Time: 2.00 hrs M.M.

100
Q.1-In the ICTEURUS INDEX-
(a) Intensities of red color of dilute serum compared with very dilute solution of KMnO 4
(b) Intensities of yellow color of dilute serum compared with very dilute solution of KMnO 4
(c) Intensities of yellow color of dilute serum compared with very dilute solution of K2Cr2O7
(d) Intensities of red color of dilute serum compared with very dilute solution of K2Cr2O7
Q.2.Which of the following test used for the bilurubin
(a)Huppert –cole test (b)Rose Bengal dye test (c)Harrison test (d)Both a&c
Q.3.If the glomerular filtrate rate=inulin and PAH=renal plasma flow and GFR is 125
&RPF is 700.what will be the filtration fraction-
(a)16 % (b)18% (c)20% (d)24%
Q.4.The correct formula for inuline clearance is/are-
(a)UV/P (b)UP/V (c)VP/U (d)All
Q.5.The low inuline clearance indicates-
(a)High renal blood flow (b)Decrease in effective GF pressure (c)Decrease in
the no of functioning glomeruli (d)b & c
Q.6.Which of the following statement is true about the Hanger test-
(a)Also called cephalin-cholesterol flocculation test
(b)Used for the detaction of abnormal amount of protein fraction
(c)Positive test indicates ↑ amount of gama globulin
(d)All statement are true
Q.7.Which of the following statement is true-
(a)Determination of pKa performed by spectral shift or visible spectroscopy
(b)Unionized form is greatly absorbed than the ionized form
(c)Drug with low pKa value,unionized form is present in the stomach but ionized in the intestine
(d)All
Q.8.Flavouring agent which is used in the formulation of oral liquids,gives the bitter test-
(a)Apricot (b)Liquorice (c)Mint (d)Vanilla
Q.9.BHT is an antioxidant functioning as-
(a)Reducing agent (b)Blocking agent (c)Synergestic (d)Chelates
Q.10.Which statement is false about the ASPARTAME
(a)200 times more sweet than sucrose
(b)No bitter after test
(c)High water solubility and stable at wide pH range
(d)Not recomonded for the pregnant or lacting woman
Q.11.Sterile water for injection is-
(a)Not contain any antmicrobial agent (b)Must be pyrogen free
(c)Filled in single dose container (d)All statement are true
Q.12.Most commonly used non aquous vehicle for sterile product is
(a)Corn oil (b)Almond oil (c)Peanut oil (d)Sesame oil
Q.13.Function of tonocity modifier for the parenterals-
(a)Minimize tissue damaze and ↓ irritation (b)↓hemolysis of blood cells
(c)Prevent electrolyte imbalance (d)All
Q.14. Surfactants which have the HLB value from 13 to 16 acts as-
(a)Solublizing agents (b)Detergents (c)Wetting agents (d)Anti foaming agent
Q.15.Polyoxyethylene sorbiton is the example of a surfactant which is-
(a)Non ionic (b)Cationic (c)Anionic (d)Amholytic
Q.16.Which of the following statement is true about the MC-
(a)Soluble in hot water but insoluble in cold water
(b)Soluble in cold water but insoluble in hot water
(c)Insoluble in all conditions
(d)Highly soluble in organic solvents
Q.17.For the preparation of W/O/W type multiple emulsion,the correct scheme of the
addition of emulsifiers-
(a)Span→tween (b)Tween→span
( c)Both scheme are follow (d)No emulsifier is added
Q.18.Plastcizer for the manicure preparation is-
(a)Caster oil (b)Cellulose nitrate (c)Butyl lactate (d)No plasticizer used
Q.19.In the preparation of liposome,material which leads to rigidity is-
(a)Cholesterol (b)Phosoholipid (c)Both (d)Any polymer
Q.20.Matarial which is most commonly used for the enteric coating of tablets-
(a)PVP (b)CAP (c)Acrylates (d)Accacia
Q.21.If the drug is mois sensitive,binding agent utilize in this condition-
(a)CMC (b)Gelatin (c)HPMC (d)Starch paste
Q.22.Titanium di oxide used in the capsule coat as -
(a)Presrevatives (b)Plasticizer (c)Opacifier (d)Inhance chewability
Q.23.Coating material which is water insoluble used in the microencapsulation-
