Professional Documents
Culture Documents
Instructions
Choose your answer by clicking the radio button next to your choice and then press
'Submit' to get your score.
Question 1
a) The study of how drugs reach their target in the body and how the levels of a drug
in the blood are affected by absorption, distribution, metabolism, and excretion.
b) The study of how drugs can be designed using molecular modelling based on a
drug's pharmacophore.
c) The study of how a drug interacts with its target binding site at the molecular level.
d) The study of which functional groups are important in binding a drug to its target
binding site and the identification of a pharmacophore.
Question 2
a) The study of how drugs reach their target in the body and how the levels of a drug
in the blood are affected by various factors.
b) The study of how drugs can be designed using molecular modelling based on a
drug's pharmacophore.
c) The study of how a drug interacts with its target binding site at the molecular level.
d) The study of which functional groups are important in binding a drug to its target
binding site and the identification of a pharmacophore.
Question 3
Question 5
Some orally active drugs do not obey the rule of five. For example, some drugs with
molecular weights greater than 500 are found to be orally active. Which of the following
mechanisms is the most likely reason for this?
Question 6
Some orally active drugs do not obey the rule of five. For example, some highly polar
drugs with a molecular weight less than 200 are found to be orally active. Which of the
following mechanisms is the most likely reason for this?
Question 7
Which type of infection could be orally treated with a highly polar antibacterial agent?
a) brain infection
b) kidney infection
c) gut infection
d) lung infection
Question 8
a) The walls of the capillaries supplying the brain have tight fitting cells making it
difficult for polar drugs to leave the capillaries.
b) The capillaries in the brain have a fatty coating making it more difficult for drugs
to enter the brain.
c) The walls of the capillaries supplying the brain are made up of several layers of
cells, which act as a barrier to the release of drugs.
d) Hydrophobic drugs pass through the blood brain barrier more easily than
hydrophilic drugs.
Question 9
Question 10
Question 11
Which of the following statements is not true about cytochrome P450 enzymes?
a) They contain haem and magnesium.
b) They belong to a general class of enzymes called monooxygenases.
c) There are over 30 different cytochrome P450 enzymes.
d) Variation in cytochrome P450 enzyme profile between individuals can explain
individual variation in drug susceptibility.
Question 12
Question 13
Alkenes and aromatic groups can be metabolised to diols. Which enzymes are involved?
Question 14
a) flavin-containing monooxygenases
b) monoamine oxidases
c) glucuronyltransferase
d) esterases
Question 15
Question 1
Correct Answer:
c)
Feedback:
Pharmacokinetics is the study of how drugs reach their target in the body and how the
levels of a drug in the blood are affected by absorption, distribution, metabolism and
excretion.
The study of how drugs can be designed using molecular modelling based on a drug's
pharmacophore is part of a process known as structure-based drug design.
Pharmacodynamics is the study of how a drug interacts with its target binding site at the
molecular level.
Structure activity relationships are studies which are carried out to find which functional
groups are important in binding a drug to its target binding site, and hence lead to the
identification of a pharmacophore.
Page reference: 152
Question 2
Correct Answer:
a) The study of how drugs reach their target in the body and how the levels of a drug in
the blood are affected by various factors.
Feedback:
Pharmacokinetics is the study of how drugs reach their target in the body and how the
levels of a drug in the blood are affected by absorption, distribution, metabolism and
excretion.
The study of how drugs can be designed using molecular modelling based on a drug's
pharmacophore is part of a process known as structure-based drug design.
Pharmacodynamics is the study of how a drug interacts with its target binding site at the
molecular level.
Structure activity relationships are studies which are carried out to find which functional
groups are important in binding a drug to its target binding site, and hence lead to the
identification of a pharmacophore.
Page reference: 152
Question 3
Correct Answer:
Feedback:
If an orally administered drug is rapidly metabolised, its lifetime will be short and this
will be detrimental to activity. The exceptions to the rule are prodrugs. These are inactive
compounds which are converted to active compounds by metabolic reactions.
