Insulin and Its Metabolic Effects By Ron Rosedale, M.D.

PresentedatDesignsforHealthInstitute's BoulderFestAugust1999Seminar Thiswebsitewillprovethateatingredmeatandnaturalanimalfatswhilerestrictingcarbohydratesisnot onlyhealthybutwillpreventandcuremanydiseases.

Clickheretoreadthe"MedicalDisclaimer."

Let'stalkaboutacoupleofcasehistories.TheseareactualpatientsthatI'veseenlet'sstartwithpatientA.Thispatient whowewilljustcallpatientAsawmeoneafternoonandsaidthathehadliterallyjustsignedhimselfoutofthehospital "AMA,"oragainstmedicaladvice.Likeinthemovies,hehadrippedouthisIV's. Thenextdayhewasscheduledtohavehissecondbypasssurgery.Hehadbeentoldthatifhedidnotfollowthroughwith thisbypasssurgery,withintwoweekshewouldbedead.Hecouldn'twalkfromthecartotheofficewithoutseverechest pain. Hewason102unitsofinsulinandhisbloodsugarswere300plus.Hewasoneightdifferentmedicationsforvariousthings. Buthisfirstbypasssurgerywassuchamiserableexperiencehesaidhewouldratherjustdiethanhavetogothroughthe secondoneandhadheardthatImightbeabletopreventthat. Tomakealongstoryshort,thisgentlemanrightnowisonnoinsulin.Ifirstsawhimthreeandahalfyearsago.Heplays golffourorfivetimesaweek.Heisonnomedicationswhatsoever,hehasnochestpain,andhehasnothadanysurgery. Hestartedanorganizationcalled"HeartSupportofAmerica"toeducatedpeoplethattherearealternativestobypass surgerythathavenothingtodowithsurgeryormedication.Thatorganization,helasttoldmehadamailinglistofovera millionpeople,alargeorganization,"HeartSupportofAmerica." PatientBisapatientwhohadatriglyceridelevelof2200.PatientBwasreferredbypatientA.Hehadatriglycerideof2200, cholesterolof950andwasonmaximumdosesofallofhismedications.Hewas42yearsold,andhewastoldthathehad familialhyperlipidemaandthathehadbettergethisaffairsinorder,thatifthatwaswhathislipidsweredespitethebest
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familialhyperlipidemaandthathehadbettergethisaffairsinorder,thatifthatwaswhathislipidsweredespitethebest medicationswiththehighestdoses,hewasintrouble.

Hewasnotfatatall,hewasfairlythin.
WheneverIseeapatientonanyofthosemedications,they'reofftheveryfirstvisit.Theyhavenoplaceinmedicine.Hewas takenoffthemedicationsandinsixweekshislipidlevels,bothhisTriglyceridesandhischolesterolwerehoveringaround 220.Sixmoreweekstheywerebothunder200,offofthemedications.Theyhavenoplaceinmedicine. IshouldmentionthatthispatienthadaCPKthatwasquiteelevated.Itwascircledonthelabreportthathebroughtin initiallywithaquestionmarkbyitbecausetheydidn'tknowwhy.Thereasonwhywasbecausehewaseatingoffhis muscles,becauseifyoutake(gemfibrozole)andanyoftheHMGcoenzymereductaseinhibitorstogether,thatisa commonsideeffectthatisinthePDR,andtheyshouldn'tbegiventogether. Sohewaschewinguphismuscles,includinghisheartwhichtheyweretryingtotreat.Soifindeedhewasgoingtodie,it wasgoingtobethattreatmentthatwasgoingtokillhim. Let'sgotosomethingtotallydifferent,aladywithsevereosteoporosis.Sheisalmostthreestandarddeviationsbelowthe norminboththehipfemeralneckandthecervicalvertebrae,andsheisveryworriedaboutgettingafracture.Afairlyyoung womanandshewasputonahighcarbohydratedietandtoldthatwouldbeofbenefit,andplacedonestrogen,whichisa fairlytypicaltreatment. Theywantedtoputheronsomeothermedicinesandshedidn'twantto,shewantedtoknowiftherewasanalternative. Althoughwedidn'thaveasdramaticaturnaround,wegothertoonestandarddeviationbelowthenorminayear,takingher offtheestrogenshewason,anyway.

Let'sgotoclaudication.
Thatissevereanginaofthelegwhenyouwalk,samethingasanginaoftheheartexceptoftheleg.Whilewalking,after walkingacertaindistance,thereispain.Therewasagentlemanwhohadextremelysevereclaudication,whohappenstobe mystepfather.Itwasatypicalcase,hewouldwalkaboutfiftyyardsandthenhewouldgetsevere,crampypaininhislegs. HewasquitewelloffandwasgoingtoseethebestdoctorsinChicago,andtheycouldn'tfigureoutwhatwaswrongwith himinitially. Hewenttoaneurologist,theythoughtitmightbeneurologicalpainorbackpain.Hefinallywenttoavascularsurgeonwho saidhethoughtitwasvasculardisease,sotheydidanarthrogramandsureenough,hehadseverevasculardisease.They wantedtodothetypicalbypasssurgerythattheynormallydoonthis.Hewasthinkingofgoinginforthesurgeryforone
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reason,theyhadatripplannedtoEuropeintwoweeks,andhewantedtobeabletowalksincetheynormallydoalotof walking. Tenyearspreviouslyhe'dhadanangioplastyforheartdisease.Atthetimetenyearsago,Itoldhimhehadtochangehis dietandhedidn'tofcourse.Butthistimehelistened.Isaidthatifhewasnotgoingtohaveabypass,thendoexactlywhat Itellyoutodoandintwoweeksyou'llbewalkingjustfinebecausebymodulatingthisoneaspectofhisdisease,Ihave neverseenitnotwork,anditworksveryquicklytoopenuptheartery.

