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Advisory Board (SAB) was unable to In March, the SAB wrote that al- quate scientific data demonstrating
reach a consensus on whether though there is “compelling evi- similar modes of action in humans
2,3,7,8–tetrachlorodibenzo-p-dioxin dence of carcinogenicity in and laboratory animals, according
(TCDD) is a human carcinogen. laboratory animals for TCDD,” the to the SAB draft.
Downloaded via 110.54.234.212 on March 14, 2019 at 14:01:35 (UTC).
This lack of consensus leaves EPA same is not true for humans. But several panel members
policy makers back where they The reason? “There is a lack of strongly support EPA’s conclusion
started, as the U.S. government consensus” in the panel over that TCDD is carcinogenic, saying
struggles to reach agreement on the whether TCDD meets current EPA there was a “broad consensus” on
seriousness of dioxin exposure to
human health.
The board was reviewing EPA’s Perfluorinated compounds linked to carcinogenicity in vitro
reassessment of dioxin and related
Michigan State University (MSU) re- the carbon–hydrogen bonds are re-
compounds, a revised document
searchers have found that perfluoro- placed by carbon–fluorine bonds
officially released by EPA last June.
octane sulfonate (PFOS) and several (Environ. Sci. Technol. 2001,35 (7)
The report was the subject of major
other perfluorinated compounds act on 154A–160A). Hu finds that the inhibitory
news coverage then, because it
cells in a way that has been linked to effect on intercellular communication
characterized TCDD as a human
the carcinogenicity of several environ- is determined by the length of the fluo-
carcinogen,
mental contaminants. rinated carbon chain, not the function-
Cl O Cl adding that
In a series of in vitro experiments al group. This result is consistent with
other dioxins
using cell lines from dolphins and rats, a 1998 study of other perfluorinated
and some
O Wenyue Hu and colleagues found that compounds (Int. J. Cancer 1998,78 (4),
Cl Cl dioxin-like
a group of perfluorinated compounds 491–495).
compounds are
inhibit gap junction intercellular com- The MSU scientists, in collaboration
likely human
TCDD isthe most munication. Gap junctions are protein with the U.S. EPA are now performing
toxic dioxin isomer. carcinogens. channels that pass chemicals between in vivo studies to verify the in vitro
The cancer risk
cells to coordinate normal growth and studies.
for people exposed to these chemi-
function. Inhibiting this function can —REBECCA RENNER
cals ranges from 1 in 100 to 1 in
promote tumor development. Hu is ex-
1000, EPA wrote.
pected to report the findings at this APRIL 1, 2001
ENVIRONMENTAL
EPA’s conclusion on TCDD is in
month’s Society of Environmental
agreement with both the World
Toxicology and Chemistry European
Health Organization’s International
Agency for Research on Cancer
meeting in Madrid, Spain.
In March, MSU researchers
Scıence Tec nology & h
http://pubs.acs.org/est
180 A I ENVIRONMENTAL SCIENCE & TECHNOLOGY / MAY 1, 2001 © 2001 American Chemical Society
TCDD among the panel members
expressed during its last meeting in
dropped by 80% from 1987 to 1995,
largely because of EPA regulations,
Government Watch
November 2000. The report from says David Cleverly, in EPA’s Office
that meeting does not reflect that of Research and Development. Global action on POPs
consensus, Clapp says. Seventy-five percent of those emis- A treaty that could ultimately elimi-
“If [EPA] were to release it today, sions were curtailed from munici- nate or at least minimize the use of
we would be agreeing to disagree,” pal, medical and cement kiln persistent organic pollutants (POPs)
says Dennis Paustenbach, SAB incinerators, and secondary around the world will be formally
member and vice president of smelter metal operations. Some of adopted this month in Stockholm,
Exponent, Inc. “But if they incorpo- the identified unregulated sources Sweden. When at least 50 govern-
rated our changes, we would just are backyard burners, residential ments have ratified it, a process
say there is inadequate science to fireplaces, and agricultural and for- that could take several years, the
refine it any further.” est fires. treaty will enter into force.
“This is largely more about poli- The SAB’s Executive Committee, The treaty was finalized in Jo-
tics than it is about science,” asserts which comprises the chairs of each hannesburg, South Africa, last
Kip Howlett, executive director of subcommittee, was scheduled to December by representatives from
the Chlorine Chemistry Council. meet late May to review the docu- 122 countries at a negotiating ses-
Howlett and those who disagree ment, which it was expected to ap- sion organized by the United Nations
with EPA’s characterization of TCDD prove. “It’s not unknown for the Environment Programme.
say that IARC acknowledged that Executive Committee to suggest im- Initially, measures will apply to
the epidemiological data were in- provements to [a] report, although a list of 12 chemicals. Production
sufficient to support a human car- it is rare,” says EPA’s Sam Rondberg, of most will be banned immediate-
cinogen classification, but went who is overseeing revisions to the ly; however, an exemption is in-
ahead and issued that determina- SAB document. “I don’t think that is cluded for DDT in some countries.
tion anyway. going to happen with dioxin,” he Continued use of PCBs in existing
“What [the IARC] did is not un- adds. And although EPA is not legal- equipment such as electrical
like what the EPA staff did in this ly bound to incorporate SAB’s cri- transformers will be allowed until
reassessment document, and that tique into its reassessment, it might 2025, provided the equipment is
is to rely on mode of action data to be hard pressed to ignore it, Rond- free of leaks.
