DRUG Class Strep Staph Entero E. coli Proteus Klebsiella H. influ M.

cat Pseudo MRSA AnaeroAtypicals

Penicillin Pen + - + - - - - - - - - Neisseria&syphilis

Ampicillin aminopenicillin + - +++ + + - + - - - - h. pylori

Amox aminopenicillin + - +++ + + - + - - - - h. pylori

Naficillin pen-ase res pen + + - - - - - - - - -
Oxacillin pen-ase res pen + + - - - - - - - - -
dicloxacillin pen-ase res pen + + - - - - - - - - -
ticarcillin Antipseudo-Carboxy + - - + + + + + + - -
piperacillin Antipseudo-Ureido + - + Static + + + + + ++ - -
Aztreonam Monobactam - - - + + + + + + - -
Ertapenem Carbipenem + + - + + + + + - - +
Mero/Doripe Carbipenem + + - + + + + + + - +
Imipenem Carbipenem + + + + + + + + + - +
1st gen Cephs + +++ - +/- +/- +/- - - - - -
2nd gen Cephs + ++ - + + + + + - - +
3rd gen Cephs + - - + + + + + - - ?
4th gen Cephs + +++ - + + + + + + - ?
5th gen Cephs + +++ - + + + + + + + ?
Tobramycin Aminoglycoside +~ +~ +~ + + + +~ +~ + - -
Gentimicin Aminoglycoside +~ +~ +~ + + + +~ +~ + - -
Amikacin Aminoglycoside +~ +~ +~ + + + +~ +~ + - -
StreptomycinAminoglycoside +~ +~ +~ + + + +~ +~ + - -
Neomycin Aminoglycoside +~ +~ +~ + + + +~ +~ + - -
Kanamycin Aminoglycoside +~ +~ +~ + + + +~ +~ + - -
ParomomycinAminoglycoside +~ +~ +~ + + + +~ +~ + - -

DRUG Class Strep Staph Entero E. coli Proteus Klebsiella H. influ M. cat Pseudo MRSA AnaeroAtypicals
Norfloxacin Fluoroquinolone NO! urine only + + + + + + - - + Anthrax
Ciprofloxacin Fluoroquinolone - NO! urine only + + + + + + - - + Anthrax
ofloxacin Fluoroquinolone NO! urine only + + + + + + - - + Anthrax
Levofloxacin Fluoroquinolone + NO! urine only + + + + + + - - + Anthrax
Gemifloxacin Fluoroquinolone NO! urine only + + + + + + - - + Anthrax
Moxifloxacin Fluoroquinolone +~ NO! NO! + + + + + - - + + Anthrax
SMX/TMP Sulfonamide NotA,B + - + + + + - - + CA -
sulfisoxazole Sulfonamide - + - + + + + - - + CA -
Sulfadiazine Sulfonamide - + - + + + + - - + CA - +
ErythromycinMacrolide ++ ++ - - - - +/- + - - +
ClarithrymyciMacrolide +++ +++ - - - - ++ + - - +
Azithromycin Macrolide + + - - - - +++ + - - +
TelithromycinMacrolide-ketolide ++++ ++++ - - - - +++ + - - +
Clindamycin Lincosamide + + - - - - - - - + CA +
Metronidazole - - - - - - - - - - +
Tetracycline Tetracycline + + urine only + - + + + - +
Demeclocycli Tetracycline + + urine only + - + + + - +
Doxycycline Tetracycline + + urine only + - + + + + CA - +
minocycline Tetracycline + + urine only + - + + + + CA - +
Tigecyclin Glycylcycline + + +VRE + - + + + - + + +
Polymixin - - - + - + - - + - - -
Vancomycin Glycopeptide + + + - - - - - - + PO C.diff -
Telavancin Lipoglyopeptide + + + - - - - - - + - -
Quin/DafoprisStreptogramin + + +VRE - - - - - - + - -
Linezolid Oxazolidinone + + +VRE - - - - - - + - -
Daptomycin Lipopeptide + + +VRE - - - - - - + - -
Nitrofurantoin + + + + - + - - - - - -

