mixture of Lysine, Proline, BONE CANCER
Ascorbic Acid and Green Tea Extract on Human Breast Cancer Lines MDA
Naturally Produced Extracellular Matrix Inhibits Growth Rate and Invasiveness
MB-231 and MCF-7. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki,
of Human Osteosarcoma Cancer Cells. V. Ivanov, S. Ivanova, M.W. Roomi,
M. Rath Medical Oncology 2005, 22(2) 129-38
T. Kalinovsky, A. Niedzwiecki, M. Rath. Medical Oncology 2007; 24(2): 209-217
Modulation of N-Methyl –N-Nitrosourea-Induced Mammary Tumors in Sprague-
Effect of Ascorbic Acid, Lysine, Proline and Green Tea Extract on Human
Dawley Rats by Combination of Lysine, Proline, Arginine, Ascorbic Acid and
Osteosarcoma Cell Line MNNG-HOS Xenografts in Nude Mice: Evaluation of
Green Tea Extract. M.W. Roomi, N.W. Roomi, V. Ivanov, T. Kalinovsky,
A. Niedzwiecki, M. Rath. Breast Cancer Research, 2005, 7:R291-R295
A. Niedzwiecki, M. Rath. Medical Oncology 2006; 23(3 ): 411-417
A combination of green tea extract, specific nutrient mixture and quercetin:
Antitumor Effect of Nutrient Synergy on Human Osteosarcoma Cells U2OS,
An effective intervention treatment for the regression of N-Methyl –N-Nitrosourea
MNNGHOS, and Ewing’s Sarcoma SK-ES.1. M.W. Roomi, V. Ivanov, T. Kalinovsky,
(MNU)-Induced mammary tumors in Wistar rats. Anup Kale, Sonia Gawande,
A. Niedzwiecki, M. Rath. Oncology Reports, 2005, 13(2), 253-257
Swati Kotwal, Shrirang Netke, M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Oncology Letters, 2010, 1:313-317
In Vivo and In Vitro Antitumor Effect of Nutrient Synergy on Human
Osteosarcoma Cell Line MNNG-HOS. M.W. Roomi, V. Ivanov, T. Kalinovsky,
A. Niedzwiecki, M. Rath. Annals of Cancer Research and Therapy, 2004, 12: 137-148
CERVICAL CANCER
Suppression of Human Cervical Cancer Cell Lines Hela and oTc2 4510 MMP
Expression and Matrigel Invasion by a Mixture of Lysine, Proline, Ascorbic Acid, PANCREATIC CANCER
and Green Tea Extract. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, Antitumor Effect of a Combination of Lysine, Proline, Arginine, Ascorbic Acid,
M.Rath International Journal of Gynecological Cancer 2006; 16:1241-1247 and Green Tea Extract on Pancreatic Cancer Cell Line MIA PaCa-2. M.W. Roomi,
V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
International Journal of Gastrointestinal Cancer 2005, 35 (2), 97-102
206 207
FIBROSARCOMA LUNG CANCER

In Vivo and in Vitro Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine, Chemopreventive effect of a novel nutrient mixture on lung tumorigenesis
and Green Tea Extract on Human Fibrosarcoma Cells HT-1080. M.W. Roomi, induced by urethane in male A/J mice. M.W. Roomi, N.W. Roomi, V. Ivanov, T.
V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath Kalinovsky, A. Niedzwiecki, M. Rath. Tumori 2009; 95: 508-513
Medical Oncology 2006; 23(1): 105-112
Modulation of MMP-2 and MMP-9 by cytokines, mitogens, and inhibitors in lung
Synergistic Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Epigallocate- cancer and mesothelioma cell lines. M.W. Roomi, J.C. Monterrey, T. Kalinovsky,
chin Gallate on Human Fibrosarcoma Cells HT-1080. M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath. Oncology Reports 2009; 22: 1283-1291
T. Kalinovsky, A. Niedzwiecki, M. Rath
Annals of Cancer Research and Therapy, 2004 12:148-157 Inhibition of Malignant Mesothelioma Cell Matrix Metalloproteinase Production
and Invasion by a Novel Nutrient mixture. M.W. Roomi, V. Ivanov, T. Kalinovsky,
A. Niedzwiecki and M. Rath. Experimental Lung Research 2006; 32:69-79
KIDNEY AND BLADDER CANCERS
In Vivo and in Vitro Anti-tumor Effect of a Unique Nutrient Mixture on Lung Can-
Pleiotropic effects of a micronutrient mixture on critical parameters of bladder
cer Cell Line A-549. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki and
cancer. M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath. In Bladder Cancer:
M. Rath. Experimental Lung Research 2006; 32:441-453
Etymology, Diagnosis and Treatments, edited by William Nilsson, Nova Science Pub-
lishers, Inc, 2010.
Inhibition of Pulmonary Metastasis of Melanoma B16FO Cells in C57BL/6 Mice
by a Nutrient Mixture Consisting of Ascorbic Acid, Lysine, Proline, Arginine, and
Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine, and Green Tea Extract
Green Tea Extract. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
on Bladder Cancer Cell Line T-24. M.W. Roomi, V. Ivanov, T. Kalinovsky,
Experimental Lung Research 2006; 32(10):517-30
A. Niedzwiecki, M. Rath. International Journal of Urology 2006; 13: 415-419
Modulation of Human Renal Cell Carcinoma 786-0 MMP-2 and MMP-9 Activity
by Inhibitors and Inducers in Vitro. M.W. Roomi, V. Ivanov, T. Kalinovsky, BLOOD CANCERS
A. Niedzwiecki, M. Rath. Medical Oncology 2006; 23(2): 245-250 Antineoplastic effect of nutrient mixture on Raji and Jurkat T cells: the two highly
aggressive non-Hodgkin’s lymphoma cell lines. M.W. Roomi, BA Bhanap,
Anticancer Effect of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract N.W. Roomi, A. Niedzwiecki and M. Rath.
on Human Renal Adenocarcinoma Line 786-0. M.W. Roomi, V. Ivanov, T. Kali- Experimental Oncology 2009; 31(3): 149-155
novsky, A. Niedzwiecki and M. Rath. Oncology Reports 2006; 16(5):943-7
Epigallocatechin -3-Gallate induces apoptosis and cell cycle arrest in HTLV-1 pos-
itive and negative leukemia cells. S. Harakeh, K. Abu-El-Ardat, M. Diab-Assaf, A.
Niedzwiecki, M. El-Sabban, M. Rath. Medical Oncology 2008; 25: 30-39
SKIN CANCER
Inhibition of 7, 12-Dimethylbenzathracene-Induced Skin tumors by a Nutrient
Ascorbic acid induces apoptosis in Adult T-cell Leukemia. S. Harakeh, M. Diab-
Mixture. M.W. Roomi, N.W. Roomi, T. Kalinovsky, V. Ivanov, M. Rath,
Assaf, J. Khalife, K. Abu-El-Ardat, E. Baydoun, A. Niedzwiecki, M. El-Sabban,
A. Niedzwiecki. Medical Oncology 2008; 25(3): 330-340
M. Rath. Anticancer Research 2007; 27: 289-298
Suppression of growth and hepatic metastasis of murine B16FO melanoma cells
Mechanistic aspects of apoptosis induction by L-Lysine in both HTLV-1 positive
by a novel nutrient mixture. M.W. Roomi, T. Kalinovsky, N.W. Roomi, V. Ivanov,
and negative cell lines. S. Harakeh, M. Diab-Assaf, K. Abu-El-Ardat, A.
M. Rath, A. Niedzwiecki. Oncology Reports 2008; 20:809-817
Niedzwiecki, M. Rath. Chem. Biol. Interactions 2006; 164: 102-114
In Vitro and In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, And Green
Apoptosis Induction by Epican Forte in HTLV-1 Positive and Negative Malignant
Tea Extract On Human Melanoma Cell Line A2058. M.W. Roomi, V. Ivanov,
TCells. S. Harakeh, M. Diab-Assaf, A. Niedzwiecki, J. Khalife, K. Abu-El-Ardat,
T. Kalinovsky, A. Niedzwiecki, M. Rath. In Vivo 2006;20(1): 25-32
M. Rath. Leukemia Research –2006; 30: 869-881
208 209
OTHER CANCERS METASTASIS

Comparative effects of EGCG, green tea and a nutrient mixture on the patterns of Micronutrient synergy – a new tool in effective control of metastasis and other key
MMP-2 and MMP-9 expression in cancer cell lines. M.W. Roomi, J.C. Monterrey, mechanisms of cancer. A. Niedzwiecki, M.W. Roomi, T. Kalinovsky, M. Rath.
T. Kalinovsky, A. Niedzwiecki, M. Rath. Oncology Reports – 2010; 24:747-757 Cancer Metastasis Review 2010; 29; 529-542
Inhibition of invasion and MMPs by a nutrient mixture in human cancer cell lines: a Suppression of growth and hepatic metastasis of murine B16FO melanoma cells
correlation study. M.W. Roomi, J.C. Monterrey, T. Kalinovsky, A. Niedzwiecki, by a novel nutrient mixture. M.W. Roomi, T. Kalinovsky, N.W. Roomi, V. Ivanov,
M. Rath. Experimental Oncology- 2010; 32:243-248 M. Rath, A. Niedzwiecki. Oncology Reports 2008; 20:809-817
In vivo and in vitro effect of a nutrient mixture on human hepatocarcinoma cell A nutrient mixture suppresses hepatic metastasis in athymic nude mice injected
line SK-Hep-1. M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath. with murine B16FO melanoma cells. M.W. Roomi, N.W. Roomi, T. Kalinovsky,
Experimental Oncology –2010;32:84-91 J.C. Monterrery, M. Rath, and A. Niedzwiecki. BioFactors 2008; 33; 85-97
Patterns of MMP-2 and MMP-9 expression in human cancer cell lines. Inhibition of Pulmonary Metastasis of Melanoma B16FO Cells in C57BL/6 Mice
M.W. Roomi, J.C. Monterrey, T. Kalinovsky, A. Niedzwiecki, M. Rath by a Nutrient Mixture Consisting of Ascorbic Acid, Lysine, Proline, Arginine, and
Oncology Reports – 2009; 21:1323-1333 Green Tea Extract. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath.
Marked inhibition of growth and invasive parameters of head and neck squamous
carcinoma FADU by a nutrient mixture. M.W. Roomi, N.W. Roomi, T. Kalinovsky,
A. Niedzwiecki, M. Rath. Integrative Cancer Therapies 2009; 8(2):168-176 ANGIOGENESE
Distinct patterns of matrix metalloproteinase-2 and -9 expression in normal
Inhibition of Glioma Cell Line A-172 MMP Activity and Cell Invasion in Vitro by human cell lines. M.W. Roomi, J.C. Monterrery, T. Kalinovsky, M. Rath, and
a Nutrient Mixture. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki and A. Niedzwiecki. Oncology Reports – 2009; 21: 821-826
M. Rath. Medical Oncology 2007; 24(2): 231-238
Patterns of MMP-2 and MMP-9 expression in human cancer cell lines.
Inhibitory of Cell Invasion and MMP Production by a Nutrient Mixture in M.W. Roomi, J.C. Monterrery, T. Kalinovsky, M. Rath, and A. Niedzwiecki.
Malignant Liposarcoma Cell Line SW-872. M.W. Roomi, V. Ivanov, T. Kalinovsky, Oncology Reports – 2009; 21:1323-1333
A. Niedzwiecki, M. Rath. Medical Oncology 2007; 24(4):394-401
Antiangiogenic properties of a nutrient mixture in a model of hemangioma.
In Vitro Anticarcinogenic Effect of a Nutrient Mixture on Human Rhadomyosarco- M.W. Roomi, T. Kalinovsky, M. Rath, and A. Niedzwiecki.
ma Cells. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath Experimental Oncology – Accepted 10/26/09
Gene Therapy and Molecular Biology 2007; 11(B):133-144
A novel nutrient mixture containing ascorbic acid, lysine, proline and green tea
In Vivo and in Vitro Anti-tumor Effect of a Nutrient Mixture Containing Ascorbic extract inhibits critical parameters in angiogenesis . M.W. Roomi, V. Ivanov, T.
Acid, Lysine, Proline, and Green Tea Extract on Human Synovial Sarcoma Cancer Kalinovsky, A. Niedzwiecki, M. Rath in Anti-Angiogenic. Functional and Medici-
Cells. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki and M. Rath. nal Foods, edited by Losso JN, Shahidi F, Bagchi D, CRC Press, Taylor& Francis
JAMA 2006; 9(2): 30-34 Group, Boca Raton, London, New York, 2007, pages 561-580.
A Specific Combination of Ascorbic Acid, Lysine, Proline and Epigallocatechin Inhibitory Effect of a Mixture Containing Ascorbic Acid, Lysine, Proline, and
Gallate Inhibits Proliferation and Extracellular Matrix Invasion of Various Human Green Tea Extract on Critical Parameters in Angiogenesis. M.W. Roomi,
Cancer Cell Lines. S.P. Netke, M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath. N.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath.
Research Communications in Pharmacology and Toxicology, Emerging Drugs, 2003; Oncology Reports 2005, 14(4), 807-815.
Vol. II, IV37-IV50.
Antiangiogenic Effects of a Nutrient Mixture on Human Umbilical Vein Endothe-
lial Cells. M.W. Roomi, N.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki,
M. Rath. Oncology Reports 2005;14(6):1399-404
210 211
Further References Important Websites

De Prithwish et al., Breast cancer incidence and hormone replacement therapy in
Canada. J. Natl. Cancer Inst. 2010; 102: 1-7
In the course of this book you may have come across some topics
Jemal A. et al., Global cancer statistics, CA Cancer J Clin. 2011; 61: 69-90. on which you would like to learn more. Here is a selection of web-
sites which we helped to create. We can assure you about the inde-
Jemal A et al., Trends in the Leading Causes of Death in the United States,
1970-2002. JAMA 2005, 294: 1255-1259 pendence of their contents.
Hirsh J, An Anniversary for Cancer Chemotherapy. JAMA 2006; 296; 1518-1520. • www.drrathresearch.org
Official website of our Research Institute in California
Phang J.M. et al., The metabolism of proline, a stress substance, modulates
carcinogenic pathways. Amino Acids, 2008; 35; 681-690
• www.wha-www.org
Duffy M.J., The urokinase plasminogen activator system: role in malignancy. Free online health education course for everyone
Curr. Pharm. Des., 2004; 10; 39-49
Henriet P et al., Contact with fibrillar collagen inhibits melanoma cell prolifera- • www.wha-www.org/en/library/index.html
tion by up-regulating p27 KIP1. Proc Natl Acad Sci USA, 2000; 97; 10026-10031. Online library of natural health for health professionals and
K. Almholt et al., Reduced metastasis of transgenic mammary cancer in urokinase
patients
deficient mice. Int. J. Cancer 2005; 113: 525-532
• www.hpcm.org (Health Professionals for Cellular Medicine)
Ruhul Amin A.R.M. et al., Perspectives for Cancer Prevention with Natural Co
pounds. J. Clin. Oncol. 2009; 27: 2712-2725
Official website of health professionals active in the field of
natural health
Oak Min-Ho et al., Antiangiogenic properties of natural polyphenols from red
wine and green tea. J. Nutr. Biochem. 2005; 16, 1-8
Morgan G et al., The Contribution of Cytotoxic Chemotherapy to 5-year Survival

in Adult Malignancies. Clin. Oncol. 2004; 16: 549-560.
212 213
Victory
Victory Over Cancer!
Part Two: Understanding History Building the Future Over Cancer!
First Edition.
© 2012 Dr. Matthias Rath und Dr. Aleksandra Niedzwiecki.
ISBN 978-90-76332-77-2
Distributet by:
Postbus 656
NL-6400 AR Heerlen
– Part Two –
Tel.: 0031-457-111 222
Fax: 0031-457-111 229
Understanding History
E-Mail info@rath-eduserv.com
Internet: www.rath-eduserv.com
All rights reserved. Distributed by Dr. Rath Health Foundation, Santa Clara, CA 95050
Building the Future
Individual pages or small portions of this book may be used for private and non-profit
educational purposes only.
Any commercial use of this book or any parts of it in any manner whatsoever without
written permission by the copyright holders is strictly prohibited.
Disclaimer:
This book is not intended as a substitute for the medical advice of a physician.
The reader should regularly consult a physician in matters relating to his or her health and
Matthias Rath, M.D.
particularly in respect to any symptoms that may require diagnosis or medical attention.
The author and publisher disclaim responsibility for any adverse effects resulting directly
or indirectly from the information contained in this book. Aleksandra Niedzwiecki, Ph.D.
4 5
Contents
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Chapter VI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Why You May Not Have Heard
About This Breakthrough Before
Chapter V . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
What You Can Do Now to Make
Victory Over Cancer Irreversible
Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Important Documents
“We will live to see a time when we no longer

have to look over our shoulder like a criminal
when we say: two and two makes four.”
Bertolt Brecht, “Life of Galilee”
6 7
Victory Over Cancer Part Two: Understanding History Building the Future Introduction
Introduction
Only once in the history of mankind is the discovery being made that
will lead to the natural control of cancer.
This book documents this discovery.
A breakthrough of this nature leads the pioneering scientists on a

path from the discovery of the underlying cellular mechanisms to
the confirmation of new therapeutic approaches at the level of
Dr. Matthias Rath Dr. Aleksandra Niedzwiecki basic research and ultimately to the clinical proof in patients suf-
fering from cancer.
This book is the report of the pioneering scientists.
One author, Dr. Matthias Rath, was privileged to contribute the

discovery of new natural ways to control cancer. Dr. Aleksandra
Niedzwiecki coordinated the scientific proof of this medical
breakthrough.
‘Victory Over Cancer’ is not an achievement that is given to us,

the people, voluntarily. Mankind has to earn the right to live in a
world without fear of cancer. The battle for that fundamental right
to become reality is being fought once.
This time is now.

Significantly, for mankind to achieve ‘Victory Over Cancer’ it was
not necessary to invent new, hi-tech approaches to control this
disease. The decisive breakthrough towards the effective preven-
8 9
tion, control and ultimately the elimination of cancer is based on

our new understanding of the critical role of micronutrients that
was unknown for decades.
The fact that the essential role of micronutrients in controlling

cancer thus far has not been understood – let alone applied
towards the control of the cancer epidemic – is no coincidence. It
has been deliberately neglected and withheld in the interest of the
pharmaceutical investment business.
As the authors of this book, our gratitude goes first and foremost to the
Diseases in general have been exploited by the pharmaceutical team of researchers at our Institute – in particular to the head of our can-
business interests as markets for their patented drugs. In cancer an cer research group, Dr. Waheed Roomi (second from left).
additional, particularly appalling, aspect deserves consideration.
The diagnosis ‘cancer’ has been kept as a ‘death verdict’ in the As the philosopher Arthur Schopenhauer already noted:
perception of people. That was not a coincidence. This fear of “Every truth passes through three stages before it is recognised.
death made millions of cancer patients accept literally any proce- In the first it is ridiculed, in the second it is opposed, in the third it
dure – as questionable as it may be – including highly toxic is regarded as self-evident.”
chemotherapy.
The key discoveries towards ‘Victory over Cancer‘ were made
This report will end this fallacy and, thereby, help to already two decades ago. Our efforts at that time to convince large
liberate mankind from the fateful dependency upon pharmaceutical companies to commit to the elimination of cancer
the pharmaceutical ‘business with disease’. were futile. In retrospect, this was no surprise: This discovery threat-
ened their multi-billion dollar market with chemotherapy drugs.
The victory over cancer ranks among the great advances in medi-
cine. One hundred and fifty years ago Louis Pasteur discovered However, we did not give up, but it took us about one decade to
that microorganisms are the cause of infectious diseases and start our own research institute in California and to launch a com-
thereby paved the way for the control of many epidemics that had prehensive cancer research project in 1999.
haunted mankind for millennia. It was more than a quarter centu-
ry later that his theories were finally accepted.
10 11
By the end of 2001 we had obtained the first research confirma-

tion that key steps of the cancer disease can be controlled natural-
ly. We decided to share this life-saving information with the world.
On March 8, 2002, we announced this medical breakthrough on
a full page in USA Today – the world’s largest newspaper.
The significance of this breakthrough for human health can per-

haps best be judged from the fierce reactions by the status quo.
Over the past ten years the pharmaceutical lobby filed more than
100 legal attacks against this breakthrough, to no avail. The publi-
cation of this book now documents that we are right.
This book will empower millions of people to take actions toward

ending the devastating dependency upon the economic interests
who have been putting profits over life for an entire century.
This book will break mankind’s psychological dependency on the

‘investment business with the cancer epidemic’. It will inspire
similar breakthroughs in the fight against other diseases and con-
tribute to a new, independent, global health care in the interest
of billions of people living today and of future generations.
Santa Clara, California,

Autumn 2011
Matthias Rath and Aleksandra Niedzwiecki
A copy of our announcement about the breakthrough in the natur-

al control of cancer in USA Today, on March 8, 2002. By present-
ing this information directly to the public we wanted to make sure
the whole world learned about it.
12 13
Even Rocks ‘Science as Art’ is an idea by August Kowalczyk.
Will Fall ‘Even Rocks Will Fall Apart Once’
Apart Once is a microscopic picture of a skin cancer (melanoma).

