NMS Labe SONFIDENTIAL 3704 Wolah Rost, PO Box 433A, Wilew Grove, PA 19080-0487 ms hone: Bs) OF-e00 Pec: (28) o8h2872 ve ‘e-mail: nms@ynmsigbs.com 2; Roba A Mdsleboig, PAD, OAEFT, DABOC-TC, Laberatry Oreste +8 Dat, Toxicology Report Patient Name MARKINGSON, BAN Report Issued 02/14/2008 10:00 Patlent ID DC04.262 Paik Chain van4004s Age 31¥ Gonder Not Given —_——1otre4——__________— a on Minnesota Regional Medical Exanier's Offies Aftn: Jeanne Reuter Workorder 08040941 1476 Nininger Ra Hastings, MN 68688 Recelved 02/07/2008 10:28 This onalysls wae performed under chain of austady, The chain of custody documentation is on filo at NME Labs. Unless alternate errangemente are made by you, the remaindar of the submitted spesimens will be discarded six (6) weeks from the date of this report; and generated data will be discarded five (5) yours from the date of this report, Sample ID 08040941001, Collect DtrTm Not Given Matrix Blood Source Not Given Pationt Name MARKINGSON, DAN Patient IB DOO4-202 Contalner Type Gray Vial Approx VolWeight 4.6 mL. Receipt Notoe None Entered Analysis and Comments it Units Reporting mit Notes 40518 Quetiapine, Blood ‘Analysis by Gas Chromatography (BO) Quetlapine 78 Synonym(s); Seroquel® Stoady state peak (1,0 to 1.6 hours) pladma tavels following a tid, dally regimon: 286 ng/ml. (226 mg/day) 888 ngimL (450 mgiaay) 828 ngiml (750 mghiay) ‘The plasms halflife is epproximately 6 hours, git 5.0 Bone afdR208 10: ROUIIS LABS 215 266 1501 Tete poon/o0s TBR N MS NMS Labs CONFIDENTIAL ie sro wee RonF ee fen eGo PA ROT | ona: (18) 667-4000 Fax, 216) 697-2872 cra ‘eal Taapemaetesen Robert A. Middleber, PhO, BABFT, DABCC, Laboreay Dieter q 1 Opies hs ‘March 3, 2908 "Ory fe ro: = MoI721 Minnesote Regional Medical Examiner's Office ‘Aan: Jeanne Reuter 1175. Nivinger Ra Hastings, MN 55033 TOXICOLOGY REPORT OF: MARKINGSON, Dat 3M MS Workorder No: 08040941 (Client ID No! DCO4-262 ‘SPECIMENS: one gray vial containing ~ 4.5 mL of Blood was received on 02/07/08 EXAMINATION: Analysis Requested ~ Test No, 18568 ~Drog Screen Panel I Test No. 40518 - Quetiapine FINDINGS: Blood QUETIAPINE 73 nanog/ml. (by Gc &. GEMS) tncidental findings by GCIMS: CAFFEINE, NICOTINE and COTININE. coer then the above findings, examination ofthe specimens submited dd not reveal any Pastis findings of toxicological significance by procedures outlined inthe Analysis Strmmery COMMENTS: uetioine (Seroquel) is an antipsychsic compound approved by the FPA for the management of the manifestations of poyehore dlsordes, including schizophrenia, tis a strctre! ano ‘of clozapine that addresses the postive and negative efoptoms of schizophrenia, but does so with few of the uadtionsl ide effects of conventional or other atypical antipsychotic medications. sendy state pea (1.010 1.5 Hout) plasma levels follwing a TTD dally regime: DOSE MEAN MAX, Coneentration (cug/Day) (nanoginil) 225 286 450 598 750 28 “The plasina half-life is approximately 6 hours.WAR-25-08 10:86 —-FROMNIS LABS 218 386 1501 ‘T-245P.008/003 F780 F "ie ee ey rasta: a orgh age 2082 Oran ‘ster an apparent qusapine overdoss in one death, «posite blood concentration of 170,000 nanop/n was Chass Ae rae ich quetiypite and 4 other drugs, postmortem carne blood contained 49,000 nanog’mL of pains, — Respectfully - FE odd edwat4 3, Barbieri PhD. Forensic Toxicologist EIB ire “This anslysis was performed under chain of eustody, The chain of custody documentaton ison Heat NMS Labs. Unies erate anangemens ae made by you the remainder af the subd specimens wil be dsarded six) weeks from the ots ie rapury and generated daa wll be discarded five (5) years rom the dato ofthis report «gate tse ANALYSISSUMMARY #44 StH ‘Test No, 18668 - Drug Screen TI - Gas Chromatography and Gas Chromatography/Mass Spectrom Analysis on Blood: “The following fs genera ls: of coropound classes included inthe Gas Chromatographic Stee. other specifi compounds outside The forewine K leo included, Please note that not al known compounds included in ach specified class or heading ae included, sree ection ef any partilar compound is concentration-dependent. Fora detalled list of all compounds included in this sereen, please contact NMS Labs. ‘Analgesics (opioid and nowopiold), Anesthetics, Ansasthmatic Agen, ‘Anticholinergic Agents, Anticonvulsant Agents AveHfopresant, Antiemetic Agents, Antihistamines, Antiparkinsonias Agents “Antipsychotic Agents, Anstussive Agents, price (Benzodiazepine and ethers), Cardiovascular Agents (von digas), Halyeven Hypnosedatives (Barbiturate and aha), Msele Relaxants, Now-Steroidal Ant-nflammatory Agents (exelading ‘Salicylate) and Stimulants (Amphetamine-like and others). “Feat No. 051B - Quetiopine ~ Gas Chromatography on Blood for: Quetapine, aeeee ENDOFREPORT *****