~+ Synergy only
DRUG gen Strep Staph Entero E. coli Proteus KlebsiH. influ M. cat Pseudo MRSA AnaerobeAtypicals
Cefadroxil 1 fad + +++ - +/- +/- +/- - - - - - -
Cefazoline 1 faz + +++ - +/- +/- +/- - - - - - -
Cephalexin 1 alex + +++ - +/- +/- +/- - - - - - -
Cefaclor 2 fac + + - + + + + + - - - -
Cefuroxime 2 fur + + - + + + + + - - - -
Cefprozil 2 pro + + - + + + + + - - - -
Cefotetan 2 fot + + - + + + + + - - + -
Cefoxitin 2 fox + + - + + + + + - - + -
Cefixime 3 fix + +/- - + + + + + - - - -
Cefotaxime 3 tax + +/- - + + + + + - - - -
Cefpodocime proxetil 3 pod + +/- - + + + + + - - - -
Ceftazidime 3 taz + +/- - + + + + + + - - -
Ceftriaxone 3 tri + +/- - + + + + + - - - -
Ceftibuten 3 tib + +/- - + + + + + - - - -
Cefdinir 3 dinir + +/- - + + + + + - - - -
Cefditoren pivoxil 3 dito + +/- - + + + + + - - - -
Cefepime 4 fep + + - + + + + + + - - -
Ceftaroline fosamil 5 caroline + + - + + + + + - + - -
 Cidal/ Conc/Ti
Class MOA Side effects/Counseling points Hematologic Renal CNS GI Hepatic Drug interaction
Static me
hypersensitivity - Allergic Rxn - 1-10%, Anaphylactic rxn -
interstitial Seizure w/ high
Penicillin Cell wall synth cidal time 0.004-0.015%. Pt's allergic to one antimicrobial have 10x Neutropenia at high doses C.diff
nephritis dose
greater risk of rxn to another structurally related.
hypersensitivity, rash>Amp. Amp less F b/c it stays in gut more interstitial
Aminopenicillin Cell wall synth cidal time Neutropenia at high doses Seizure C.diff + allopurinol = increase rash x 3
--> more GI effects, food effects absorb. nephritis
Methicillin: Inter.
Penicillinase Oxacillin: Inc
Cell wall synth cidal time Thrombophebitis w/ Naficillin. Dicloxacillin is PO. Neutropenia nephritis --> off Warfarin: DEC INR d/t inc excretion.
Res. LFT's
market.
Antipseudomon Hypernatremia (T:5.2mEq Na/g, P:1.85mEq Na/g), Neutropenia, Dec platelet
Cell wall synth cidal time Inc LFT's
al hypokalemia. Piperacillin-Dose dependent pharmacokinetics. aggregation - inc bleeding
Can be used in pt's w/ pen allergy. But may have rxn in pt's
monobactam Cell wall synth cidal time Cross sensetivity with Ceftaz (sidechain)
allergic to ceftaz (same side chain)
Drug fever, pruritus, urticaria, rash, hypotension, dizziness from
Seizures -
fast infusion. Induces Res 3rd Gen Cephs, Pen cross rx is 0.9- DEC VPA by 50-70%. Induces beta
Carbapenem Cell wall synth cidal time elderly, hx, high Inc LFT's
47.7%. imipenem-Combo w/ Cilastin-blocks renal lactamase, esp in 3rd gen cephs
dose, renal
dehydropeptidase which inactivates imipenem
Ceftriazone and Ca - contraindicated in
Cefepime: Diarrhea,
Cefotetan: Inc INR, neonates. Prodrugs:cefpodoxime,
Cephalosporins hypersensitivity, Disulferam rx (cefotetan- neurotoxicity in pseudobiliary
Cell wall synth cidal time Ceftaroline:+Combs Inc LFT's cefuroxime and cefditoren have dec
… Methotetrathiazole side chain). Cefdinir: red stool. acute renal lithiasis
test/hemolytic anemia bioavailability with H2 antag and PPI.
failure (ceftriaxone)
Cefotetan: Inc INR