IV. Why You May Not Have
Heard About This
Breakthrough Before
Victory Over Cancer Part Two: Understanding History Building the Future Chapter IV − Why You May Not Have Heard About This Breakthrough Before
What You Will Learn in This Chapter

In this chapter, we will share with you the answers to the • In order to comprehend the unspeakable consequences of
important question why you may have not heard about all this the ‘business with disease’ it is necessary to analyse the his-
before. toric past of these investment interests.
You will learn about the ‘laws’ of the pharmaceutical invest- • The chemical/pharmaceutical investment industry was behind
ment ‘business with disease’. the two world wars of the 20th Century with the purpose of
expanding its global markets and control.
You will also learn that:
• This book is not primarily targeting specific drugs or drug • The directors of the largest pharmaceutical company at that
companies but the very nature of the investment ’business time, BAYER, were sentenced in the 1948 Nuremberg War
with disease’. Crimes Tribunal for slavery, genocide and other crimes
against humanity.
• The ongoing cancer epidemic is the result of a business
model that economically benefits from expanding diseases • These investment interests are still active today, trying to
– not from delivering health. expand their global markets in disregard of the health and
lives of millions of people.
• The largest obstacle for the elimination of cancer and other
common diseases and real progress in health is the invest- • We, today, have to make a choice: Do we tolerate the contin-
ment nature of the pharmaceutical industry. uation of diseases as investment markets – or do we unite to
eliminate both of them.
• The genocidal dimension of the ‘business with disease’ has
been a result of the people of the world not recognising its
operating principles for almost a century.
Our common goal: Handing over to future generations a world in which cancer is largely unknown!
18 19
The ‘Laws’ of the Pharmaceutical Industry
1 8
The pharmaceutical industry is an investment indus- For that reason the pharmaceutical industry is conduct-
try driven by profits for its shareholders. Curing dis- ing research and development of new drugs almost
eases is secondary to this objective. exclusively with new, synthetic – and patentable –
molecules.
2 The marketplace of the pharmaceutical industry is

the human body as long as it is sick.
9 Natural therapies, including vitamins and other
micronutrients are not patentable, do not yield high
3 Expanding diseases is essential for the growth of the profits and, therefore, are being disregarded by the
pharmaceutical industry. pharmaceutical investment business.
4 In order to expand disease markets, pharmaceutical

drugs are primarily targeting symptoms – while ignor-
ing the cellular root causes of diseases.
10 Science-based natural health approaches – effective but
non-patentable – threaten the economic foundation of
the pharmaceutical investment business with disease.
5 Prevention, root cause treatment and, above all, the

eradication of diseases threatens the very foundation of
the pharmaceutical investment business.
11 Science-based natural health approaches that can effec-
tively prevent and eliminate the root causes of diseases
on one side, and an investment industry based on the
continuation and expansion of diseases on the other, are
6 The eradication of diseases on one side, and the

expansion of the pharmaceutical investment ‘busi-
ness with disease’ on the other, are fundamentally
incompatible by their very nature and, therefore, cannot
coexist.
12
incompatible. Our generation today has the opportunity and responsi-
bility to undertake the eradication of today’s most com-
7 The enormous return on investment, i.e., the prof-

itability of the pharmaceutical industry, is based on
the royalties from patented synthetic drugs.
mon diseases as its most urgent global goal!
20 21
The Huge Royalties From Patented 5-(4-Benzylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,3-dihydro-indol- -2-one

N-(4,6-Dimethyl-3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-N-methyl-methanesulfonamide
‘Chemo’-Cancer Drugs Drive the Investment 5-(4-tert-Butylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,3-d- ihydro-indol-2-one

5-[4-((1R,5S,6S)-3-Methanesulfonyl-3-aza-bicyclo[3.1.0]hex-6-ylamino)-5-t- rifluoromethyl-pyrimidin-2-ylamino]-1,3-dihydro-indol-2-one
N-Methyl-N-{3-methyl-3-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-butyl}-methanesulfonamide
Business With the Cancer Epidemic N-(6-Methyl-3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
5-{4-[(2-Methanesulfonyl-pyridin-4-ylmethyl)-amino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one
2-[2-(2-Oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4- -ylamino]-ethanesulfonic acid amide
N-(3-{Methyl-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-- pyrimidin-4yl]-amino}-propyl)-methanesulfonamide
N-(2-{Methyl-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-- pyrimidin-4-yl]-amino}-ethyl)-methanesulfonamide
5-[4-(2-Methanesulfonylmethyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-- ylamino]-1,3-dihydro-indol-2-one
Patents are the key economic and legal tools of the entire pharma- 2-[2-(2-Oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4- -ylamino]-ethanesulfonic acid dimethylamide
N-Methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyrazin-2-yl)-methanesulfonamide
ceutical business model. They allow the drug companies owning Ethanesulfonic acid methyl-(2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-amide
these patents a monopoly on these drugs and control of global mar- Ethanesulfonic acid (2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin- -4-ylamino]-methyl}-phenyl)-amide
N-Ethyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl- -pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
kets. Moreover, by arbitrarily defining the size of the patent royalties, N-{1,1-Dimethyl-3-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-propyl}-methanesulfonamide
N-(5,6-Dimethyl-3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrazin-2-yl)-N-methyl-methanesulfonamide
the drug companies became the largest and most profitable corpora- 5-{4-[((R)-4-Methanesulfonyl-morpholin-3-ylmethyl)-amino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one
Propane-1-sulfonic acid (2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin- -4-ylamino]-methyl}-phenyl)-amide
tions in the world. 5-{4-[2-((R)-4-Methanesulfonyl-morpholin-3-yl)-ethylamino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one
Ethanesulfonic acid methyl-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-amide
Trifluoro-N-methyl-N-{3-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-propyl}-methanesulfonamide
On these pages we show just one example from the tens of thousands Cyclopropanesulfonic acid methyl-{3-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-propyl}-amide
of drug patents currently owned by pharmaceutical companies US N-Ethyl-N-(2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl- -pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide
Ethanesulfonic acid methyl-(5-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-amide
Pat. No. 7,109,337, granted to drug maker Pfizer on September 6, Ethanesulfonic acid ethyl-(2-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-amide
thanesulfonic acid ethyl-(5-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-amide
2006, for anti-cancer chemicals (www.uspto.gov). N-Ethyl-N-(5-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide
Ethanesulfonic acid (5-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-- pyrimidin-4-ylamino]-methyl}-phenyl)-amide
Ethanesulfonic acid (3-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-- pyrimidin-4-ylamino]-methyl}-phenyl)-amide
These two pages list more than one hundred chemical structures that Ethanesulfonic acid methyl-(3-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-amide
2-[2-(2-Oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4- -ylamino]-ethanesulfonic acid methylamide
Pfizer ‘owns’ as its property. Each chemical substance (line) may only Ethanesulfonic acid {3-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-- 4-ylamino]-propyl}-amide
C-Methanesulfonyl-N-{3-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-propyl}-methanesulfonamide
differ by one or a few atoms from the other substances listed. As long Ethanesulfonic acid {2-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-ethyl}-amide
as the chemotherapy ‘fallacy’ continues, each of these toxic drugs can C-Methanesulfonyl-N-{2-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-ethyl}-methanesulfonamide
N-Methyl-N-(4-methyl-3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
translate into multi-billion dollar profits for Pfizer – and further 5-(4-{[1-(2,2,2-Trifluoro-acetyl)-piperidin-3-ylmethyl]-amino}-5-trifluoromethyl-pyrimidin-2-ylamino)-1,3-dihydro-indol-2-one
2,2,2-Trifluoro-ethanesulfonic acid {3-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-- 4-ylamino]-propyl}-amide
increase already exploding health care costs. N-Methyl-N-(4-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyrimidin-2-yl)-methanesulfonamide
N-Cyclopropyl-N-(2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide
N-Methyl-N-(2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyrimidin-4-yl)-methanesulfonamide
N-Methyl-N-(6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyrazin-2-yl)-methanesulfonamide
A compound selected from the group consisting of: N-Methyl-N-(2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyridin-3-yl)-methanesulfonamide
N-Methyl-N-{3-[({methyl-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-yl]-amino})-methyl]-phenyl}-methanesulfonamide N-Methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyridin-4-yl)-methanesulfonamide
N-Methyl-N-{4-methyl-3-[({methyl-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino- )-5-trifluoromethyl-pyrimidin-4-yl]-amino})-methyl]-phenyl}-methanesulfonamide N-Cyclopropyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
N-(5-Methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide N-Methyl-N-(6-methyl-3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrazin-2-yl)-methanesulfonamide
N-(3-Methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide 5-{4-[(2-Methanesulfonylmethyl-pyridin-3-ylmethyl)-amino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one
N-(4-Methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide N-Methyl-N-(4-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyridin-3-yl)-methanesulfonamide
N-(2-Methyl-6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide N-Methyl-N-(3-methyl-6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
5-[4-(3-Methanesulfonyl-propylamino)-5-trifluoromethyl-pyrimidin-2-ylamin- o]-1,3-dihydro-indol-2-one N-Methyl-N-(5-methyl-3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
N-Methyl-N-(5-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide N-Methyl-N-(4-methyl-6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
N-(3-Methanesulfonylamino-5-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-- trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide N-Methyl-N-(2-methyl-5-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-3-yl)-methanesulfonamide
N-Methyl-N-(3-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide N-Methyl-N-(5-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrimidin-4-yl)-methanesulfonamide
5-{4-[((1S,2R)-2-Hydroxy-cyclohexylmethyl)-amino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one N-Methyl-N-(5-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-3-yl)-methanesulfonamide
5-[4-((1R,2S)-2-Hydroxy-indan-1-ylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-1,3-dihydro-indol-2-one N-Methyl-N-(4-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-3-yl)-methanesulfonamide
5-[4-((S)-1-Hydroxymethyl-2-phenyl-ethylamino)-5-trifluoromethyl-pyrimidi- n-2-ylamino]-1,3-dihydro-indol-2-one N-Methyl-N-(3-methyl-4-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
N-(3-(Methanesulfonyl-methyl-amino)-5-{[2-(2-oxo-2,3-dihydro-1H-indol-5-y-lamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-N-methyl-me-thanesulfonamide N-Methyl-N-(5-methyl-4-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrimidin-2-yl)-methanesulfonamide
5-{4-[(1-Hydroxy-cyclopentylmethyl)-amino]-5-trifluoromethyl-pyrimidin-2-- ylamino}-1,3-dihydro-indol-2-one N-Methyl-N-(6-methyl-5-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-3-yl)-methanesulfonamide
N-Methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide N-Methyl-N-(6-methyl-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrimidin-4-yl)-methanesulfonamide
N-(3-Fluoro-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-phenyl)-N-methyl-methanesulfonamide N-Methyl-N-(5-methyl-4-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
5-{4-[2-((S)-1-Methanesulfonyl-pyrrolidin-2-yl)-ethylamino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one N-Methyl-N-(2-methyl-3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-4-yl)-methanesulfonamide
5-{4-[(1-Hydroxy-cyclobutylmethyl)-amino]-5-trifluoromethyl-pyrimidin-2-y- lamino}-1,3-dihydro-indol-2-one N-Methyl-N-(6-methyl-4-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
5-{4-[2-((R)-1-Methanesulfonyl-pyrrolidin-2-yl)-ethylamino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one N-Methyl-N-(5-methyl-3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-4-yl)-methanesulfonamide
N-(2-Fluoro-6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-phenyl)-N-methyl-methanesulfonamide N-Methyl-N-(5-methyl-6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrimidin-4-yl)-methanesulfonamide
N-(4-Fluoro-2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-phenyl)-N-methyl-methanesulfonamide N-Methyl-N-(5-methyl-4-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-3-yl)-methanesulfonamide
N-Methyl-N-(4-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide N-Methyl-N-(6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyrimidin-4-yl)-methanesulfonamide
N-{2,2-Dimethyl-3-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-propyl}-N-methyl-methanesulfonamide N-Methyl-N-(6-methyl-4-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrimidin-2-yl)-methanesulfonamide
N-Methyl-N-(6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide N-Methyl-N-(2-methyl-4-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-3-yl)-methanesulfonamide
N-(2,4-Difluoro-6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-N-methyl-methanesulfonamide N-Methyl-N-(5-methyl-6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrazin-2-yl)-methanesulfonamide
5-[4-((R)-1-Methanesulfonyl-piperidin-3-ylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-1,3-dihydro-indol-2-one N-Methyl-N-(5-methyl-3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrazin-2-yl)-methanesulfonamide
N-Methyl-N-(6-methyl-3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide N-Methyl-N-(2-methyl-6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrimidin-5-yl)-methanesulfonamide
N-Methyl-N-(5-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethy- l-pyrimidin-4-ylamino]-methyl}-pyridin-3-yl)-methanesulfonamide N-Methyl-N-(3-methyl-6-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrazin-2-yl)-methanesulfonamide
5-[4-(1-Methanesulfonyl-piperidin-4-ylamino)-5-trifluoromethyl-pyrimidin-- 2-ylamino]-1,3-dihydro-indol-2-one N-Methyl-N-(6-methyl-5-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyrimidin-4-yl)-methanesulfonamide . . .-
5-{4-[Methyl-((R)-1-phenyl-ethyl)-amino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one
22 23
The Economic Burden of the

The ‘Pharmaceutical Business With Cancer’
‘Business With the Cancer Epidemic’
The pharmaceutical business with the cancer epidemic is one
of the driving forces of the global pharmaceutical investment Global Market of Chemotherapy and Oncology Drugs
business, with devastating economic consequences:
Billion
US$
In summary, the pharmaceutical business model with cancer
has the following elements: 50
1. Using ‘fear of cancer as a death verdict’.

40
2. Maintaining toxic chemotherapy and radiation as the basis
of cancer therapy administered to millions of patients.
3. Risking the development of an epidemic of ‘side effect dis- 30
eases’ in patients receiving these toxic treatments.
4. Taking economic advantage of these ‘side effect epidemics’
2006 2008 2010
by offering a myriad of other drugs to alleviate symptoms
caused by chemotherapy and radiation. Since many of these
additional drugs can trigger new cancers and other dis-
eases, a ‘self-perpetuating’ business model is being created.
5. Compelling cancer patients, corporations and governments 12 x Around the Globe
worldwide to pay for this ‘self-perpetuating’ business.
6. In the long run, creating economic and political dependen-
cies of entire nations by this strangulating ‘business with
disease.’
Not surprisingly, the pharmaceutical business became the

largest and most profitable investment industry on our planet.
Moreover, pharmaceutical drug sales are led by the group of
cancer (oncological) drugs with a staggering $56 billion in 2010
alone. Piled up in quarters, this huge amount would circle
around the globe more than twelve times.
The skyrocketing market of chemotherapy and related cancer drugs. In
2010, this market surpassed $56 billion US dollars. This sum would
amount to a pile of quarters reaching more than twelve times around
the globe.
24 25
Creating Future Cancer Markets

The Estrogen Drug Cancer Spiral
The drug markets for ‘side-effect diseases’ are not the only
way the ‘business with cancer’ can be expanded. Another way
to increase the cancer business is based on the use of drugs,
which themselves can promote the development of cancers.
Here we only document one example of such a ‘marketing
synergy’.
Estrogen drugs, for example, are being offered to millions of

young women in the form of hormonal contraceptives and to Cancer Market
mature women as ‘hormone replacement therapy’ to prevent Estrogen Drugs
osteoporosis and menopause-related symptoms.
The fact that estrogen promotes the development of cancer

has been known since 1941. Even the mechanism of this
action has been elucidated. Among others, estrogen increas-
es the production of collagen-digesting enzymes that facili-
tate growth and spread of cancer cells (see chapter II).
Despite the indisputable scientific evidence linking estrogen

to cancer, the pharmaceutical companies continue promoting
estrogen drugs. Inevitably, they have to factor in the risk of a
dramatically increased rate of cancer in women taking these
drugs over an extended period of time. The long-term use of
}
estrogen drugs increases particularly the rate of hormone Target Markets Hormonal Drugs
dependent forms of cancer including breast cancer, uterine
cancer, cervical and ovarian cancers. In short, the estrogen Continously
Young Women Anti-Contraceptives Elevated
drug market fuels the cancer drug market.
Estrogen
Levels
After the results of an alarming study connecting the increased Promote
Mature Women Hormone Replacement
rate of breast cancer in menopausal women to the intake of Cancer
Therapy
estrogen drugs was published in 2002*, the use of these drugs
dropped sharply. Not surprisingly, in the following years the
rate of breast cancer also decreased significantly.
The promotion of estrogen drugs increases the risk
for breast, uterine, cervical and ovarian cancers.
Thus, the estrogen drug market fuels cancer drug markets.
*http://www.ncbi.nlm.nih.gov/sites/entrez/12117397?dopt=Abstract&holding=f1000,f1000m,isrctn
26 27
You may say: To answer this question,

This is impossible! we will need to look at
the darkest chapters
Even the greediest companies of recent history ...
will not risk the lives of millions
of people for profits ...
28 29
Putting Profit Over Life (I)

Do You Know This Man?
Any business or industry dealing with the health and lives of
people has to adhere to particular ethical standards. Above all,
it is the trust of millions of patients and people that demands
this special code. Unfortunately, the pharmaceutical ‘business
with disease’ model is incompatible with these principles.
In order to understand the unspeakable business practices

feeding on the cancer epidemic, we have to go back to the ori-
gins of this industry. About 150 years ago, scientists started to
elucidate the chemical nature of the elements composing our
world, i.e., their atomic structure. Soon after, large compa-
nies emerged based on selling products that had been synthe-
sised as a result of this new understanding.
Moreover, the patenting of these substances gave these com-

panies a monopoly on these artificially created substances,
elevating the corporate leaders to the status of ‘new gods’, as
they referred to themselves.
Leading this process were three German companies: BAYER,

