Professional Documents
Culture Documents
Chronic Respiratory
Asthma
Clinical Guide
Building
Healthy 388-6654
1-866-506-6654 Lifestyles
Asthma
Specialist Consultants
Utilizing the Chronic Care model, these groups developed the Asthma Clinical Guide as a decision-
support tool for improved functional and clinical outcomes. This Guide supports primary care
interdisciplinary team-based practice with a strong focus on self-management.
Please use and reproduce with acknowledgement to the Chinook Health Region.
Table of Contents
1. Diagnosis
a. Definition ............................................................................................................5
b. Risk Factors .........................................................................................................5
c. Screening .............................................................................................................6
d. Signs and Symptoms............................................................................................6
e. Testing and Evaluation ........................................................................................6
f. Further Testing ....................................................................................................7
g. Algorithm ............................................................................................................8
2. Classification/Type/Staging
a. Stages/Types of Disease ........................................................................................11
7. References
a. Evidence ..............................................................................................................29
b. On-line Resources ...............................................................................................29
c. Supplementary Handouts Available .....................................................................29
Loose Index: any wheezing during the first 3 years of life plus 1
major or 2 minor risk factors
f. Further Testing
• Referral to a medical specialist for bronchoprovocation testing to
help confirm or rule out asthma.
• Appropriate allergy assessment is warranted in patients with
asthma and must be interpreted in light of patient’s history.
Allergen exposure is a risk factor for severe, acute asthma,
especially if the patient is exposed to high concentrations of
the specific allergen. Therefore, allergens to which a person
is sensitized should be identified through allergy testing.
Once identified, steps should be taken to eliminate or at least
substantially reduce allergen exposure.
g. Algorithms
Approach to Asthma Diagnosis in Clients Able to Perform Spirometry Tests
Reliably (usually 6 years of age or greater) in the Primary Care Setting
NO
Does pre & post spirometry test meet the following criteria to be considered normal
• FEV1.0/FVC ratio > 0.7
• FVC > 80% of predicted value
• FEV1.0 > 80% of predicted value
NO YES
YES NO
YES NO
Asthma
Approach to Asthma Diagnosis in Clients Able to Perform Peak Expiratory Flow Tests
Reliably (usually 6 years of age or greater) in the Primary Care Setting
>20% improvement in PEF 10 minutes after >20% or greater diurnal variability in PEF
administration of short-acting B-2 agonist over a period of several weeks
YES NO YES NO
YES NO
Initiate proper asthma therapy of inhaled Repeat PEF if and when symptoms recur
corticosteroids and short-acting bronchodilators
for one month then follow up and reassess
YES NO
Asthma diagnosis may be confirmed Consider a referral to have pre & post spirometry done or referral to a
Consider retesting with spirometry specialist for bronchoprovocation test to help confirm / rule out
Initiate treatment and asthma asthma diagnosis and investigate other conditions that mimic asthma
education (i.e. Gastroesophageal Reflux Disease (GERD), vocal cord
Consider a referral to an asthma dysfunction).
educator
Note:
• PEF is less reliable than spirometry for confirming the diagnosis of asthma
To calculate a 20% improvement in PEF following administration of a short-acting B-2 agonist:
1. Obtain a peak flow reading prior to medication, e.g. 400 lpm
2. Multiply that number by 1.2 to give value needed to confirm a 20% improvement in PEF (400 x 1.2 = 480).
3. Give B-2agonist, wait 10 minutes then repeat PEF; this value must be > 480 lpm to show a 20% improvement in
PEF and confirm diagnosis of asthma
To calculate diurnal variation of PEF:
1. Client is to measure peak flows in the am and pm of each day for 2-4 weeks and record the best value of 3 tries
in a diary
2. Once this data has been recorded, calculate the diurnal variation of each day by using the following formula:
Highest PEF – Lowest PEF (on the same day) x 100
Highest PEF
For example: Day 1 Day 2 Day 3
PEF am pm am pm am pm
400 500 400 450 350 500
500 – 400 x 100 450 – 400 x 100 500 – 350 x 100
500 450 500
= 20% diurnal variation = 11.1% diurnal variation = 30% diurnal variation
• Children as young as 5 years of age may be able to properly perform PEF. There are no predicted values for children
under 5 years of age for peak flow.
First, determine the presence of airway sensitivity – by inquiring about symptoms such as cough,
wheeze, limited physical activity, chest tightness and shortness of breath.
Second, look for evidence of inherited ability to react to stimuli - is there a family history of atopy
and a personal history of eczema or atopy.