Protein synth 30S Nephrotoxicity, Ototoxicity (irreversible) Neuromuscular Administer AG at end of PCN dosing
Aminoglycoside Cidal Conc Nephrotoxicity Ototoxicity
inhibitor blockade (IV bolus dosing) interval

Neuropsychotic
rxn, HA,
Rash, Pruritis, Arthropathy and Tendon rupture (Inc risk with:
Nephritis, Dizziness, sleep
fluoroquinolone >60, steroids, physical activity, kidney failure, RA), Steroids, Ca and Vitamins, Sucralafate,
DNA gyrase cidal Conc crystalluria, disturbances, N/V/D Liver failure
s Photosensitivity: Cipro>moxy>Levoquin. Prolong QTc Avoid other QTc prolongating drugs
nephropathy seizure (Inc w/
interval Cipro<Moxy IV, Hypo/hyperglycemia
NSAIDs d/t dec
GABA)
Neutropenia,
Cidal Take with plenty of H2O. hypersensitivity, SJS, Hyperkalemia
thrombocytopenia, aplastic Crystalluria, False
Sulfonamides Folic acid metab (w/ Conc (TMP is K-sparing diuretic) Pregnancy X near term (kernicterus- N/V/D Warfarin: Inc INR
anemia, anemia, elevation of SCr
TMP) displaces bilirubin). DOC for UTI
agranulocytosis
Estolate salt should not be used in pregnancy - hepatitus. Not
good for bcteremia b/c it goes into tissue. Good for URTI. Inc N/V/D, Pain,
estolate:
Protein synth 50S motility in GI-often used for that. Thrombophebitis, Urticaria, cramping. Dose Avoid other QTc prolongating drugs.
Macrolide/Ketolide thrombophebitis Ototoxicity cholestatic
inhibitor rash, Prolongs QTc interval. Telithromycin - CI in pt's w/ related . Less with Inhibit P450: Eryth>Clarith>Telith
hepatitis
myasthenia gravis. Visual disturbances and TRANSIENT LOSS OF azith/clarith
CONCIOUSNESS
static/
Cidal Neutropenia, C.diff (more
Protein synth 50S Allergic - rash, fever, eythema multiforme, anaphylaxis. Inhibits hepatotoxicity
Lincosamide (conc thrombocytopenia, anaerobes in
inhibitor toxin release from Staph/Strep: TSS (IV)
depend agranulocytosis normal flora)
ent)
peripheral N/V/D, anorexia,
Pancreatitis, Disulferam rxn, Urine discoloration, Pregnancy X neuropathy epigastric disease,
Metronidazole Frags DNA Cidal Conc Warfarin, Alcohol
1st trimester (long term tx), Metallic taste,
seizures, ataxia ect.
Esophogeal
Inc BUN when Vertigo, tinnitus ulcerations take Divalent/trivalent cations dec absorption,
Protein synth 30S Anaphylaxis, rash, photosensitivity. Teeth & Bone discoloration
Tetracycline Static Conc given with a (mino - on 2-3 with lots of H2O Hepatotoxicity avoid Ca, Al, Mg, Fe, Zi, milk, Mismuth
inhibitor (avoid in pregnancy and <8)
diuretic day of tx) and don’t lay subsalicylates
down!
High tissue penetration - bad for bacteremia. Needs LD d/t
Protein synth 30S
glycylcyline Static time T1/2=42H. Teeth & Bone discoloration (avoid in pregnancy and N/V/D
inhibitor
<8), Rash, Pancreatitis
Used for really resistant Gram(-), neuromuscular blockade.
Membrane Cidal Aerosolized tx (CF pt's) --> broncoconstriction - Give albuterol Nephrotoxicity Neurologic
Polymixin Conc
disruption (fast) prior. FDA Medwatch: mix & use immediately or it 50-60%! complications
becomes toxic!
Nephrotoxicity -
C.diff - PO vanco b/c poor F. Ototoxicity, Red man syndrome -
inc when Inc nephrotoxicity when administered
Glycopepetide Cell wall synth cidal time infusion rate dependent so infuse 1g over 1h. Previous Ototoxicity
administered with with Aminoglycoside.
Pseudoallergic rxn - have benadryl handy
aminoglycoside
Metallic taste, N/V HA, Foamy urine d/t cyclodextrin
Lipoglycopeptid interfere w/ coagulation Nephrotoxicity -
Cell wall synth cidal Conc solublizing agent. Red man syndrome. May be less effective than
e tests more than Vanco!
Vanco. QTc prolongation in 1% of pts. Avoid in pregnancy!
Protein synth 50S Central line d.t veinous irritation. Arthralgias and myalgias Inc conjugated
Streptogramin cidal Conc N/V/D P450 interactions
inhibitor 20-30% of pt's bilirubin
peripheral and SSRI's, TCA's, Triptans, meperidine,
Protein synth Myelosuprression/thrombo N/V/D (Lactic
Oxazolidinone static time Serotonin syndrome and Tyramine Rxn optic neuropathy, buspirone, MAOIs --> serotonin
tRNA ctopenia - CBC weekly Acidosis)
convulsions syndrome
Membrane Low pulmonary penetration. Muscle pain - Monitor CPK levels
Lipopeptide cidal Conc
depolarization weekly and stop statins
UTI ONLY. Needs acidic environment and proteus inc pH so Avoid in CrCl<60
Inactivates bact Hemolytic anemia in pt's peripheral
Nitrofurantoin Cidal ineffective for. Rash, Pulmonary fibrosis. Avoid in nursing moms d/t poor Hepatitis
ribosomes with G6PD deficiency neuropathy
w/ baby <1 mo. penetration.
Peak serum concentrations of Gent/tobramycin
Lower UTI < 3mcg/ml
Synergy w/ entero and staph 3-5mcg/ml
intra-abd, sepsis or mod-sev infections 5-8mcg/ml
pneumonia 8-10mcg/ml