Wecantalkaboutapatientwithaveryhighcancerrisk.
Shehadamotherandasisterwhobothdiedofbreastcancerandshedidn'twantto,soshecameinandIputheronthe exactsametreatmentastheothercasesIjustmentioned.Theywerealltreatedvirtuallyidenticallybecausetheyallhadthe samethingwrongwiththem. Whatwouldbethetypicaltreatmentofcardiovasculardisease?Firsttheycheckthecholesterol.Highcholesterolover200, theyputyouoncholesterolloweringdrugsandwhatdoesitdo?ItshutsoffyourCoQ10.WhatdoesCoQ10do?Itisinvolved intheenergyproductionandprotectionoflittleenergyfurnacesineverycell,soenergyproductiongoeswaydown. AcommonsideeffectofpeoplewhoareonalltheseHMGcoenzymereductaseinhibitorsisthattheytellyoutheirarms feelheavy.Well,theheartisamuscletoo,andit'sgoingtofeelheavytoo.Oneofthebesttreatmentsforaweakheartis CoQ10forcongestiveheartfailure.ButtheyhavenotroubleshuttingCoQ10productionoffsothattheycantreatanumber. Andthecommontherapiesforosteoporosisaredrugs,andthecommontherapyforcalaudicationissurgery.Forcancer reductionthereisnothing.Butallofthesehaveacommoncause. Thesamecauseasthreemajoravenuesofresearchinaging.Oneiscalledcaloricrestriction.Therearethousandsof studiesdonesincethefiftiesoncaloricrestriction.Theyrestrictcaloriesoflaboratoryanimals. Theyhaveknownsincethefiftiesthatifyourestrictcaloriesbutmaintainahighlevelofnutrition,called"C.R.O.N.'s:"Caloric restrictionwithoptimalnutrition,oradequatenutrition,whichwouldbeCRAN"S,theseanimalscanliveanywherebetween thirtyandtwohundredpercentlongerdependingonthespecies. They'vedoneitonseveraldozenspeciesandtheresultsareuniformthroughout.Theyaredoingitonprimatesnowanditis workingwithprimates,wewon'tknowforsureforaboutanothertenyears,theyareabouthalfwaythroughtheexperiment, ournearestrelativesarealsolivingmuchlonger.