(a)PVP (b)Polymethacrylate (c)CAP (d)PVA
Q.24.Chitosan is a
(a)Natural phospholipid (b) Natural polysachharide (c) Natural peptide (d)Synthetic hormone
Q.25.DMSO function as-
(a)An emulsifying agent(b)A suspending agent(c)A preservative(d)A penetration enhancer
Q.26 G- protein coupled receptors (GPCRs) are the-
(a) Type -1 receptor (b) Metabotropic receptor (c) Inotropic receptor (d) none
Q.27 .Drug targets are except-
(a) Enzyme (b) Receptor (c) Transportors (d) None
Q.28 In G- protein structure unit responsible for GTPase activity-
(a) α unit (b) β unit (c) αβ units (d) βγ- units
Q.29 Receptor gives response in milliseconds is-
(a) Inotropic & Metabotropic receptor (b) Type 1 (c) Both (d) Nuclear Receptor
Q.30 GPCRS Agonist & G- protein bind WITH respectively-
(a) Extracellular loops & cytosolic loope (b) cytosolic loope & Extracellular loops
(c) Intracellular loop & Extracellular loops (d) C- Domains & N- Domains
Q.31. Toxin which prolong the activated state of G-protein receptors-
(a) Tereodo toxin (b)Pertussis toxin (c) Cholera toxin (d) All
Q.32 Above toxin show these effect by-
(a) Prevention of dissociation of G-protien subunits (b) Prevent the G- protein coupling
(c) block GTPase activity (d) None
Q.33 Agonist pleotropy shown by the-
(a) M- Receptor (b) D2- Receptor (c) GABAB - Receptor (d) all
Q.34 All are GPCRS EXCEPT-
(a) 5-HT3- Receptor (b) PGS - Receptor (c) Chemokine – Receptor (d) Opiod- Receptor
Q.35 cAMP pathway starts with the-
(a) Activation of adenyl cyclase (b) Activation of protein kinase
(c) Exchange of GDP with GTP in α – Units of G-protein
(d) Exchange of ATP with ADP in α – Units of G-protein
Q.36 Receptor which have Monometric structure-
(a)GPCRS (b) Nuclear receptor (c) Inotropic receptor (d) A&B
Q.37 Effettor pathway followed by the GPCRS-
(a) cAMP pathway (b) Phospholipase –C Pathway (c) Phospholipase –A Pathway (d) All
Q.38 Blood Glycogen rises when-
(a) cAMP increases (b) cAMP increases (c) IP3/ DAG increase (d) A&C
Q.39 Picrotoxin agonist for the -
(a) Voltage gatted Ca++ channel (b) Voltage gatted Na+ channel
(c) Nicotinic receptor (d)GABA gatted Cl- channel
Q.40 How many molecules of acetylcholine bind to the one nicotinic receptor-
(a) 1 (b) 2 (c) 3 (d) Not calculated
Q.41 Drug which produce opposite effect to agonist is called-
(a) Antagonist (b) Partial agonist (c) Invese agonist (d) Blocker
Q.42 Quantitative aspects of drug receptor interaction explained by the-
(a) Hill Langumir equation (b) Occupation theory (c) Two step receptor model (d) None
Q.43 Iproniazid is the-
(a) Antitubercular drug (b) MOA-A inhibitors (c) Anticancer drug (d) Antileprotic drug
Q.44 Occupation of receptor is governed by the-
(a) Affinity (b) Intrinsic activity (c) Confermation chages (d) all
Q.45 Intrinsic activity for DMCM is-
(a) 0----(-1) (b) 0-----(+1) (c) 0 (d) 1
Q.46 Correct sequence by which the drug work-
(a) Binding to receptor----- confermation change---- Transducer steps ----response
(b) Binding to receptor----- confermation change ----response---- Transducer steps
(c) Binding to receptor----- Transducer steps ----response--- confermation change
(d) Binding to receptor----- chemical change---- Transducer steps ----response
Q.47 Albumin is the -
(a) Silent receptor (b) nuclear receptor (c) Protien channel (d) A& C
Q.48 Choose incorrect statement when drug is given by oral route
(a) Slower action not suitable for emergency (b) Streptomycin is not absorbed by oral route
(c) Can not used for uncooperative patient (d) None
Q.49 Choose correct statement when drug is given by parentral route
(a) Parenteral route is invasive and painful (b) Chance of local tissue injury
(c) Gastric irritation are not provoked (d) All
Q.50 Levodopa and Methyl dopa are absorbed by the following mechanism