Amikacin will be 4-5x above values

Trough serum concentrations

Gent/tobra <1-2mcg/ml
Amikacin <4mcg/ml

Lung - only 20% gets in lung, so use in combo only

Empiric dosing:
IBW
CrCl
Ke
T1/2
Vd
Tau
Infusion rate
Dose
Check
Gram + Gram - PseudomonaAnaerobes Atypical
Staph E. coli Bacteroids Mycoplasma
Strep Klebsiella Chlamydia
Entero Proteus Legionella
H. influenza
M. catarrhalis
Bug 1ST CHOICE MAY ALSO USE OPTION
Strep
Pen and Clinda (binds to toxin)
(Group A)
Entero Aminopenicillins
Amp + Gent = amp has high Tigecycline - but
VRE concentrations in urine so may still be Linezolid poor urine
used in setting of a high MIC penetration
MSSA Amox, Cephalexin

Inpatient: Vanco 1g
Outpatient: Clindamycin, TMP-
Q12h (trough 15),
MRSA (CA) Incision and drainage if possible SMX, Doxycycline, mincycline,
linezolid, dapto,
linezolid
clinda, telavancin

TMP-SMX, Linezolid, daptomycin,

MRSA (HA) Vanco 15-20mg/kg/dose Q8-12h
telavancin, quinpristin/dalfoprisin
Dapto, linezolid,
quinpristin/dafpristin, tigecycline
VRSA depends on susceptibility data
& rifampin, bactrim(last 2 not for
monotherapy)
Carbapenems ONLY - even though they
ESBLs
appear susceptible in vitro
Klebsiella possibly send in bacterial strain
pneumonia Tigecycline or polymixinsare the only to Center for Disease Control
carbapente options (CDC) to see what combo of
mase (KPC) drugs may work.

