Dr. D. Y.

Patil Vidyapeeth
(Deemed University) Pimpri, Pune 411 018

Department of Pharmacology
MD (PHARMACOLOGY) (1) GOALS To gain thorough knowledge about that subject and to implement for betterment to the mankind. OBJECTIVES 2.1 To produce M.D. Pharmacology for: 2.1.1 Pharmaceutical industry purpose. 2.1.2 Professional teaching purpose. 2.1.3 High-level institutional research. INTEGRATION OF TEACHING Not applicable for M.D. Pharmacology. TRAINING SCHEDULE 4.1 There will be Weekly Seminars Weekly Journal Club Discussion on Biostatics, Recent Advances Discussion on other Topics Acute Study 4.2 Experimental Pharmacology Toxicological Study 4.2.1 4.2.2 Whole Animal Mounting Isolated Tissue Mounting Dog - B.P, Respiratory Rate, Spleenic volume and Renal Volume. Cat - Nictitating membrane. Rabbit Langendorffs preparation, Ear vein injection, Mydriatics, Local Anaesthetics Rat - Analgesics, Psychopharmacological Study, Tail vein Injection Colon, Fundus of stomach, Uterus, Anaesthetics. Guinea. Pig - Ileum Finkleman method, Local Anaesthetics, Histamine aerosol method Frog - Rectus, failing heart, Oesophagus, Local Anaesthetics. Mice - Analgesics, Psychopharmacological Study, Skeletal Muscle Relaxants.

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4.3 Biochemical Pharmacology 4.3.1 Evaluation of drug by spectrophotometer and different chemical tests. 4.3.2 Toxicological Study spectrophotometer, calorimeter and autoanalyser. 4.3.3 Hormonal Estimation. 4.4 Clinical Pharmacology 4.4.1 Pharmacokinetics study Tub bath techniques clearance, distribution study, elimination. 4.4.2 Pharmacodynamics study 4.4.3 Biochemical Methods a. Liver Function Test SGOT, SGPT Input b. Kidney Function Test Volume of Urine, Fluid Output c. Autoanalyser

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Clinical Methods B.P E.C.G I.V. Injection Oral feeding tubing technique.

4.5 Period of training : M.D.- After M.B.B.S 3 years course after registration. (5) DETAILS OF SYLLABUS : 5.1 Topics 5.1.1 General pharmacology, Molecular aspects of pharmacology, Methods of measurement in Clinical pharmacology e.g. Clinical trial, Bioassay. 5.1.2 Clinical trial Evaluation of Pharmacokinetics study Elimination, Distribution 5.1.3 Evaluation of Pharmacodynamics study by (a) Biochemical methods (b) Clinical Methods. 5.1.4 Systemic Pharmacology, Neurotransmitter, CNS, ANS, CVS, Endocrinology, GIT, RS. 5.1.5 Chemotherapy, Gene Therapy, Clinical Pharmacology. 5.1.6 Recent advances in Pharmacology, Role of Biostatics, Pharmaceutical Industry. (6) TITLE OF THEORY PAPERS WITH CONTENTS: 6.1 Paper I :

- General pharmacology, Molecular aspects of Acute Study pharmacology, Methods of measurement in Clinical pharmacology e.g. Clinical trial, Bioassay. Clinical trial Evaluation of Pharmacokinetics study Elimination, Distribution Evaluation of Pharmacodynamics study by - Biochemical methods - Clinical Methods. - Recent trends 6.2 Paper II :- Systemic Pharmacology, Neurotransmitter, CNS, ANS, CVS, Endocrinology, GIT, RS & Recent trends. 6.3 Paper III : - Chemotherapy, Gene Therapy, Clinical Pharmacology & Recent trends. 6.4 Paper IV : - Recent advances in Pharmacology, Role of Biostatics, Pharmaceutical Industry. (7) PRACTICALS DETAILS OF PRACTICALS Acute Study 7.1 Experimental Pharmacology Toxicological Study 7.1.1 7.1.2 Whole Animal Mounting Isolated Tissue Mounting

Dog - B.P, Respiratory Rate, Spleenic volume and Renal Volume. Cat - Nictitating membrane. Rabbit Langendorffs preparation, Ear vein injection, Mydriatics, Local Anaesthetics Rat - Analgesics, Psychopharmacological Study, Tail vein Injection Colon, Fundus of stomach, Uterus, Anaesthetics. G. Pig - Ileum Finkleman method, Local Anaesthetics, Histamine aerosol method Frog - Rectus, failing heart, Oesophagus, Local Anaesthetics. Mice - Analgesics, Psychopharmacological Study, Skeletal Muscle Relaxants. 7.2 Biochemical Pharmacology 7.2.1 Estimation of drug by spectrophotometer and different chemical tests. 7.2.2 Toxicological Study spectrophotometer, calorimeter and autoanalyser.

7.2.3 Hormonal Estimation. 7.3 Clinical Pharmacology 7.3.1 Pharmacokinetics study Tub bath techniques clearance, distribution study, elimination. 7.3.2 Pharmacodynamics study 7.3.3 Biochemical Methods a. Liver Function Test SGOT, SGPT Input b. Kidney Function Test Volume of Urine, Fluid Output c. Autoanalyser 7.3.4 Clinical Methods a. B.P b. E.C.G c. I.V. Injection d. Oral feeding tubing technique. (8) DISSERTATION 8.1 Aim Thesis is a must for P.G. students. Here P.G. students learn different techniques on whole animal, isolated tissue mounting, Biostatics and clinical pharmacology and most important thing How to write a scientific paper in a standard national and international journals. 8.2 Objective To learn various technique which are essential for M.D. Degree General guideline and topic to the dissertation is given by P.G. the teacher. 8.3 Material and methods The techniques concern to dissertation, which may include: experimental pharmacology, biochemical pharmacology and clinical pharmacology and it depends upon which topic is given to the students by P.G. teacher. Result of dissertation will be statistically analyzed. Discussion It is most important part of dissertation where impartially the results are discussed on the background, concerned literature of the subject. For this P.G. student has to go to various references, articles in the journals. Again, guide plays a very important role to present dissertation in more scientific manner.

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(9) METHODS OF EVALUATION OF STUDENTS 9.1 Final Year University Examination

Final Year University Examination shall be at the end of three years and shall have 9.1.1 Theory Four theory papers each of 100 marks total 400 marks Paper I, II & III will have following pattern 5 SAQs of 10 marks each 2 LAQ of 25 marks each - 50 marks - 50 marks

Paper IV 200 MCQs of 1/2 mark each) 100 marks 9.1.2 Practical Examination : 400 Marks 1 2 3 Long Experiment Isolated Tissue Experiment including bioassay Short Experiments Technique demonstration i. Instruments used in experimental Pharmacology, Oral feeding, I.V. Injection. ii. Biochemical Pharmacologyiii. Clinical Pharmacology.Grand Viva Total Marks 100 Marks 100 Marks 100 Marks

100 Marks 400 Marks