ThenthereareCentenarianstudies.
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Therearethreemajorcentenarianstudiesgoingonaroundtheworld.Theyaretryingtofindthevariablethatwouldconfer longevityamongthesepeople.Whydocentenariansbecomecentenarians?Whyaretheysolucky?Isitbecausetheyhave lowcholesterol,exercisealot,liveahealthy,cleanlife? Wellthelongestrecordedknownpersonwhohaseverlived,JeanCalumetofFrancewhodiedlastyearat122years, smokedallofherlifeanddrank. Whattheyarefindingonthesemajorcentenarianstudiesisthatthereishardlyanythingincommonamongthem.They havehighcholesterolandlowcholesterol,someexerciseandsomedon't,somesmoke,somedon't.Somearenastyascan beandsomeniceandcalmandnice.Someareornery,buttheyalllowsugar,relativelyfortheirage.Theyallhavelow triglyceridesfortheirage. Andtheyallhaverelativelylowinsulin.InsulinisthecommondenominatorineverythingI'vejusttalkedabout.Theywayto treatcardiovasculardiseaseandthewayItreatedmystepfather,thewayItreatedthehighriskcancerpatient,and osteoporosis,highbloodpressure,thewaytotreatvirtuallyallthesocalledchronicdiseasesofagingistotreatinsulin itself. Theothermajoravenueofresearchinaginghastodowithgeneticstudiesofsocalledlowerorganisms.Weknowthe geneticsinvolved.We'vegottheentiregenesmappedoutofseveralspeciesnow,ofyeastandworms.Wethinkoflifespan asbeingfixed,sortof. Humanskindofhaveanaveragelifespanofseventysix,andthemaximumlifespanwasthisFrenchladyatonehundred andtwentytwo.Inhumanswefeelitisrelativelyfixed,butinlowerformsoflifeitisveryplastic.Lifespanisstrictlya variabledependingontheenvironment.Theycanlivetwoweeks,twoyears,orsometimestwentyyearsdependingonwhat theywantthemselvestodo,whichdependsverymuchontheenvironment. Ifthereisalotoffoodaroundtheyaregoingtoreproducequicklyanddiequickly,ifnottheywilljustbidetheirtimeuntil conditionsarebetter.Weknownowthatthevariabilityinlifespanisregulatedbyinsulin. Onethinksofinsulinasstrictlytolowerbloodsugar.Todayintheclinictherewasapatientlistingoffherdrugs,shelisted abouteightdrugsshewasonanddidn'tevenmentioninsulin.Insulinisnottreatedasadrug.Infact,insomeplacesyou don'tevenneedaprescription,youcanjustgetitoverthecounter,it'streatedlikecandy. Insulinisfoundasinevensinglecelledorganisms.Ithasbeenaroundforseveralbillionyears.Anditspurposeinsome organismsistoregulatelifespan.Thewaygeneticsworksisthatgenesarenotreplaced,theyarebuiltupon.Wehavethe samegenesaseverythingthatcamebeforeus.Wejusthavemoreofthem.
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Wehaveaddedbookstoourgeneticlibrary,butourbaseisthesame.Whatwearefindingisthatwecanuseinsulinto regulatelifespantoo. Ifthereisasinglemarkerforlifespan,astheyarefindinginthecentenarianstudies,itisinsulin,specifically,insulin sensitivity. Howsensitiveareyourcellstoinsulin.Whentheyarenotsensitive,theinsulinlevelsgoup.Whohasheardoftheterm insulinresistance? Insulinresistanceisthebasisofallofthechronicdiseasesofaging,becausethediseaseitselfisactuallyaging. Weknownowthatagingisadisease.TheothercasestudiesthatImentioned,cardiovasculardisease,osteoporosis, obesity,diabetes,cancer,allthesocalledchronicdiseasesofaging,autoimmunediseases,thosearesymptoms. Ifyouhaveacoldandyougotothedoctor,youhavearunnynose,IdidEar,NoseandThroatfortenyears,Iknowwhatthe commontreatmentforthatis,theygiveyouadecongestant.Ican'ttellyouhowmanypatientsIsawwhohadbeengiven Sudafedbytheirfamilydoctorsforacoldandtheycametoseemeafterbecauseofareallybadsinusinfection. Whathappenswhenyoutreatthesymptomofarunnynosefromacoldandyoutakeadecongestant?Itcertainly decongestsyoubyshuttingoffthemucus.Whydoyouhavethemucus,becauseyouaretryingtocleanandwashoutthe membranes,andwhatelse?Whatelseisinmucus?SecretoryIgA,averystrongantibodytokillthevirusisinthemucus.If thereisnomucus,thereisnosecretoryIgA. Decongestantsalsoconstrictbloodvessels,thelittlecapillaries,orarteriolesthatgotothosecapillaries,thecilia,thelittle hairlikeprojectionsthatbeattopushmucusalongtocreateastream,theygetparalyzedbecausetheydon'thaveblood flowsothereisnomoreciliarymovement.Whathappensifyoudamastreamandcreateapond? Indaysyou'vegotlarvaegrowing.Ifthestreamismoving,youarefine.Youneedaconstantstreamofmucustogetridof andpreventaninfection.Iamgoingintothisinsomedetailbecauseinalmostallcasesifyoutreatasymptom,youare goingtomakethediseaseworsebecausethesymptomisthereasyourbody'sattempttohealitself. Now,themedicalprofessioniscontinuouslysegregatingmoreandmoresymptomsintodiseases,theycallthesymptoms diseases.UsingENTforexample,thatpatientwillwalkoutoftherewithadiagnosisofRhinitiswhichisinflammationofthe nose.Isthereareasonthatpatienthasinflammationofthenose?Ithinkso.Wouldn'tthatunderlyingcausebethedisease asopposedtothedescriptivetermofRhinitisorPharyngitis? SomeonecanhavethesamevirusandhaveRhinitisorPharyngitis,orSinusitis,theycanhaveallsortsof"itis's"whichisa
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descriptivetermforinflammation.Thatiswhatthecodewillbeandthatiswhatthediseasewillbe.Sotheytreatwhatthey thinkisthediseasewhichisjustasymptom.

Itisthesamethingwithcholesterol.
Ifyouhavehighcholesterolitiscalledhypercholesterolemia.Hypercholesterolemiahasbecomethecodeforthedisease whenitisonlythesymptom.Sotheytreatthatsymptomandwhataretheydoingtotheheart?Messingitup. Sowhatyouhavetodoifyouaregoingtotreatanydiseaseisyouneedtogettotherootofthedisease.Ifyoukeeppulling adandelionoutbyit'sleaves,youarenotgoingtogetveryfar.Buttheproblemisthatwedon'tknowwhattherootis,orwe haven't. Theyknowwhatitisinmanyotherareasofscience,buttheproblemisthatmedicinereallyisn'tascience,itisabusiness, butIdon'twanttogetintothat,wecantalkhoursonthat.Butifyoureallylookattherootofwhatiscausingit,wecanuse thatcoldasafurtherexample.

