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Rajiv Gandhi University of Health Sciences, Karnataka

IV Year B.Pharm Degree Examination - Jan 2014
Time: Three Hours Max. Marks: 70 Marks

PHARMACY PRACTICE – II (RS-3)

a. Pharmacokinetics and therapeutic Drug Monitoring

Q.P. CODE: 2623

Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks

1. Discuss the mono-exponential decline with the help of graphs and equations for a drug
administered as i.v. bolus following one compartment model.
2. Explain in detail protein binding, its kinetics and clinical significance.
3. Discuss the various methods that can be used for plasma/serum concentration measurement in
TDM.

SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks

4. What do you understand by a model? Give the differences between compartment and non-
compartment model.
5. Explain the factors affecting distribution.
6. Give the schematic diagram, graph and bi-exponential equation for a drug following two
compartment model.
7. Explain the need for adjusting the dose in patients with hepatic impairment.
8. Give the criteria for a valid TDM.
9. Explain briefly the TDM of carbamazepine.
10. Write a short note on physiological model.
11. Discuss the kinetics of drugs (metabolized) given as i.v. bolus following one compartment
model when urine samples are collected.

SHORT ANSWERS 10 x 2 = 20 Marks

12. Define TDM.
13. Explain the organization of a TDM service.
14. Define AUC and give the formula to calculate the same.
15. Give the schematic representation differentiating two compartment model from three
compartment model.
16. Write brief note on patient compliance.
17. What are the consequences of multiple dosing? Give the formula for accumulating index and
Css.
18. Give the relationship between clearance and volume of distribution.
19. How do you calculate absorption rate constant. Enumerate the methods.
20. What are the advantages of pharmacokinetic models? Explain.
21. Explain briefly the kinetics of a drug administered orally following one compartment model.
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