Product Information

S1261 Celecoxib
Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 381.37 C17H14F3N3O2S DMSO 99% at -20 2 years 169590-42-5
N N F F F O S NH2 O

Novel Life Science Reagents

for Cell Signaling Research

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Synonyms: Celebrex,

Celebra

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Biological Activity
Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase (and thus causes inhibition of prostaglandin production). [1] Celecoxib is more selective for COX-2 (IC50=0.04M)inhibition over COX-1(IC50=15M). [2] It binds with its polar sulfonamide side chain to a hydrophilic side pocket region close to the active COX-2 binding site. [1] Celecoxib is a nonsteroidal antiinflammatory drug (NSAID) that is used to treat arthritis, pain, menstrual cramps, and colonic polyps. [1]

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References
[1] http://en.wikipedia.org/wiki/Celecoxib [2] Neelam Seedher and Sonu Bhatia. AAPS PharmSciTech. 2003,4(3):33

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Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

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