BASF and HOECHST. Not surprisingly, these ‘modern gods’ Fritz Ter Meer (1884-1967) was the Director of BAYER – at that
developed the desire to conquer and own the entire world. time the world’s largest pharmaceutical company – and mem-
ber of the Board of Directors of the IG Farben Cartel. He was a
member of the Nazi Party and an official in Hitler’s War Min-
Towards this end they ‘commissioned’ German Emperor Wil-
istry, coordinating the production of explosives and other war
helm II to launch World War I. After this attempt had failed, supplies for the Nazi Wehrmacht almost 100% of which came
these companies formed the infamous IG Farben Cartel, from IG Farben.
called themselves the ‘Council of Gods’, and soon became the
single largest financier of the Nazis' rise to power. On July 30, 1948, Ter Meer was sentenced in the Nuremberg
War Crimes Tribunal to seven years in prison for slavery, mur-
As we all know, this attempt at world conquest also failed – at der and other crimes against humanity.
the cost of more than 60 million lives. Twenty-four directors of
the IG Farben Cartel were tried in Trial VI of the Nuremberg
Imagine, the director of the world’s largest pharmaceutical
War Crimes Tribunal in 1947/48. Several IG Farben directors company – the leader of an industry claiming to be at the ser-
were sentenced for slavery, spoliation, torture, murder and vice of mankind – was sentenced for crimes against humanity!
other crimes against humanity.
More information: www.profit-over-life.org
30 31
Putting Profit Over Life (II)

Have You Heard About This Place?
World Wars I and II, the two military attempts at world con-
quest by BAYER, BASF and other German chemical/pharma-
ceutical companies, cost the lives of nearly 100 million people.
A
In the course of these two global conquest wars, entire cities
and even countries were annihilated. Among all the crimes
committed, one location stood out for its brutality and disre-
spect for human life: Auschwitz.
Your history books may have told you that the concentration B
camp Auschwitz was an outburst of racially motivated mass
murder. It was more than that. The transition from a Nazi con-
centration camp into an industrial-size slave labor and exter-
mination camp was directly connected to economic interests:
only 4 miles from the site of the concentration camp
Auschwitz, the chemical/pharmaceutical cartel IG Farben con- C
structed the largest industrial plant of war-time Europe. The
chemicals produced there, namely artificial rubber and gaso-
line, were to supply the Nazi/IG Farben coalition in its con-
quest of Eastern Europe and Asia.
Tens of thousands of innocent Auschwitz concentration camp

inmates died under horrible circumstances during their slave
labour for the chemical/pharmaceutical Cartel.
A. With six thousand acres, the IG Auschwitz plant was the largest industrial
Some of the slave laborers of this historic ‘crime scene’ are complex in wartime Europe. It was a 100% subsidiary of the IG Farben
Cartel (BAYER, BASF, etc.).
still alive. They serve mankind as witnesses of history and
B. The gate of the Auschwitz concentration camp from which tens of thou-
guardians of memory. One of them is August Kowalczyk,
sands of slave labourers were drawn for construction of the IG Auschwitz
Auschwitz prisoner number 6804. Until his escape from the plant.
camp, he was forced into daily slave labour at the construc- C. August Kowalczyk, Auschwitz prisoner No. 6804, in front of the infa-
tion site of the IG Auschwitz plant. mous ‘Block 10’ where medical experiments were conducted.
August Kowalczyk’s contribution to this book conveys a clear The directors of the world’s largest chemical/pharmaceutical
message: Once before, global chemical/pharmaceutical inter- company, IG Farben, were found responsible for slavery, tor-
ests have put their profits over the lives of millions. ture and murder committed in connection with the industrial-
size expansion of Auschwitz concentration camp.
If we ignore these lessons of history, they could do it again.
32 33
Putting Profit Over Life (III)

The BAYER-Auschwitz Connection
In a similar way, our history books have been trying to tell us
that the deadly medical experiments in the concentration
camps were conducted by psychologically deviated SS doc-
tors – essentially as a pastime activity of their perversion. A Test Drug
Inscription:
The records of the Nuremberg War Crime Tribunals reveal a BAYER

different picture: IG Farben Inc.
• The majority of unethical experiments conducted with con-
centration camp inmates were not individual ‘experiments’,
but large scale experimental studies on humans.
• The physicians conducting these deadly experiments were B
not only members of the SS, but commissioned ‘pharma-
ceutical drug testers’, in some cases even doctors directly
employed and paid by the BAYER company.
• The tested substances were not prepared by SS doctors, but
were highly sophisticated chemical substances from the
laboratory of the world’s largest and most advanced phar-
maceutical companies at that time, BAYER and HOECHST
BAYER employee and The concentration camp doctors typically
(today part of Sanofi).
SS-doctor in the KZ: wore two uniforms, black (SS) and white:
• The drugs were shipped from these companies directly to Dr. Vetter Dr. Josef Mengele, a.k.a. ‘Dr. Death’
the concentration camps and the results of these often dead-
A. Records from the Jerzy met Mengele
ly drug studies were reported directly back to the headquar- Nuremberg War during his imprison-
ters in Leverkusen (BAYER) and Frankfurt (HOECHST). Crimes Tribunal show- ment in the Auschwitz
ing a newly patented concentration camp.
• The drugs tested were not established medications, but new-
BAYER drug tested in
ly invented and patented chemicals, hence the code names Auschwitz.
like ’Preparation Be 1034’ (see facing page). Today he supports the
B. Doctors commis-
sioned to test the phar- work of the authors of
How much effort must these special interests have taken to maceutical drugs on this book as a ‘witness
of history’.
keep these facts ‘buried’ for over half a century. All these facts concentration camp Jerzy Ulatowski,
are now available online at www.profit-over-life.org. Moreover, inmates with often Auschwitz Prisoner
deadly outcomes. No. 192,823
‘witnesses of history’ are still alive today, like Jerzy Ulatowski,
who had a personal encounter with Dr. Mengele as a prisoner
The pharmaceutical companies BAYER and HOECHST
of the Auschwitz concentration camp. (IG Farben) used thousands of concentration camp inmates
as ‘human guinea pigs‘ to test their patented drugs.
34 35
The History of Chemotherapy

First Half of 20th Century Second Half of 20th Century
BAYER, BASF, HOECHST Multinational Drug Companies

(Controlled by Rockefeller and
(German IG Farben Cartel)
Rothschild Investment Groups)
Chemical warfare with mustard gas during WWI Mustard gas burns
S N
R
Mustard Gas Mustard Gas Derivatives Became the First

and Largest Group of Chemotherapy Drugs
After documenting the unethical history of the pharmaceuti- After WW II, tens of thousands of BAYER/IG Farben chemical
cal ‘business with disease’, we also owe our readers a short substance patents came under the control of allied invest-
overview on the history of ‘chemotherapy’ in cancer. ment groups active in the international pharmaceutical busi-
ness, namely Rockefeller (US) and Rothschild (UK/France).
During World War I, BAYER produced the first large scale
chemical warfare agent, mustard gas. It was also called ‘LOST’ By replacing one sulfur (S) atom of the mustard gas molecule
after W. Lommel and W. Steinkopf, the two scientists who with a nitrogen (N) atom, the first basic structure for ‘cancer
developed this deadly chemical substance. On July 12, 1917 chemotherapy’ was created. A myriad of chemical modifica-
the German Army used this new weapon for the first time tions (R) of this ‘N-mustard’ structure – each of them protect-
near the Belgium city of Ypres – with such a deadly effect that ed by patents – propelled the multi-trillion dollar industry that
mustard gas, to this day, is also named Yperite. began to thrive on the cancer epidemic.
36 37
The Chemical/Pharmaceutical Cartel –

From Europe to the World
Expanding Its Global Control
With so much money to be made from the business with can-
cer and other diseases it was no surprise that the war criminals
from BAYER, BASF, HOECHST and other IG Farben companies
were soon released from prison. Obviously, their ‘know how’
and their commitment to ‘profit over life’ were needed for the
– now internationalised – pharmaceutical investment business
to achieve global control.
If we want to understand the global dimension of the pharma-

Fritz Ter Meer Carl Wurster Friedrich Jähne
ceutical ‘business with disease’ today, we need to recognise
Member Nazi Party, Member Nazi govern- Member Nazi Party,
that soon after 1945 the economic masterminds of WWII were War Criminal, ment, Cyclon B ‘super- War Criminal,
reinstated into their previous positions: becomes Chairman visor’, becomes becomes Chairman
of BAYER in 1956. CEO of BASF in 1952. of HOECHST in
• Fritz Ter Meer, War criminal, responsible for IG Auschwitz, 1955.
sentenced in Nuremberg to 7 years imprisonment was

released from jail in 1951. In 1956, Ter Meer became Chair- The Brussels EU – Politburo of the Chemical/Pharmaceutical
man of the BAYER company. Cartel for its 21st Century Global Conquest
Walter Hallstein, a Nazi-era professor of international and
• Carl Wurster, Supervisory board member of ‘Degesch’, the corporate law was the key architect of the legal and adminis-
IG Farben subsidiary that was thriving under Wurster’s trative plans for Europe and the world under Nazi/IG Farben
control. He was an official member of the German dele-
‘supervision’ from delivering ‘Cyclone B’ to the gas cham- gation that met in Rome in 1938 to divide Europe between
bers of Auschwitz. In 1952 Wurster became CEO of the Fascist Italy and Nazi Germany.
BASF company.
After lying to Allied officials about his Nazi past, Hallstein was
• Friedrich Jaehne, IG Farben Director, sentenced in Nurem- appointed to the role of architect of the ‘Brussels EU’ and
became its founding president in 1957. For 10 years, with the Walter Hallstein
berg as a War Criminal. In 1955, Jaehne became Chairman
help of an administrative body of several thousand bureaucrats,
of the Board of the HOECHST company, today Sanofi. he realised the Nazi/IG Farben plan of a ‘Central Cartel Office’ – the ‘Brussels EU Commis-
sion’ – operating beyond any democratic control.
Thus by 1956, the BAYER, BASF and HOECHST companies
One of the key targets of the ‘Brussels EU’ has been to protect the multi-billion dollar
were directed again by the architects of a dictatorial Nazi/IG drug markets - by outlawing the competition from natural health.
Farben world. No surprise, therefore, that in the same year www.nazi-roots-of-brussels-eu.org
the Cartel launched a new international ‘politburo’ by form-
ing the Brussels-based ‘EU Commission’. Its key architect was
Walter Hallstein (see facing page). Today’s international chemical/pharmaceutical Cartel
pursues the same global goals of economic and political control
as the Nazi/IG Farben coalition – only with other means.
38 39
The Role of Medical Schools

For Example: The University of Muenster
For decades after the end of World War II, the entire West Ger-
man society was penetrated with figureheads dedicated to pro-
moting the interests of the Chemical Cartel – and particularly its
pharmaceutical investment ‘business with disease.’
With IG Farben stakeholders again in all key positions, the State

of West Germany, founded in 1949, became the first State in
modern history conceived, constructed and controlled by
chemical/pharmaceutical interests. Protecting the interests of
this investment industry became part of the political foundation
of the Federal Republic of Germany.
O. v. Verschuer H. Juergens
Dean of the Dean of the
Medical schools and universities were also part of this strategy. Muenster Medical School Muenster Medical School
Take, for example, the Medical School of the University of 1953-54 2002 - 2006
Muenster. A mere 8 years after 1945, Otmar von Verschuer, the Obviously, neither Dr. Juergens nor the University of Muenster have any-
mentor and collaborator of Josef Mengele, was appointed Dean thing to do with Nazi ideology.
of this Medical School.
However, by trying to block the medical breakthrough in natural health
documented in this book, they serve the same economic interests that
In 2002, half a century later, the University appointed Heribert were the economic driving force behind WW II.
Juergens, a pediatric oncologist and protagonist of chemothera-
py, as their new Dean. In his capacity as Dean of the Medical
School of Muenster University, Juergens tried to stop this break-
through in the natural control of cancer by filing several lawsuits
against it.
One of these – now historic – lawsuits filed in 2003 accused us of

conducting subversive activities against the State of Germany.
The key argument of the Muenster University: Since the phar-
maceutical investment business is vital for the German State,
any attack on this business represents an attack on the State. The main building of the University of Muenster, Germany.
Founded in 1780, this university – with a long standing tradition –
In this context, it is noteworthy that a German Appellate Court may now be remembered for its futile efforts
in 2004 allowed the chemotherapy proponents at the Muenster to block mankind’s ‘victory over cancer’.
Medical School to be described as “pharma-puppets”. Medical schools and other academic institutions are being
targeted by pharmaceutical companies in order to
attach credibility to their ‘business with disease’.
40 41
In the Name of Mankind

The Decade-Long Battle For the Truth
The lawsuits against our medical breakthrough, brought by
this University in an attempt to block the scientific advance,
were not the only legal challenges we faced.
Over the past decade the pharmaceutical interest groups and

lobby organisations filed more than one hundred lawsuits
against us. Between the years 2000 and 2005 there were some
months when we had to fight ten different legal battles at the
same time.
This massive attack by the pharmaceutical interests against one

research group and against one medical breakthrough is the
Above: A fraction of the records of the
best indication of the importance of our cancer research find-
more than one hundred lawsuits brought
ings and of the threat these discoveries pose to the status quo. against this breakthrough in cancer.
Never before has a medical advance towards the control of can- Right: Dr. Rath leaving the Court House
cer been so heavily fought. Obviously our opponents realise of Hamburg, Germany, after one of the
legal battles.
that this is the decisive breakthrough towards a ‘victory over
cancer’. The fact that this book is now in your hands is proof
that all these legal assaults could not stop the scientific truth.
MAYO
Our decade-long battle for the right of mankind to rid itself CLINIC
from the scourge of cancer inspired many others. Over the
past decade, the number of scientific publications reporting
health benefits of micronutrients in fighting cancer multiplied
and science publishers dedicated entire journals to this new
health field. Natural health approaches are
now becoming mainstream.
Once again philosopher Arthur Schopenhauer was proven
right: All truth passes through three stages. First, it is Left: 2010 Press Release from the
Mayo Clinic about the benefits of
ridiculed. Second, it is violently opposed. Third, it is accepted
Green Tea extract in leukemia
as being self-evident. patients.
No army can withstand the strength of an idea

whose time has come.
Victor Hugo
42 43
The facts presented in this book and other

historic documents exposing the business
practices and the unethical past of the phar-
maceutical ‘business with disease’ pose a
major threat to this multitrillion dollar invest-
ment industry.
In particular, we exposed that this invest-
ment business was hiding facts of utmost
importance, namely that:
• They were the driving economic force
behind World War I
• They were the driving economic force
behind World War II
• They use the cancer epidemic as a critical
tool to expand their global economic pow-
er and control.
It would be naive to assume that these inter-
est groups will let the dissemination of these
facts remain unopposed. Their main strategy
of counter attack is – not surprisingly – the
discrediting of the ‘messengers’.
On the following pages we will present just a

few prominent examples of this counter
strategy. We decided to address this aspect
here in order to allow you to make your own
judgment.
44 45
Special Interests Use Social Media

For Example: Wikipedia and Facebook
The counter strategy of the status quo to block this medical break-
through by discrediting the authors of this book and their research
team is not limited to the printed media these interests control. Special Investment Interests
Increasingly, they take advantage of the developing social net-
works on the Internet. A case in point is Wikipedia.
You may have considered Wikipedia as an independent source of

information on the internet and may have thought that since
everyone is invited to contribute to this site it is a tool of democra-
cy in the information age. Nothing can be further from the truth.
Under the cloak of ‘democracy’, ‘free speech’ and ‘open society’,
Wikipedia is being used as a vehicle to influence and control pub- George Soros D. Rockefeller Peter Thiel
lic opinion worldwide.
One of the ‘founding fathers’ and a prominent financier of the Wikipedia Facebook
Wikipedia Foundation is George Soros, chairman of Soros Fund
In its attempt to cement its global control, corporate special interest
Management, LLC, one of the world’s leading investors in the oil
groups are using social media to distort any information that threatens
and drug business. To conceal their interests, the Oil and Drug their global markets. Peter Thiel, the controlling investor behind the
Cartels use individuals under their control and portray them as ‘social’ network Facebook stands for rather ‘unsocial’ values: “I think
‘founders’ of Wikipedia. healthcare is too important to be a public good, in a sense. So I think
that it’s too important to be left to the very incompetent government
programs.” Not surprisingly, he is closely associated with D. Rockefeller,
Consequently, any information you attempt to publish on
the man behind the world’s leading oil and drug investment group.
Wikipedia that threatens the interests of the oil and drug Cartel is
being carefully monitored and swiftly removed by the ‘gatekeep-
ers’ of these special interests within Wikipedia. The targeted topics
of these ‘gatekeepers’ are not only science-based natural health We encourage you to test it for yourself! Try to write a contribution
to Wikipedia about the health benefits of micronutrients, other
but also the benefits of alternative energy. The Wikipedia ‘gate-
natural health therapies or about the advantages of renewable
keepers’ systematically discredit the value of these new indepen- energies, try to write about the dangers of chemotherapy for can-
dent technologies and openly defame their pioneers. cer patients and the pollution of our planet by the Oil Cartel. You
will see: a ‘magic hand’ will instantly erase your text on Wikipedia.
You can find more information at: www.wiki-rath.org.
Wikipedia is not an independent, democratic ‘encyclopedia’ – but

an important media tool of the status quo to cement its continued rule
behind the veil of a ‘democratic’ online tool.
More information: www.wiki-rath.org
46 47
Summary of This Chapter

We are aware that the information in this chapter is new to many of
our readers – and rather challenging. We therefore consider it help-
ful to summarise the messages of this chapter that, in our opinion,
are particularly important. We would like our readers to under-
stand that:
1. The business model of the largest and most profitable industry on

our planet, the pharmaceutical investment business, is profiting
from the continuation and expansion of diseases.
2. The goal of this investment business is to control the world mar-

kets of chemical/pharmaceutical products – and thereby estab-
lish a global monopoly on health care. “We have to understand that
health will not be given to us
3. Towards this goal they have established a historic track record voluntarily.
of putting ‘profit over life’, e.g., as the economic driving forces
behind World War I and World War II. We have to fight for it!”
4. After the failure of their military attempts at world conquest,
Dr. Rath
these interests today embark on economic and political means
to pursue this goal.
5. The ‘chemotherapy’ business with the cancer epidemic serves

this global goal by creating the dependency of entire societies –
both economically and psychologically.
6. You need to be particularly critical when accessing public infor-

mation in the area of natural health and alternative energy,
because these are the life lines of the Oil and Drug Cartels and
the status quo.
48 49
Where Do ‘Science as Art’ is an idea by August Kowalczyk.
the Oceanic ‘Where Do the Oceanic Shoals Go?’
Shoals Go? is a microscopic picture of gingival fibroblasts.

