Professional Documents
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SIMPLE PRESENT
USE
We use for:
1. Facts
2. Routines
SIMPLE PAST
USE
We use for completed actions in the past.
STRUCTURE
PRESENT CONTINUOUS
USE
STRUCTURE
Introduction
Comparatives are special forms of adjectives. They are used to compare two things. Generally, comparatives are formed using -er .
1. Forming comparatives
How these forms are created depends on how many syllables there are in the adjective. Syllables are like “sound beats”. For
instance, “sing” contains one syllable, but “singing” contains two — sing and ing. Here are the rules:
Only one syllable, ending in E. Examples: wide, fine, cute Add -r: wider, finer, cuter
Only one syllable, with one vowel and one consonant at the end. Double the consonant, and add -er: hotter, bigger,
Examples: hot, big, fat fatter
Only one syllable, with more than one vowel or more than one consonant
Add -er: lighter, neater, faster
at the end. Examples: light, neat, fast
Two syllables, ending in Y. Examples: happy, silly, lonely Change y to i, then add -er: happier, sillier, lonelier
Two syllables or more, not ending in Y. Examples: modern, interesting, Use “more” before the adjective: more modern, more
beautiful interesting, more beautiful
Comparatives are used to compare two things. You can use sentences with “than”.
Comparatives
Social Themes
Álvaro Uribe Vélez (nacido el 4 de julio de 1952 en Medellín, Antioquia) es un político y abogado colombiano que ejerció
como presidente de la República de Colombia para los períodos anterior administración (2002-2006) y 2006-2010 después de que
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presentara un acto legislativo que modificó la constitución. La coalición de gobierno de Uribe intentó modificar la Consitución
colombiana para permitir una segunda reelección, pero la Corte Constitucional falló en su contra, imposibilitando al mandatario para
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ser a candidato a un tercer mandato.
Uribe se graduó en derecho en la Universidad de Antioquia y cursó posteriormente estudios en administración, gerencia y
5 6
negociación de conflictos en la Escuela de Extensión de la Universidad Harvard; fue también "miembro senior asociado" de un
7 6
college de la Universidad de Oxford.
Como político ha desempeñado diferentes cargos en las Empresas Públicas de Medellín, en el Ministerio del Trabajo y la Aeronáutica
Civil, sirviendo como Alcalde de la ciudad de Medellín durante (1982), ejerciendo de senador de la República (1986-1994) y, más
tarde, de gobernador de Antioquia(1995-1997), siendo finalmente elegido presidente de la República de Colombia en 2002.
República de Colombia / Republic of ColombiaCronología de PresidentesChronology of Presidents
1921 - 1922 Jorge Holguin Conservative 2nd term took over after Suárez
1918 - 1921 Marco Fidel Suárez Conservative resigns office of Presidency
1892 - 1894 Rafael Nuñez Moledo National 3rd term; died in office
1866 - 1867 Tomás Cipriano de Mosquera Liberal 3rd term; died in office
1862 - 1864 Tomás Cipriano de Mosquera Liberal 2nd term: president by civil war
Math Themes
Eratosthenes
276-195 B.C.E.
It can be said that Eratosthenes is most widely known as a famous Greek mathematician. What most people
probably do not know is that Eratosthenes is not only a famous mathematician but also a well known
geographer, astronomer and historian.
Before I get into a few of his accomplishments, let me tell you a little about his personal history. Eratosthenes
was born in Cyrene, Greece, which is now known as Libya, in South Africa, in 276 B.C.E.. It is believed that he
starved himself to death in 195 B.C.E. due to the fact that he became blind and could no longer work. As a
young man, Eratosthenes studied in Athens. Eventually, he made such a name for himself in his many fields
that he caught the attention of the ruler of Egypt, Ptolemy III. Ptolemy III invited Eratosthenes to Alexandria,
Egypt for two reasons; to tutor his son and to be the librarian for the great Alexandrian University. Eratosthenes
jumped at the chance. At the University, he was able to at most interested him and associate with other
scholars. Now on to his accomplishments. . .