Whydoesthatpersonhaveacold?
Ifhesawthedoctor,thedoctormighttellhimtotakeanantibioticalongwiththedecongestant.Youseethisallthetime becausethedoctorwantstogetridofthepatient.Wellweallknowthatinalmostallcasesofanupperrespiratoryinfection itisavirus,andtheantibioticisgoingtodoworsethannothingbecauseitisgoingtokillthebacterialflorainthegutand impairtheimmunesystem,makingtheimmunesystemworse. Thepatientmightseesomeoneelsemoreknowledgeablewhowillsayno,youcaughtavirus,don'tdoanything,gohome andsleep,letyourbodyhealitself.That'sbetter.Youmightseesomeoneelsewhowouldaskwhyyoucaughtavirus withoutbeingouttheretryingtohuntforviruseswithanet.Wearebreathingviruseseverydayrightnowwearebreathing viruses,coldviruses,rhinoviruses.

Whydoesn'teverybodycatchacoldtomorrow?
TheChinesewilltellyouthatitisbecausethemilieuhastoberight,iftheChineseweretoquotetheFrench.Yourbodyhas tobereceptivetothatvirus.Onlyifyourimmunesystemisdepressedwillitallowthatvirustotakehold. Somaybeadepressedimmunesystemisthedisease.SoyoucanbegivenabunchofvitaminCbecauseyourimmune systemisdepressedanditislikelythatthepersonhasavitaminCdeficiency.That'swheremostofusareatrightnow, wherewewouldgiveabunchofvitaminCtotrytopickuptheimmunesystem.
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ButwhyisthevitaminCnotworking.VitaminCismakeinalmostalllivingmammalsexcepthumansandacoupleother species.VitaminCismadedirectlyfromglucoseandactuallyhasasimilarstructureandtheycompeteforoneanother.

We'veknownformanyyearsthatsugardepressestheimmunesystem.
Wehaveknownthatfordecades.Itwasonlyinthe70'sthattheyfoundoutthatvitaminCwasneededbywhitebloodcells sothattheycouldphagocytizebacteriaandviruses.Whitebloodcellsrequireafiftytimeshigherconcentrationatleast insidethecellasoutsidesotheyhavetoaccumulatevitaminC. Thereissomethingcalledaphagocyticindexwhichtellsyouhowrapidlyaparticularmacrophageorlymphocytecangobble upavirus,bacteria,orcancercell.Itwasinthe70'sthatLinusPaulingknewthatwhitebloodcellsneededahighdoseof vitaminCandthatiswhenhecameupwithhistheorythatyouneedhighdosesofvitaminCtocombatthecommoncold. ButifweknowthatvitaminCandglucosehavesimilarchemicalstructure,whathappenswhenthesugarlevelsgoup?They competeforoneanotheruponenteringthecells.AndthethingthatmediatestheentryofvitaminCintothecellsisthe samethingthatmediatestheentryofglucoseintothecells.Ifthereismoreglucosearoundthereisgoingtobelessvitamin Callowedintothecellanditdoesn'ttakemuch.Abloodsugarvalueof120reducesthephagocyticindexseventyfive percent. Herewearegettingalittlebitfurtherdownintotherootsofdisease.Itdoesn'tmatterwhatdiseaseyouaretalkingabout, whetheryouaretalkingaboutacommoncoldoraboutcardiovasculardisease,orosteoporosisorcancer,therootisalways goingtobeatthemolecularandcellularlevel,andIwilltellyouthatinsulinisgoingtohaveitshandinit,ifnottotally controllingit.

Whatisthepurposeofinsulin?
AsImentioned,insomeorganismsitistocontroltheirlifespan,whichisimportant.Whatisthepurposeofinsulinin humans?Ifyouaskyourdoctor,theywillsaythatit'stolowerbloodsugarandIwilltellyourightnow,thatisatrivialside effect.Insulin'sevolutionarypurpose,amongothersatleastknownrightnow,wearelookingatothers,istostoreexcess nutrients. Wecomefromatimeoffeastandfamineandifwecouldn'tstoretheexcessenergyduringtimesoffeasting,wewouldall notbehere,becauseweallhavehadancestorsthatencounteredfamine.Soweareonlyherebecauseourancestorswere abletostorenutrients,andtheywereabletostorenutrientsbecausetheywereabletoelevatetheirinsulininresponseto anyelevationinenergythattheorganismencountered.
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Whenyourbodynoticesthatthesugariselevated,itisasignthatyou'vegotmorethanyouneedrightnow,youarenot burningitsoitisaccumulatinginyourblood.Soinsulinwillbereleasedtotakethatsugarandstoreit.Howdoesitstoreit? (Someoneintheaudiencesuggesttheanswerglycogen)Glycogen?

Howmuchglycogendoyoustore?
Doyouknowhowmuchglycogenyouhaveinyourbodyatanyonetime?Verylittle.Alltheglycogenstoredinyourliver andalltheglycogenstoredinyourmuscleifyouhadanactivedaywouldn'tlastyoutheday. Onceyoufillupyourglycogenstoreshowisthatsugarisstored,aswhatparticularkindoftriglyceride,orfattyacid? Palmiticacid.Saturatedfat,ninetyeightpercentofwhichispalmiticacid. Sotheideaofthemedicalprofessiontogoonahighcomplexcarbohydrate,lowsaturatedfatdietisanabsoluteoxymoron, becausethosehighcomplexcarbohydratedietsarenothingbutahighglucosediet,orahighsugardiet,andyourbodyis justgoingtostoreitassaturatedfat.Thebodymakesitintosaturatedfatquitereadily.