V. What You Can Do To Make
the Victory Over Cancer
Irreversible –
And To Create A
Healthier World For You
And Your Children
Victory Over Cancer Part Two: Understanding History Building the Future Chapter V − What You Can Do To Make the Victory Over Cancer Irreversible
Imagine: A World Without Cancer

This book has been written for cancer patients, health professionals,
political decision makers – and for the general public.
Above all, it is written for the young people of the world, who now
have the historic opportunity to become the first generation who
could live their lives without the fear of cancer.
Whether this breathtaking perspective becomes a reality depends

on one factor only: Will you stay indifferent or will you help to
spread this life-saving information among your friends, colleagues
and in your community.
We encourage you to read this book not just once, because the
information on every page is very compact. In some cases we had
to condense several research experiments in one graph or sum-
marise half a century of history on one page. We encourage you to
explore the facts of this book, its analysis and its logic. Be critical
and also conduct your own research about what you read here.
As we discussed in the previous chapter, when browsing the inter-

net you will come across negative information about this research,
about the authors of this book, etc. When you read such informa-
tion, ask yourself who wrote it and who benefits from spreading
such deceptive information.
The greater the economic privileges the status quo has to defend,
the fiercer the attacks on those threatening its privileges. The phar-
maceutical investment business has amassed a fortune of tens of tril-
lions (!) of dollars. It is by far the largest economic power in history.
So, there is no reason to be surprised at anything you read.
56 57
Business With Diseases – Our Nonprofit Organisation –

Or Nonprofit Health Care A Model For Future Healh Care
For almost two decades, our research organisation has been leading
the scientific transformation of medicine driven by patented synthet-
ic and often toxic drugs towards effective, natural and safe health
Research
approaches.
But we have also taken on a leadership role in the ethical transfor-

mation from the ‘Age of the investment business with disease’
towards the ‘Age of effective prevention and eradication of diseases’. 100% of Profits
For More Research
Better Natural Health
Solutions
This goal to facilitate an ethical transformation of medicine And Education Health
required us to lead by example. Cognizant of this fact, we created
an international research organisation that is 100% owned by a
nonprofit foundation.
As illustrated on the facing page, all profits resulting from research

Revenues
are being reinvested to further natural health research and educa-
tion. Since no money is being diverted to shareholders or for per-
sonal gain in general, our business model is propelling a spiral of
continuously better health.
Moreover, the definite absence of any private profit motive This circle describes not just the model of how our organisation
becomes a guiding principle for the research directions. As works today. It is also a model for a future health care system
opposed to the pharmaceutical ‘business with disease’ where new that is no longer controlled by special investment interests.
drug development is determined by the highest profits, our non-
profit organisation conducts its research according to the biggest In a desperate attempt to delay this inevitable transition of
health needs of millions of people and society at large. health care, the lobbyists of the status quo use some old
deception tactics: Blaming us, the pioneers of progress, of
For the status quo this ethical transformation is a particular chal- profiteering from the ‘business with disease’.
lenge – for they are unable to follow it without betraying the
investment nature of its business. Exposing these obvious tactics helps the people of the world
to draw their own conclusions. Just ask the question: ‘Who
benefits?’.
58 59
Now We All Have A Choice:
Choice Continued Choice

A Health B
For Patients
‘Cancer’ Diagnosis Cancer Becomes a
Equals Death Verdict Manageable Disease
Like Any Other
Ultimately
Death
Highly Toxic Patient Is

‘Chemo’ Drugs Confronted With Use of Effective, Justified Hope
Damage Patient’s Body Fear of Death Bio-Compatible Through
Natural Health Patient Education
Patient Succumbs to Patient makes

Toxic ‘Chemotherapy’ Informed Choice
As the Only Choice of Treatment
Once you, the reader, have vaccinated yourself against the pre- First and foremost, this New Age will be characterised by turning
dictable demagoguery of the status quo described in this book, cancer from a ‘death verdict’ into a manageable disease. Mankind
there is no more holding back from inaugurating the New Age of now has the opportunity to turn Fear into Hope.
Modern Health.
60 61
The Goals of this Book: Demystifying Med-

icine And Democratising Health Role of Pharmaceutical Investment
This Book ‘Business With Disease’
On a wider scope, this book is an important contribution towards
the urgently needed transition of medicine:
1. The origin of cancer and many other diseases has been kept a
mystery until now. The public ‘health illiteracy’ of the nature of STOP
cancer and other diseases has been a precondition for the phar-
maceutical business with ineffective and dangerous drugs like
chemotherapy. Health Illiteracy is a Strategic
Precondition for the Continuation of the
Through public education, this book demystifies the nature of Multi-billion Dollar Market
cancer and thereby opens up the way for a universally effective With Toxic Chemotherapy Drugs
biological management of this disease. Obviously, this is just a
beginning and our understanding of the nature of many other
diseases will follow soon.
2. Until now the delivery of patented medicines has been tightly STOP
controlled and a privilege of the prescribing medical profes-
sion. Now, many health professionals realise that – they too –
have been deceived and their professional ethical principles
degraded by investment interests to become a mere ‘sales force‘ Millions of People Patients and Govern -
for the questionable merchandise of the pharmaceutical ‘busi- Die from Prevent - ments Pay Billions
ness with disease’. able Diseases for Dangerous Drugs
By providing understandable health care solutions for every-
one, this book goes one step further. It democratises health by
allowing people to take advantage of effective, safe and afford-
able health solutions in the form of micronutrients and other STOP
science-based natural approaches.
The demystification of today’s medicine and the democratisation

of health are preconditions for a modern, prevention-orientated Feeding on Fear and Misery of Millions
health care worldwide.
Economic Drainage of Entire Nations
62 63
Liberation of Human Health Imagine ...

Mankind has celebrated many steps of progress, the development 16th Century:
of the steam engine, electricity, telephones and recently the Inter- ‘Liberation of the human mind’
net are just some of them. But there are only two advances in the ended the Dark Ages and
course of history that literally affect every human life today and advanced mankind
the lives of all future generations. to Modern Times.
By the light of candles in their

The first of these universal advances was the liberation of the huts, millions of peasants seized
human mind. After the invention of the printing press in 16th Cen- the opportunity to learn to read
tury Europe, thousands of books were translated into the spoken from printed books.
languages and became available to millions of ordinary people.
Schools sprang up in every village and universities were founded
in every country. In short, 16th Century Europe became the cra- Imagine ...
dle of liberation of the human mind. In the following centuries,
all areas of society, science, trade, craftsmanship, art, and even ... it took James Lind four decades until
political life prospered, replacing a millennium of Dark Ages his discovery was accepted that citrus
under autocratic rulers with Modern Times and democracy. juice can cure scurvy –
... how many people died during these
The second of these universal advances is the liberation of the ‘years of transition’ –
human body and human health from centuries of illiteracy ... if you lived at that time, wouldn’t you
and false dependencies. This step still lies ahead of us. With have helped him?
the publication of this book and with its contents becoming James Lind (1716 - 1794)
widely known, the doors to the global liberation of human
... it took Louis Pasteur 25 years until his
health are widely open. discovery was accepted that microor-
ganisms are the cause of infectious
The goal of this global liberation is the prevention of today’s most diseases –
common diseases and ultimately their eradication for all future ... how many people died during these
generations, with the financial resources freed by ending the eco- ‘years of transition’ –
nomically strangulating ‘business with diseases’. Hundreds of tril- ... if you lived at that time, wouldn’t you
lions of dollars will be freed to address the most urgent needs of Louis Pasteur (1822 - 1895) have helped him?
mankind including hunger, unemployment and environmental
challenges. This is the next great task uniting all of mankind. Imagine ...
How much the liberation of human health
can benefit and advance mankind today,
in the 21st Century and beyond!
64 65
Public Education as the Basis Fighting Health Illiteracy

of Modern Health Care Through World Health Alphabetization
Modern health care will no longer be exclusive, delegated to just
a few professional groups – it will be inclusive, integrative and
participatory in nature. Not only patients, but the community as a
whole – from school children to seniors – will actively participate
in providing health education and basic health care in the form of
lifestyle consultations and nutritional recommendations.
We are confident that the contents of this book will spread quickly
among the cancer patient community around the world. We also
know that the attacks on this book by pharmaceutical lobbyists in
medicine and media will further accelerate the dissemination of
this book. But all that is not enough.
We have created an opportunity for every reader who wants to

actively contribute to finally achieve ‘victory over cancer’ and to
change health care towards prevention and eradication of diseases.
The World Health Alphabetization is an open access online health

education course for everyone. You can log on to At www.wha-www.org you can learn more about your health
and get a free certificate as a ‘Community Health Educator’.
www.wha-www.org and:
• Study the advances of natural health not only in the area of can-
cer, but also in cardiovascular diseases and other health problems; Websites you should also visit:
• Take a test and acquire a certificate as a ‘Community Health
Educator;
• www.drrathresearch.org – Our Research Institute
• With a mouse click you can recommend this free health educa-
• www.dr-rath-health-foundation.org – Our Foundation
tion course to your friends, colleagues and to anyone you know.
• www.hpcm.org –
Contact for interested health professionals
• www.profit-over-life.org –
History of ‘business with disease’
66 67
What you can do – if you are ... Movement of Life

We have reached the end of this book. Some of our readers may
put it aside and allow themselves some time to reflect on its far-
reaching implications. The dimension by which the information in this book affects
human lives dwarfs many other social movements and causes
Other readers may be looking to take immediate action in order to currently being promoted online and offline in the form of so-
terminate the ‘business with the cancer epidemic’ as quickly as called social networks.
possible. Following are some actions you can take if you are:
Considering this dimension – and taking into account the facts
• A cancer patient: share the information of this book, and your outlined in the previous chapter that the status quo is hiding
positive health experiences with natural therapies with other behind social online networks to thwart human progress –
cancer patients. there exists an objective need for a global social movement
• A medical doctor: familiarise yourself with the rapidly growing dedicated to the goals presented in this book.
scientific evidence of natural health approaches in cancer,
introduce micronutrients in your medical practice, in particular These goals are self-evident: protecting our basic right to
in your care for cancer patients. health, to life, to healthy and unmodified food and other fun-
damental human health rights. There is no need for us to pre-
• A natural health professional: join national or international
sent in detail how to defend those human rights. You are best
professional organisations dedicated to the promotion of sci-
to judge what to do in your community and your country.
ence-based natural health, such as Health Professionals for Cel-
lular Medicine.
We, the authors of this book, support this ‘Movement of Life’.
• A health food store owner: recommend this book to your cus- We consider our role to provide a framework and an online
tomers, invite health professionals from your community to give platform to connect the multitude of activities that will start
lectures in your store about the documented health benefits of everywhere. Precisely that is the nature of our call for a
natural health. “Movement of Life” (see chapter ‘Appendix’).
• A teacher: introduce nutritional health information and educa-
tion in your classes at school, college or other educational insti-
tution, organise extracurricular activities to promote preventive
and nutritional health in your community.
• A political decision maker: Take action now and make sure that
every person in your city, district or country learns about the
breakthrough in cancer and its dramatic consequences for sav-
ing lives and health care costs.
www.movement-of-life.org
68 69
Knowledge: the way to one’s own health
The Proof
Successes with cellular nutrients

confirm vitamin research findings
Dr. Rath Health Foundation

Knowledge: the way to one’s own health
The Proof –
Successes with cellular nutrients confirm vitamin research findings
The Proof Successes with
1st edition
cellular nutrients
© 2012 Dr. Matthias Rath
confirm
vitamin research
Distribution:
findings
Postbus 656
NL-6400 AR Heerlen
Tel.: 0031-457-111 222

Fax: 0031-457-111 229
email info@rath-eduserv.com
website: www.rath-eduserv.com
All rights reserved. Published by the Dr. Rath Health Foundation. Single pages of this book
can be copied for private and non-commercial purposes. Any direct or indirect commercial
use of this book or parts thereof in any form is strictly prohibited without written permission
from the authors.
For legal reasons we are obliged to issue the following statement:

This book does not aim to replace medical consultation with a doctor.
In relation to health concerns the reader should consult a doctor or therapist,
especially where symptoms of illness require medical diagnosis or treatment.
The authors, the publisher and the publishing company cannot accept liabili-
ty should side effects arise in direct or indirect consequence of the recom-
mendations in this book.
CONTENT
Foreword by Dr. Rath .................. 10
What is cancer? . . . . . . . . . . . . . . . . . . . . . . . . 15
Common types of cancer . . . . . . . . . . . . . . . 19
Breast cancer
Ovarian cancer
Uterine cancer
Testicular cancer
Prostate cancer
Leukaemia
Other types of cancer .................. 65

Cancer of the appendix
Colon cancer
Bladder cancer
Sinus cancer
Thyroid cancer
Kidney cancer
Lung cancer
Cancer of the parotid gland
Non-Hodgkin lymphoma
Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103
The Proof Successes with cellular nutrients confirm vitamin research findings
Foreword
Cancer is no longer a death sentence! sure put on them by doctors to subject themselves at all costs to
chemo- and radiotherapy, then their battles with themselves about
The scientific foundations for ending the right course of action through to finding the courage to say
the cancer epidemic have been “No” to systematic poisoning of their body – and finally the realisa-
described in detail in the book “Vic- tion that they had made the right choice!
tory over Cancer”, which has already
been translated into numerous lan- Naturally this book does not hold out the promise to readers that
Dr. Matthias Rath
guages. micronutrients – or cellular nutrients as we call them – can heal all
types of cancer. In particular this will not be possible if the cancer is
The present book, “The Proof”, now documents accounts by already far advanced or if numerous cycles of chemotherapy have
patients who have put their faith in these scientifically founded nat- severely damaged or even destroyed a patient’s own immune sys-
ural medical approaches. Most of these patients have been living a tem.
normal life for many years now – without suffering the agonies of
chemotherapy, radiotherapy or other desperate measures used in I know of no other research institute in recent years that has pub-
orthodox cancer treatment. lished more scientific studies on breakthroughs in natural cancer
treatment than our research institute in California. These studies have
The reports by cancer patients which we have compiled here docu- been published online and are freely available at www.cancer-
ment better than any clinical study the historic breakthrough that free-world.org/scientific_facts/index.php .
we are currently witnessing in this field of medicine – the transfor-
mation that is creating a world without fear of the “cancer” diagno- The momentum built up by the intensity of this fundamental scien-
sis. tific research has ensured that a large number of major clinical
studies on cellular nutrients in relation to cancer are now being car-
The letters published here are representative of many hundreds of ried out at leading research centres and university clinics.
others received from cancer patients who wish to pass on to others
– to you - their experiences with this disease. As you read this book, over a hundred such clinical studies are
underway in the USA alone. It is foreseeable that within a few years
The patients describe their “journey”, from the terror of the first cancer will change from being a “death sentence” to a treatable –
moment when they receive the cancer diagnosis, followed by pres- and above all avoidable – disease.
10 11
Important notes
The only interest group that still opposes the breathtaking prospect
of a “world without cancer” is the pharma lobby with its billion-
dollar investment in the “chemo” business. We must therefore
recognise that the right to live in a world free of cancer is not going
to be handed to us on a plate. We are going to have to work hard to Some of the letters published here, from patients to Dr. Rath, were
achieve it. abbreviated for reasons of space. Every single letter, in the form
published here, received its author’s renewed confirmation and
If you wish to play a part in this great task, you will need to get all approval in the form of a signature.
the information you can. If you do not already know it, you should
read the book, “Victory over Cancer”. Part 1 of this book sets out Each patient also signed a declaration of agreement to publish. As
the basic scientific information in an accessible way, and part 2 the publishers of this book we guarantee the authenticity of all
explains why you have not yet heard about this breakthrough. reports and letters reprinted here, specifically also in cases where
– to protect privacy – we were asked to remove the patient’s full
It is self-evident that we cannot achieve this important goal of a name.
“world without cancer” as isolated individuals. This is why we have
launched an initiative in which all who wish to achieve this goal Many users of cellular nutrients also submitted their full medical
with us can work together. You will find further information on this records to us. We have printed copies here of some of these medi-
at the websites listed below. If you can see your way to doing this, cal reports and x-rays in order to ensure that readers can under-
you could found an initiative in your locality, to make your town or stand this important documentation without medical knowledge.
city a “cancer-free” zone.
If these reports give you pause for thought, and if you think that
I invite you to join us in this common endeavour. We should do this they might help people in your family circle, or your friends and
for ourselves, our children, and for all future generations. acquaintances, or also your neighbours and people in your local
community or area, then do pass this documentation on.
The time to act is now!
By doing so you will be helping others,
Cordially yours and possibly even saving lives!
Dr. Matthias Rath
www.cancer-free-world.org
12 13
What is cancer?
All cells, even healthy ones, that wish to migrate through
the body, have to first dissolve the surrounding connective
tissue consisting of a dense network of collagen fibres (con-
nective tissue matrix). For this purpose cells can secrete
special enzymes capable of digesting this collagen matrix.
Under normal conditi-

ons, certain cells alrea-
dy use the same mecha-
nism – the ovum, for
instance, at ovulation,
or the white blood cor-
puscles when ‘migra-
ting’ to the site of an
infection. When whole
organs, too, are reconfi-
Cancer cells produce unlimited gured - for example the
amounts of enzymes that enable womb during pregnancy
them to spread and migrate. or the female breast
Further information on this can while breast-feeding –
be found in the book, “Victory this occurs through con-
over Cancer”. trolled tissue breakdown
and subsequent resyn-
thesis. Under normal (physiological) conditions, the producti-
on and activity of these enzymes is carefully controlled so
that they are only active for a short period, thus preventing
continuous breakdown of collagen and permanent damage to
tissue.
14 15
The Proof Successes with cellular nutrients confirm vitamin research findings Was ist Krebs?
Unlike these normal, physiological processes, the control Orthodox cancer treatment and
function is lost in the case of cancer cells. Not only do they
multiply without hindrance but they also continually pro-
its side effects
duce these enzymes that attack and destroy surrounding
connective tissue. The degree of aggression of a malignant Cancer has been treated for decades by standard methods
tumour is dependant primarily on the quantity of collagen- such as surgery, chemotherapy and radiotherapy. The most
digesting enzymes produced. commonly used forms of treatment – chemotherapy and
radiotherapy – indiscriminately attack not only cancer cells
All cancer cells – irrespective of their origin – produce large but also healthy cells, which is why they are associated with
quantities of these enzymes, leading to destruction of sur- severe side effects. The most common side effect is the
rounding connective tissue. With the aid of these “cutting growth of new cancer, since both chemo- and radiotherapy
tools”, the cancer cells release themselves from the tumour cause damage to genetic material (DNA).
and migrate into other organs via the blood or lymph sys-
tems – a process known as metastasis.
Cellular nutrients can control decisive
stages of cancer cell migration
Cellular nutrients can help inhibit the spread of cancer cells
in four major ways:
1. They can inhibit the reproduction of cancer cells.
2. They can inhibit the spread of cancer cells, a precondition

of metastasis.
3. They can inhibit the formation of tumour blood vessels by

Two important dietary supple- means of which the growing tumour is nourished
ments are vitamin C and lysine,
neither of which can be produced 4. They can kill cancer cells.
by the body itself. Lysine (green
wedges) blocks the collagen-diges-
ting enzymes, thus hindering
decomposition. Vitamin C, by con-
trast, promotes the development
of connective tissue.
16 17
Important cellular nutrients for combating cancer