Third, establish that there is no underlying lung disease - look for anything else that could be
causing cough.
Beta-2 agonists for relief of symptoms such as wheeze, chest tightness and shortness of breath (SOB)
AND
OR
Oral prednisone for therapeutic trial for coughing, 1mg/kg per day up to a maximum of 50 mg x 5 days
CAUTION: ensure child is not incubating varicella virus. A comprehensive varicella history should be
done
YES NO
• NOTE- there is no age criteria for the diagnosis of asthma as it can be diagnosed at any age. However,
caution should be used when diagnosing asthma in children less than one year of age. Persistent
respiratory symptoms in infants and children may warrant a referral to a specialist.
2. Classification/Type/Staging
Determining the Severity of Asthma
Note: FEV1.0 = Forced Expiratory Volume in 1 second; PEF = Peak Expiratory Flow
0 = none
+ = minimal (infrequent)
++ = moderate (frequent)
+++ = severe (very frequent)
Note: Children will “auto-scale” their inhaled medication dose, (take proportionately smaller inspiratory volumes compared to adults, which
results in less of the dispensed dose of inhaled medication reaching the lungs). The same dose can be used for all medications at all ages.
Year of Diagnosis
Symptoms ≥ 4 days/week
A client that is not reducing exposure to allergens and asthma triggers will be difficult to control. Referral to asthma program
Does client have a written asthma action plan
* If not, provide a written CHR asthma action plan
Controller medications:
Reliever Medications:
* If any comorbidities exist with asthma, treat appropriately as these may affect proper asthma control
Perform Pre & Post Spirometry testing yearly & prn
Tests
Treatment options from the Canadian Asthma Consensus Guidelines update 2003, medications updated as of January 12, 2006
To be considered controlled asthma, all the above criteria must Education and Follow-up:
be met. If they are not met, it is then considered uncontrolled
asthma. Education is an essential component of asthma therapy and should
be offered to all patients. Educational interventions may be of
Control can be achieved in uncontrolled asthma through patient particular benefit to patients with high asthma-related morbidity or
education, trigger avoidance and medications. severe asthma and at the time of emergency department visits and
admissions to hospital.
• All patients should self-monitor their asthma using symptoms or
PEF or both
• Ensure regular follow-up (every 6 months). Asthma control
criteria should be assessed at each visit. Measurement of
pulmonary function, preferably spirometry, should be done
regularly in adults and children 6 years of age and older. Review
written action plan and medication required with an aim to
reduce amount of medication while maintaining asthma control.
Smoking Cessation:
• Smoking cessation interventions (4A model) should be offered
to patients who smoke, or parents of children with asthma who
smoke.
• Well-controlled asthma is not a contraindication for • For patients who cannot or will not use ICSs, leukotriene
immunotherapy for allergic rhinoconjunctivitis or insect venom receptor antagonists (LTRAs) should be the primary treatment
hypersensitivity choice, although they are less effective than low dose ICSs
• Fluticasone (Flovent) MDI 50, 125 & 250 mcg per dose
• Immunotherapy must be administered only by trained personnel ○ BID dosing most effective
in centres where there is medical supervision and resuscitative
equipment (for both children & adults) • Fluticasone (Flovent) Diskus 50, 100, 250, 500 mcg per dose
○ BID dosing most effective
Immunotherapy in Children:
• Although debate about the value of immunotherapy continues, • Budesonide (Pulmicort) Turbuhaler 100, 200 & 400 mcg per
meta-analysis and review of immunotherapy support the dose
potential value of immunotherapy in childhood; early ○ BID dosing most effective
immunotherapy may prevent development of asthma in children • Beclomethasone (Q-var) MDI 50 & 100 mcg per dose
sensitized to house dust mite allergen ○ BID dosing most effective
• Physicians should consider injection immunotherapy using
appropriate allergens for the treatment of allergic asthma only
when allergic component is well documented
• Physicians should not recommend the use of injection
immunotherapy in place of avoidance of environmental allergens
• Physicians may consider injection immunotherapy in addition to
