Effect of Chromium Supplementation

on Fasting blood glucose, Postprandial Glucose and A1C levels in T2DM

A Systematic Literature Review of Randomized Controlled Trials
Study Population Interventions Outcomes
Free-Living Adults ≥40 years old RCT 1: 100 mcg/day Cr yeast for 2 In 2 studies 42-200 mcg
weeks, then 200 mcg for 6 weeks chromium brewer’s yeast
RCT 2: 42 mcg/day Cr yeast for 3 months significantly improved FPG and
RCT 3: 1000 mcg/day Cr for 6 months A1C levels over 2-3 months
RCT 4: 600 mcg/day CrPic for 4 months
In 1 study 1000 mcg of Cr for 6
Comparison: Placebo months showed inconsistent
With T2DM effects on glycemic control
PLACEBO
In 1 study 600 mcg chromium
picolinate over 4 months
Study Periods showed an improvement in
4 RCT’s in 4 countries (n=259) 6 weeks - 6 months FPG, PPG and A1C
Slovak Republic, India, USA, Brazil

Racek, J., Sindberg, C.D., Moesgaard, S. et al. Biol Trace Elem Res (2013) 155: 1. Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. J Trace Elem Med Biol. A Systematic Review
2011;25(3):149-153. Cefalu WT, Rood J, Pinsonat P, et al. Metab. 2010;59(5):755-762. Paiva AN, Lima JGd, Medeiros, Anna C. Q. de, et al. J Trace Elem Med Biol. 2015;32:66-72. by Annie Lin, APN 760