Pathophysiology

Predisposing Factors Precipitating factors

-Age (70 Years Old) -Diet
-Genetics -Sedentary Lifestyle

Insulin resistance

Exhaustion of beta
cells

Decrease insulin
production

Decrease
Decrease insulin absorption of Decrease
production glucose by the sell breakdown of fats

Cell Starvation

Stimulation of hunger via

hypothalamus

Hunger

Polyphagia
RAAS stimulation Hyperglycemia Increase LDL and
(RBS= 10.98 Cholesterol
mmmol)

Increase peripheral Decrease blood

vascular resistance viscosity

Hypertension
(140/90)

Ineffective tissue
Metabolic
perfusion Syndrome

Endothelial injury

Desquamation of endothelial
lining

Increase Permeability/adhesion
molecules

Lipids and Platelets accumulate in the area

LDL attracts monocytes and

macrophages
(Inflammatory Response)

Formation of Plaque

Reduced Coronary tissue perfusion

 Diminished Myocardial
Oxygenation

Anaerobic metabolism
Myocardial Ischaemia

Lactic Acid production

Decreases
Cardiac Output (Lactic Acidosis)

Decrease O2
supply in the body
Chest Pain

-Fatigue
-Difficulty in
Breathing

Partial
blockage

Unstable
Angina