appropriate environmental control and pharmacotherapy when
asthma control remains inadequate
• Immunotherapy is not recommended when asthma is unstable
AND
Add on Therapy as Required: SECOND OPTION- Increase the inhaled corticosteroids (ICSs)
• If after reassessment of compliance with treatment, trigger to a moderate dosage as per chart or add in a leukotriene receptor
avoidance strategies, inhaler technique and co-morbidities, antagonist (LTRAs)
asthma is not controlled by low dose ICSs, additional therapy • Montelukast (Singulair) 4, 5 & 10 mg chewable tablet
should be considered: ○ Adults and children 15 years of age and older one 10 mg
tablet daily at bedtime
FIRST OPTION – Add long-acting beta-2 agonist to existing ○ Children 6 to 14 years of age one 5 mg tablet daily at
therapy of ICSs and short-acting beta-2 agonist, or replace ICSs bedtime
with a combination medication. ○ Children 2 to 5 years of age one 4 mg tablet daily in the
• Salmeterol (Serevent) MDI 25 mcg per dose evening
○ Adults 1 or 2 inhalations BID • Zarfirlukast (Accolate) 20 mg tablet
○ Children 4 years of age and older 1 or 2 inhalations BID ○ Adults and children 12 years of age and older two 20 mg
• Salmeterol (Serevent) Diskus 50 mcg per dose tablets daily
○ Adults 1 inhalation BID
○ Children 6 years of age and older 1 inhalation BID THIRD OPTION – Consider theophylline; severe asthma may
require additional treatment with prednisone. If required to
• Formoterol (Oxeze) Turbuhaler 6 or 12 mcg per dose maintain control, refer to the CPS for dosing requirements and
○ Adults 1 inhalation of 6 or 12 mcg BID (max 48 mcg per refer to a medical specialist.
day)
○ Children 6-16 1 inhalation of 6 or 12 mcg BID (max 24 Prednisone:
mcg day)
For acute exacerbations of asthma, use the following dosages:
OR • For ages 12 and over: 50 mg po daily for 3-10 days
• Advair (Serevent 50 mcg/Flovent 100, 250 & 500 mcg per dose) • For ages under 12: 1mg/kg po daily for 3-10 days (maximum
Diskus dose: 2 mg/kg po daily)
○ Adults and children 12 and older, 1 inhalation BID
○ Children 6-11 years of age, 1 inhalation BID No Prednisone dose tapering required if less than 2 weeks
• Advair (Serevent 25 mcg/Flovent 125 & 250 per dose) MDI
○ Adults and children 12 and older, 1 or 2 inhalations BID
○ Children 4 years of age and older, 1 or 2 inhalations BID
• Symbicort (Oxeze 6 mcg/Pulmicort 100 & 200 mcg per dose)
Turbuhaler
○ Adults and children 12 years of age and older, 1 or 2
inhalations BID
○ Children 6 to 11 years of age, 1 or 2 inhalations BID
Management of Acute Asthma Exacerbations (excluding ER and • There is some evidence for the potential benefit of a more
acute care facilities) substantial increase in the dose of ICS such as tripling or
quadrupling the regular maintenance dose at the first sign of an
Acute asthma exacerbation – is defined as deterioration of asthma asthma exacerbation.
control that is not responding to B-2 agonist rescue treatment in
the usual manner or a sustained worsening of asthma symptoms • The standard of care is that ICS dose should be increased during
leading to increased use of B-2 agonists as well as increased use of an asthma exacerbation, but there is not enough good evidence
maintenance medications and/or supplementation with additional to make a generic recommendation as what dose to increase the
medicine. The following are loose criteria that can define an acute ICS from the maintenance dose during the exacerbation.
asthma exacerbation: • Through the COPD & Asthma Network of Alberta (CANA),
• Bronchodilator use ≥ 4 times/week (excluding 1 dose/day for as well as consulting local CHR specialists we have summarized
exercise) current clinical practices utilized by both pediatric and adult
respiratory specialists throughout Alberta in managing acute
• Nocturnal awakenings due to asthma ≥ 2 times/week asthma exacerbations:
• Daytime asthma symptoms ≥ 4 days/week ○ If the client is on high doses of ICS for maintenance
(or maximum daily dosage for that client as decided by
• Recent absence from work or school due to asthma
physician), the clinical practice is to double the maintenance
• Recent unscheduled physician visit due to asthma dose of ICS or maintain the current dose of ICS and add in
• Spirometry testing shows FEV1.0 < 80% of predicted normal a long-acting beta agonist (LABA) or leukotriene receptor
antagonist (LTRA) for a period of approximately 2 weeks.
