MAY AIIMS 2019 Solved

NB:-Few doubts are there as I m not getting the options correctlyKindly help me.

1 .A person starts eating raw egg for protein.He used develop fatigue on moderate exercise .The
doctor prescribes a vitamin .Which enzyme is deficient in him?

A. Pyruvate Carboxylase
B. PEPCK
C. Glucose 6 Phosphatase
D. Glycogen Phosphorylase

2. Which does not happen from 5’ to 3’ direction?

A. DNA Relication
B. DNA Repair
C. RNA Editing
D. Transcription

3. The estimation of thiamine status is done by

A. RBC Transketolase
B. RBC Glutathione reductase
C. Serum Thiamine
D. RBC Glutathione Peroxidase

4. Insulin structure image

Which of the following doesn’t cause error in insulin formation?

A. Breaking disulphide linkages

B. Interchange of A1 & A4
C. Interchange of B29 and B 30
D. Interchange of A 5 & A6
 Intra chain disulphide bond is A 6-A 11
 Interchain disulphide bonds are A7- B7 & A 20 –B19
 Species variation confined only to A 8,9,10 & B30
 So anything which don’t involve any of these would be less error So I took A1 to A4 to the
best of my knowledge

5. Assertion:According to central dogma DNA………>RNA………………>Proteins

Reason:Reverse of central dogma in retro virus ie Reverse Transcriptase convert

RNA………>DNA………..>RNA………>Proteins

A. Assertion is True Reason is true Reason is the correct explanation for assertion
B. Assertion is true Reason is True but assertion is not the correct explanation for assertion
 C. Assertion is True Reason is false
D. Assertion is False Reason is False

6.Type of mutation in sickle cell anaemia

A. Insertion
B. Deletion
C. Point mutation
D. ?

7.Which of the following TCA cycle intermediate is a part of heme metabolism?

A. Alpha ketoglutarate
B. Fumarate
C. Succinyl CoA
D. Malate

8. The graph shown below is the titration curve of a biochemical compound. Which of the following statementistrue?
(AIIMS May2016)

a. The maximum buffering capacity of the compound is represented by points A and B

b. The points A and B represent the range of maximum ionisation of the amine and carboxyl group
c. The compound has three ionisable side chains
d. The compound has one ionisable group

9. Which of the following regarding ?reducing activation energy is? false

A. Entropy is lowered
B. Desolvation of active site
C. Conformational change in the active site of enzyme at the time of binding/?after the
binding of substrate to enzyme
D. Complementarity of active site of enzyme and substrate

Answer depends on correct recalled options and qn

Factors that reduce activation energy

 1. Solvation of active active site
2. Conformational change in active site when the substrate binds( Koshlands induced fit
theory)
3. Complementarity between active site and substrate.( Fischers theory)
4. Negative free energy (∆G is negative)
∆G=∆H-T∆S where G is Gibbs Free energy.H is enthalpy ,S is entropy and T is Temperature
5. Entropy increase(∆G=∆H-T∆S hence ∆S should be high as ∆G can be negative,)

10 Kcat/Km measured in vivo???? Qn not getting from recall kindly help

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