Professional Documents
Culture Documents
Michael Frank
Page 1
Better helping you solve your problems
My boss will never
y
They want shorter turnaround
h h d
approve an UHPLC
times but cutting my staff...
system...
If the system fails again
I will have production Can‘t I get a higher
y
on my back all day!y resolution with
resolution with
How can I differentiate to
H I diff ti t t
my competitors? my HPLC?
We don‘t have time to We not even have the
get everybody trained to time to implement
a new system
a new system... improvements!
Page 2
The new Agilent 1200 Infinity Series
1220 Infinity
Infinitely more affordable
Page 3
The new Agilent 1200 Infinity Series
1200 Infinity
Series
new
Quaternary
Bio-Inert
new
Isocratic
Page 4
The new Agilent 1200 Infinity Series
Mostt affordable
M ff d bl Up tto 10
U 10x UV S
Sensitivity
iti it Highest
Hi h tP Performance
f
HPLC and RRLC 100% HPLC Compatible Highest Flexibility
Easy to use HPLC Price – RRLC Capability HPLC Service Costs
Page 5
The new Agilent 1200 Infinity Series
¾ All analytical
y columns
pressure
¾ Method Transfer
1200
¾ Higher Resolution
1000 ¾ Faster
F t Analysis
A l i
400
1260 IInfinity
fi it Bi
Binary LC
200 1260 Infinity Quat./Iso LC
1220 Infinity LC
0
0 2 4 6 8 10 flow
Page 6
1260 Quaternary LC and 1220 Gradient LC
RRLC Performance for EVERY LAB!
Conventional
4.6x150, 5µm
Resolution peak 5 = 4.20
Run time 11 min
0 2 4 6 8 10 min
Resolution optimized
3.0x100mm, 1.8µm
Resolution peak 5 = 7.16
Run time 7 min
0 2 4 6 8 10 min
0 2 4 6 8 10 min
Page 7
NEW: 1220 Infinity LC
Isocratic and Gradient RRLC at most affordable Price
Most affordable access to 1260 Infinity Quality & Performance
• Available flavors:
• 1220 Infinity manual isocratic system
• 1220 Infinity manual binary gradient system
• 1220 Infinity automated binary gradient system
• Productivity: 10x higher than conventional HPLC systems
• 600 bar up to 5 mL/min (10 mL/min at 200 bar) and 80 Hz data rate
• Technology and Quality: 1260 and 1290 Infinity inside!
• Degassing
D i unit:
it Same
S P t as 1260 Q
Parts Quat/1290
t/1290 Bi
Bin degassing
d i unit
it
• Pump: Same Parts/Design as 1260 Quat Pump (limited to two channels)
• Autosampler: Same Parts/Design as 1260 ALS (no Cooling)
• VWD: Same Parts/Design as 1260/1290 VWD
• Price: significantly lower than 1260 Infinity Isocratic / Quaternary
Systems!
Page 8
NEW: 1260 Quaternary LC System
Enhanced Quaternary RRLC at Quaternary HPLC Price
* ) 60,000
systems sold!
Page 9
NEW: 1260 Binary LC System
Enhanced Binary RRLC Capability at HPLC Price
Page 10
1290 Infinity LC
More Affordable Access to the World‘s
World s Best LC
Page 11
How could they reduce all the prices?
There must be a trick!
600 bar as
Actually
Act all there is a trick
trick: standard
Less
modules
Cost
All cost savings were
Less
savings
transferred directly to storage
the product! space/logi L
Less t
set-
stics up times
in
production
Less
That is, to you! parts -
better
prices
Page 12
Method Transferability – how is this possible?
Run Method and Get Same Result?
1220
Infinity
1200
Series
1260
? Infinity
1100
Series
1290
Infinity
Page 13
What is required for seamless Method Transfer?
Either comparable
p systems...
y
Page 14
Method Transferability: 1260 Quat / 1220 Grad
100% HPLC Methods Compatibility – Riskless Replacement
Page 15
Method Transferability: 1290 Infinity LC
...or a superior LC
LC-system
system like the 1290 Infinity LC
%B
time
Page 16
Method Transferability: 1290 Infinity LC
System Emulation Technology (available 2011)
2011)*
Concept
p
Emulated
FA System A
1100/1200 Series
Quat Pump
1290 Infinity
+ 900 µL hold
Page 18
NEW: Instrument Control Framework (ICF)
The Ultimate 3rd Party Connectivity Solution
3rd
3 d party
t SW provider
id Pump
RC.net
driver Sampler
RC.net
driver
3rd party New Agilent
adapter
ICF
CDS
Col.Comp.
RC.net
Detector driver
RC.net
driver
• g
Agilent pp and specified
developped p the ICF
• Agilent provides RC.net drivers for its LC-modules
• Agilent provided ICF for free to 3rd party CDS provider
• 3rd party CDS provider only needs to implement the ICF into their software
Page 19
NEW: Instrument Control Framework
The Ultimate 3rd Party Connectivity Solution
Page 20
NEW 1200 Infinity Series
More workflow-automation and application-based solutions
New New
Analytical
y Bio-inert Nano LC Preparative
p GPC Isocratic
SFC HPLC & Cap LC LC & LC/MS SEC LC
New
Page 22
Summary
Page 23
Appendix
Page 24
Where to find more information?
Web-sites: www.agilent.com/chem/infinity
Online System Configurator: www.agilent.com/chem/1200configurator
Agilent LC Expert eSeminar Series: www.agilent.com/chem/LC-eSeminars
Overview Brochure
Selection Guide
System Brochures
Page 25
NEW: 1260 Infinity Diode Array Detector
10x higher Sensitivity for lower Price
Page 26
NEW 1260 Infinity Bio-inert HPLC
Infinitely Better for Bio-molecule Analysis
100% Bio-inert
• Metal-free sample flow path (instrument and column)
• Stainless steel–free solvent flow path
• Widest pH range (1-13, short-term 14)
10x sensitivity and 600bar power range
• Lowest LOD and highest resolution per time
• From lowest pressure up to highest pressure STM columns
• Unique resolution for protein applications
Bio-analysis
Bio analysis and Bio
Bio-purification
purification
• Analytical flow and semi-prep fraction coll. up to 10 mL/min
Most complete offering for NBE Characterization
• Therapeutic protein analysis using SEC, IEX, peptide mapping
Page 27
NEW 1260 Infinity Bio-inert HPLC
Infinitely Better for Bio-molecule Analysis
Resulting in
• Highest salt tolerance
• Lowest surface interaction
• Widest pH-range (1-13, short-term 14)
Page 28
NEW 1260 Infinity Analytical SFC System
Infinitely Better for Supercritical Fluid Chromatography
Lowest Operating
p g Cost, Green Chemistry
y
• 10-15x lower operating costs by compatibility with
standard grade CO2 instead of liquid SFC grade CO2
• Lowest solvent consumption and waste generation
Page 29