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Predisposing
Geographical area – tropical islands in the Precipitating
Pacific (Philippines) and Asia Environmental conditions (open spaces with water
pots, and plants)
Mosquito carrying dengue virus

Aedes aegypti (dengue virus carrier): 8-

12 days of viral replication on mosquitos’
salivary glands

Bite from mosquito (Portal of Entry in Redness & itchiness in

the Skin) the area

Allowing dengue virus to be inoculated

towards the circulation/blood (Incubation
Period: 3-14 days)

Virus disseminated rapidly into the blood Diagnostic:

and stimulates WBCs including B Hematology :
lymphocytes that produces and secretes Increased WBC:
immunoglobulins (antibodies), and 12,900/cumm
monocytes/macrophges, neutrophils (5,000- 10,000/cumm)
Diagnostic: Increased
Hematology : Lymphocytes: 49% (20-
Decreased Antibodies attach to the viral 40%)
Monocytes: antigens, and then
4%(8-14%) monocytes/macrophages will
Decreased perform phagocytosis through Fc
Neutrophils: receptor (FcR) within the cells and
49%(50-70%) Entry to the Entry to the
dengue virus replicates in the cells
spleen, and bone marrow
liver
Recognition of dengue viral
antigen on infected monocyte
by cytotoxic T cells
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Release of cytokines which consist of
vasoactive agents such as interleukins,
tumor necrosis factor, urokinase and
platelet activating factors which
stimulates WBCs and pyrogen release

Signs/ symptoms:
Febrile: 38.6C
Diaphoresis, warm skin, Dengue
flushed; headache;
whitish spots; body Fever
weakness
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Virus ultimately targets liver Cellular direct destruction and

and spleen parenchymal cells infection of red bone marrow Diagnostic:
where infection produces precursor cells as well as Hematology :
Decreased
apoptosis/cell death immunological shortened platelet
Platelet:
survival causing platelet lyses 68,000/cumm
Hepatosplenomeg (150,000-
Thrombocytop 400,000)
aly
enia Signs/
symptoms:
Signs/ symptoms: Red sclera in
>Abdominal pain both eyes
Dengue Hemorrhagic
Petechiae
Fever
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Legend:

- Pathophsiology

- Medications - Signs and symptoms

- Diagnostic exams - Complications

- Interventions - Early signs