(a) Faciliated diffusion (b) Active transport (c) Filtration (d) Passive diffusion
Q.51 A patient take combination of aspirin and ciprofloxacin, during the testing of urine,
the urine was found alkaline, in this condition which drug is back diffuse in the kidney
tubules
(a) Aspirin (b) Ciprofioxacin (c) both (d) none
Q.52 Which factor does not affect the absorption of drug
(a) Aq. Solubility of drug(b) Concentration of the drug (c) Vascularity of absorption area (d) All
Q.53 Find the volume of distribution of drug if plasma concentration of drug is 50 Mg/L and
the totel drug in body is 100Mg
(a) 2L (b) 20ML (c) 2000ML (d) 50ML
Q.54 Which combination of drug mainly bind to the α 1 acid glycoprotein
(a) Phenytoin, penicillin (b) Losertan ,Sulfonamide
(c) Verapamil , methadone (d) Lignocain, Flurouracil
Q.55 Which drug produce active metabolite after metabolism
(a)Digitoxin (b) Levodopa (c) Sulindac (d) Fluorouracil
Q.56 Which of the following cytochrome enzyme responsible for the biotransformation of
large no. of drug
(a) CYP2D6 (b) CYP3A4/5 (c) CYP1A1/2 (d) CYP2C19
Q.57 Which of the following enzyme responsible for the conversion of the codeine to
morphine and this is inhibited by
(a) CYP2E1, Cispride (b) CYP2D6, Quinidine
(c) CYP2C19 ,Astemizole (d) CYP2C8/9 , Diltiazim
Q.58 Benzopyren found in cigratte smoke , which is responsible for the
(a) Inhibition of CYP1A isoenzyme (b) Inhibition of CYP3A isoenzyme
(c) Induction of CYP1A isoenzyme (d) Induction of CYP2B1 isoenzyme
Q.59 A doctor have prescribed paracetamol to the patient , but by mistak patient take
enzyme inducer with them, what would happened
(a) Increase intensity of response (b) Increase duration of action (c) Toxicity (d) both a & b
Q.60 Drug which is given only by other then oral route
(a) Isoprenaline (b) Lignocain (c) Phenobarbitone (d) Both a & b
Q.61 When drug follow first order kinetics what change will be occur in the
pharmacokinetic parameter
(a) Clereance decrease with increasing conc. (b) Rate of elimination remain constant
(c) Rate of elimination α drug concentration (d) Both a & b
Q.62 In which condition therapeutic drug monitoring is useful
(a) Drug with low safty margin (b) potentially toxic drug used in presence of reanl failure
(c) In case of poisoning (d) All
Q.63 In which condition therapeutic drug monitoring have not value
(a) Drug with irrerversible action (b) Drug activated in body
(c) Drug whose response is measurable (d) All
Q.64 Probenacid prolong the duration of action of penicillin and ampicilline by
(a) By reducing rate of metabolism (b) By increasing plasma protein binding
(c) By prolonging absorption from absorption site (d) By reducing rate of excretion
Q.65 Tachyphylaxis is shown by
(a) Ephedrine & Tyramine (b)Tyramine & nicotine (c) Nicotine &Atropine (d) Both a & b
Q.66 Which of the allergen reaction classified in the cell mediated type
(a) Type 1 (b) Type 4 (c) Type 3 (d) Type 2
Q.67 Find the incorrect statement about the photoallergic reaction
(a) Occur when exposure to light longer wave length 320 to 400 nm
(b) sulfonamide & Sulfonylurea gives these type reaction
(c) Occur when exposure to light short wave length 290 to 320 nm
(d) Chloroquine and chlorpromazine produce reaction
Q.68 Which of the following is not a „physian induced disease‟
(a) Peptic ulcer by salicyclate (b) Parkinsonism by phenobarbiton
(c)Hepatitis by isoniazid (d) none
Q.69 Which of the following is example of non competitive inhibitors
(a) Physostigmine (b) Allopurinol (c) Theophylline (d) Carbidopa
Q.70 Choose correct one for the non equilibrium type enzyme inhibition
(a) Km increase ,Vmax increase (b) Km constant , Vmax decrease
(c) Km decrease , Vmax constant (d) Km decrease ,Vmax increase
Q.71 Choose correct example for supra additive combination