Whatelsedoesinsulindo?
Itdoesn'tjuststorecarbohydrates,bytheway.Somebodymentionedthatitisananabolichormone,itabsolutelyis.Body buildersareusinginsulinnowbecauseitislegal,sotheyareinjectingthemselveswithinsulinbecauseitbuildsmuscle,it storesproteintoo. Alesserknownfactisthatinsulinalsostoresmagnesium.Wementionedit'sroleinvitaminC,itstoresallsortsof nutrients.Butwhathappensifyourcellsbecomeresistanttoinsulin?Firstofallyoucan'tstoremagnesiumsoyouloseit, that'soneeffect,youloseitouttheurine.

Whatisoneofmagnesium'smajorroles?
Torelaxmuscles.Intracellularmagnesiumrelaxesmuscles.Whathappenswhenyoucan'tstoremagnesiumbecausethe cellisresistant?Youlosemagnesiumandyourbloodvesselsconstrict,whatdoesthatdo? Increasesbloodpressure,andreducesenergysinceintracellularmagnesiumisrequiredforallenergyproducingreactions thattakeplaceinthecell.Butmostimportantly,magnesiumisalsonecessaryfortheactionofinsulin.Itisalsonecessary forthemanufactureofinsulin.
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Sothenyouraiseyourinsulin,youlosemagnesium,andthecellsbecomeevenmoreinsulinresistant.Bloodvessels constrict,glucoseandinsulincan'tgettothetissues,whichmakesthemmoreinsulinresistant,sotheinsulinlevelsgoup andyoulosemoremagnesium.Thisistheviciouscyclethatgoesonfrombeforeyouwereborn. Insulinsensitivityisgoingtostartbeingdeterminedfromthemomentthespermcombineswiththeegg.Ifyourmother,while youwereinthewombwaseatingahighcarbohydratediet,whichisturningintosugar,wehavebeenabletoshowthatthe fetusinanimalsbecomesmoreinsulinresistant. Worseyet,theyareabletousesophisticatedmeasurements,andifthatfetushappenstobeafemale,theyfindthatthe eggsofthatfetusaremoreinsulinresistant.Doesthatmeanitisgenetic?No,youcanbebornwithsomethingandit doesn'tmeanthatitisgenetic.Diabetesisnotageneticdiseaseassuch.Youcanhaveageneticpredisposition.Butit shouldbeanextremelyraredisease.

Whatelsedoesinsulindo?
Wementionedhighbloodpressure,ifyourmagnesiumlevelsgodownyougethighbloodpressure.Wementionedthatthe bloodvesselsconstrictandyougethighbloodpressure. Insulinalsocausestheretentionofsodium,whichcausestheretentionoffluid,whichcauseshighbloodpressureandfluid retention:congestiveheartfailure. Oneofthestrongeststimulantsofthesympatheticnervoussystemishighlevelsofinsulin.

Whatdoesallofthisdototheheart?Notverygoodthings.
Therewasastudydoneacoupleofyearsago,agood,downtoearthnicelyconductedstudythatshowedthatheartattacks aretwotothreetimesmorelikelytohappenafterahighcarbohydratemeal.TheysaidspecificallyNOTafterahighfatmeal.

Whyisthat?
Becausetheimmediateeffectsofraisingyourbloodsugarfromahighcarbohydratemealistoraiseinsulinandthat immediatelytriggersthesympatheticnervoussystemwhichwillcausearterialspasm,constrictionofthearteries.Ifyou takeanybodypronetoaheartattackandthatiswhentheyaregoingtogetit.

Whatelsedoesinsulindo?
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Insulinmediatesbloodlipids.Thatpatientwhohadatriglycerideof2200,oneoftheeasiestthingswecandoislower triglyceridelevels.Itissosimple.TherewasjustanarticleinJ.A.M.A.anarticleandtheyweresayingthatthemedical professiondoesn'tknowhowtoreducetriglyceridesdietarily,thatdrugsstillneedtobeused. Itissoridiculousbecauseyouwillfindthatitistheeasiestthingtodo.Theycometumblingdown.Thereisalmostadirect correlationbetweentriglyceridelevelsandinsulinlevels.Insomepeoplemorethanothers.Thegentlemanwhohada triglyceridelevelof2200whileonallthedrugsonlyhadaninsulinlevelof14.7. Thatisonlyslightlyelevated,butitdoesn'ttakemuchinsomepeople,allwehadtodowasgethisinsulinleveldownto8 initiallyandthenitwentdowntosixandthatgothistriglyceridesdowntounder200.

