Professional Documents
Culture Documents
The removal of toxins and the waste from metabolism from the body.
Kidney:
• The function of the kidney is to remove urea (excretion), and excess water
(osmo-regulation of water AND pH).
• Enters from renal artery, leaves through renal vein. Capillaries branch
throughout kidney in a complex fashions.
• Urine, formed in the kidneys, drains via the ureters into the bladder, for
storage, until appropriate time for release through the urethra.
• Made of cortex and medulla.
• Cortex: Outer dark red region, protected by fibrous capsule on the outside.
• Medulla: Inner thicker region, which is pale red.
o Consists of 12 to 16 conical structures called pyramids.
o The radial stripes on these pyramids indicate numerous uriniferous tubules, or
nephrons.
o The pyramids project into a funnel-like space called the renal pelvis.
Production of urine
Blood leaving kidney has lower concentration of mineral salts and nitrogenous waste
products than blood entering kidneys. It also has less oxygen and more carbon
dioxide.
1. Osmosis
- Water
- Possible due to blood capillary networks surrounding PCT
- More negative water potential of blood in capillaries (due to RBC and proteins
present) allow for osmosis
- Most reabsorption of water occurs at PCT; Water also reabsorbed at loop of
Henle and DCT and collecting duct into surrounding blood capillaries
2. Active transport
- All glucose and amino acids and some sodium chloride (NaCl also reabsorbed
at DCT)
- Against concentration gradient
- Needs energy
3. Diffusion
- Urea
• Excess water, excess salts and metabolic waste products such as urea, uric
acid and creatinine pass out of collecting duct into renal pelvis as mixture
called urine
Loop of Henle – water conservation
- Large amount of sodium chloride pumped out of loop of Henle via active
transport
- Retained in medullary region of kidney, providing high salt concentration
- Water potential of medulla decreases
- Water in loop of Henle travel from less negative water potential (LOH) to more
negative water potential (medulla) via osmosis down concentration gradient
- Osmotic concentration within kidney increases from outer cortex to medulla
Loop of Henle is long to increase surface area for osmosis to take place.
Osmoregulation
1. Loss of water through sweating
Kidney failure:
• Retention of waste in the blood and imbalance of salts in the internal
environment, which prevents proper cell function.
• Kidney failure may develop suddenly, leading to death within a few days
(acute kidney failure), or there may be a slower progressive loss of kidney
function until a stage is reached when the remaining kidney tissue is unable
to carry out the normal function of the kidney (chronic kidney failure).
• Can be treated by: kidney transplant or dialysis.
Kidney transplant:
• Permanent and successful
• Patient does not require to go for daily dialysis treatments if receptive
• The patient’s health status would also be unaffected by mechanical errors.
• The patient would not be susceptible to infection. This is unlike peritoneal
dialysis, where the patient is required to have a catheter coming out from
within his body.
• Body might still reject the kidney.
• Immunosuppressant drugs cause immune system to weaken, to prevent the
body’s immune system from attacking the foreign kidney. Patient more
susceptible to bacterial or viral attack. Diminished immunity can increase the
risk of contracting cancer. Can cause cataracts, diabetes, extra stomach acid,
high blood pressure, and bone disease.
• Suggested diet after a kidney transplant/ kidney disease:
o No/ low (10g) protein as urea cannot be excreted.
o No salt, since salt cannot be excreted.
o Low water intake (500ml) as water cannot be expelled as urine.
o Restricted fruit (no banana/ papaya), to control potassium which
cannot be excreted.
Dialysis
Method of removing toxic substances from blood when kidneys are unable to do so.
Haemodialysis:
• The diffusion of small molecules through a partially permeable membrane into
dialysate in a dialyser.
• The patient’s arterial blood is taken from the arm, and passed through a
dialysing unit where it exchanges urea and other salts by diffusion with
warmed dialysing fluid (dialysiate: containing ions, glucose and amino acid).
• The blood is then passed through a bubble trap (which removes air bubbles in
the blood), before the blood is returned to a vein.
• Blood travels in a counter-current opposite to the flow of dialysis liquid, to
maintain a concentration gradient.
• If blood travels in the same direction as the dialysate, the waste products are
not able to diffuse outward, because with the dialysate travelling with the
blood at the same rate, the concentration gradient will be reduced and
maintained at zero.
Peritoneal dialysis:
• The diffusion of small molecules through the partially permeable peritoneal
membrane into the dialysate in the abdominal cavity.
• Instead of blood being purified outside body like haemodialysis; purified inside
body using peritoneum as natural filter
• Abdomen is filled with dialysis fluid via a catheter. Fluid then removes toxins
and water from blood via peritoneum by absorbing it.
• “Dirty fluid” drained out and replaced with further new, clean fluid for further
dialysis.
• Toxins absorbed via diffusion
• Water passes through to the fluid known as ultrafiltration. The lower water
potential in the fluid causes water to pass over.
Importance of kidneys
• Excretory organ – remove mainly nitrogenous waste products like urea,
excess water and mineral salts in form of urine
• Osmoregulators: regulate salt and water balance of body fluid.
• Increased intake of liquid food, tissue respiration or reduction of sweat
secretion will increase water amt in blood. Kidneys reabsorb less water.
Remove more water from urine. Vice versa
• Remove metabolic waste and control water and solute levels in blood
• Vital role in blood volume control and blood pressure
• IF blood volume increases, blood pressure rise
• Blood volume same but diameter of blood vessels decreases, blood pressure
rise too.
• Large increase in blood pressure ◊ blood vessels in brains burst, stroke.
• Drugs called antidiuretics which reduce production of ADH.
• Large amt of dilute urine produced and volume of water in blood decreased,
lowering blood pressure