Conceptual Framework: Pathophysiology of the Disease Process

Predisposing Factors Etiologic Factor Signs and Symptoms

 Increasing age, genetic, √ Headache

diet, stress, left ventricular
√ Light headedness
hypertrophy,
hypertension, aortic √ Dizziness
regurgitation, incompetent
Genetic factor, increasing age, √ Chest pain
mitral valve high intake of fatty and/or salty
foods, stress √ Dyspnea

√ Fatigue
Accumulation of fats in the
Increase in peripheral resistance vessel walls √ Weight loss

Plaque formation
(atherosclerosis)

Loss of elasticity in arteries

Atrial stenosis
Increase systolic blood pressure

Thrombus formation

Isolated systolic hypertension

Platelet aggregation

Increase left atrium volume and

pressure Activation of platelet

Left atrial dilatation

Consolidation

Left atrial hypertrophy

Vasoconstriction
Left ventricular filling
Thicken mitral valve leaflet
Coagulation
Blood ejected in the aorta
Incomplete valve closure
Small infarcts occur
Systemic circulation
Some blood regurgitate to left
atrium