Thewayyoucontrolbloodlipidsisbycontrollinginsulin.
Wewon'tgointoalotofdetail,butwenowknowthatLDLcholesterolcomesinseveralfractions,anditisthesmall,dense LDLthatplaysthelargestroleininitiatingplaque.It'sthemostoxidizable.Itisthemostabletoactuallyfitthroughthesmall cracksintheendothelium.Andthat'stheonethatinsulinactuallyraisesthemost.WhenIsayinsulin,Ishouldsayinsulin resistance.Itisinsulinresistancethatiscausingthis. Cellsbecomeinsulinresistantbecausetheyaretryingtoprotectthemselvesfromthetoxiceffectsofhighinsulin.They downregulatetheirreceptoractivityandnumberofreceptorssothattheydon'thavetolistentothatnoxiousstimuliallthe time.Itislikehavingthisloud,disgustingrapmusicplayedandyouwanttoturnthevolumedown. Youmightthinkofinsulinresistanceaslikesittinginasmellyroomandprettysoonyoudon'tsmellitanymorebecause yougetdesensitized. Youcanthinkaboutit,itsnotthatyouarenotthinkingaboutitanymore.Butifyouwalkoutoftheroomandcomeback, thesmellisback.Youcangetresensitizediswhatthatistellingyou.Itwouldbelikeyouarestartingtogodeafandyour aretellingotherstospeakupbecauseyoucan'thearthem,soifIwasyourpancreas,Iwouldjuststarttalkinglouder,and whatdoesthatdotoyourhearing? Youwouldbecomedeafer.Mostcasesofdeafness,especiallyinoldageisduetoexcessivenoiseexposure.Allthenoise exposureyourearshavebeenexposedto,wellthehaircellsthatenduptriggeringyourbraintoallowyoutoheareventually getkilled.Sometimesitjusttakesasinglefirecracker. Thisisthesamethingwithinsulinresistance.Whathappensisthatifyourcellsareexposedtoinsulinatalltheygetalittle bitmoreresistanttoit.Sothepancreasjustputsoutmoreinsulin.Isawapatienttoday,herbloodsugarwas102andher insulinwas90!Shewasn'tsureifshewasfastingornot,butI'veseenotherpatientswheretheirbloodsugarwasunder100
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andtheirfastinginsulinhasbeenover90. Thatisafastinginsulin.I'mnotsurehowmanypeoplearefamiliarwithseeingfastinginsulins.ButifIdrankalltheglucoseI couldpossiblydrinkmyinsulinwouldnevergoaboveprobably40.Soshewasextremelyinsulinresistant. Whatwashappeningwasshewascontrollingherbloodsugar.Statisticallyshewasnotdiabetic.Sheisnotevenimpaired glucosetolerant.Herglucoseistotallynormalsupposedly.Buthercellsaren'tlisteningtoinsulin,shejusthasan exceptionallystrongpancreas. Herisletcellsthatproduceinsulinareextremelystrongandareabletocompensateforthatinsulinresistancebyproducing thirtytimesmoreinsulinthanwhatmyfastinginsulinis.Andjustbymassactionherpancreasisyellingsoloudthather cellsareabletolisten,buttheyarenotgoingtolistenforever.Herpancreasisnotgoingtobeablekeepupthatproduction forever. Welltheusualtreatmentonceshebecomesdiabetic,whichwouldbeinevitable,onceherproductionofinsulinstarts slowingdownorherresistancegoesupanymore,thanherbloodsugargoesupandshebecomesadiabetic.Formany years,decadesbeforethatherinsulinlevelshavebeenelevated. Theyhavebeenelevatedforthirtyyearsprobablyandhaveneverbeenchecked.Thatinsulinresistanceisassociatedwith thehyperinsulinemiathatproducesallofthecocalledchronicdiseasesofagingoratleastcontributestothem.Asfaras weknowinmanyvenuesofscience,itisthemaincauseofaginginvirtuallyalllife. Insulinisthatimportant.Socontrollinginsulinsensitivityisextremelyimportant.

Howelsedoesinsulinaffectcardiovasculardisease?
We'veonlyjusttoucheduponit.Insulinisasocalledmytogenichormone.Itstimulatescellproliferation.Itstimulatescells todivide.Ifallofthecellsweretobecomeresistanttoinsulinwewouldn'thavethatmuchofaproblem.Theproblemisthat allofthecellsdon'tbecomeresistant. Somecellsareincapableofbecomingveryresistant.Theliverbecomesresistantfirst,thenthemuscletissue,thenthefat. Whentheliverbecomesresistant,whatistheeffectofinsulinontheliver,itistosuppresstheproductionofsugar. Thesugarfloatingaroundinyourbodyatanyonetimeistheresultoftwothings,thesugarthatyouhaveeatenandhow muchsugaryourliverhasmade.Whenyouwakeupinthemorningitismoreofareflectionofhowmuchsugaryourliver hasmade.Ifyourliverislisteningtoinsulinproperlyitwon'tmakemuchsugarinthemiddleofthenight.Ifyourliveris resistant,thosebrakesareliftedandyourliverstartsmakingabunchofsugarsoyouwakeupwithabunchofsugar.
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Thenexttissuetobecomeresistantisthemuscletissue.Whatistheactionofinsulininmuscles?Itallowsyourmuscles toburnsugarforonething.Soifyourmusclesbecomeresistanttoinsulinitcan'tburnthatsugarthatwasjust manufacturedbytheliver.Sotheliverisproducingtoomuch,themusclescan'tburnit,andthisraisesyourbloodsugar. Wellthefatcellsbecomeresistant,butnotforawhile.Itisonlyafterawhilethattheybecomeresistant.Ittakesthem longer.

