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P
rotein is reemerging as an important nutrient in
contemporary diet plans for improving weight
management. Whether the directives of current
approaches are as extreme as the Atkins diet or a more
subtle approach such as the Zone or South Beach plans,
protein has regained equal footing with carbohydrates.
For many health/fitness professionals, the reemergence of
this essential nutrient is a welcome change. Indeed, the vital
role of protein in the maintenance, repair, and synthesis
of skeletal muscle and other body tissues in physically active
men and women has long been known.
Protein as a Macronutrient
Proteins serve a number of structural (i.e., skeletal muscle)
and functional (i.e., enzymes) roles in the body. As a
macronutrient, protein is unique, given that it contains
essential amino acids that cannot be produced by the
body and must be consumed as part of the diet (Table 1).
Additionally, protein can be distinguished from
carbohydrate or fat, the other macronutrients, because
proteins are made from amino acids that contain nitrogen.
Whereas all three of the macronutrients can be used for
fuel by the body, this fate is the least preferable for protein.
Rather, amino acids, in general, and the essential amino
acids, in particular, should be used in the synthesis (growth),
repair, or maintenance of body proteins. These processes
are often referred to as protein turnover.
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protein needs may be higher initially, given the heightened individuals who routinely participate in endurance exercise
effect of resistance exercise on increasing skeletal muscle has been debated for several years. It is likely that significant
protein turnover. However, given that typical protein increases in protein needs (up to 1.6 g/[kg day]) apply
intakes for those who strength train is usually in excess only to ‘‘elite’’ endurance athletes exercising at high
of current recommendations, consuming adequate protein intensities for several hours a day (14). For people who
is likely not a concern unless they are restricting calorie engage in routine endurance exercise and have adequate
intake to lose weight. energy intake, the recommendations for protein intake
Much research has been done on the timing, (1.0 g/[kg day]) are not much greater than for
composition, and quantity of amino acids needed in nonexercisers (0.8 g/[kg day]) (14). Although evidence
relation to resistance exercise to optimize muscle protein exists that suggests people beginning an endurance
synthesis. Studies have found no difference in protein exercise program may have increased protein needs during
synthesis when amino acids are consumed before versus the initial few weeks (15), consumption of calories
1 hour after exercise, and no difference when amino sufficient to maintain energy balance during this time
acids are consumed at 1 hour versus 3 hours after exercise, will improve protein utilization in response to aerobic
providing individuals with some flexibility with timing training (12, 16).
of protein intake (9). Interestingly, when amino acids are
consumed at 1 hour and again at 3 hours after exercise (10), Considerations for Protein in Weight Management
there is an increase in synthesis after consumption of
Habitual reduction in energy intake for weight loss
amino acids at both time points, suggesting an added
has been shown to have a negative impact on protein
benefit to two small feedings after exercise. The amount
utilization because of the simultaneous slowing down of
of amino acids needed to elicit this anabolic effect is
metabolic processes (17). Typically, weight loss is associated
surprisingly small, with as little as 6 g of essential amino
with a reduction in both body fat and lean body (i.e.,
acids (in combination with 35 g of sucrose) eliciting an
muscle) mass, although the intent of diet interventions
increase in synthesis and resulting in a positive protein
remains the loss of fat and maintenance of muscle mass.
balance in muscle (9). Quality, and not quantity, of
Recent reports by Donald K. Layman, Ph.D., et al (18, 19)
protein is an important concept, with studies showing
have demonstrated that consumption of reduced calorie
that nonessential amino acids are not necessary to increase
diets for which protein provides a greater percentage of
protein synthesis (11); rather, provision of adequate
calorie intake than conventional weight loss diet plans
amounts of essential amino acids is important to
(i.e., 30% vs. ~15%, respectively) is associated with better
maximize protein utilization in response to routine
maintenance of muscle mass during weight loss. When
resistance exercise.
exercise is added to a weight loss program that uses a
higher-protein diet intervention, reductions in body fat and
The Role of Protein in Endurance Exercise
sparing of muscle mass is even greater (19). These studies
The impact that endurance exercise has on protein
encourage integration of exercise programs with nutrition
turnover is far less studied than resistance exercise. Protein
plans that provide a higher amount of dietary energy
has typically not been considered to play a major role in
in the form of protein for weight management.