• PEF tests fall below 80% of personal best value, or predicted ○ If client is on low to moderate doses of ICS for maintenance,
value if personal best is not known the clinical practice is to increase to the full dose of the
• Studies have shown that the major cause (80%) of asthma specific ICS for approximately 2 weeks, then return to
exacerbations is viral upper respiratory infections. With viral maintenance dose.
upper respiratory infections the inflammatory response tends to
be more neutrophilic than eosinophilic. Inhaled corticosteroids Full dose:
may not be effective during neutrophilic inflammatory responses
Fluticasone (Flovent) 500 – 1000 mcg/day
seen with viral upper respiratory infections.
Beclamethasone (Q-Var) 400 – 800 mcg/day
Non-Pharmacologic Strategies: Budesonide (Pulmicort) 800 – 1600 mcg/day
• Avoid contact with environmental tobacco smoke ○ The clinical practice of many respiratory specialists is to
• Continue to avoid personal asthma triggers increase the dose of ICS at the first sign of an exacerbation
and whether the dose is doubled or quadrupled depends on
• Refer to personalized written asthma action plan as to how to the client’s maintenance dose as well as personal history of
temporarily modify asthma medications exacerbations. Those who become ill quickly upon exposure
Pharmacologic Strategies: to triggers treat more aggressively than those who generally
manage trigger exposure without significant incident.
• Prevention of asthma exacerbations needs to be the primary ○ If the asthma exacerbation is not responding to increased
target of asthma treatment and ICSs. This can be accomplished doses of ICS and add on therapy, a short course of oral
through regular use of ICSs as maintenance treatment for prednisone should be considered. Recommended doses:
asthma.
• Previous asthma guidelines have recommended the use of an For ages 12 and over: 50 mg po daily for 3-10 days
action plan to manage asthma exacerbations. Many of these For ages under 12: 1mg/kg po daily for 3-10 days
plans advocate a doubling of the dose of maintenance ICS as (maximum dose: 2 mg/kg po daily)
one of the first steps in the management of worsening asthma.
However, there are no randomized controlled trials to support No Prednisone dose tapering required if less than 2 weeks
doubling the dose of ICS on identification of exacerbations of
asthma.
The above evidence is based on the opinions of those who have written
• 2 recent studies (adult & pediatric populations) have provided and reviewed the asthma guidelines, based on their experience,
evidence that early or impending asthma exacerbations are knowledge of the relevant literature and discussion with their peers.
not always effectively treated by doubling the dose of inhaled
corticosteroids at the first sign of an exacerbation. These results
apply to those patients with asthma who regularly use their
preventer or controller medication as maintenance therapy when
well.
Special Considerations: • Physicians should discuss medication choices and the rationale
for treatment plan; they should emphasize that the treatment
Asthma in the Elderly program is considered to entail less risk than the uncontrolled
illness that could result in its absence.
Diagnosis
• The use of systemic glucocorticosteriods for severe asthma,
• A diagnosis of asthma should be more widely considered in
especially for prolonged periods, may be associated with a greater
elderly patients with dyspnea, wheezing or nocturnal cough.
risk of pre-eclampsia, antepartum or postpartum hemorrhage,
Asthma may be difficult to diagnosis in the elderly because of
low birth weight, preterm birth and hyperbilirubinemia.
misconceptions about its prevalence and also because older
patients have diseases and disorders that mask the classic features • Patients requiring systemic glucocorticosteroid therapy should be
of asthma. considered to be in a higher risk pregnancy.
Treatment Treatment
• In the elderly patient with asthma, it is particularly important to • Avoidance of allergic and non-allergic triggering factors should
take a careful medication history. Use of self-prescribed ASA has be the first form of therapy for asthma during pregnancy.
become common and may go unrecognized. ASA and NSAIDS • Treatment should take the same approach as the non-pregnant
are commonly prescribed in the elderly and may cause late-on- patient and may include inhaled B-2 agonists, inhaled
set asthma. Oral and topical B-adrenergic blocking agents and corticosteroids, ipratropium bromide, cromolyn and systemic
other anti-arrhythmic agents, including verapamil and others steroids. Theophylline may increase nausea and reflux and is less
with acknowledged B-blocker potential, can exacerbate or cause desirable. There is significantly less information about the effects
asthma in those who are predisposed to the disease. Whenever of long-acting B-2 agonists and leukotriene inhibitors and there
possible, medications that might induce or aggravate asthma is less clinical experience with these drugs than with other classes
should be withdrawn. of drugs. These drugs should be used only for patients whose
• Special care should be taken to allow elderly patients with asthma asthma cannot be controlled using the more studied therapies.
to choose an inhaler device with which they are both comfortable • For drugs with a longer history of usage, there tends to be more
and competent. data to support a lack of adverse effects. Use of most common
• Measures should be taken to prevent osteoporosis in elderly asthma medications (B-2 agonists, theophylline, cromolyn,
patients with asthma who require prolonged treatment with oral inhaled glucocorticosteroids) during pregnancy has not been
corticosteroids. shown to be associated with increased perinatal risks including
congenital malformations.