One of his major accomplishments in mathematics is his creation of a sieve that determines prime numbers up
to any given limit. This sieve, which is called, the Sieve of Eratosthenes, is still important today in number
research theory. Prime numbers are natural numbers greater than 1 that can be divided without remainder only
by itself and by 1. Eratosthenes figured out that if you were to write down all the natural numbers from 2 to
infinity and "sieve out" every second number after two (or multiples of two), then move to the next available
number (3) and continue to "sieve out" every multiple of 3 and so on, one would end up with a list of prime
numbers.
Eratosthenes is also known for his achievement in astronomy. Several astronomers and mathematicians before
and after Eratosthenes tried to accurately measure the circumference of the Earth, but is was Eratosthenes that
came through. He found the circumference of the Earth to be nearly 250,000 stadia (25,000 miles).
Eratosthenes observed that the sun shone directly down a well at high noon on the day of the summer solstice
in Syene and that it cast a shadow in Alexandria, directly south of where the well was. To calculate the
circumference of the Earth, Eratosthenes measured the angle of the shadow to the Earth. Until he realized this,
Eratosthenes believed that the sun was so far away that its rays were parallel. It is also believed that
Eratosthenes made a star catalog with approximately 675 stars and created a calendar that included leap
years.
As a historian, Eratosthenes decided to work on giving a systematic chronography of the known world by
figuring out the dates of literary and political events from the siege of Troy up until his time. However, this was
only a beginning. Others built on his foundation.
There is still more. Eratosthenes also contributed to geographic source of the river. Many scholars that
preceded Eratosthenes in the study of the Nile river, tried to figure out the reason why parts of the river flooded
while other parts did not. It was not until Eratosthenes that a correct answer was proposed. He believed that
heavy rains near the source of the Nile was the cause of Many of Eratosthenes' peers nicknamed him "Beta"
which is the second letter of the Greek alphabet, indicating that he just fell short of first place. Eratosthenes
contributed greatly to many different areas of knowledge, more than I could cover in this short paper. Maybe in
his time period, his peers did not feel that he contributed enough in one area or maybe they were jealous that
he had contributed so much to so many areas. For a man who was nicknamed Beta, it is pretty impressive that
so much of his work in these areas is still discussed today, so many years late
Pythagoras' Theorem
Years ago, a man named Pythagoras found an amazing fact about triangles:
... and you made a square on each of the three sides, then ...
... the biggest square had the exact same area as the other two squares put together!
2 2 2
a +b =c
Note:
Definition
The longest side of the triangle is called the "hypotenuse", so the formal definition is:
In a right angled triangle:
the square of the hypotenuse is equal to
the sum of the squares of the other two sides.
Sure ... ?
If we know the lengths of two sides of a right angled triangle, we can find the length of the third side. (But remember it only works on
right angled triangles!)
2 2 2
a +b =c
Now you can use algebra to find any missing value, as in the following examples:
2 2 2
a +b =c
2 2 2
5 + 12 = c
2
25 + 144 = c
2
169 = c
2
c = 169
c = √169
c = 13
You can also read about Squares and Square Roots to find out why √169 = 13
2 2 2
a +b =c
2 2 2
9 + b = 15
2
81 + b = 225
Take 81 from both sides:
2
b = 144
b = √144
b = 12
Example: Does this triangle have a Right Angle?
2 2 2
Does a + b = c ?
2 2 2
a + b = 10 + 24 = 100 + 576
2
= 676
2 2
c = 26 = 676
Pascal's Triangle
To build the triangle, start with "1" at the top, then continue placing numbers
below it in a triangular pattern.
Each number is just the two numbers above it added together (except for the
edges, which are all "1").
Introduction to Cells
2) Living things respire. Respiration is the breakdown and use of energy contained in food.
ANIMAL CELL
The cell is the basic unit of life. All organisms are made up of cells (or in some cases, a single cell). Most cells are very small; most are
invisible without using a microscope. Cells are covered by a cell membrane and come in many different shapes. The contents of a cell
are called the protoplasm.