Important substances and their functions: Common types
Vitamin C
is needed for forming collagen and thus for connective tissue sta-
bility. Trials at the US National Institute of Health (NIH) have
of cancer
shown that vitamin C at high concentrations can kill cancer cells
without impairing healthy cells.
Lysine and Proline
are natural amino acids which primarily serve as constituents of
In their book, “Victory over Cancer”, Dr. Matthias
collagen molecules and thus support tissue stability. They are Rath and Dr. Aleksandra Niedzwiecki explain why
also capable of at least partially inhibiting the collagen-digesting cancer is especially common in organs in which
enzymes and thus counteracting the unhindered spread of can- breakdown of connective tissue already occurs under
cer cells. normal physiological conditions.
Polyphenols
are likewise capable of inhibiting the activity of collagen-digest- The reproductive organs Breast cancer
ing enzymes, and thus combat the spread of cancer cells. are the first such or-
N-acetyl cysteine (NAC)
gan group, susceptible Ovarian cancer
is a strong anti-oxidant and important for the synthesis of glu- to cancer types that
tathione, another effective anti-oxidant. include breast cancer, Uterine cancer
ovarian cancer, uter-
Arginine
ine cancer, cervical
Cervical cancer
improves the action of the immune system and inhibits the
reproduction of cancer cells. cancer, testicular can- Testicular cancer
cer and prostate can-
Selenium
is an important component of the anti-oxidative defence system
cer. Prostate cancer
and protects cells against toxins. It can also inhibit the growth of
tumour cells. Below you will first Leukaemia
find a few examples of
Specific plant extracts people affected by these types of cancer, who report
have important protective functions for the human body, especially
here on their experiences with cellular nutrients.
as a natural means to counteract cell mutation and cancer, due to
their strong anti-oxidative properties and their ability to combat
bacteria, viruses and other harmful agents.
18 19
The Proof Successes with cellular nutrients confirm vitamin research findings Common types of cancer
Breast cancer
Dear Dr. Rath At this I told her about Cellular Medicine and she was
pleasantly surprised.
I thank my lucky stars every day that I found out about
Cellular Medicine. In 2008, during a routine mammogram, a small cancerous
tumour was found. My family urged me to have an opera-
In 2002, at the age of 60, I stopped working due to heart tion: a small piece was removed from my breast and a few
arrhythmia and high blood pressure. lymph nodes in my armpit.
These complaints arose from long periods of stress. Following this I was meant to take pharma pills for five
For two long years I took pharma pills but my condition years to prevent a recurrence of cancer, and also to
did not improve. receive precautionary radiotherapy – but I categorically
refused.
By now my pulse rate had fallen to 35 bpm, and 49 after
exertion. Then I remembered the lecture of yours I had I am very pleased that I did so, for today I am in the best
attended years before in Hamburg, and I started to take of health. No cancer ever recurred, for I kept using cellular
cellular nutrients. nutrients throughout.
After a week I already felt a slight improvement in the heart I have absolute confidence in cellular nutrients, and my
arrhythmia. After a month it had almost disappeared. Then health could not be better!
I went to my GP and she found that my blood pressure and
pulse rate had also improved. She was astonished and said, Warm and healthy greetings
“This has nothing to do with the pills you’re taking.” Ilse Goersch
20 21
Breast cancer
Dear Dr. Rath
My name is Bozena Herzner. During an examination on 28.3.2005, a My follow-up care chart from 2005 to 2011 shows that no subsequent
mammary carcinoma was found in my breast, and this was confirmed in deterioration occurred in my state of health.
mammograms and blood tests on 6.4.2005 and 12.4.2005. No metasta-
ses were found. I am glad that I pursued my own path, and I’d like to encourage others to
do the same!
After diagnosis I underwent breast-conserving surgery. According to my
medical records, on removal the carcinoma was found to be deeply Yours sincerely
embedded within healthy tissue. I dispensed with all chemo- and radio-
therapy, and also with hormone-inhibiting medicines. Directly after sur- Bozena Herzner
gery I took cellular nutrients and am still taking them to this day.
Further mammograms on 23.3.2006 and 15.11.2006 showed that no

secondary carcinoma developed, nor did any relapse occur.
Besides using cellular nutrients I also changed my diet. I started with food
combining and I eat only organic food. I attribute my health to all these
measures.
Medical reports for Mrs Herzner are

documented on the following pages.
22 23
Medical report for Bozena Herzner dated 6.4.2005, Medical report for Bozena Herzner, dated 6.4.2005 and lab report
confirming that she had breast cancer. dated 20.4.2005. Diagnosis: Breast cancer.
CEA and CA are so-called “tumour markers” measured in the blood.
Assessment: Mammary screening of right side showed

invasive ductal mammary carcinoma (G2, score 6).
24 25
Medical report for Bozena Herzner, dated 15.3.2006, Medical report for Bozena Herzner, dated 14.11.2006,
confirming that no breast cancer can be detected. likewise confirming that no breast cancer can be detected.
Assessment: Following mammary carcinoma on right side and

surgery, no further indication of secondary carcinoma or relapse. No suspected malignant tumour.
26 27
Breast cancer
Medical report for Helga-Maria Leipnitz, dated 10.8.2011,
confirming the absence of any breast cancer.
Dear Dr. Rath
I am very pleased to write to you to report on my experiences with cellu-

lar nutrients.
I heard about Cellular Medicine by chance in 2004. Since I felt very

weakened by breast surgery, and chemo- and radiotherapy in 2000, as
well as by a borreliosis infection in 2003, which may not have been prop-
erly treated, I saw Cellular Medicine as an opportunity to improve my
health by natural means.
In February 2004 I attended an information event on Cellular Medicine in

Leipzig, and learned many interesting things about this approach. I was
struck by the clear presentations and accessible information material,
with reports from grateful patients who had regained their health, and so
I immediately started taking cellular nutrients.
Complemented by regular saunas, swimming,
Nordic walking and fitness training, my current
good state of health remains stable.
Despite my 77 years I am now very happy, and

pleased at the success achieved by the Health
Alliance. I very much hope you will gain greater
publicity, and an ultimate victory over the rigid,
conventional pharmaceutical industry. I feel
renewed gratitude every day that I heard about
your work.
Yours sincerely
Helga-Maria Leipnitz
Assessment: Currently no reason to suspect malignancy.
28 29
Breast cancer
Dear Dr. Rath Dear Dr. Rath
I fell ill with breast cancer in May 2007: the tumour was already 1.8 cen- Ten years ago I was diagnosed with breast cancer that had
timetres in size. Fortunately I knew someone who had herself had breast also gone into the lymph nodes. Not for a moment did I
cancer, and had found cellular nutrients to be an excellent remedy. From contemplate amputation of the breast or chemotherapy.
her I obtained information material including a DVD with your series of
lectures from 2007. The understandable, logical explanations helped me I decided instead to take natural cellular nutrients, which I
decide to undergo surgery to remove the tumour and then start immedia- have been using successfully to this day. I also received
tely with a course of cellular nutrient treatment. mistletoe injections and took anti-oestrogens for three years,
and homeopathic remedies. So far there has been no recur-
The tumour was removed at Berlin’s Charité Hospital. Naturally I was rence of cancer.
advised to have radio- and chemotherapy. I refused both and instead tur-
ned to cellular nutrients. None of the doctors agreed with this plan, of I feel well –
course, but they accepted my decision. except for the fact
that I was given a
A few days after the operation I received the diagnosis that the tumour new knee in May
was a so-called inflammatory carcinoma – an inflammatory form of can- 2011, and had to
cer with a very poor prognosis due to its metastasising mechanism. take painkillers
However, I kept to my decision. My gynaecologist was opposed to this. and anti-inflam-
matory medicines
Four years later, on 31 May 2011, I went for a check-up. My doctor said for five weeks. I
that he could find ‘nothing of concern’. My good state of health, due to believe that cellu-
cellular nutrients, left me optimistic throughout that I had made the right lar nutrients
decision. And confirmation of this by the medical examination made this helped me recover from the knee operation and get fit
day the happiest of my life. again quickly.
It is high time that I thanked you and your whole team, Dr. Rath, for your
great endeavours and for the incalculable value of insights that have Yours sincerely
saved me much suffering and literally saved my life. Erika Raetzer
Yours sincerely
G.M.
30 31
Breast cancer
My name is Bärbel Saliger. Twelve years ago, in January, I thought my For my 60th birthday we will both
life was at an end. The diagnosis of breast cancer pulled the rug out open the dance. And there will be
from under my feet. another special reason for celebra-
tion: in February my daughter gave
Heavy chemotherapy sessions made me a wheelchair invalid. Then me the gift of my first grandchild.
there were financial problems as well, and I was battling alone since
the husband who had sworn to love me could no longer cope with I can only say, to anyone who is
me in the low state chemotherapy left me in. With just one breast he still doubtful about Dr. Rath and
no longer considered me a woman. I could have had breast recon- his team, that chemical concoc-
struction, but I always say: If someone loves me, they will accept me tions are only good for those who
as I am. make money from them. I thank
you, Dr. Rath and your team.
Now someone may ask: heavy
chemo, wheelchair – how come I also want to thank Werner Pilniok and his wife who encouraged
she’s thriving now and looks so me to take the right course of action at the time, and who remain
well? my very good friends.
Since 2001 I have been taking cellu- With warmest regards, your Bärbel Saliger
lar nutrients. After only three weeks,
the pains in my legs faded. After a
month I said: “Cheerio wheelchair!”
In March 2002 I celebrated my

birthday with my whole family. After
agonising months, my father gave
me his hand for the first dance. He
was 83 on 30 October, and on 29 September heard that he had can-
cer. His doctor told him he would be having chemo or radiotherapy
after surgery.
My father immediately refused this, relating the bad experiences I

had gone through with these forms of treatment. He had watched
me suffering. He decided to take cellular nutrients, for he too had
repeatedly been astonished at the way I was getting my life back
after such difficult times.
32 33
Breast cancer
Dear ladies and gentlemen
In May 2007 I received the greatest shock of my 66 years. I had felt a To sum up: All regular check-ups since then have shown positive
lump in my breast for a while. My naturopath sent me to the gynaecol- results, with no sign of cancer. Even a major follow-up examination in
ogist, who in turn sent me to the hospital. All the preliminary tests, and the hospital in February 2011, including ultrasound and a rigorous
a biopsy, showed that the lump in my right breast was a cancerous blood test, was absolutely fine – to the doctors’ astonishment – with no
tumour, measuring around 3 cen- pathological findings.
timetres – it was slow-growing and
not aggressive. The doctors were so surprised that they had the tests repeated twice by
various different specialists in the breast cancer department.
The subsequent breast-conserving
operation with removal of the I have frequently passed onto others my experiences with Cellular Med-
tumour and surrounding tissue icine. These patients too reported back to me on their outstanding suc-
went well, without complications. cess and confirmed their recovery.
Before surgery, and after it too, my
general state of health was very Since I and my family are thriving on our daily intake of cellular nutri-
good. All tests and my bloodcount ents, and feel well, we can recommend this mode of precautionary
were in order. After my 8-day stay healthcare with a very good conscience.
in the hospital, I was told that fol-
low-up care would include three In the hope that we will continue to maintain our good health for many
cycles of chemotherapy and 28 years to come, I remain
radiotherapy sessions.
As soon as I knew that I had breast yours, with best regards

cancer I was absolutely clear that I Rita Strauch
would not submit to chemotherapy or radiation treatment. My decision
met with fierce opposition from the doctors at the hospital. My hus-
band was present at all consultations and supported my decision.
When we asked about other forms of follow-up care, the doctors were
unable to offer anything else!
I was therefore discharged from hospital and was initially happy and
relieved that I had got rid of the tumour. I was clear that my ‘follow-up
care’ would be based on Cellular Medicine; and I have been taking cel-
lular nutrients regularly ever since. Frau Strauch’s medical report is
documented on the following page
34 35
Medical reported for Rita Strauch, dated 30.5.2007,

confirming breast cancer diagnosis.
Diagnosis: Right-side mammary carcinoma
36 37
Frau Strauch also kindly sent her “patient information

sheet” – a document that has to be signed by every
patient before radiotherapy can be carried out.
The side effects listed in it, including the development
of further cancer (which it describes as “secondary
growth” to make it seem less important), give a striking
sense of the current impasse in which modern cancer
treatment finds itself. (The full sheet is available).
38 39
Breast cancer
Dear Dr. Rath
The continual good health I have enjoyed in recent years has led In a few weeks’ time it will be 2012. All medical examinations -
me to update an earlier letter I sent you about my experiences, and tumour marker and blood tests in November 2011 – have been
send it to you once again. very satisfactory. Little aches and pains are fully under control,
and I combat them by natural methods.
I am now 64, and almost twelve years have passed since the
“breast cancer” diagnosis, followed by surgery, chemo- and radio- My husband and I have both long since recognised that there are
therapy. I am still well – though that hardly does justice to it. In fact natural alternatives to pharmaceutical drugs and conventional
I am even better than I was nine, ten and more years ago! therapies. It really is high time that other people realised this, and
took the opportunity to improve their lives. What I keep saying to
When I received the “breast cancer” diagnosis in 1999 I felt people is this: Health isn’t the be-all and end-all, but without it
despair, and my consultants’ efforts to reassure me were of little all’s at an end!
help. Barely two years before this I had come through a complex
gastric operation. Were things about to get even worse? And precisely for this reason we are going to keep working for a
new, better health system, for the Health Alliance, and above all
Fortunately all took a for you Dr. Rath!
turn for the better –
two books by you, Once again, Dr. Rath, we offer you our appreciation and thanks
Dr. Rath, made it easy for your exemplary commitment and your battle to create a
for me to decide to healthy world. As ever, we wish you and your research team con-
start taking cellular tinuing success with your socially responsible research work.
nutrients alongside
clinical treatment. I
was able to avoid all Warm greetings
the feared side effects Your Anna-Luise Korkowsky
of chemo- and radio-
therapy by using cellu-
lar nutrients. My hair
didn’t fall out but actually grew thicker – a fact that astonished my
hairdresser.
This was in March 2000. In the years following my last chemother-

apy treatment I stopped taking any pharmaceutical drugs, having
decided I would rather be naturally well than pharma-sick!
40 41
Breast cancer
My name is Hannelore Wagner.

A few days later, after the second operation, I was discharged with
On 28 June 2007, as required by my health insurer, I went for a notification that I would receive chemotherapy in the near future, and
screening test (mammogram). Around 14 days later a radiologist sent subsequently also radiotherapy. My gynaecologist explained what
me a message asking me to contact her. would happen. She said I would have to have five months of aggres-
sive chemotherapy and then one month of radiotherapy.
At this second consultation the radiologist did an ultrasound scan and
took a punch-biopsy tissue sample. She told me this would be exam- However, I first wanted to try something else, since I had seen the
ined by a pathologist and that I would receive the result in a few days. effects of chemotherapy on my, sadly, late husband.
However, she said she already knew the lump was malignant.
I had heard about cellular nutrients from my sister-in-law in 2003, and
This diagnosis was like a blow to the head. I just kept thinking: “I have now immediately started to take them. From the first day onwards I
cancer.” The tears were streaming down my face as I drove home. have been feeling fine. That was four years ago, and I never regretted
for a moment deciding against chemo- and radiotherapy.
The following Tuesday I knew for certain: the lump in my breast was
7 millimetres in size. My gynaecologist advised me to have surgery as I am proud and happy that instead I decided to take cellular nutrients,
soon as possible. After thinking hard about it, I applied to a gynaeco- and would like to encourage everyone to do the same if they are diag-
logical clinic in Munich and underwent surgery there on 26 Septem- nosed with cancer.
ber 2007.
Medical reports and x-rays are attached.
After a few days the doctor
came to my bed and told
me the pathologist had
found no signs of cancer.
She was unable to explain
it. Once again I had to have
a mammogram and mag-
netic resonance imaging. It
turned out that the wrong
lump had been removed!
On the initial mammogram
images there were two dis-
cernible lumps, and the
malignant one was still
there! The medical report and
x-rays follow below.
42 43
Medical report for Hannelore Wagner, dated 20.6.2007, X-ray for Hannelore Wagner, dated 28.6.2007,
confirming breast cancer. confirming breast cancer.
Before
4 years later: X-ray for Hannelore Wagner, dated 24. 1. 2011,

confirming that no breast cancer can be detected.
After
Assessment: Invasive ductal mammary carcinoma
44 45
Breast cancer Ovarian cancer
Dear Dr. Rath Dear ladies and gentlemen
I am 64. In 2000 I felt a lump in my right breast, and breast cancer was In 2004, while searching on the internet, we became aware of
subsequently diagnosed. In July 2000 the right breast was therefore Dr. Rath’s findings in relation to various cellular nutrient compounds.
removed completely, and chemotherapy began about two months later My mother had been diagnosed with ovarian cancer in 2003.
– a hellish experience, during which I felt I was wasting away. The specific diagnosis was: Fallopian tube cancer right side FIGO III c,
ED 11/03.
Up to December 2000 I submitted to four cycles of chemotherapy and,
in the following months, a total of 25 radiotherapy sessions. My immu- After surgery at the end of 2003, my mother was to undergo chemo-
ne system was radically weakened, and for a few days I could neither therapy in the context of a research study. Because of her poor health
eat nor drink, so that by the end of February I needed to recover at a after the operation, and leg paralysis, we refused chemo treatment. In
health spa. the view of the doctors, without necessary chemotherapy my mother
would have no more than 18 months to live.
Good friends then told me about cellular nutrients, and I started
carefully studying books and brochures about it. All I read struck me as My mother is now 82, and no further cancer was found at the six-
incredible – that entirely natural medical help was indeed available. monthly examinations. The last examination was on 5.7.2006, and after
that we dispensed with further check-ups.
Since March 2001 I have been taking cellular nutrients every day. After
just four weeks I found that I was recovering quickly from chemothera- Today we are very pleased that we took the right decision (which was
py, and my immune system has stabilised, For me it was like a miracle very difficult to make at the time).
to take something, at last, that was effective but had NO SIDE EFFECTS.
It is not just that I am feeling very well, but the lab findings also give me Nowadays our whole family takes cellular nutrients as precaution.
a clean bill of health. I have conquered the cancer – and eleven years
after the devastating diagnosis there are no longer any signs of it.
Yours sincerely
Since I started taking cellular nutrients, I have no longer caught flu or B.B.
similar illnesses either, and still feel well. What more can one ask?
I also changed my diet and play sport regularly.
It is simply astonishing what a tough fight you have on your hands,

Dr. Rath. I admire you and am very grateful.
With the very best wishes and regards

Your Marlies Schwietzer
46 47
Uterine cancer
Dear Dr. Rath
In April 2000 I was diagnosed with uterine carcinoma, which the doc-
tors said was aggressive. Luckily, no lymph nodes had as yet been affec-
ted. My womb and ovaries were removed. I was devastated.
During this time a friend told me about

Cellular Medicine. I immediately got
someone to bring me cellular nutrients at
the clinic, and started to take them.
The doctors advised me to have several

radiotherapy sessions after the operation,
but I refused. I was worried that my
bowel or bladder might be harmed.
I went back to work just twelve days
after the operation – I felt well.
Subsequently, I felt increasingly that cellu-
A world
lar nutrients did me a lot of good. I have
now been taking them regularly for ten years. All medical tests are clear,
and my GP and gynaecologist are very pleased.
Although I am now 71, I am still very lively, youthful and energetic.
I am so grateful that you are there! without cancer

With many warm greetings
Your Hildegard Mayer
is at hand!
48 49
Prostate cancer
Finding his own way to health
Resignation and despair don’t suit him. Herr Büttner is someone
Walter Büttner is a good who faces up to critical and difficult situations, and takes his own
example of someone who destiny in hand.
consistently takes responsi-
bility for his own health. His professional career as a pilot has reinforced his willingness to
act decisively and responsibly. Still today – as “unretired pension-
His motto is: Take destiny in er” – his special qualifications as expert on electrohydraulics and
your own hands instead of aircraft are called upon in the development of ultra-modern sim-
following blindly what oth- ulation technology, both in Germany and abroad. His profession-
ers tell you; and this has al work always required a high degree of responsibility and criti-
stood him in good stead cal judgement, and naturally this stood him in good stead in rela-
through the most difficult tion to his own health.
periods of his life.
How it all began

How would most of us react
if a doctor, in a distanced,
professional tone of voice, gave us the shocking diagnosis that
we had advanced cancer? Such a statement usually triggers
despair in patients, and makes them subject themelves, in blind
obedience, to conventional, pharma-oriented medicine. No
doubt this was what Walter Büttner’s consultant expected when
he gave him this diagnosis in 2001. Walter Büttner did not con-
form to type, however, but replied in his usual calm manner:
“So?” Visibly irritated, the doctor referred to the urgency of hav-
ing surgery within the next few days. Bladder, parts of the small
intestine and the prostate were affected, making it essential to
remove these organs. Walter Büttner refused, despite the doctor
urging this and suggesting that he would otherwise only have
three months to live. Unimpressed by this threat, Walter Büttner
pursued his own path, repeatedly refused surgery, and today – six
years later – feels, in his own words, “healthy and fit as a fiddle”.
50 51
“It was clear to me that the envisaged orthodox procedures