Antipseudo, cipro, levofloxacin,

carbapenems (not ertapenem)
Pseudo
aminoglycosides, Cefazidime, Cefepime,
Aztreonam, Polymixin/colistin

S.aureus,
Warm compress, topical Mupiocin or For recurrences: tx nares w/
Folliculitis Pseudomonas,
other antibiotics, clotrimazole. muprocin
Candida
Furuncles S.aureus Moist heat, incision and drainage
 Warm compress. Topical: Clinda,
PO: Diclocacillin, clinda,
Carbuncles S.arureus, strep erythro, muirocin, benzoyl peroxide
Cephalexin, TMP-SMX
BIDx7days
Group A or G
Erysipelas Pen, Clinda
Strep
S.aureus,
S.pyogenes Bullous (S.aureus):Dicloxacillin, 1st gen Non-Bullous (S.pyogenes): Pen,
Impetigo
(glomerulonephr ceph. Dicloxacillin, Cefalexin
itis)
Lymphangiti Pen IV x2-3days then PO PenVK
S.pyogenes Clindamycin
s x10days
S.pyogenes,
Empiric: PO: Cephalexin, Dicloxacillin
S.aureus, Many Pen allergy: Clinda, Cephalexin,
Cellulitis IV: Oxacillin/Nafcillin, (MRSA or PCN
others, Gram vanco
allergy: Vanco, dapto, Linezolid
(-), Fugi
Necrotizing Broad spectrum: Amp-Sul + Clinda +
Multiple
fasciitis Cipro
Cx usually
Topical Abx x 2wks: Silver sulfadiazine,
Decubitus useless. Need
combo abx ointments, propylene glycol
ulcer deep tissue or
"skin renu"
blood culture
IV: Amp-Sul,
Pateurella, Augmentin, Doxycycline, PenVK,
Cat/Dog Avoid: 1st gen, dicloxacillin, Zosyn, cafoxitin,
Staph, strep, (Quinolones, TMP-SMX or Cefuroxime)
bite Macrolides, clinda carbapenems,
anaerobes + (metronidazole or Clinda)
anarobe coverage
Avoid: 1s Gens,
Prophylactic Abx for everyone:
Human Bite Multiple Amp-Sul, Cephoxitin Macrolides, clinda,
Dicloxacillin + Pen x3-5days
aminoglycosides
Diabetic
Foot 1st Gens, Clinda, Augmentin, TMP-SMX,
S.arureus, strep Quinolones - if sucseptable
Infection dicloxacillin
(Acute)
Diabetic
Multiple, Gram
Foot Broad spectrum. Empiric is unknown.
+, Gram -,
Infection Save combo tx for resistant or severe.
anaerobic
(Chronic)
 Staph but need
Joint
cutlure and antistaphylococci abx
infection
gram stain
Osteomylitis Abx x6wks!

Nitrofurantoin,
1st occurance (tx 3 days): TMP-SMX,
Reocurrences (tx 7 Days): TMP- Augmentin(entero)
UTI E.coli Cipro, Amocicillin. Pregnant: Amox,
SMX, Cipro, B-lactams Cephs, Doxycycline,
Cephs x7 days
Fosfomycin