The following is a glossary of animal cell terms:
cell membrane - the thin layer of protein and fat that surrounds the cell. The cell membrane is semipermeable, allowing some
substances to pass into the cell and blocking others.
centrosome - (also called the "microtubule organizing center") a small body located near the nucleus - it has a dense center and
radiating tubules. The centrosomes is where microtubules are made. During cell division (mitosis), the centrosome divides and the two
parts move to opposite sides of the dividing cell. The centriole is the dense center of the centrosome.
cytoplasm - the jellylike material outside the cell nucleus in which the organelles are located.
Golgi body - (also called the Golgi apparatus or golgi complex) a flattened, layered, sac-like organelle that looks like a stack of
pancakes and is located near the nucleus. It produces the membranes that surround the lysosomes. The Golgi body packages
proteins and carbohydrates into membrane-bound vesicles for "export" from the cell.
lysosome - (also called cell vesicles) round organelles surrounded by a membrane and containing digestive enzymes. This is where
the digestion of cell nutrients takes place.
mitochondrion - spherical to rod-shaped organelles with a double membrane. The inner membrane is infolded many times, forming a
series of projections (called cristae). The mitochondrion converts the energy stored in glucose into ATP (adenosine triphosphate) for
the cell.
nuclear membrane - the membrane that surrounds the nucleus.
nucleolus - an organelle within the nucleus - it is where ribosomal RNA is produced. Some cells have more than one nucleolus.
nucleus - spherical body containing many organelles, including the nucleolus. The nucleus controls many of the functions of the cell
(by controlling protein synthesis) and contains DNA (in chromosomes). The nucleus is surrounded by the nuclear membrane.
ribosome - small organelles composed of RNA-rich cytoplasmic granules that are sites of protein synthesis.
rough endoplasmic reticulum - (rough ER) a vast system of interconnected, membranous, infolded and convoluted sacks that are
located in the cell's cytoplasm (the ER is continuous with the outer nuclear membrane). Rough ER is covered with ribosomes that give
it a rough appearance. Rough ER transports materials through the cell and produces proteins in sacks called cisternae (which are sent
to the Golgi body, or inserted into the cell membrane).
smooth endoplasmic reticulum - (smooth ER) a vast system of interconnected, membranous, infolded and convoluted tubes that
are located in the cell's cytoplasm (the ER is continuous with the outer nuclear membrane). The space within the ER is called the ER
lumen. Smooth ER transports materials through the cell. It contains enzymes and produces and digests lipids (fats) and membrane
proteins; smooth ER buds off from rough ER, moving the newly-made proteins and lipids to the Golgi body, lysosomes, and
membranes.
vacuole - fluid-filled, membrane-surrounded cavities inside a cell. The vacuole fills with food being digested and waste material that is
on its way out of the cell.
PLANT CELL
Unlike animal cells, plant cells have a cell wall. The cell wall is made of cellulose, a rigid fiber layer. It gives the cell structure and
allows for adhesion with other plant cells. Inside the cell wall is the cell membrane, a fluid structure made up of lipids and proteins. Cell
membranes have channels and pumps that allow certain molecules in and out of the cell. Most pumps and channels are specific to
certain molecules, like sodium and potassium.
All the components inside the plant cell, called organelles, sit in a jelly-like fluid called cytoplasm. The vacuole, a fluid-containing
organelle, takes up most of the cell and allows the cell to maintain its shape.
The nucleus contains the DNA, the genetic material that encodes for all the plant’s proteins and also contains other organelles. The
nuclear membrane encloses it. Inside the nucleus is an organelle called the nucleolus, where the DNA synthesizes RNA. The smooth
endoplasmic reticulum (ER) is where the RNA goes to make proteins and the rough ER transports molecules throughout the cell. Next
to the nucleus is the Golgi Body, whose function is to package proteins and carbohydrates that will be leaving the cell. An organelle
called a centrosome sits near the nucleus and is important for cell division.
Two organelles only found in plants are amyloplast, which store starch compounds, and chloroplasts. Chloroplasts contain chlorophyll
and convert sunlight into energy the plant cell can use in a process called photosynthesis.
The mitochondrion is known as the “powerhouse” in all cells. Adenosine triphosphate (ATP) is produced from glucose specifically in
the christae, the little projections that are inside the mitochondrial membrane. ATP drives many important chemical reactions in cells.