– surgery and chemotherapy – were not for me. I was and still
am convinced that chemotherapy using substances originally APPEAL BY WALTER BÜTTNER
developed as poison gas and combat weapons would harm TO HIS FELLOW MEN
rather than help me. By lucky chance, I found out about
Cellular Medicine.”
“I would be very pleased if my own path
In fact, this chance had a name, and was the neighbour of one
of Walter Büttner’s colleagues: Horst Ramershoven, a member
could act as an example to others.
of the Health Alliance for many years, met Herrr Büttner short-
ly after his cancer diagnosis, and had a long talk with him, dur- It is so important to recognise that we are res-
ing which he explained the scientific foundations of Cellular
Medicine. ponsible for our own health, and to take this
responsibility seriously. Patients should never
Walter Büttner was convinced by the clarity and logic of
Dr. Rath’s scientific outlook: “From the outset, Cellular Medi-
just blindly obey – however authoritative the
cine was a key aspect of my ‘self-therapy’. This also included person commanding.
intense scrutiny of myself and my circumstances at the time.
Focussing on and resolving professional tensions and conflicts
was likewise an important step in healing myself by my own Whichever course of action one ultimately
powers.” decides to pursue, this will at least be the out-
come of critical examination, and should also
Appeal to his fellow men include questioning of the supposed unassai-
Today, Walter Büttner is a happy and active person, and con- lable truths of conventional medicine.
tinues to use cellular nutrients. He is proud and happy that he
found the strength to pursue his own path of treatment, and
feels the importance of sharing these experiences with others,
and encouraging other patients.
We document his appeal on the opposite page.
52 53
Prostate cancer Prostate cancer
Dear Dr. Rath team Dear Dr. Rath
My husband, born 1930 and I, In March 2003, during a routine check-up, my doctor found my PSA
born 1938, are well. levels were much increased. After this a biopsy was taken, and I was
Thanks for being there! diagnosed with “medium-aggressive cancer”.
At the proud age of 81 and 73 Around the same time I heard of the positive effects of cellular nutrients
we do not need any pharma- on cancer. My urologist recommended radiotherapy, but I decisively
ceutical drugs, thanks to cellular rejected this idea.
nutrients.
I used cellular nutrient therapy, which brought the hoped-for outcome.
I had stomach cancer and was To begin with I included apricot kernels in this regimen.
operated on in 2004. Thank
goodness I did not receive any In March 2004, I had my PSA levels measured for the last time, and
chemotherapy but “only” radio- they stood at 36. Since then I have had no more such tests.
therapy. Since then I have used
cellular nutrients, quickly Over eight years have now passed since the cancer was discovered,
regaining my strength. So far I and I have absolutely no further complaints.
am very well, and the cancer
has not returned. In the past I also used to suffer from tonsil and gum inflammations. Both
these conditions have disappeared too. I don’t even get flu any more.
My husband was diagnosed with prostate cancer in 2006. He did not
accept surgery and also refused the chemotherapy offered to him. His
doctors were very annoyed. With warm thanks to you and the research team, and many greetings
Your Werner K., Münchenstein
He also recovered well thanks to vitamin therapy, and so far has had no
further complaints.
We, Family E. Geissler, would like to thank you, and wish the whole
team, and Dr. Rath, much continuing success and the best of health.
Thank you!
Your family E + E Geissler
54 55
Prostate cancer
Dear Dr. Rath! The tests showed worrying findings: prostate carcinoma and wide-
spread metastasis throughout the bones of the trunk. My subsequent
At the end of 2008 I had breathing prob- discussion with the urologist did not come up with a satisfactory solu-
lems and anxiety attacks. The doctor diag- tion. However, a colleague at work told me about the possibility of nat-
nosed cardiac insufficiency (heart weak- ural therapy, and obtained extensive advice for me. I also received infor-
ness) and I was given medication. This mation about cellular nutrients. After long discussions with my partner, I
went some way to resolving the prob- decided to pursue the path of Cellular Medicine.
lems. I returned to work and went to the
gym regularly. But during a balancing Today I can truly say that I am pain-free: I no longer need painkillers
exercise I fell and broke my fourth cervical vertebra. Surgery had to be and feel generally lively and well. The check-ups are no longer worry-
postponed due to the medication I was on. While waiting, I got a severe ing, and I enjoy my life as a pensioner. PSA levels are measured every
infection in the hospital, and the operation had to be postponed until six months, and they have fallen from 707 to 268, and then further to
the infection had subsided and my blood levels were OK again. 44. The last reading showed a level of 19. A bone radio-imaging test
will be done again in the near future, but I am not in the least worried
Questions kept surfacing and I was very doubtful whether everything about it: in fact I look forward to the results.
was really in order. I was working, working out, and taking my medica-
tion; and I went on holiday. Suddenly, as if from nowhere, I had terrible It is important to use cellular nutrients in a rigorous way. There really is
back pains. Still in Ticino, I went to the emergency department at a risk that one starts to be a bit lax when one feels better. It is a long-
Locarno Hospital, and was given painkillers, and advised to get an term application that should be strictly adhered to.
examination on my return home to find out the cause of the pain.
My partner supported me in whatever way she could, particularly when
At the hospital and at my GP’s surgery I was told it could be due to soft it came to strict use of cellular nutrients. Regular contact and discussion
tissue rheumatism. I was again given painkillers – but they didn’t really with my advisor was also very helpful. I am glad that I went down this
help. Over time I found that passing water was also becoming painful. I route, and therefore suffered no deleterious side effects.
was feeling worse and worse: continually plagued by pain and losing
weight. However, I hoped that each examination I attended would I would like to thank you warmly Dr. Rath for your work, and that of
bring a solution. your team. Without your research and tireless commitment, many peo-
ple might no longer be alive.
I decided to go to my GP, who knew my whole case history. He did a
blood test and then referred me to a urologist. The urologist did an
ultrasound test and took blood for further tests. He found problems in With warm greetings
the prostate area. I was also referred to Zurich University Hospital for a Your Max Baur
bone radio-imaging test.
56 57
Prostate cancer
Dear Dr. Rath
In the spring of 2008, due to ongoing back and stomach complaints, I refused the chemotherapy I was offered and instead started to take
I went to the hospital for a check-up. My troubles were ascribed to cellular nutrients. As accompaniment to this I drank various herb
gall stones, and these were surgically removed. teas in alternation as indicated in herbalism: green tea, equisetum,
rosebay willow herb and stinging nettle. I also took apricot kernels
However, this because of their B 17 content.
brought no improve-
ment. On the con- I am now in a stable condition, almost without pain – as one can see
trary, a few weeks from the attached medical report. I will leave it to others to decide
after the gall stone what they think of the verdict by specialists three years ago that I did
operation, I found not have long to live.
myself incapacitated
and unable to walk, I would like to thank the whole Dr. Rath team for their wonderful
alongside the pain. work, and wish them the very best success for the future.
A further examination
at the hospital finally Warm greetings
brought to light the Siegfried Obereigner
real cause of my bad
state of health.
Tumours in the spine
were responsible for
laming me, and were
diagnosed as metas-
tases of a prostate
carcinoma.
According to the doctor, immediate surgical intervention was need-

ed on my spine if I was not to face a life confined to the wheelchair.
After surgery and radiotherapy, I and my family were told that I must
prepare myself for my imminent end, since the cancer was so
advanced.
58 59
Prostate cancer
Dear Dr. Rath
About two-and-a-half years ago I was diagnosed with suspected

prostate carcinoma. The orthodox medical treatment resulting
from this diagnosis – biopsy, surgery, rehab etc. – was not some-
thing I wished to embark on. The latest information on vitamin research in
relation to cancer is compiled in these books.
I therefore decided to use cellular nutrients, alongside another
alternative therapy. At the same time I think it is important to take Information on how to order them can be found
one’s own health in hand and to change one’s own circumstances in the appendix.
and lifestyle accordingly.
All in all, this seems to have been successful so far,

for I am feeling well.
Yours sincerely
Dr. W. M.
60 61
Basic knowledge about leukaemia Leukaemia
Dear Dr. Rath

Leukaemia is another
common form of cancer. Following blood tests in 2002 my doctor gave me the devastating
diagnosis of chronic lymphatic leukaemia. To begin with I was in
In chapter 2 of the book despair, believing this would soon prove to be my death sentence.
“Victory over Cancer!” I calmed down a little after discussion with my family and my
an explanation is given therapist.
as to why blood cancer
Since I did not wish to undergo chemotherapy if possible, my
(leukaemia) is one of the
therapist immediately advised me to take cellular nutrients, which
most common forms of I have been taking every day since then. I also attended a lecture
cancer. by Dr. Rath at the conference centre in Zurich.
In healthy people, white My blood levels (leucocytes and lymphocytes) stayed quite sta-
blood corpuscles move Leukaemia cells under a ble; and so far – and ten years have passed now - I have had no
through body tissue with high-resolution electron need of chemotherapy, and am very pleased and hopeful in con-
the aid of so-called col- microscope. The ongoing sequence.
lagen-digesting enzymes. creation of collagen-digest-
I am convinced that cellular nutrients have helped me in recent
The production of these ing enzymes is illustrated
years and I continue to have faith in their health-promoting effect.
enzymes is limited in by the red “Pac-Men” (see
time, and only occurs the book “Victory over
until the leucocytes Cancer!”). Yours sincerely
have arrived at their des- E.K.
tination, e.g. a site of
infection.
When leucocytes become malignant, however, these

tissue-dissolving enzymes continue to be incessantly
produced.
We can therefore now understand why leukaemia is

one of the most common types of cancer.
62 63
Other types of cancer

Every part of the body can in principle be attacked by
cancer. The possible causes of cancer are very diverse
and multi-faceted. Key factors, in particular, are cellular
nutrient deficiencies, unhealthy diet, psychological
pressures, stress, environmental pollution (radiation, car
and chemical emissions, pesticides, fungicides etc.),
pharmaceutical drugs and suchlike.
Irrespective of the cause and originating organ of can-

cer, the disseminating mechanism is always the same:
the production of collagen-digesting enzymes by cancer
cells which thereby create their capacity to spread
through the body’s tissues.
64 65
The Proof Successes with cellular nutrients confirm vitamin research findings Other types of cancer
Cancer of the appendix Medical report for H.K. dated 3.3.1999,

confirming the appendix tumour.
Dear Dr. Rath
I have been a faithful user of Cellular Medicine for over ten years. The
reason for starting to take cellular nutrients was an appendix opera-
tion, following which I was diagnosed with carcinoma of the appen-
dix. I turned down a further, medically recommended colon operation
with subsequent chemotherapy, due to negative experiences amongst
my friends.
Intake of cellular nutrients led immediately to two health improve-

ments:
- My gums stopped bleeding, which they had always previously done

when I brushed my teeth
- I no longer got so many colds and bouts of flu during the winter
months
I am now almost 45, and no further cancer has occurred. The tumour
marker CEA shows no pathological findings, and generally I am in
very good health.
My mother, M.K., started to take cellular nutrients a few months after I

did. She is now 77 and fortunately very sprightly. Her high blood pres-
sure is mostly under good control.
Yours sincerely
H.K.
Diagnosis: Highly differentiated adenocarcinoma

of the appendix.
66 67
Colon cancer
Dear Dr. Rath
I want to thank you from the bottom of my heart for your research ents helped me a great deal, and I am also endlessly grateful to you!
work, and briefly tell you how I am now, and how helpful cellular Today, at the age of 69, I still feel very well.
nutrients have been for me.
If there were more people like you, more people like me could prob-
In June 2009 I was diagnosed with carcinoma of the rectum. I was to ably be helped.
undergo surgery and received chemo and radiotherapy beforehand,
to make the carcinoma smaller. In the subsequent operation I was to During convalescence in a clinic I had to witness that patients are
be given an artificial anus (stoma). This would have severely not well-fed, but given food without any real vitamin content that
impaired my quality of life, and I would probably not have been the might help them recover. We were continually offered meat and
same person I used to be. sausage – which in my view is unacceptable.
I underwent chemo- and radiotherapy (though reluctantly) but took Particularly in the case of colon cancer one should avoid meat
cellular nutrients and high-dose vitamin C injections to accompany because it easily ferments in the digestive tract.
the treatment.
I am convinced that many people would recover more quickly if
I am convinced that the cellular nutrients a) made the chemotherapy they ate fresh, healthy food.
tolerable for me and b) made a major contribution to the final out-
come. My heartfelt thanks to you. I will continue to use cellular nutrients!
In a consultation before the planned operation, the doctor told me

that the tumour could no longer be detected. Nevertheless I was due With sunny greetings
to undergo colostomy surgery the next day. Since the clinical find- M.K.
ings showed that none of the tumour could be detected apart from a
small remnant, I refused the operation, and instead continued to
take cellular nutrients on a daily basis.
At my daughter’s urging, after almost two years I underwent another

colonoscopy, which found NOTHING at all. The doctor said that I
no longer had any cancerous tissue.
If I had allowed myself to be intimidated by the doctors, I would

today have a hole in my stomach and a colostomy bag – quite
unnecessarily so. I am a hundred percent certain that cellular nutri- Medical reports follow
on the next pages.
68 69
Medical report for M.K. dated 17.7.2009,

confirming colon cancer.
Two years later the patient had a check-up which found no

evidence of the tumour. We have documented these reports
on the following pages.
Although the patient asked us to give her initials only when

publishing these facts, we have access, of course, to the full
medical reports.
Diagnosis: Deep-seated rectal carcinoma
70 71
Medical report (page 1) for M.K. dated 6.7.2011, Medical report (page 2) for M.K., dated 6.7.2011,
confirming that cancer is no longer present. confirming that cancer is no longer present.
Following the check-up, which included colonoscopy and MRI

(magnetic resonance imaging), the medical report concludes
with the following summary:
“The findings give no grounds to suspect disseminated* tumour

processes.”
* Spreading or metastasing
72 73
Colon cancer Colon cancer
My dear wife fell ill with colon cancer over 14 years ago now. Ten years ago I had aggressive cancer of the
Friends of ours recommended cellular nutrients, and today we are colon, and 35 centimetres (about 14 inches)
both well. of my intestine were removed.
I decided to take cel- At that time, unfortunately, I did not yet

lular nutrients too, in know anything about the potentially positive
sympathy – and now effects of cellular nutrients, and although no
I enjoy the same metastases were present, I allowed myself to
good health as my be persuaded – I really have to say unfortu-
wife, and am very nately - to have chemotherapy.
pleased. We take our
‘dose’ every day with After a year-and-a-half a doctor in Salzgitter told me that one might
meals. We also pass achieve a positive outcome with high-dose vitamins even without
on our experiences chemo. Since then I have sworn by Cellular Medicine, and I am very
with this ongoing well indeed! My GP, who does an annual blood test on me, asked
theme of “health” in me what I was taking since my blood levels were so good – and I
our discussion group. told him.
Of course my “statutory” health insurer refused to help with the I also try to buy products at the supermarket without E numbers.
costs of this provision. They had no wish to acknowledge that we This is very difficult but it can be done.
scarcely need to call on their support any more.
My cancer operation was ten years ago, and I feel very well.
It would be a good thing if chemotherapy could be replaced by
micronutrients. And so I thank Dr. Rath and all his helpers for their research work!
To the end of my life I will use natural remedies. People don’t believe
that I am 70 – they think I might be about 55. I never smoked either.
With good wishes to the team Usually I feel strong enough to uproot trees!
Your
Rudi & Christel Kressner
Yours sincerely
Your Renate Lai
74 75
Dear Dr. Rath Dear ladies and gentlemen
Cellular nutrients have saved my life. In 1999 I fell ill with colon cancer
and was operated on in August of
Firstly, they made my life possible again after a heart attack. The doctors
the same year. Following subsequent
were predicting that I would not live very long – but many years have
check-ups in 2001 it was discovered
passed since then. In 1991 I suffered a heart attack. In subsequent years I
that a metastasis had migrated to
was given three dilatations and in 1993 even a stent.
my lungs during the operation and
Despite a daily dose totalling ten pharmaceutical drugs, my heart attacks had grown into a new tumour there.
did not diminish. After I learned about cellular nutrients in 1994, and During further surgery the top left
from then on took them instead of pharmaceutical drugs, the heart lobe of my lung was removed.
attacks grew fewer. After about half a year they stopped altogether, and
my heart capacity got better and better. After surviving the operation, a good friend suggested I find out
about Cellular Medicine online. I was very interested and, after an
Secondly, after my colon cancer, a malig-
advisory session, started to take cellular nutrients.
nant tumour, cellular nutrients helped me
regain my health. I received this diagnosis
After a couple of months I had the feeling that my general state of
in 2009. The tumour was surgically
health had improved, and this was confirmed in subsequent
removed along with 36 centimetres (about
check-ups.
14 inches) of intestine and a stoma insert-
ed. At the time the doctors were unable to
Colonoscopy and MRI scans resulted in no pathological findings.
understand that there were no metastases.
My GP also told me that my test results were on a par with those
The anaesthesiologist even asked me
of a healthy person, and that I could be considered cured.
whether I was taking cellular nutrients,
since this type of cancer is usually very
Since then I still continue to take cellular nutrients,
aggressive.
and feel very well.
Fortunately, after about a year, it was pos-
sible to reverse the stoma procedure
again. Yours sincerely
B. Rohrbach
For several years now I have been completely free of cancer through
using cellular nutrients. I am now 78 and feel very well. I owe all this to
you Dr. Rath, and I thank you most warmly for it.
Yours sincerely
Hermann Lehnert
76 77
Dear Dr. Rath team Dear Dr. Rath MD
In 2000 I received a devastating diagnosis: aggressive colon cancer. In 2002 and 2003, I had to undergo two colon cancer operations,
I had to undergo an operation immediately. A year later a liver with stoma. The last reversal of the procedure took place in
metastasis was discovered, which likewise had to be operated on. August 2003.
I started searching for ways of supporting my body with natural Since then I have been taking cellular nutrients on a daily basis,
substances. and find I have no complications affecting my digestion, let alone
any recurrence of the colon cancer.
In 2002 someone recommended Cellular Medicine to me,
and I found it convincing. I attribute this fact to regular use of cellular nutrients.
I placed my trust in cellular nutrients and am sure that they helped

me to recover my health. Naturally I also changed my diet. Yours sincerely
K.-R. T.
Happily I can report that I am well. To ensure things stay like that
I will carry on in the same way.
At every opportunity I recommend cellular nutrients and tell people

about my good state of health. I am so convinced that I now work
in the Health Alliance and am glad to help others by providing
education and information.
Yours sincerely
Lore Krenedics
78 79
Bladder cancer
Dear Dr. Rath
In August of this year I will be 75. When I was about 60 (1996) But now to you, Dr. Rath! Around the time of my last bladder
my GP found blood in my urine. operation an acquaintance told me of the positive effects of cellu-
lar nutrients. Since then I have been taking them regularly, and am
Subsequently a urologist did an endoscopy of my urinary tract, pretty sure that they prevented a recurrence of the tumour by
and diagnosed bladder carcinoma. In the following eight years I strengthening my immune system.
underwent eight operations to remove the tumour. Each year it
grew back again with continuous regularity. For the sake of completeness I would also mention that my health
lifestyle also includes other factors such as regular exercise, physi-
Until… yes, until, due to a misdiagnosis by the urologist who had cal activity, healthy diet, enough fluids, and almost no alcohol. I
treated me so far, I changed doctors. At a check-up he had failed am also a non-smoker!
to notice the presence of a tumour in the bladder.
I would ask you to use a pseudonym when publishing this letter.
After an endoscopy, the new urologist I had chosen found a
tumour in the front of the bladder, and explained the misdiagnosis
by the fact that until then the focus had been only on the rear Yours sincerely
bladder wall, so that the tumour was not noticed. G.B.
At the hospital – also a new one that I chose! – I was operated on

twice in five weeks, since the danger of bladder perforation meant
that just one operation was not possible. Subsequently, at the rec-
ommendation of the chief urology consultant, treatment with
Metamycin was started in order to prevent the tumour from grow-
ing back again. This was a kind of localised chemotherapy, since
the substance was injected straight into the bladder and had to
stay there for several hours.
Seven years have passed since then without any detectable recur-
rence of the bladder tumour. My bladder was checked a total of
35 times by a urologist, using endoscopy. By nature I am rather
sceptical, and my anxiety after every check-up remains, until the
good results come through.
80 81
Sinus cancer Medical report for Otto Hölzemann dated 10.12.2007,

confirming sinus cancer
Dear Dr. Rath
Below I will give you a short account of how I came to cellular

nutrients.
In 1998 I had angina. I was unable to walk even 30 metres with-

out having to rest. My next stop was my GP. What did he pre-
scribe? Betablockers.
My professional work had brought me into contact with a profes-

sor (of medicine). We often had conversations about illness. At
each conversation he told me, “Let me warn you against chemo.”
This comment encouraged me to look for natural remedies on the
market. By chance I obtained your address. Within the first four
weeks, cellular nutrients improved my health. After three months I
was problem-free.
In 2007 I had to have surgery on a sinus tumour. After the opera-

tion, 30 sessions of radiotherapy were prescribed, which I
refused. In the meantime I had had good experience with cellular
nutrients. In addition I received vitamin C infusions from a natur-
opath.
I am well, and the illness never returned.
Yours sincerely
Otto Hölzemann
Indications: Condition following nasal sinus exploration on both

sides with rhinoplasty following histologically ascertained
adenocarcinoma of the right nostril and nasal sinus. Medical report follows
on the following pages
82 83
Medical report for Otto Hölzemann dated 26.4.2011,

confirming that cancer is no longer present.
Findings (extract):
No evidence of intracranial tumour mass.

