Product Information

S1531 BIX 02189

MEK

Novel Life Science Reagents

for Cell Signaling Research

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Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 440.54 C27H28N4O2 DMSO 99% at -20 2 years 1094614-85-3
N H N O N H O N

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Biological Activity
BIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. [1] It inhibited catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells. The compounds also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system. [2]

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References
[1] Tatake RJ et al. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5 [2] Obara Y et al. J Biol Chem. 2009 Aug 28;284(35):23564-73

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MSDS & CoA

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Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

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