• Elderly patients with asthma require careful follow-up because
they have an increased risk for exacerbations, which may be • Although no asthma medications can be considered proven
related to impaired perception of their disease severity. safe for use during pregnancy, the ones listed above are used
to prevent the potential direct and indirect consequences of
Asthma in Pregnancy uncontrolled asthma.
• Asthma is present in 4 – 7 % of pregnant women and is the • The patient must be aware of the risks and benefits of
respiratory disorder that most frequently complicates pregnancy. appropriate asthma control and must give her informed consent
• The course of asthma during pregnancy is variable and asthma to the therapeutic approach recommended during pregnancy.
control may remain unchanged or become worse or improve
and return to the pre-pregnancy state within 3 months after
parturition.
• Overall, asthma control improves significantly in the last 4 weeks
of pregnancy.
• Asthmatic, pregnant women have been variably reported to
have an increased risk of pregnancy-induced hypertension, pre-
eclampsia, caesarean section, placenta previa and antepartum or
postpartum hemorrhage.
Recommendations
• Do not stop asthma therapy during pregnancy. Poorly controlled
asthma may affect maternal comfort, safety and pregnancy
outcome for both mother and child. Several well designed
studies have shown fewer adverse infant and maternal outcomes
than those without therapy.
Metered Dose Inhalers can be used with any age group. A spacer or
chamber should be used with children and elderly adults. A spacer
should also be used if patient is receiving inhaled corticosteroids.
• Under one year of age - a valved spacer and face mask should be
used with MDI. (orange infant aerochamber with face mask)
• From 2 to 6 years of age - a valved spacer and face mask should
be used with MDI. (yellow pediatric aerochamber with face
mask)
• More than 6 years of age - a valved spacer with a mouthpiece
should be used, rather than a face mask. (blue aerochamber)
• Try to use a valved spacer with mouthpiece in children at the
earliest age it becomes feasible. This will eliminate breathing
through the nose and maximize the chance of increased airway
deposition in the lungs. It has been clearly shown in children
that breathing through a mask via the nose decreases lung
deposition by up to 67% compared with breathing through a
mouthpiece using a jet nebulizer.
Dry Powder Inhalers can be used by most patients by the time they
reach 5 years of age. Spacer devices are not required with these
devices. The two devices in Canada are the Turbuhaler and the
Diskus inhaler.
MDIs vs Nebulizers:
Action:
YELLOW ZONE
• Avoid your personal asthma triggers
YOUR ASTHMA CONTROL IS DECREASING IF: • Avoid tobacco smoke exposure
• Check your peak flow _______ per day
• You wheeze, cough, feel tight or have if not already doing so
trouble breathing with your usual activities,
• Controller(s): ____________________________
with exercise or at night
• You develop cold symptoms ____________________________
• You require your reliever medicine more than • Reliever(s): ____________________________
three times per week
____________________________
• Your peak flow is
between ________ and ________ • Other Actions: ____________________________
(60% to 80% of personal best)
____________________________
• Seek medical attention if your asthma control is
not improving within 2 or 3 days
Action:
ORANGE ZONE • Avoid your personal asthma triggers
• Avoid tobacco smoke exposure
YOUR ASTHMA IS OUT OF CONTROL IF: • Check your peak flow _______ per day
if not already doing so
• You wheeze, cough, feel tight or have
trouble breathing even at rest • Controller(s): ____________________________
• Your symptoms are interrupting your sleep
____________________________
• You require your reliever medicine more than
four times in twenty four hours • Reliever(s): ____________________________
• Your peak flow is below _________ ____________________________
(60% of personal best)
• Other Actions: ____________________________
____________________________
• Seek medical attention if your asthma control is
not improving within 12-24 hours
RED ZONE
Action:
• Call 911 or go to the nearest emergency department
YOU ARE IN THE DANGER ZONE IF: immediately
• You can repeat your reliever medicine every ____
• You are getting little relief to no relief in 20
minutes times ____ doses while assistance is being
to 30 minutes after your reliever medicine
arranged
• You are struggling to breathe or having
trouble walking or talking
• Your lips or fingernails are turning blue
Asthma is an inflammatory disease of the small airways in the As a general rule, asthma diagnosed in childhood is a lifelong
lungs that results in recurring episodes of difficult breathing due to condition. Asthma symptoms may diminish in adolescence, but
the airways becoming more narrow (smaller) than normal. These can often return in adulthood. People with the following factors
episodes may occur quite often or may come and go intermittently. are most likely to have asthma that persists into adulthood:
Asthma ranges from very mild to severe. • A parent with asthma
WHAT ARE THE SYMPTOMS OF ASTHMA? • A history of eczema (scaly red rashes on the skin)
When the small airways in lungs begin to narrow, people with • Allergies or hay fever; allergic rhinitis (inflammation of the lining
asthma usually notice some or all of the following problems: in the nose)
What is asthma?