No evidence of pathologically enlarged lymph nodes.
No evidence of bone changes indicative of malignancy.
No evidence of tumour mass in the thoracic sections

included in imaging.
84 85
Thyroid cancer Kidney cancer
First of all I would like to thank you for your outstanding work I have been a cancer patient since 1993
and commitment! (metastasing kidney carcinoma). In October
1993 my left kidney was surgically removed,
I have been using cellular nutrients for the past eleven years with and then in 2003/04, metastases in the right
complete satisfaction. Back then I was diagnosed with thyroid buttock, left thigh and both lungs. After
cancer, and had to undergo two operations which filled me with surgery in December 2003, chemotherapy fol-
anxiety and uncertainty. I was devastated. Then a friend told me lowed in January/February 2004, but this had
about you. to be stopped again after two sessions since three further opera-
tions were due.
I followed the principles of Cellular Medicine and soon felt better.
After this I decided to pursue biological cancer therapy based on
At the clinic I met a couple of women who had also been using cellular nutrients. I gathered extensive information about scientific
cellular nutrients with great satisfaction. I also told the professor findings relating to the use of cellular nutrients, and reports by
about this, and he said this was a good thing and I should contin- those who had used them. I also completed the basic and further
ue. Now I felt absolutely sure. training course at the Dr. Rath Health Alliance, and took an active
part in many Health Alliance events.
Almost eleven years have passed since then. The 10-year check-
up is now behind me. My body is free of disease, and thanks to “Biological cancer therapy” was accompanied by regular radio-
cellular medical treatment the illness never recurred. logical tests and blood analyses. These confirmed that my health
was stable, thus demonstrating how effective my chosen therapy
I wish you much continued success with your research, and hope was. At 75 I now feel in a good state.
that you will be able to go on helping many more like me.
I am convinced that cellular nutrients, which I have been taking
since April 2004, have had a very positive effect on my overall
With warm thanks health.
Your Antonia Pail
This is why I am a member of the Dr. Rath Health Alliance, and
have also passed my experiences on to others, to good effect.
Yours sincerely
Professor Dr. Manfred Reiss
86 87
Lymph gland cancer
Dear friends
I would like to tell you about my wife’s state of health: Two years later she had a relapse. We found another doctor who
seemingly gave “gentler” chemotherapy in his practice. This time
My wife, Marthe Robert (born 1929) was diagnosed with lymph my wife coped well with the treatment (without losing her hair).
gland cancer in 2002.
The doctor later told us that in the case of recurrence there was
As usual (!) chemotherapy was prescribed. However, this affected usually only a 25 percent chance of recovery. However, already
her so badly that it was stopped after six treatments (rather than during treatment, and also at its conclusion, the results were
eight). This led to a week in hospital with acute shingles. good. Clearly the cellular nutrients had helped bring about a cure.
After five years (with annual medical check-ups) my wife was at
It seemed the doctors had no other choice than to prescribe last well again.
radiotherapy. But when we heard that her whole body was to be
exposed to this treatment, which would, at the same time, have Now seven years have passed and – by God’s help too – we are
led to nerve damage, we decided against it. This was also in the best of health, for which we are very grateful.
because we had started to take cellular nutrients at this time, at
the recommendation of a Dr. Rath Health Alliance advisor.
Yours sincerely
A. and M. Robert
88 89
Lung cancer Top: scan of Herr Pilniok’s lung at the time

that lung cancer was diagnosed.
My name is Werner Pilniok
In September 1999, during a routine x-

ray, I was diagnosed with a fast-growing
lung tumour. According to the doctor, a
pneumologist, this tumour measured
1.5 x 1 centimetres (0.6 x 0.4 inches). I
underwent a series of further tests, after
which the doctors recommended surgi-
cal intervention and removal of the
whole lung section where the tumour
was situated.
But since I suffered from heart disease, an operation would have

been very risky for me. I therefore started to look around for alter-
natives. I read about the research by Dr. Rath, who was studying
the role of cellular nutrients in natural treatment of cancer and
other illnesses.
I decided to cancel the planned operation and to give micronutri-

ents a chance. From October 1999 on, I supplemented my diet
with a large quantity of micronutrients.
On 3 April 2000 I had a CT scan which showed that the tumour

found six months before had disappeared! My doctors couldn’t
believe it. They asked me to come back again a few days later,
since clearly they thought the scanning machine must be faulty.
But the new scan showed the same result – the tumour was no
longer there.
Before After 7 months
This was more than a decade ago. In 2011 I celebrated my 80th
birthday in good health. Thanks to micronutrients I hope to live Bottom left: enlarged section of the lung scan.
many more years still. Bottom right: scan of the same portion of lung after seven months
of taking cellular nutrients.
Werner Pilniok
90 91
Lung cancer
Dear Dr. Rath
Six years ago, in May 2005, I was found to have lung cancer, and
my top right lung lobe was surgically removed. Since then I have
been taking cellular nutrients. My state of health is very good, and
above all stable. I am not taking any additional medicines.
The lung specialist whom I go to see regularly is amazed at
my recovery.
My wife is also taking cellular nutrients and, since she began,

has no longer suffered from heartburn and stomach pain. Her
digestion is in order again. My daughter also swears by cellular
nutrients, which she has been taking for a year now. Her allergy
is much better and she no longer gets colds although she is in
daily contact with patients.
In conclusion we can say that we are all in much better health.

I hope that this continues.
Yours sincerely
Rudolf Schernhammer
92 93
Cancer of the parotid gland
Dear Dr. Rath

I am very glad to have avoided
My name is Bozana Schneeberger. I live in the Tyrol but was born
chemotherapy – which does
in Croatia.
no good since it is just big
business. I would like to advise
In 2007, I was found to have severe cancer of the parotid gland.
everyone not to wait until can-
My world fell apart.
cer strikes but to prevent it
with cellular nutrients!
I was first operated on shortly after the diagnosis, in 2007. The
surgery lasted for eight hours. Afterwards the surgeon told me
Finally I would like to thank
that the tumour was interwoven with the facial nerve, and that he
you Dr. Rath for giving me
was unable to help any further. The tumour was 3.6 centimetres
back my life so that I can tell
(about 1.4 inches) in size!
my story to others.
A week after the operation, my condition had further deteriorat-
ed. An MRI scan showed that the tumour had spread to an artery.
Your Bozana Schneeberger
On 12.6.2007 a friend brought me cellular nutrients and I took a
triple dose every day since my only hope was that it would help
me, that it must help me, as it had helped others.
On 18.7.2007, shortly before my second operation, another MRI

scan was taken. On the afternoon of the same day, the Professor
told me that my tumour had almost completely vanished: only a
small dot could now be seen.
I knew this would be so, and I immediately told him about

cellular nutrients, which I always had beside my bed. The doctor
was from Germany and said he knew who Dr. Rath was and that
I should carry on taking them. After surgery my medical report
stated: ‘Tumour-free’. At the time I said that I would like to meet
Dr. Rath in person. On 18.2.2008, therefore, I got into my car and
drove to Holland. I just wanted to have a picture of Dr. Rath, and
to promise him that I will help others and tell them what cellular
nutrients did for me, and how they work in the body.
94 95
Non-Hodgkin lymphoma
Dear Dr. Rath
In 2005 my husband received the devastating diagnosis of cancer.

He was operated on, since the doctors thought he was suffering
from colon cancer. However this was not the case, and it later
turned out that it was very malignant non-Hodgkin lymphoma.
My husband started with chemotherapy, but stopped it again after

a while.
At the recommendation of my brother-in-law, Gabriel Lommer, we

are now taking cellular nutrients.
In the meantime my husband is very well again. The information you provide, such as Rath International and
your Health letters, frequently contain valuable tips. In the mean-
I myself was thankfully never seriously ill, though my husband’s time we have also been able to get a few friends very interested
cancer was a very stressful period for me. I had high cholesterol in Cellular Medicine.
levels, but got a grip on them thanks to cellular nutrients.
Our day starts with cellular nutrients, and we are pleased
We feel fit and energetic and like working in our large garden. that we can cope so well with our active workload.
I myself am still working part-time in catering, after working in a
bank for 35 years. I also often look after our three grandchildren!
Yours sincerely
The Schütt family
96 97
Non-Hodgkin lymphoma Medical report for Edeltraud Schwörer on 14.4.2008,

showing a tumour size of 5.6 x 3.8 cm.
Dear ladies and gentlemen
On 1.4.2008 I was diagnosed with a tumour in the upper

abdomen measuring 5.6 x 3.8 centimetres (about 2.2 x 1.5 inch-
es), and a second tumour of 2 centimetres (about 3/4 inch) in
diameter (CT scan). After undergoing all tests I was told that this
was a grade 2 non-Hodgkin lymphoma of low malignancy.
I rejected the route of orthodox medicine involving surgery,

chemo or radiotherapy in order to pursue my own path. I got
information about cellular nutrients and started to take them at
the end of July 2008.
Alongside this I used homeopathic remedies and was given vita-

min C infusions. I did this for a year, and continued working full-
time in absolute certainty of what I was doing.
On 6.10.2008 an MRI scan showed that the lymphoma had

reduced in size to 4.5 x 2.3 centimetres (1.7 x 0.9 inches), and
the second tumour to a diameter of 1.6 centimetres (0.6 inch). In
other words, my decision had been right.
On 24.11.2010, the large tumour measured only 2.2 x 1.8 x 2.1

centimetres (3/4 x 0.7 x 3/4 inch), and the small one could no
longer be detected at all.
My goal is clear and I will carry on. I feel very well, and am happy
that I took this route. Summary of findings and assessment (excerpt):
Tumour mass on the left side, at kidney hilum level,
measuring 5.6 x 3.8 cm.
Yours sincerely
Edeltraud Schwörer In summary, evidence of an retroperitoneal tumour suspected of
being an NPL*
* Neoplasm = cancer
98 99
Edeltraud Schwörer: At the check-up 1/2 a year later, Edeltraud Schwörer: At the check-up three years later,
the tumour only measured 4.5 x 2.3 cm (1.7 x 0.9 inches), the tumour had shrunk still further and now measured
and had therefore diminished considerably in size. 2.3 x 2.1 x 1.8 cm.
Summary of findings and assessment: The para-aortal tumour mass

on the left side, at the level of the kidney hilum, now measures 4.5 x
2.3 cm in the MRI scan, and is clearly regressing compared to the
previous examination. The more caudally situated lymph node now
measures 1.6 cm and is thus likewise regressing. Kidney cyst left, of
no concern. No other detectable symptoms.
100 101
Appendix
Acknowledgements Publication of our findings
Heartfelt thanks to all patients who had the courage to share their experiences PROSTATE CANCER
in this book. In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline and Green Tea Extract on
Human Prostate PC-3 Xenografts in Nude Mice: Evaluation of Tumor Growth and
Our special recognition goes to all patients, young and old, who had no Immunohistochemistry. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki,
opportunity to fight their illness, and who might have had a chance if they had M. Rath. In Vivo , 2005, 19(1), 179-184.
not wasted so much time in the dead-end of conventional medicine.
Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine and Epigallocatechin
Our thanks to Dr. Rath, Dr. Aleksandra Niedzwiecki, director of our research Gallate in Prostate Cancer Cell Lines PC-3, NCaP, and DU145. M.W. Roomi,
institute, and our whole research team, who have corroborated this medical V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
breakthrough with creativity and persistence. Our special thanks goes to Research Communications in Molecular Pathology and Pharmacology, 2004, 115:1-6
Dr. Waheed Roomi, head of our cancer research department, who has been
undertaking and supervising these important experiments for over a decade.
We also thank Dr. Shrirang Netke, Dr. Vadim Ivanov, Dr. Raxit Jariwalla, TESTICULAR CANCER
Nusrath Roomi and Tatiana Kalinovsky for helping this innovative research Inhibitory Effects of a Nutrient Mixture on Human Testicular Cancer cell Line
to progress and develop. NT 2/DT Matrigel Invasion and MMP Activity. M.W. Roomi, V. Ivanov,
T. Kalinovsky, A. Niedzwiecki, M. Rath. Medical Oncology 2007 24(2): 183-188
A very special thanks to Manja Heidemann for her work in compiling this
book, and to Renate Ottofrickenstein and Bernd-Ulrich Rüller for their assis- BREAST CANCER
tance. We thank Jörg Wortmann for his work on the layout and Anke Warten- In Vitro and In Vivo Antitumorigenic Activity of a Mixture of Lysine, Proline,
berg for proofreading. Ascorbic Acid and Green Tea Extract on Human Breast Cancer Lines MDA
MB-231 and MCF-7. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki,
Special thanks to the many thousands of members of our international Health M. Rath Medical Oncology 2005, 22(2) 129-38
Alliance, which has been supporting our research work for over a decade.
Without them this breakthrough would not have been possible. Modulation of N-Methyl –N-Nitrosourea-Induced Mammary Tumors in Sprague-
Dawley Rats by Combination of Lysine, Proline, Arginine, Ascorbic Acid and
Finally we would like to thank all those whose scepticism and resistance has Green Tea Extract. M.W. Roomi, N.W. Roomi, V. Ivanov, T. Kalinovsky,
provided an invaluable stimulus to our own motivation. A. Niedzwiecki, M. Rath. Breast Cancer Research, 2005, 7:R291-R295
A combination of green tea extract, specific nutrient mixture and quercetin:

Dr. Rath Health Foundation An effective intervention treatment for the regression of N-Methyl –N-Nitrosourea
(MNU)-Induced mammary tumors in Wistar rats. Anup Kale, Sonia Gawande,
Swati Kotwal, Shrirang Netke, M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Oncology Letters, 2010, 1:313-317
102 103
The Proof Successes with cellular nutrients confirm vitamin research findings Appendix
CERVICAL CANCER PANCREATIC CANCER

Suppression of Human Cervical Cancer Cell Lines Hela and oTc2 4510 MMP Antitumor Effect of a Combination of Lysine, Proline, Arginine, Ascorbic Acid,
Expression and Matrigel Invasion by a Mixture of Lysine, Proline, Ascorbic Acid, and Green Tea Extract on Pancreatic Cancer Cell Line MIA PaCa-2. M.W. Roomi,
and Green Tea Extract. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
M.Rath International Journal of Gynecological Cancer 2006; 16:1241-1247 International Journal of Gastrointestinal Cancer 2005, 35 (2), 97-102
OVARIAN CANCER FIBROSARCOMA

In vitro modulation of MMP-2 and MMP-9 in human cervical and ovarian cancer In Vivo and in Vitro Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine,
cell lines by cytokines, inducers and inhibitors. M.W. Roomi, J.C. Monterrey, and Green Tea Extract on Human Fibrosarcoma Cells HT-1080. M.W. Roomi,
T. Kalinovsky, M. Rath, A. Niedzwiecki. Oncology Reports 2010; 23(3):605-614 V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Medical Oncology 2006; 23(1): 105-112
Inhibition of MMP-2 Secretion and Invasion by Human Ovarian Cancer Cell Line
SKOV-3 with lysine, proline, arginine, ascorbic acid, and Green Tea Extract. M.W. Synergistic Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Epigallocate-
Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath chin Gallate on Human Fibrosarcoma Cells HT-1080. M.W. Roomi, V. Ivanov,
Journal of Obstetrics and Gynaecology Research 2006; 32(2): 148-154 T. Kalinovsky, A. Niedzwiecki, M. Rath
Annals of Cancer Research and Therapy, 2004 12:148-157
COLON CANCER
In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline and Green Tea Extract on KIDNEY AND BLADDER CANCER
Human Colon Cancer Cell HCT 116 Xenografts in Nude Mice: Evaluation of Pleiotropic effects of a micronutrient mixture on critical parameters of bladder
Tumor Growth and Immunohistochemistry. M.W. Roomi, V. Ivanov, T. Kalinovsky, cancer. M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath. In Bladder Cancer:
A. Niedzwiecki, M. Rath. Oncology Reports, 2005, 12 (3), 421-425 Etymology, Diagnosis and Treatments, edited by William Nilsson, Nova Science Pub-
lishers, Inc, 2010.
Synergistic Effect of Combination of Lysine, Proline, Arginine, Ascorbic Acid and
Epigallocatechin Gallate on Colon Cancer Cell Line HCT 116. M.W. Roomi, Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine, and Green Tea Extract
V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath on Bladder Cancer Cell Line T-24. M.W. Roomi, V. Ivanov, T. Kalinovsky,
Journal of the American Nutraceutical Association, 2004, 7 (2): 40-43 A. Niedzwiecki, M. Rath. International Journal of Urology 2006; 13: 415-419
BONE CANCER Modulation of Human Renal Cell Carcinoma 786-0 MMP-2 and MMP-9 Activity
Naturally Produced Extracellular Matrix Inhibits Growth Rate and Invasiveness by Inhibitors and Inducers in Vitro. M.W. Roomi, V. Ivanov, T. Kalinovsky,
of Human Osteosarcoma Cancer Cells. V. Ivanov, S. Ivanova, M.W. Roomi, A. Niedzwiecki, M. Rath. Medical Oncology 2006; 23(2): 245-250
T. Kalinovsky, A. Niedzwiecki, M. Rath. Medical Oncology 2007; 24(2): 209-217
Anticancer Effect of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract
Effect of Ascorbic Acid, Lysine, Proline and Green Tea Extract on Human on Human Renal Adenocarcinoma Line 786-0. M.W. Roomi, V. Ivanov, T. Kali-
Osteosarcoma Cell Line MNNG-HOS Xenografts in Nude Mice: Evaluation of novsky, A. Niedzwiecki and M. Rath. Oncology Reports 2006; 16(5):943-7
A. Niedzwiecki, M. Rath. Medical Oncology 2006; 23(3 ): 411-417 SKIN CANCER
Inhibition of 7, 12-Dimethylbenzathracene-Induced Skin tumors by a Nutrient
Antitumor Effect of Nutrient Synergy on Human Osteosarcoma Cells U2OS, Mixture. M.W. Roomi, N.W. Roomi, T. Kalinovsky, V. Ivanov, M. Rath,
MNNGHOS, and Ewing’s Sarcoma SK-ES.1. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki. Medical Oncology 2008; 25(3): 330-340
A. Niedzwiecki, M. Rath. Oncology Reports, 2005, 13(2), 253-257
Suppression of growth and hepatic metastasis of murine B16FO melanoma cells
In Vivo and In Vitro Antitumor Effect of Nutrient Synergy on Human by a novel nutrient mixture. M.W. Roomi, T. Kalinovsky, N.W. Roomi, V. Ivanov,
Osteosarcoma Cell Line MNNG-HOS. M.W. Roomi, V. Ivanov, T. Kalinovsky, M. Rath, A. Niedzwiecki. Oncology Reports 2008; 20:809-817
A. Niedzwiecki, M. Rath. Annals of Cancer Research and Therapy, 2004, 12: 137-148
In Vitro and In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, And Green
Tea Extract On Human Melanoma Cell Line A2058. M.W. Roomi, V. Ivanov,
T. Kalinovsky, A. Niedzwiecki, M. Rath. In Vivo 2006;20(1): 25-32
104 105
LUNG CANCER OTHER TYPES OF CANCER