characterize the risk of cancer from berg notes. “The outside world gen-
dioxin exposure,” Howlett says. erally pays a lot of attention to what
Both IARC and EPA based their we say.” For a copy of SAB’s “Draft Canada’s ozone plan
classification on toxicological data, Report, Review of Revised Sections
a decision Howlett called “too con- of ORD’s Reassessment of Dioxin, Environmentalists charge that
servative”. March 12, 2001”, go to www.epa. Canada is unlikely to meet the com-
At the same time, total dioxin gov/sab/drrep.htm. mitments of the Canada–U.S. Ozone
releases to the environment have —CATHERINE M. COONEY Annex announced on February 19,
because of the lack of a coherent
plan and opposition from the
province of Ontario.
CDC holds back detailed national exposure data Signed in December 2000, the
Annex commits both countries to re-
Public health scientists welcome 2002, according to a CDC spokes- duce smog-forming nitrogen oxides
the publication of the first person. (NOx ) and volatile organic com-
National Report on Human The publication, released on pounds by 43% by 2010 during the
Exposure to Environmental March 21, summarizes results from summer ozone season in Ontario,
Chemicals with open arms. But the first nationwide study to directly Quebec, Atlantic Canada, and 18
researchers, who can’t wait to get measure a wide range of chemicals U.S. states (Environ. Sci. Technol.
their hands on the raw data, will and biomarkers in humans. In 1999, 2000,34 (21), 453A). To meet this
have to sit on them. Thanks to CDC scientists traveled across the goal, Canada’s $77 million plan
“limitations in the data,” the U.S. United States in a convoy of three would match U.S. emission stan-
Centers for Disease Control and tractor-trailers to sample blood and
Prevention (CDC) won’t be releas- urine from 3800 children and adults Continued on Page 183A
ing the raw data until the fall of representative of the U.S. popula-
CDC
three years’ worth of formation about organophosphate
data before releasing it pesticide exposures is likely to be
to the public. This particularly challenging, Portier
means that the data says. This is because none of the
from 1999 to 2001 will six metabolites is unique to just
not be available until one pesticide. They come from 18
the fall of 2002. different pesticides. “We’ve tried it
Christopher Portier, before. You need to make adjust-
head of the National ments and assumptions. It’s tricky,”
Institutes of Environ- he says.
CDC’smobile labshitthe road to examine the blood and
urine ofthousandsofAmericans. mental Health Sci- Although he’s itching to see the
ences, is one of the raw data, Portier says that publish-
researchers keen to see ing the summary report first is a
3800 people, limits the accuracy the raw data. Portier wants to es- good strategy. “It feeds the debate
with which it reflects the entire tablish a multiagency data interpre- about how to analyze and interpret
population, according to report tation group. He is also currently the data. Everybody who is inter-
coauthor Jim Pirkle of CDC’s trying to interpret phthalate expo- ested has a chance to get involved,
Environmental Laboratory in sures based on a much smaller and that makes for a better result
Atlanta, GA. In addition, analyses study published last year (Environ. in the end,” he says. —REBECCA
of most contaminants were con- Sci. Technol. 2000, 34 (21), 451A). RENNER
ducted on smaller subsamples,
from more than 3000 for lead and
cadmium, down to 700 for some
other substances. For 1999, the
Joint Global Change Research Institute
CDC convoy traveled to 12 loca- College Park, MD, will soon become the home of a new institute that will bring togeth-
tions. The year 2000 study sampled er some of the world’s leading researchers to explore the scientific, social, and eco-
about 5000 people from 15 loca- nomic aspects of global climate change. Taking advantage of what researchers say are
tions and added 24 new chemicals, synergies and similar research interests, the University of Maryland and Pacific
including arsenic. Northwest National Laboratory (PNNL) will team up to create the Joint Global Change
Compared with previously mea- Research Institute.
sured cotinine and lead levels, the In late summer, some 25 PNNL climate change researchers with expertise in ener-
results offer good news. Lower gy conservation and the interactions between climate, energy, economics, and the en-
blood cotinine levels show that vironment, will relocate from Washington, DC, to nearby College Park, where they will
nonsmoker’s exposure to cigarette join some of Maryland’s top faculty and research scientists in economics, public poli-
smoke has plummeted to one- cy, earth and environmental sciences, engineering, and social sciences.
fourth of 1991 exposures. Blood “This promises to be a major science collaboration to explore climate change and
lead levels in children also contin- its impact on energy, the environment, and society,” says Gerald M. Stokes, a former
ue to decrease. PNNL associate laboratory director, who will head the new institute. William Destler, vice
The report’s first look at mer- president for research and dean of the University of Maryland’s graduate school, views
cury exposure across the nation the new institute as an opportunity to attract scholars from around the world as visit-
revealed that levels in children ing faculty. “The two institutions are already bonding faculty, students, and lab re-
were lower than expected and searchers through research projects and student research advisory committees, and
well below federal limits. But for we expect our collaborations to grow quickly,” he says. —BRITT E. ERICKSON
women of childbearing age, mer-
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