Page reference: 152
Question 4
Correct Answer:
Feedback:
The molecular weight should be less than 500. There should be no more than 5 hydrogen
bond donor groups and no more than 10 hydrogen bond acceptor groups. Statement d) is
correct.
Page reference: 153
Question 5
Some orally active drugs do not obey the rule of five. For example, some drugs with
molecular weights greater than 500 are found to be orally active. Which of the following
mechanisms is the most likely reason for this?
Correct Answer:
c) Pinocytosis.
Feedback:
Some polar drugs can be transported across cell membranes by transport proteins if the
drug resembles the molecule which is normally carried by that transport protein. Small
polar drugs with a molecular weight less than 200 can squeeze through the pores between
the cells lining the gut wall. Large polar molecules can be transported across cells by a
process known as pinocytosis. Ion channels are not relevant to the absorption process.
Page reference: 154
Question 6
Some orally active drugs do not obey the rule of five. For example, some highly polar
drugs with a molecular weight less than 200 are found to be orally active. Which of the
following mechanisms is the most likely reason for this?
Correct Answer:
Feedback:
Some polar drugs can be transported across cell membranes by transport proteins if the
drug resembles the molecule which is normally carried by that carrier protein. Small
polar drugs with a molecular weight less than 200 can squeeze through the pores between
the cells lining the gut wall. Large polar molecules can be transported across cells by a
process known as pinocytosis. Ion channels are not relevant to the absorption process.
Page reference: 154
Question 7
Which type of infection could be orally treated with a highly polar antibacterial agent?
Correct Answer:
c) gut infection
Feedback:
A highly polar antibacterial drug will not be able to cross the gut wall, since it will not be
able to pass through hydrophobic cell membranes. It will, therefore, remain in the gut and
can be used to treat gut infections.
Page reference: 154
Question 8
Correct Answer:
c) The walls of the capillaries supplying the brain are made up of several layers of cells,
which act as a barrier to the release of drugs.
Feedback:
The cells making up the walls of capillaries supplying the brain are only one cell thick,
but the cells are more tightly packed than those supplying other parts of the body. As a
result, drugs have to cross cell membranes to depart the blood vessels and enter the brain.
There is also a fatty coating which surrounds the blood vessels and acts as a further
barrier. This fatty coating is not part of the capillary wall.
Page reference: 155
Question 9
Correct Answer:
Feedback:
Option c) is the closest description. Options b) and d) are incorrect. Some phase I
metabolic reactions can occur in the blood supply or the gut wall, but they do not take
place exclusively at either of these sites. Most Phase I reactions take place in the liver.
Option a) describes Phase II metabolism where a polar molecule is attached to a polar
functional group already present on the drug, or placed there by Phase I metabolism.
Page reference: 156-157
Question 10
Correct Answer:
a) Reactions which add a polar molecule to a functional group already present on a drug
or one of its metabolites.
Feedback:
Question 11
Which of the following statements is not true about cytochrome P450 enzymes?
Correct Answer:
Feedback:
The cytochrome P450 enzymes contain haem and iron. Statements b, c and d are
accurate.
Page reference: 157-160
Question 12
Correct Answer:
Feedback:
Question 13
Alkenes and aromatic groups can be metabolised to diols. Which enzymes are involved?
Correct Answer:
Cytochrome P450 enzymes catalyse the formation of an epoxide from an aromatic ring or
alkene. Epoxide hydrolase then catalyses the hydrolysis of the epoxide to form a diol.
Page reference: 157-160
Question 14
Correct Answer:
c) glucuronyltransferase
Feedback:
Question 15
Correct Answer:
b) conjugation to alcohols
Feedback:
Reactions which introduce, modify or reveal functional groups are Phase I metabolic
reactions. Conjugation reactions involve the attachment of a polar molecule to a polar
functional group and are Phase II metabolic reactions.
The reduction of a ketone is a functional group modification (ketone to alcohol). The
oxidation of an alkyl group introduces a functional group (alcohol, ketone or carboxylic
acid). Ester hydrolysis reveals functional groups (the carboxylic acid and the alcohol).
Conjugation to an alcohol is a Phase II metabolic reaction.
Page reference: 160-161