Chemopreventive effect of a novel nutrient mixture on lung tumorigenesis Comparative effects of EGCG, green tea and a nutrient mixture on the patterns of
induced by urethane in male A/J mice. M.W. Roomi, N.W. Roomi, V. Ivanov, T. MMP-2 and MMP-9 expression in cancer cell lines. M.W. Roomi, J.C. Monterrey,
Kalinovsky, A. Niedzwiecki, M. Rath. Tumori 2009; 95: 508-513 T. Kalinovsky, A. Niedzwiecki, M. Rath. Oncology Reports – 2010; 24:747-757
Modulation of MMP-2 and MMP-9 by cytokines, mitogens, and inhibitors in lung Inhibition of invasion and MMPs by a nutrient mixture in human cancer cell lines: a
cancer and mesothelioma cell lines. M.W. Roomi, J.C. Monterrey, T. Kalinovsky, correlation study. M.W. Roomi, J.C. Monterrey, T. Kalinovsky, A. Niedzwiecki,
A. Niedzwiecki, M. Rath. Oncology Reports 2009; 22: 1283-1291 M. Rath. Experimental Oncology- 2010; 32:243-248
Inhibition of Malignant Mesothelioma Cell Matrix Metalloproteinase Production In vivo and in vitro effect of a nutrient mixture on human hepatocarcinoma cell
and Invasion by a Novel Nutrient mixture. M.W. Roomi, V. Ivanov, T. Kalinovsky, line SK-Hep-1. M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath.
A. Niedzwiecki and M. Rath. Experimental Lung Research 2006; 32:69-79 Experimental Oncology –2010;32:84-91
In Vivo and in Vitro Anti-tumor Effect of a Unique Nutrient Mixture on Lung Can- Patterns of MMP-2 and MMP-9 expression in human cancer cell lines.
cer Cell Line A-549. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki and M.W. Roomi, J.C. Monterrey, T. Kalinovsky, A. Niedzwiecki, M. Rath
M. Rath. Experimental Lung Research 2006; 32:441-453 Oncology Reports – 2009; 21:1323-1333
Inhibition of Pulmonary Metastasis of Melanoma B16FO Cells in C57BL/6 Mice Marked inhibition of growth and invasive parameters of head and neck squamous
by a Nutrient Mixture Consisting of Ascorbic Acid, Lysine, Proline, Arginine, and carcinoma FADU by a nutrient mixture. M.W. Roomi, N.W. Roomi, T. Kalinovsky,
Green Tea Extract. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath A. Niedzwiecki, M. Rath. Integrative Cancer Therapies 2009; 8(2):168-176
Inhibition of Glioma Cell Line A-172 MMP Activity and Cell Invasion in Vitro by
BLOOD CANCER a Nutrient Mixture. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki and
Antineoplastic effect of nutrient mixture on Raji and Jurkat T cells: the two highly M. Rath. Medical Oncology 2007; 24(2): 231-238
aggressive non-Hodgkin’s lymphoma cell lines. M.W. Roomi, BA Bhanap,
N.W. Roomi, A. Niedzwiecki and M. Rath. Inhibitory of Cell Invasion and MMP Production by a Nutrient Mixture in
Experimental Oncology 2009; 31(3): 149-155
Malignant Liposarcoma Cell Line SW-872. M.W. Roomi, V. Ivanov, T. Kalinovsky,
A. Niedzwiecki, M. Rath. Medical Oncology 2007; 24(4):394-401
Epigallocatechin -3-Gallate induces apoptosis and cell cycle arrest in HTLV-1 pos-
itive and negative leukemia cells. S. Harakeh, K. Abu-El-Ardat, M. Diab-Assaf, A. In Vitro Anticarcinogenic Effect of a Nutrient Mixture on Human Rhadomyosarco-
Niedzwiecki, M. El-Sabban, M. Rath. Medical Oncology 2008; 25: 30-39 ma Cells. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Gene Therapy and Molecular Biology 2007; 11(B):133-144
Ascorbic acid induces apoptosis in Adult T-cell Leukemia. S. Harakeh, M. Diab-
Assaf, J. Khalife, K. Abu-El-Ardat, E. Baydoun, A. Niedzwiecki, M. El-Sabban, In Vivo and in Vitro Anti-tumor Effect of a Nutrient Mixture Containing Ascorbic
M. Rath. Anticancer Research 2007; 27: 289-298 Acid, Lysine, Proline, and Green Tea Extract on Human Synovial Sarcoma Cancer
Cells. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki and M. Rath.
Mechanistic aspects of apoptosis induction by L-Lysine in both HTLV-1 positive JAMA 2006; 9(2): 30-34
and negative cell lines. S. Harakeh, M. Diab-Assaf, K. Abu-El-Ardat, A.
Niedzwiecki, M. Rath. Chem. Biol. Interactions 2006; 164: 102-114 A Specific Combination of Ascorbic Acid, Lysine, Proline and Epigallocatechin
Gallate Inhibits Proliferation and Extracellular Matrix Invasion of Various Human
Apoptosis Induction by Epican Forte in HTLV-1 Positive and Negative Malignant Cancer Cell Lines. S.P. Netke, M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath.
TCells. S. Harakeh, M. Diab-Assaf, A. Niedzwiecki, J. Khalife, K. Abu-El-Ardat, Research Communications in Pharmacology and Toxicology, Emerging Drugs, 2003;
Vol. II, IV37-IV50.
M. Rath. Leukemia Research –2006; 30: 869-881
METASTASIS
Micronutrient synergy – a new tool in effective control of metastasis and other key
mechanisms of cancer. A. Niedzwiecki, M.W. Roomi, T. Kalinovsky, M. Rath.
Cancer Metastasis Review 2010; 29; 529-542
106 107
Suppression of growth and hepatic metastasis of murine B16FO melanoma cells Further references:
by a novel nutrient mixture. M.W. Roomi, T. Kalinovsky, N.W. Roomi, V. Ivanov, De Prithwish et al., Breast cancer incidence and hormone replacement therapy in
M. Rath, A. Niedzwiecki. Oncology Reports 2008; 20:809-817 Canada. J. Natl. Cancer Inst. 2010; 102: 1-7
A nutrient mixture suppresses hepatic metastasis in athymic nude mice injected Jemal A. et al., Global cancer statistics, CA Cancer J Clin. 2011; 61: 69-90.
with murine B16FO melanoma cells. M.W. Roomi, N.W. Roomi, T. Kalinovsky,
J.C. Monterrery, M. Rath, and A. Niedzwiecki. BioFactors 2008; 33; 85-97 Jemal A et al., Trends in the Leading Causes of Death in the United States,
1970-2002. JAMA 2005, 294: 1255-1259
Inhibition of Pulmonary Metastasis of Melanoma B16FO Cells in C57BL/6 Mice
by a Nutrient Mixture Consisting of Ascorbic Acid, Lysine, Proline, Arginine, and Hirsh J, An Anniversary for Cancer Chemotherapy. JAMA 2006; 296; 1518-1520.
Green Tea Extract. M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath.
Experimental Lung Research 2006; 32(10):517-30 Phang J.M. et al., The metabolism of proline, a stress substance, modulates
carcinogenic pathways. Amino Acids, 2008; 35; 681-690
ANGIOGENESIS
Distinct patterns of matrix metalloproteinase-2 and -9 expression in normal Duffy M.J., The urokinase plasminogen activator system: role in malignancy.
human cell lines. M.W. Roomi, J.C. Monterrery, T. Kalinovsky, M. Rath, and Curr. Pharm. Des., 2004; 10; 39-49
A. Niedzwiecki. Oncology Reports – 2009; 21: 821-826
Henriet P et al., Contact with fibrillar collagen inhibits melanoma cell prolifera-
Patterns of MMP-2 and MMP-9 expression in human cancer cell lines. tion by up-regulating p27 KIP1. Proc Natl Acad Sci USA, 2000; 97; 10026-10031.
M.W. Roomi, J.C. Monterrery, T. Kalinovsky, M. Rath, and A. Niedzwiecki.
Oncology Reports – 2009; 21:1323-1333 K. Almholt et al., Reduced metastasis of transgenic mammary cancer in urokinase
deficient mice. Int. J. Cancer 2005; 113: 525-532
Antiangiogenic properties of a nutrient mixture in a model of hemangioma.
M.W. Roomi, T. Kalinovsky, M. Rath, and A. Niedzwiecki. Ruhul Amin A.R.M. et al., Perspectives for Cancer Prevention with Natural Co
Experimental Oncology – Accepted 10/26/09 pounds. J. Clin. Oncol. 2009; 27: 2712-2725
A novel nutrient mixture containing ascorbic acid, lysine, proline and green tea Oak Min-Ho et al., Antiangiogenic properties of natural polyphenols from red
extract inhibits critical parameters in angiogenesis . M.W. Roomi, V. Ivanov, T. wine and green tea. J. Nutr. Biochem. 2005; 16, 1-8
Kalinovsky, A. Niedzwiecki, M. Rath in Anti-Angiogenic. Functional and Medici-
nal Foods, edited by Losso JN, Shahidi F, Bagchi D, CRC Press, Taylor& Francis Morgan G et al., The Contribution of Cytotoxic Chemotherapy to 5-year Survival
Group, Boca Raton, London, New York, 2007, pages 561-580. in Adult Malignancies. Clin. Oncol. 2004; 16: 549-560.
Inhibitory Effect of a Mixture Containing Ascorbic Acid, Lysine, Proline, and

Green Tea Extract on Critical Parameters in Angiogenesis. M.W. Roomi,
N.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath.
Oncology Reports 2005, 14(4), 807-815.
Antiangiogenic Effects of a Nutrient Mixture on Human Umbilical Vein Endothe-

lial Cells. M.W. Roomi, N.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki,
M. Rath. Oncology Reports 2005;14(6):1399-404
108 109
Order information:
“Victory over Cancer”
Part 1: Making the Unthinkable Possible
Part 2: Understanding History – Building the Future

Postbus 656
NL-6400 AR Heerlen
Tel.: 0031-457-111 222

Fax: 0031-457-111 229
Email: info@rath-eduserv.com
Website: www.rath-eduserv.com
Important websites
During reading this book you probably met some topics that you
want to know more about. Here is a collection of websites which
we helped to build. We can guarantee that the contents of these
sites are independant from the pharma business with disease:
• www.drrathresearch.org
The official website of our research institute in California.
• www.drrathresearch.org/research/publications/cancer.html
Direct link to the cancer studies of our research institue.
• www.wha-www.org/en/library/index.html
Online library for health professionals who are engaged in
natural therapies and patients.
Appendix
Important Documentation
Victory Over Cancer Part Two: Understanding History Building the Future Appendix - Important Documentation
Acknowledgements
Our thanks go to our entire research team who confirmed this Particular thanks go to the thousands of members of our interna-
medical breakthrough with ingenuity and perseverance. First and tional Health Alliance who have supported our research for more
foremost we owe our appreciation to Dr. Waheed Roomi, the than a decade. Without you this breakthrough would not have
head of our cancer research department who conducted and been possible.
supervised these important experiments for more than a decade.
We also thank Dr. Shrirang Netke, Dr. Vadim Ivanov, Dr. Raxit Jari- We thank our families for their support and patience.
walla, Nusrath Roomi and Tatiana Kalinovsky for promoting this
breakthrough research. We also thank Andy and Jamie Kerr for an inspirational environ-
ment when we wrote this book.
Our thanks go to Lisa Smith for assistance in the layout of this
book as well as Cathy Flowers and John Journey for reading cor- Finally, our thanks go to all those who have remained an invaluable
rections. source of motivation to us through their skepticism and opposition.
We are grateful to Betsy Long, Earle Hall, Christian Kammler and

Thomas Wenn, and Paul Anthony Taylor for organisational support.
We also wish to express our gratitude to all members of our inter-

national legal team that have worked for more than a decade to
protect this breakthrough against the legal attacks of the status quo
lobby.
We thank Werner Pilniok, Baerbel Saliger and all other patients

who had the courage to publicly tell their life story.
We pay special reverence to those patients, young and old, who

failed in their efforts to fight the disease, and who may have had a
chance had they not lost so much time in the deadlocks of con-
ventional medicine.
We are especially grateful to August Kowalczyk, Jerzy Ulatowski

and other survivors of the Auschwitz concentration camp. They
remain a lasting inspiration to us and our work. We are united
with them in the commitment: ‘Never again!’
76 77
Important Websites
In the course of this book you may have come across some topics
on which you would like to learn more. Here is a selection of web-
sites which we helped to create. We can assure you about the inde-
pendence of their contents:
• www.dr-rath-health-foundation.org
Overview of the work of our Foundation
• www.relay-of-life.org
Receiving the ‘highest honour of our time’
• www.profit-over-life.org
History of the ‘business with disease’
• www.nazi-roots-of-brussels-eu.org
History of the new ‘government of Europe’
• www.wiki-rath.org
Exposing the undemocratic nature of an allegedly ‘democrat-
ic encyclopedia’
• www.chemo-facts.com
Facts about the chemotherapy business with the cancer epi-
demic
• www.pharma-fact.org
Facts about the pharmceutical investment ‘business with dis-
ease’
• www.movement-of-life.org
A Call for Change!
78 79
CALL FOR ‘MOVEMENT OF LIFE’ THE RIGHT TO NATURAL FOOD

The most fundamental human rights are the rights to health and life. Likewise, the genetic information of all plants, and the food that has
These rights are threatened by global corporate interests that consid- been growing in our fields and gardens for millennia belongs to all
er the human body as their marketplace and source of unlimited mankind. Manipulation and alteration of the genetic code of plants,
profits. Today, at the beginning of the 21st Century, the people of the with the goal of patenting them and creating global market monopo-
world must unite to protect inalienable human rights. lies of human nutrition, bears the danger that our food supplies are
abused to benefit corporate interests. The monopolisation of our
THE RIGHT TO HEALTH food enables corporate control over the fate of entire societies. This
undermines the fundamentals of democracy and violates human
The protection of our health is the most important human right. rights. Access to healthy, unaltered food is a precondition for a
Over the past century, our health has come under the increasing healthy society.
influence of an investment industry that thrives from the continua-
tion and expansion of diseases as markets for patented drugs. The A BREATHTAKING PERSPECTIVE
efforts by pharmaceutical corporations to monopolise human health
on a global level have become the greatest obstacle to the preven- As a consequence, the giant economic and human resources that
tion, and ultimately the eradication, of today’s most common dis- will be freed following the liberation of human health can be used to
eases. fight the most burning global problems of our time, including;
hunger, malnutrition, poverty, illiteracy, unemployment and environ-
Any business model that is based on the deliberate expansion of dis- mental threats.
eases violates the fundamental human right to health and must be
prohibited worldwide. This will pave the way for mankind to largely SUPPORT THE MOVEMENT OF LIFE
eliminate heart disease, cancer and many other diseases within this
These basic rights will not be given voluntarily to you by the status
century.
quo. We, the people of the world, need to defend our fundamental
human rights, now. This is the goal of the ‘Movement of Life’!
THE RIGHT TO LIFE
In a similar way, the right to the biological foundation of life is threat-
ened by these very same corporate interests. The human genome – the
blueprint of life and the biological basis of our existence – has become
the target of large-scale commercial exploitation through the patent-
ing of genes.
The genetic code is the inalienable property of all mankind. All efforts
to commercialise this genetic code, with the goal to rebuild, sell and
manipulate the human body or parts of it for corporate gain, must be
prohibited worldwide. The knowledge of our blueprint of life should
To learn more about the ‘Movement of Life’
be exclusively used to benefit all mankind.
and to support this call visit our website at:
www.movement-of-life.org
80 81

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Victory

Victory Over Cancer!

© 2012 by Dr. Matthias Rath and Dr. Aleksandra Niedzwiecki.

ISBN 978-90-76332-76-5 – Part 1 –

Tel.: 0031-457-111 222

Dr. Matthias Rath

Chapter III . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109

“We will live to see a time when we no longer

This book documents this discovery.

A breakthrough of this nature leads the pioneering scientists on a

This book is the report of the pioneering scientists.

One author, Dr. Matthias Rath, was privileged to contribute the

‘Victory Over Cancer’ is not an achievement that is given to us,

This time is now.

The fact that the essential role of micronutrients in controlling

Diseases in general have been exploited by the pharmaceutical

The significance of this breakthrough for human health can per-

This book will empower millions of people to take actions toward

This book will break mankind’s psychological dependency on the

Santa Clara, California,

Matthias Rath and Aleksandra Niedzwiecki

Above: A copy of our announcement about the breakthrough in the

B. In North America and Europe, 5.6 million people

Reference: WHO Mortality Statistics for 2008

The Dimension of the Cancer Epidemic Visualising the Dimension:

Translating the Global Scope of the

• Nottingham + Leicester + Sunderland + 24 other cities of this size

• Stoke-on-Trent + Wolverhampton + 29 other cities of this size

• Belfast + Newcastle upon Tyne + 26 other cities of this size

• Brighton + Hull + Plymouth + 28 other cities of this size

• If a disease still increases, it means that the mechanisms for its

Cancer Patient Age 50 - 59

Statistics for USA; data for developed countries are comparable.

To make things worse, chemotherapy affects particularly those

Even a lay person can understand that if medicine has to resort to

Any ‘shotgun’ approach to a disease reflects the desperation on

Both radiation and chemotherapy kill cancer cells and – at

Besides these derivatives of mustard gas, there are several other

The toxicity of chemotherapy is also reflected in the ‘safety pre-

Entire companies flourish on the sales of protective gear and

Damaging Side Effects of Chemotherapy

To apply these substances to the cancer patient, nevertheless, a

• Destruction of the bone - Vision and hearing impairment

• Organ damage • Triggering the growth of new can-

Why Cancer Patients Voluntarily Subject The Psychological War

Fact # 6: Many Widely Used Prescription

mone replacement therapy.’

Fact # 7: Biological Regulation Instead of

The 20th Century will go into history as a deadlock in the

The prevailing therapeutic approaches to this disease by

The statistics prove that this approach of ‘intoxication’ was a

Once that is accomplished, cancer can largely be eliminat-

“Doctor, how long?”

In the next chapters

You will realise that

The picture was taken at the Dr. Rath Research Institute.

Chapter Introduction by Dr. Rath

Immediately after this publication, ‘collagen-digestion’ took a

The race failed – or so they say. It is easy for drug companies to

For full text, see Appendix

• These ‘biological scissor’ enzymes are not confined to cancer

Let’s have a first look at a cancer cell ‘Biological Scissors’ Enzymes

Cancer cells do not produce these destructive enzymes just for a