CELL NUTRITION
We discussed how small particles can diffuse across the cell membrane through either passive transport or active transport. However,
large food particles, whether they be grains of sugar or other organisms, cannot simply diffuse
across the membrane; they are just too big. Instead, they are engulfed by the cell
membrane through a process known as endocytosis.
As a cell approaches a food particle, either the food particle pushes into the cell membrane forming
an indentation, or pseudopodia are extended from the cell around the particle. When the two
extensions of the cell membrane meet on the other side of the particle, they close and form
a vacuole around the food inside the cell. This process of called endocytosis.
Exocytosis is a very similar process. In fact, it's just endocytosis run in reverse order. A vacuole within the cell moves toward and fuses
with the cell membrane. In this manner, the contents of thevacuole are expelled into the external environment. This may occur, for
example, after a cell has taken in a large particle through endocytosis, digested it using the enzymes in the lysosome, and then needs
to expel the waste products.
Endocytosis and exocytosis are general terms which refer to the process by which anything is taken into or expelled from
the cell through the action of vacuoles. Phagocytosis refers to endocytosis of a solid particle.Pinocytosis indicates the taking in of
liquid and dissolved molecules through endocytosis.
CELL REPRODUCTION
Before we can fully discuss cell reproduction, we must look briefly at the organization of DNA in cells. Recall from Chapter One
that DNA is an indirect way of controlling what proteins a cell will produce; based upon the DNA's genetic code (which will be
discussed in Chapter Six), different proteins will be produced.
When a cell reproduces, it basically just splits down the middle. While the process is of course a bit more complex than that, what is
important to realize is that two cells form from the original parent. The parent cell cannot simply cut it's DNA in half and pass half to
either of the new cells; doing so would result in cells which do not have the "code" for all of the proteins. Instead, cells must actually
make a complete copy of their DNA so that each new cell has a full copy of the entire "code."
In prokaryotes, the organization of DNA is fairly simple. It is just one long circular molecule. As you might
expect, eukaryotes have developed a more complex way of organizing their DNA. When the cell is not dividing,
the DNA of a eukaryote appears is a large mass called chromatin. However, immediately before the cell reproduces,
the chromatin (which has already been replicated) condenses into distinct structures. Each of these structures
contains two identical copies of portions of the cell's DNA. The individual copies are known as sister chromatids, and
they are attached at a region called the centromere. During division, the chromatids split, and each half is referred to
as a chromosome. In this manner, each new cell gets an exact copy of the original cell's DNA.
Cell division in prokaryotic organisms is significantly simpler than that in eukaryotes. This is
because prokaryotes have much less complex DNA, and they do not have to worry about ensuring that each of the newcells receives
an approximately equal number of organelles.
All cells reproduce by actually dividing down the middle until the cell membrane pinches closed and two new "daughter" cells are
formed. In prokaryotes, there is very little else to discuss. Once the DNA of thecell is replicated (using a process which will be
discussed in the next chapter), each copy moves toward an opposite side of the cell by attaching to the cell membrane. The cell then
elongates until it is approximately double its original size. Finally, the cell membrane on either side pinches inward and forms two
new cells.
During their lifetime, cells undergo a process of growth which ends either in death or reproduction. Since the general stages of this
cycle are the same for all eukaryotic cells, it has been called the cell cycle. It has two main stages. The first stage, mitosis, refers to
the division of the nucleus and the DNA. The other stage is called interphase (which literally means "the phase between each
division"), which is in turn divided into three smaller periods. The three periods, listed in the order in which they occur, are G1, S, and
G2.
After a cell divides, the daughter cells enter a period of growth called the G1 period. Since each daughter cell is roughly half the size of
the normal-sized parent, the daughter cells must grow and synthesize new organelles. Once the cell has grown to normal size, it may
remain stagnant (stationary) in the G1 phase. However, usually some change (which is currently being researched) occurs in
the cell which causes it to enter the S phase. The S phase simply refers to the time when the cell's DNA is replicated in preparation
for cell division. Once this is completed, the cell enters the G2 phase, in which it synthesizes the structures required for cell division.