TMP-SMX 80/400 1/2 tab daily or Postcoital: TMP-SMX 80/400 1/2-

UTI
3x/week, TMP 100mg QD, Nitrifurantoin 1 tab, Nitrofurantoin 50-100mg,
(prophylaxis)
50-100mg QD Cipro 250mg, Levo 250mg
IV: Quinolones (not Moxy),
Pyelonephri PO: TMX-SMX, Quinolones (Not Moxy), Amp+Gent,
tis Augmentin Cephs+aminoglycoside, Amp-
Sulbactam + Aminoglycoside
Ptrostatitis Quinolones, TMP-SMX Ampicillin + Gent, Doxy
Drug resistant: Hig
Virus, dose Amox or
Acute Symptomatic Tx: Decongestants, nasal Amoxicillin, Doxy, TMP-SMX,
S.pneumoniae, augmentin,
Sinusitis saline, nasal steroids Azithro, 2nd/3rd gen cephs
H.influ Levo/Moxy,
Ceftiraxone
Virus, Strep-A
(+stomach
1.Pen VK 2.Amox 3.Benzathine PCN
ache= rhumatic
Pharyngitis 4.Cephalexin/Cefadroxil 5.Clinda 6.
fever -->
Azith 7.Clarith
damaged H
valve)
S.pneumoniae,
Mycoplasma Risk factors for DRSP: Moxy or
CAP pneumoniae, Empiric Tx w/ no risk factors for DRSP: Levo, B-lactam (Amox 1g TID,
(Outpatient) H.influ, Macrolide, Doxy Augm 2g BID, 2nd or 3rd) +
Chlamydlopilia, Macrolide or Doxy
virus
 S.pneumoniae,
Mycoplasma
pneumoniae,
CAP H.influ, Moxy or Levo, B-lactam + Macrolide
(Inpatient) Chlamydlopilia, (usually Ceftriaxone 1g QD + Z pack
legionella,
anaerobes,
virus
S.pneumoniae,
S.aureus,
Sdd Oseltamivir or
H.influ, Pseudo: (Pip/tazo, cefepime,
Zanamivir if
CAP (ICU) legionella, Gram B-Lactam + (Azith or Quinolone) imi/mero) + Cipro, Levo,
influenza and <48
neg bacilli aminoglycoside, Z-pack
H
(entero and
pseudo), virus
Legionella-
Severe
presentation.
CAP Macrolide, Quinolone
Urinary antigen
test for
confirmation
M.pneumoniae
(Walking
pneumonia)
CAP Macrolide, Quinolone
RASH, flu-like
Sx. No good Dx
test.
CAP MRSA Clinda 900mg, Linezolid, Vanco
HAP (1st 4
S.pneumo,
days - no Ceftriazone, Levo or Moxy or Cipro,
H.influ, MSSA,
MDR risk Amp/Sulbactam, Ertapenem
Gram (-)
foactors)
 Pseudo, ESBL
Pseudo coverage + more pseudo
HAP (Late klebs,
coverage+MRSA coverage. Streamilne
onset - MDR Acinetobacter,
tx when cultures come back. Tx 10-21
risk) MRSA,
days
Legionella
Isoniazid 300mg QD (x 6-9 mo.) + B6
Tuberculosis Isoniazid + Rifampin 600mg
25-50mg QD to prevent periphral
(Latent) QD (Both Hepatotoxic)
neuropath
Sttreptomycin,
Culture Postitive: Isoniazid + Ethambutol (no hepatotoxicity) is Cycloserine, P-
Rifampin + Pyrazinamide + emperic only. Remove when sus Aminosalicyclic
Ethambutol QD x 8wks. --> repeat results are good for INH and RIF. acid, ethionamide,
Tuberculosis
Xray. If (-) = tx x 4 more mo. If (+) = Pyrazinamide 15-30mg/kg/day capreomycin,
(Active)
tx x 7 more mo. Culture Negative: same (Hepatotoxicity, hyperuricemia Corticosteroids
but @ 2 mo. If Xray has no change --> and myalgias), Fluoroquinolones used as adjunctive
not TB. If no PZA --> 7 mo. - Moxy or Levo w/ meningitis and
pericardiis