Liverfirst,musclesecond,andthenyourfatcells.
Soforawhileyourfatcellsretaintheirsensitivity.Whatistheactionofinsulinonyourfatcells?Tostorethatfat.Ittakes sugaranditstoresitasfat.Sountilyourfatcellsbecomeresistantyougetfat,andthatiswhatyousee.Aspeople becomemoreandmoreinsulinresistant,theygetfatandtheirweightgoesup. Buteventuallytheyplateau.Theymightplateauatthreehundredpounds,twohundredandtwentypounds,onehundredand fiftypounds,buttheywilleventuallyplateauasthefatcellsprotectthemselvesandbecomeinsulinresistant. Asallthesemajortissues,thismassivebodybecomesresistant,yourliver,musclesandfat,yourpancreasisputtingout moreinsulintocompensate,soyouarehyperinsulinemicandyou'vegotinsulinfloatingaroundallthetime,90units,more. Buttherearecertaintissuesthataren'tbecomingresistantsuchasyourendothelium,theliningofthearteriesdonot becomeresistantveryreadily.Soallthatinsuliniseffectingtheliningofyourarteries. Ifyoudripinsulinintothearteryofadog,therewasaDr.Cruzwhodidthisintheearly70'sbyaccident,hewasdoinga diabeticexperimentandfoundoutthatthefemoralarterythattheinsulinwasbeingdrippedintowasalmosttotallyoccluded withplaqueafteraboutthreemonths. Thecontralateralsidewastotallyclear,justcontactofinsulininthearterycausedittofillupwithplaque.Thathasbeen knownsincethe70's,ithasbeenrepeatedinchickens,indogs,itisreallyawellknownfact.Insulinfloatingaroundinthe bloodcausesaplaquebuildup.Theydidn'tknowwhy,butweknowthatinsulincausesendothelialproliferation,that'sthe firststep,itcausesatumor,anendothelialtumor.

Insulincausesthebloodtoclottooreadily.
Insulincausestheconversionofmacrophagesintofoamcells,whicharethecellsthataccumulatethefattydeposits.Every stepoftheway,insulin'sgotitsfingersinitandiscausingcardiovasculardisease.Itfillsitwithplaque,itconstrictsthe
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arteries,itstimulatesthesympatheticnervoussystem,itincreasesplateletadhesivenessandcoaguabilityoftheblood. Anyknowncauseofcardiovasculardiseaseinsulinisapartof.Itinfluencesnitricoxidesynthase.Youproducelessnitric oxideintheendothelium.Weknowthathelpsmediatevasodilatationandconstriction,i.e.angina. Imentionedthatinsulinincreasescellularproliferation,whatdoesthatdotocancer?Itincreasesit.Andtherearesome prettystrongstudiesthatshowthatoneofthestrongestcorrelationstobreastandcoloncancerarewithlevelsofinsulin. Hyperinsulinemiacausestheexcretionofmagnesiumintheurine.Whatotherbigmineraldoesitcausetheexcretionof? Calcium.

Whatisthecauseofosteoporosis?
Therearetwomajorcauses,oneisahighcarbohydratedietwhichcauseshyperinsulinemia.Peoplewalkingaroundwith hyperinsulinemiacantakeallthecalciumtheywantbymouthandit'sallgoingtogooutintheirurine. Insulinisoneofthefirsthormonesthatanyorganismeverdeveloped,andasImentionedingenetics,thingsarebuiltupon whatwastherebefore.Soalltheotherhormoneswehaveinourbodywereactuallybuiltuponinsulin.Inotherwords,insulin controlsgrowthhormone.

Howdoesgrowthhormonework?
Thepituitaryproducesgrowthhormone,andthenitgoestotheliverandtheliverproduceswhatarecalledIgF1thru4,there areprobablymore.WhatdoesIgFstandfor?Insulinlikegrowthfactor.Theyaretheactiveingredients.Growthhormonehas somesmalleffectsonitsown,butthemajorgrowthfactorsaretheIgF'sthatthencirculatethroughoutthebody. WhyaretheycalledIgF'sorinsulinlikegrowthfactors?Becausetheyhaveanalmostidenticalmolecularstructureto insulin.WhenIsaidthatinsulinpromotescellularproliferation,itisbecauseitcrossreactswithIgFreceptors.So somewhereintheevolutionarytree,IgF'sdivergedfrominsulin.Insulincanworkverywellallbyitself,itdoesn'tneedgrowth hormone.Growthhormonecan'tdoanythingwithoutinsulin.