(a) Acetylcholine & Physostigmine (b) Aspirin & paracetmol
(c) Ephedrine & Theophylline (d) Nitrous acid & Ether
Q.72 Drug which show therapeutic window phenomenon
(a) Imipramine (b) Glipizid (c) Clonidine (d) all
Q.73 Which one is most common mechanism for transport of the drug across the biological
membrane
(a) Carrier transport (b) Filtration (c) Pincocytosis (d) none
Q.74 Atropine, ephedrine & chloroquine is classified under the category of
(a) Strongly acidic (b) Weakly acidic (c) Weakly basic (d) Strongly basic
Q.75 Cytokine receptor is the
(a) Kinase Receptor (b) Nuclear receptor (c) G-protein receptor (d) None
Q.76. Which of the following statement about prokaryote are incorrect
(a) DNA is without protein sheath (b)Nuclear material present in cytoplasm
(c) Ribosome scattered in matrix (d) Nucleolus present in Nucleous
Q.77.All of the statement are true EXCEPT
(a) Degradation of protein take place in ribosome (b) Golgi complex participate in lysosome
formation
(c) Chromosome can be self reproduce (d) None
Q.78.Term “Ergastic” implies
(a) All living substance of plant metabolism (b) All Non -iving substance of plant
metabolism
(c) Reserve food material of plant (d) All of the above
Q.79.Which of the following cell organelle are absent in plant
(a) RER (b) Chromosome (c) Starch granule (d) Lysosome
Q.80.Which of the following is a water soluble polysaccharide
(a) Insulin (b) Starch (c) Inulin (d) Cellulose
Q.81.Biogenesis of Ribosomal Protein take place in
(a) Nucleus (b) Nucleolus (c) RER (d) b & c
Q.82.Latex obtained from lateciferous tissue is
(a) Suspension (b) Emulsion (c) Solution (d) None
Q.83.Nector a sugar solution is a
(a) Reserve Food (b) Excretory Product (c) Secretary Product (d) Metabolite
Q.84.Among from the following select the living supporting tissue
(a) Epidermis (b) Parenchyma (c) Schlerenchyma (d) Collenechyma
Q.85. Term Schizolysigenous implies
(a) Seperation of cell (b) Lysis of cell (c) Seperation lysis of cell (d) a & c
Q.86. Herbaceous woody stem is present in
(a) Gokhru (b) Gymnema (c) Ipomoea (d) Ephedra
Q.87. Fruits, like Rose, Straberry are modified form of
(a) Peduncle (b) Thalamus (c) Calyx (d) Receptale
Q.88.Adulteration implies debasement of an article it include
(a) Sophistication (b) Substitution (c) Spoilage (d) All of the above
Q.89. Quantitative microscopy is carried out by
(a) Leaf constant (b) Trichome (c) Stomata (d) Lycopodium spore method
Q.90. Diacytic /Caryophyllaceous/Cross celled stomata is a type of
(a) Moss type (b) Gymnospermous type (c) Gramineous type (d) Dicotyledonous type
Q.91.As per I.P. total no. type of stomata are
(a) Four type (b) Five type (c) Three type (d) b & c
Q.92. All of the following are classified as Biological assay method EXCEPT
(a) Toxic technique (b) Symptomatic technique (c) Tissue method (d) None
Q.93. In herbal drugs Afflatoxin is identified by
(a) GLC (b) TLC (c) Paper chromatography (d) None
Q.94. As per I.P. dried yeast should be free from
(a) Salmonella (b) E.coli (c) Both (d) None
Q.95. As per I.P. microbial limit, choose the odd one from the following
(a) Gelatin (b) Tragacanth (c) Starch (d) Gum acacia powder
Q.96.Tincture of Aloe-vera is estimated by
(a) HPTLC (b) TLC (c) GC (d) HPLC
Q.97. Evaluation of crude drug is necessary because
(a)Biochemical variation (b) Deterioration due to storage (c) Adulteration (d) All of the
above
Q.98. Multiseriate unbranched trichomes are present in
(a) Datura (b) Digitalis (c) Belladona (d) Male fern
Q.99.As per WHO guideline herbal drug “Swelling Index” is categories under -------------
monograph.
(a) Botanical (b) Physiochemical (c) Pharmacological (d) Toxilogical
Q.100. All of the following character associated with seed EXCEPT
(a) Hilum (b) Strophiole (c) Micropyle (d) Raphe