C. diff C.diff Metronidazole 250mg PO QID Vanco 125mg PO QID Bacitracin

Primary other 3rd Gen Cephs, extended
Cefoxatin (+ metronidazole if anaerobes
Peritonitis E.coli spectrum pens, aztreonam,
suspected)
(Cerrhosis) imipenem, quinolones
Cefazolin + Aminoglycoside.
Primary Skin flora: Empirically: Cefazolin +Ceftaz or Imipenem/Cilastin
Avoid prolonged aminoglycoside
Peritonitis Staph, Strep. Cefepime. Cover Gram+/- and pseudo or Cefepime or
use to preserve residual renal
(Dialysis) Gram +/- x2-3wks Quinolones
function
Secondary
Peritonitis
 Staph (coag MSSA: Naf/Oxacillin, 1st Gens, vanco,
Catheter neg), S.aureus, TMP-SMX. MRSA: Vanco, VRSA:Dapto,
Postive blood culture: Always
Related Aerobic gram Pseudo: Cefepime, Carbapenem, Zosy,
treat S.aureus x2wks IV
Infections neg bacilli, Aminogycoside. Femoral catheter:
Candida, Pseudo Vanco + broad spectrum + fungal

Catheter
Amp resistant: Vanco+/-Gent.
Related Amp or PCN +/- Gent x7-14days.
Enterococcal VRE:Linezolid, Dapto or
Infections Alternative: Vanco
Quin/Dalfopristin
(Entero)
Endocarditis On following
(STREP) page
 MIC

Penicillin (high dose) x 4 High dose Pen G or

Endocarditi S.viridan, < 0.12mcg/ml
weeks or Ceftriaxone X 4 Ceftriaxone + Gentamycin x
s (STREP) S.bovis (LOW)
weeks 2 weeks - Gent pk-3-4, tr<1

>0.12- Penicillin (high dose) x 4

Endocarditi S.viridan,
0.5mcg/ml weeks or Ceftriaxone X 4
s (STREP) S.bovis
(MODERATE) weeks + Gent for 2 wks
Endocarditi S.viridan, >0.5mcg/ml
Amp or PCN + Gent x 4-6wks
s (STREP) S.bovis (HIGH)

MSSA: Nafcillin or Oxacillin

Endocarditi
Staph x4-6 wks + Short course of MRSA: Vanco
s (STAPH)
Gentamycin.

Endocarditi MSSA: Nafcillin or Oxacillin x MRSA: Vanco + rifampin x 6

s (Prosthetic 6 weeks + aminoglycoside for weeks + aminoglycoside for
valve) 1st 2 weeks. 1st 2 weeks.
Endocarditi
s High dose Pen G or Amp + Vanco or Amp/sulbactam +
Enterococcal
(ENTEROCO Gent x 6 weeks Gent x 6 weeks
CCAL)

NOT FINISHED!!!
Pen allergy: Vancomycin.
Resistant organisms: vanco
+ Pen or Ceftriaxone for 1st
2 weeks.

Mild Pen alergy: 1st gen

ceph. True Pen allergy:
Vanco - slow and less
effective - candidate for pen
desensitization
DRUG Class Strep Staph Entero E. coli Proteus Kleb H. influ M. cat Pseudo MRSA AnaerobeAtypicals
Penicillin
Ampicillin
Amox
Naficillin
Oxacillin
dicloxacillin
ticarcillin
piperacillin
Aztreonam
Ertapenem
Mero/Doripenem
Imipenem
1st gen Cephs
2nd gen Cephs
3rd gen Cephs
4th gen Cephs
5th gen Cephs
Tobramycin
Gentimicin
Amikacin
Streptomycin
Neomycin
Kanamycin
Paromomycin
Norfloxacin
Ciprofloxacin
ofloxacin
Levofloxacin
Gemifloxacin
Moxifloxacin
SMX/TMP
sulfisoxazole
Sulfadiazine
DRUG Class Strep Staph Entero E. coli Proteus KlebsiH. influ M. cat Pseudo MRSA AnaerobeAtypicals
Erythromycin
Clarithrymycin
Azithromycin
Telithromycin
Clindamycin
Metronidazole
Tetracycline
Demeclocycline
Doxycycline
minocycline
Tigecyclin
Polymixin
Vancomycin
Telavancin
Quin/Dafopristine
Linezolid
Daptomycin
Nitrofurantoin