Mitosis is the process by which the cell gives identical copies of its DNA to each of the daughter cells. Although the process does not
start and stop into different stages, biologists have separated it into four phases in which major changes occur. These phases
are prophase, metaphase, anaphase, and telophase.
During prophase, the chromatin mass in the nucleus condenses into sister chromatid structures. Both
the nucleolus and the nuclear membrane disappear during prophase. Also, two structures called
the centrioles (which were previously adjacent to one another near the nucleus) begin to move toward
opposite ends of the cell. As they do this, a network of fibers begins to form between them. These fibers
are called the spindle fibers, and they become very important later on.
When prophase ends, the centrioles are at opposite ends of the cell and
the chromatin has fully condensed. The cell is now said to enter metaphase, during
which the spindle fibersattach to the centromeres (or rather a part of
the centromere called the kinetochore) and pull the sister chromatids to the center of
the cell. Metaphase ends when all of the chromatid pairs are aligned in the center.
During the next phase, called anaphase, the centromeres of all of the sister chromatid pairs break
simultaneously. Once separated, each chromatid is referred to as a chromosome. Thechromosomes from
each pair are tugged toward opposite ends of the cell by the spindle fibers still attached to it. At the end
of anaphase, the chromosomes are completely at opposite ends of the cell.
The final stage of mitosis is telophase. The spindle fibers, no longer needed to direct the motion of
the chromosomes, break apart. New membranes begin to form around each of the two sets
of chromosomes, which begin to disperse back into the mass of chromatin. Nucleoli reappear
around each set as well, and a second centriole is formed next to each of the existing in preparation for the
next division. Finally, cytokinesis (the division of the cytoplasm, which is discussed in the next section) begins
to occur.
Cytokinesis is the final stage of cell reproduction; it is the division of the cytoplasm into approximately equal
halves, resulting in a roughly equal distribution of organelles in each of the daughter cells. Cytokinesis usually begins intelophase. We
will discuss cytokinesis separately for organisms which do not have a cell wall (mostly heterotrophs) and those which do have a cell
wall (generally autotrophs).
For a cell without a cell wall, cytokinesis begins with the pinching inward of the cell membrane caused by the action of a ring of special
contractile proteins called actin and myosin. The pinching inward forms a deep grove, often called the cleavage furrow. Eventually, the
opposite sides of the furrow meet and the cell splits into two new daughter cells.
Whereas cytokinesis in cells lacking a cell wall occurs through a pinching inward, organisms with a cell wall undergo a process
through which a so-called cell plate is built from the middle of the cell outward to the membrane.Vesicles from the Golgi bodies flatten
and fuse in the center of the cell, forming the cell plate, which elongates toward the cell membrane as more vesicle are added. When
the cell plate reaches the cell membrane, the parentcell is effectively separated into two new daughter cells, which then proceed to
build a cell wall along the cell plate.
Viruses
Viruses are extremely small infectious agents that invade cells of all types. Once inside another cell, viruses become hijackers, using
the cells' machinery to produce more viruses. Whether viruses constitute living organisms or merely conglomerations of molecules has
been a source of debate for many years.
One of the fundamental hallmarks of life is the ability to reproduce. Whether viruses have this ability is key to a debate over their status
as living things. Some argue that since viruses cannot reproduce independently, they are not alive. However, similar to viruses, there
are a few prokaryotes that are obligate parasites and cannot reproduce without a host. But these prokaryotes show another hallmark
of life that viruses lack: growth. Once assembled, a virus does not change in size or chemical composition. They lack the machinery
for producing energy to drive such biological processes. This makes them radically different from any known organism.
Viruses do, however, show some characteristics of living things. They are made of proteins and glycoproteins like cells are. They
contain genetic information needed to produce more viruses in the form of DNA or RNA. They evolve to adapt to their hosts. So while
it is doubtful viruses are truly alive, they are clearly very similar to living organisms.
Virus Diversity
There is more diversity among viruses than among all groups of living organisms combined. New varieties are constantly being
described. It would be nearly impossible to describe all of the groups of viruses and their characteristics briefly. Instead, we will look at
the characteristics shared by all viruses, such as their basic structure and general replicative cycle. Then we will discuss the features
used to classify new viruses, such as shape and form of genetic material.