the diets of endurance athletes because carbohydrates and fat
are the primary fuel sources during endurance exercise and
because muscle hypertrophy is not typically observed with Summary and Recommendations
endurance training. However, protein metabolism is Protein is essential to the diets of healthy, physically
affected by endurance exercise, especially when either energy active men and women. The essential amino acids
intake or carbohydrate intake is inadequate (12, 13). provided by high-quality proteins are important to
During exercise, it is generally thought that protein synthesis maximize rates of protein synthesis and to optimize protein
is decreased and breakdown is either increased or not utilization in response to habitual participation in resistance
different from rest. After exercise, rates of protein training and endurance exercise. The role of energy balance
synthesis are restored. should not be overlooked. Clearly, anabolic processes
At rest, the use of amino acids for energy is very low. (i.e., tissue building) require energy. Therefore, attention
During aerobic exercise, however, amino acid oxidation should be given to sufficient consumption of calories for
for energy to support muscular work increases, especially either weight maintenance or increases in muscle mass if
with increasing intensity, duration, and low glycogen amino acids are to be directed to synthetic (i.e., anabolic)
stores. Whether this increases the protein requirements for rather than catabolic processes. When negative energy
16 ACSM’S HEALTH & FITNESS JOURNALA MARCH/APRIL 2007 VOL. 11, NO. 2
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balance is intended for the purpose of weight loss, a 8. Phillips, S.M. Protein requirements and supplementation in strength
sports. Nutrition 20:689–695, 2004.
small amount of additional protein in the diet is likely
beneficial to maintenance of lean body mass. 9. Rasmussen, B.B., K.D. Tipton, S.L. Miller, et al. An oral essential
amino acid-carbohydrate supplement enhances muscle protein
anabolism after resistance exercise. Journal of Applied Physiology
88:386–392, 2000.
Nancy Rodriguez, Ph.D., R.D., FACSM, 10. Tipton, K.D., E. Borsheim, S.E. Wolf, et al. Acute response of net
is an associate professor of Nutritional muscle protein balance reflects 24-h balance after exercise and amino
Sciences with joint appointments in acid ingestion. American Journal of Physiology, Endocrinology and
Metabolism 284:E76–E89, 2003.
Kinesiology and Allied Health Sciences at
the University of Connecticut. She also 11. Tipton, K.D., B.E. Gurkin, S. Matin, et al. Nonessential amino acids
are not necessary to stimulate net muscle protein synthesis in healthy
is director of the Sports Nutrition Program volunteers. The Journal of Nutritional Biochemistry 10:89–95, 1999.
at the University. Her research focuses on
12. Todd, K.S., G.E. Butterfield, and D.H. Calloway. Nitrogen balance
the relationships between protein intake, exercise, and protein in men with adequate and deficient energy intake at three levels of work.
utilization in children, athletes, and healthy adults. The Journal of Nutrition 114:2107–2118, 1984.
13. Lemon, P., J. Berardi, and E. Noreen. The role of protein and amino
acid supplements in the athlete’s diet: does type or timing of ingestion
P. Courtney Gaine, Ph.D., R.D., matter? Current Sports Medicine Reports 4:214–221, 2002.
is a postdoctoral research fellow in the 14. Tarnopolsky, M. Protein requirements for endurance athletes.
Department of Nutritional Sciences at Nutrition 20:662–668, 2004.
the University of Connecticut. Her research 15. Gontzea, I., P. Sutzescu, and S. Dumitrache. The influence of
is directed at characterization of cellular adaptation to physical effort on nitrogen balance in man. Nutrition
Report International 11:231–236, 1975.
proteins involved in the regulation of skeletal
muscle protein utilization and gender-specific 16. Pikosky, M.A., P.C. Gaine, W.F. Martin, et al. Aerobic exercise training
increases skeletal muscle protein turnover in healthy adults at rest.
responses to diet and exercise interventions with particular The Journal of Nutrition 136:379–383, 2006.
regard for protein metabolism.
17. Stein, T.P., W.V. Rumpler, M.J. Leskiw, et al. Effect of reduced
dietary intake on energy expenditure, protein turnover, and glucose
cycling in man. Metabolism 40:478–483, 1991.
References 18. Layman, D.K., D.J. Erickson, J.E. Painter, et al. A reduced ratio
1. Mahoney, D.J., G. Parise, and M.A. Tarnopolsky. Nutritional and of dietary carbohydrate to protein improves body composition and
exercise-based therapies in the treatment of mitochondrial disease. blood lipid profiles during weight loss in adult women. The Journal
Current Opinion in Clinical Nutrition and Metabolic Care of Nutrition 133:411–417, 2003.
5:619–629, 2002. 19. Layman, D.K., D.J. Erickson, H. Shiue, et al. Increased dietary
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protein and energy. Journal of Nutrition 105:914–923, 1975. during weight loss. The Journal of Nutrition 133:405–410, 2003.
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