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Disolusi Obat
03 Apr Jelaskan penetapan kadar disolusi untuk theophylin ? (dilampirkan jurnal) Claims: What is claimed is:

A theophylline sustained release tablet comprising (i) core granules having a theophylline content of 98% or more, (ii) at least one coating film layer composed of a hydrophobic material, and a plastic excipient to form coated granules and (iii) a disintegrating excipient, and coated granules and said disintegrating excipient being compression molded to form the theophylline sustained release tablet, wherein the sustained release action is obtained by the tablet disintegrating into the coated granules that are dispersed immediately and the theophylline is gradually dissolved from the dispersed coated granules. A theophylline sustained release tablet as claimed in claim 1, wherein the coated granules are obtained by coating core granules mainly composed of theophylline coated with at least one layer coating film composed of a hydrophobic material, an enteric polymer material and a plastic excipient. A theophylline sustained release tablet as claimed in claim 1 or 2, wherein the core granules mainly composed of theophylline have a high hardness, a particle size of 50 to 1700 m. A theophylline sustained release tablet as claimed in claim 1 or 2, wherein the coated granules are coated with two layers. A theophylline sustained release tablet as claimed in claim 1 or 2, wherein the coated granules are a mixture of at least two coated granules having different coating compositions or coating amounts. A theophylline sustained release tablet as claimed in claim 1 or 2, wherein the hydrophobic material in the coating is a water insoluble polymer material. A theophylline sustained release tablet as claimed in claim 1 or 2, wherein the plastic excipient in the coating is triethyl citrate, glyceryl fatty acid ester, cetanol, hardened castor oil, hardened rapeseed oil, or carnauba wax. A theophylline sustained release tablet as claimed in claim 2, wherein the enteric polymer material in the coating is a methacrylic acid copolymer or hydroxypropylmethylcellulose phthalate. A theophylline sustained release tablet as claimed in claim 1 or 2, wherein the amount of the coating in the coated granules is 5 to 50 parts by weight based upon 100 parts by weight of the core granules. A theophylline sustained release tablet as claimed in claim 1 or 2, wherein the amount of the disintegrating excipient is 5 to 15 parts by weight based upon 100 parts by weight of the theophylline. A theophylline sustained release tablet comprising (i) core granules having a theophylline content of 98% or more, (ii) 5 to 50 parts by weight, based upon 100 parts by weight of the core granules, of at least one coating film layer composed of a hydrophobic material and a plastic excipient to form coated granules, and (iii) 1 to 25 parts by weight, based upon parts by weight of theophylline of a disintegrating excipient, and coated granules and said disintegrating excipient being compression molded to form the theophylline sustained release tablet, wherein the the sustained release action is obtained by the tablet disintegrating into the coated granules that are dispersed immediately and the theophylline is gradually dissolved from the dispersed coated granules. A theophylline sustained release tablet as claimed in claim 6, wherein the water insoluble polymer material is selected from the group consisting of ethylcellulose, ethyl acrylate-methyl methacrylate copolymers, and amino alkyl-methacrylate polymers. A theophylline sustained release tablet as claimed in claim 11, wherein the coated granules are obtained by coating core granules mainly composed of theophylline coated with at least one layer coating film composed of a hydrophobic material, an enteric polymer material, and a plastic excipient.

Jelaskan suatu proses tablet bila diberikan secara oral sampai ke saluran darah ? Sediaan obat yang diberikan secara oral di dalam saluran cerna harus mengalami proses pelepasan dari sediannya kemudian zat aktif akan melary dan selanjutnya diabsorpsi. Proses pelepasan zat aktif dari sediaannya. Proses pelarutannya sangat dipengaruhi oleh sifat-sifat kimia dan fisika zat tersebut serta formulasi sediaanya. Salah satu sifat zat aktif yang penting untuk diperhatikan adalah kelarutan, karena pada umumnya zat baru diabsorpsi setelah terlarut dalam cairan cerna. Oleh karena itu salah satu usaha untuk meningkatkan ketersediaan hayati suatu sediaan adalah dengan menaikan kelarutan zat aktifnya (Astuti, dkk.,2007) Mengapa kelarutan bahan obat PH 1-8 ? Uji disolusi dilakukan dalam berbagai medium disolusi dengan rentang pH 1 6.8 , seperti halnya cairan fisiologi dalam salur cerna (GI) manusia. pH sangat mempengaruhi kelarutan zat-zat yang bersifat asam maupun basa lemah. Zat yang bersifat basa lemah akan lebih mudah larut jika berada dalam suasana basa. Tentukan zinc condition apabila kelarutan paracetamol 1:20000 dengan dosis 100mg apabila kelarutan disolusinya 1/3 volume kelarutan disolusinya ? 1 g ~ 20.000 0,1 ~ ? 0,1g / 1g x 20.000 2000 x 3 = 2000 ~ 100 mg = 6000

Bagaimana meningkatkan laju disolusi pada obat secara in vitro? Untuk meningkatkan laju disolusi obat secara in vitro dipengaruhi beberapa faktor, antara lain:

Sifat fisika kimia obat yaitu sifat fisika kimia obat berpengaruh besar terhadap kinetika disolusi. Luas permukaan efektif dapat diperbesar dengan memperkecil ukuran partikel. Laju disolusi akan diperbesar karena kelarutan terjadi pada permukaan solut. Kelarutan obat dalam air juga mempengaruhi laju disolusi. Obat berbentuk garam, pada umumnya lebih mudah larut dari pada obat berbentuk asam maupun basa bebas. Obat dapat membentuk suatu polimorfi yaitu terdapatnya beberapa kinetika pelarutan yang berbeda meskipun memiliki struktur kimia yang identik. Obat bentuk kristal secara umum lebih keras, kaku dan secara termodinamik lebih stabil daripada bentuk amorf, kondisi ini menyebabkan obat bentuk amorf lebih mudah terdisolusi daripada bentuk kristal (Shargel dan Yu, 1999). Faktor formulasi adalah berbagai macam bahan tambahan yang digunakan pada sediaan obat dapat mempengaruhi kinetika pelarutan obat dengan mempengaruhi tegangan muka antara medium tempat obat melarut dengan bahan obat, ataupun bereaksi secara langsung dengan bahan obat. Penggunaan bahan tambahan yang bersifat hidrofob seperti magnesium stearat, dapat menaikkan tegangan antar muka obat dengan medium disolusi. Beberapa bahan tambahan lain dapat membentuk kompleks dengan bahan obat, misalnya kalsium karbonat dan kalsium sulfat yang membentuk kompleks tidak larut dengan tetrasiklin. Hal ini menyebabkan jumlah obat terdisolusi menjadi lebih sedikit dan berpengaruh pula terhadap jumlah obat yang diabsorpsi (Shargel dan Yu, 1999). Faktor alat dan kondisi lingkungan yaitu adanya perbedaan alat yang digunakan dalam uji disolusi akan menyebabkan perbedaan kecepatan pelarutan obat. Kecepatan pengadukan akan mempengaruhi kecepatan pelarutan obat, semakin cepat pengadukan maka gerakan medium akan semakin cepat sehingga dapat menaikkan kecepatan pelarutan. Selain itu temperatur, viskositas dan komposisi dari medium, serta pengambilan sampel juga dapat mempengaruhi kecepatan pelarutan obat (Swarbrick dan Boyland, 1994b; Parrott, 1971).

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keseringan d leb... hafh... View all posts by itnaijrun Leave a comment Posted by itnaijrun on April 3, 2011 in Farmasi Fisika Previous Post Macam-Macam Sujud Like Be the first to like this post.

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