As the swelling in the airway increases,
the lining of the airway becomes very
sensitive and small muscles around it
start to twitch and tighten. 6 Emergency room visit
5 Muscles around
airway tighten
coug
g
g
cough
1 Normal airway =
normal function h ee
w he ezze
2 Something starts
inflammation
3 Inflammation of
airway and mucous
Aim to reduce asthma medication dosage while maintaining proper control of asthma
Screening for osteoporosis if on inhaled corticosteroids for asthma and you have the following risk factors:
• Age > 60 years
• Postmenopausal state without hormone replacement therapy
• Male impotence or infertility
• Previous fractures with minor trauma
• Family history of fractures (parental)
• Past or current chronic glucocorticoid therapy
• Smoking or alcoholism
• Physical inactivity
Vaccinations
Or
7. References
a. Evidence
1. Becker, Allan, MD; Berube, Denis, MD; Montgomery, Mark, MD; Sears, Malcolm, MD; Spier, Sheldon, MD; on behalf of
the Canadian Pediatric Asthma Consensus Guidelines 2003 (updated to December 2004) Supplement to CMAJ 2005; 173
(6 suppl): S1-S56
2. Boulet,Louis-Philippe, MD; Becker, Allan, MD; Berube, Denis, MD; Beveridge,Robert, MD; Ernst, Pierre MD; on behalf
of the Canadian Asthma Consensus group. Canadian Asthma Consensus Report 1999. Supplement to CMAJ 1999; 161
(11 suppl)
3. British Columbia Guidelines & Protocols Advisory Committee, Diagnosis and Management of Asthma July 1, 2003
4. FitzGerald JM, Becker A, Sears MR, et al. Doubling the dose of budesonide versus maintenance treatment in asthma
exacerbations. Thorax 2004;59:550-6
5. Green RH, Brightling CE, McKenna S, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled
trial. Lancet 2002; 360:1715-21
6. Harrison TW, Oborne J, Newton S, et al. Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations:
randomised controlled trial. Lancet 2004;363:271-5
7. Jarjour NN, Gern JE, Kelly EA, et al. The effect of an experimental rhinovirus 16 infection on bronchial lavage neutrophils.
J Allergy Clin Immunol 2000;105:1169-77
8. Johnston SL, Pattemore PK, Sanderson G, et al. Community study of role of viral infections in exacerbations of asthma in
9-11 year old children. BMJ 1995;310:1225-9
9. Lemiere,C; Bai,T; Balter, M, et al, on behalf of the Canadian Adult Consensus group of the Canadian Thoracic Society.
Adult Asthma Consensus guidelines update 2003. Can Respir J 2004; 11 (Suppl A); 9A – 18A
10. Respiratory Division, Cardio-Respiratory diseases and diabetes bureau, laboratory centre for disease control, Health Canada.
The national asthma control task force. The prevention and management of asthma in Canada 2000
b. On-line Resources
1. Canadian Lung Association www.lung.ca
2. Canadian Thoracic Society www.lung.ca/cts/
3. COPD & Asthma Network of Alberta (CANA) www.canahome.org
4. Family Physicians Airways Group of Canada www.fpagc.com
5. Canadian Network for Asthma Care (CNAC) www.cnac.net
6. Child Asthma Network iCan www.calgaryhealthregion.ca/ican/
7. National Institute of Health www.nhlbi.nih.gov
8. Canadian Society of Allergy & Clinical Immunology www.csaci.medical.org
9. Global Initiative for Asthma www.ginaasthma.com
10. Calgary Allergy Network www.calgaryallergy.ca
11. American Academy of Allergy, Asthma & Immunology www.aaaai.org
12. Asthma Society of Canada www.asthma.ca