Thyroid.Howdoesthyroidwork?
ThethyroidproducesmostlyT4.T4goestotheliverandisconvertedtoT3,mostlythere,othertissuestoo,butmostlyin theliver.Wearegettingtheideathatinsulincontrolsalotofwhatgoesonintheliver,andtheliveristheprimaryorganthat becomesinsulinresistant.
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Whenthelivercannolongerlistentoinsulin,youcan'tconvertT4toT3verywell.Usuallyinpeoplewhoare hyperinsulinemicwithathyroidhormonethatcomesbacktotallynormal,itisimportanttomeasuretheirT3.TheirfreeT3 willjustasoftenasnotbelow.Gettheirinsulindownanditcomesbackup. Sexhormones,estrogen,progesterone,andtestosterone,doesinsulinhelpcontrolthem?Absolutely,invariousways. Insulinhelpscontrolthemanufactureofcholesterolandwheredoallthesexhormonescomefrom?Allthestearichormones areoriginallyderivedfromcholesterol,sothat'soneway.DrNestlerfromtheUniversityofVirginiawhohasspentthelast eightyearsdoingmultiplestudiestoshowthatDHEAlevelsaredirectlycorrelatedwithinsulinlevels,orIshouldsayinsulin resistance. Themoreinsulinresistantyouare,theloweryourDHEAlevels.Hefirmlybelievesthisandhasalotofstudiestobackitup, thatthedeclineinDHEAisstrictlyduetotheincreaseininsulinresistancewithage.Ifyoureducetheinsulinresistance, theDHEArises. Andhowarethesesexhormonescarriedaroundthebody?Somethingcalledsexhormonebindingglobulins.Themorethat isbound,thelessfree,activehormoneyouhave.Sexhormonebindingglobuliniscontrolledbywhat?Insulin.Thereisnota hormoneinthebodythatinsulindoesn'taffect,ifnotdirectlycontrol.

Let'stalkaboutosteoporosis.
Youtakeabunchofcalcium.Themedicalprofessionjustassumesthatithasahomingdeviceanditknowstogointoyour bone.Whathappensifyouhighlevelsofinsulinandyoutakeabunchofcalcium.Numberone,mostofitisjustgoingtogo outinyoururine.Youwouldbeluckyifthatwerethecasebecausethatpartwhichdoesn'tdoesnothavetheinstructionsto gotoyourbonebecausetheanabolichormonesaren'tworking. Thisisfirstofallbecauseofinsulin,thenbecauseoftheIGF'sfromgrowthhormone,alsotestosteroneandprogesterone, theyareallcontrolledbyinsulinandwhentheyareinsulinresistanttheycan'tlistentoanyoftheanabolichormones.So yourbodydoesn'tknowhowtobuildtissueanymore,sosomeofthecalciummayendupinyourbone,butagooddealofit willendupeverywhereelse.

Metastaticcalcifications,includinginyourarteries.
Diseasesarearesultofalackofcommunication.Therearecertainthingsthatyourcellsneedtobehealthy.Ifyoulearn nothingelsetoday,youshouldknowthateverythingisatthecellularandmolecularlevelandwearenothingbuta communityofcells.Weareacommuneofcells.Weareametropolisofcellsthathavebeengiveninstructionstocooperate.
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Whenyouhavealargenumberofcells,likeweare,tentrillionorso,theremustbepropercommunicationsothattherewill beproperdivisionoflabor.Youcantakemostanycellinyourbodyandundertherightconditionsyoucanputitinapetrie dishanditcanliveallonit'sown.Theyeachhavealifeoftheirown. Youcanmanipulatethegeneticsofacell,andwe'venowmadeabloodcellintoanervecell.Prettysoonwearegoingtobe abletotakeanycellwewantandmakeitintoanyothercell,becauseeverycellinyourbodyhastheidenticalgenetics,all derivedfromthateggandthatspermthatcametogether.Whyisonecelldifferentfromanother?Becausetheyarereading differentpartsofthesamelibrary. Youcaninfluencewhichpartofthatgeneticlibrarythateverycellreadsbytheenvironmentofthatcell.Theenvironmentof thatcellisgoingtobeverymuchdictatedby,numberone,hormones,andwhatyoueat.Eatingisjustinternalizingthe externalenvironment.Thatiswhatyouhavecirculationfor,tobringthatexternalenvironmenttoeachandeveryoneofthose cellsthatisinsideofyou. Ihopethatbynowyouhavegottentheideathathighinsulinresistanceisnotverygoodforyou.Sonowlet'stalkaboutwhat causesinsulinresistance.Wehavebeentalkingabouthighcarbohydratediets,let'sstarttalkingaboutthatalittlebitmore.

Thisiswhatcausesinsulinresistance.
Thatisdefinitelywhatworsensit.Anytimeyourcellisexposedtoinsulinitisgoingtobecomemoreinsulinresistant.That isinevitable,wecannotstopthat,buttheratewecancontrol.Aninevitablesignofagingisanincreaseininsulinresistance. Thatrateisvariable,ifyoucanslowdownthatrateyoucanbecomeacentenarian,andahealthyone.Youcanslowthe rateofaging.Notjusteventherateofdisease,buttheactualrateofagingitselfcanbemodulatedbyinsulin.Wetalked aboutsomeoftheloweranimalsandthereissomeprettygoodevidencethateveninhumanswestillretainthecapacityto controllifespanatleastpartially.Weshouldbelivingtobe130,140yearsoldroutinely. Let'stalkaboutcarbohydrates,whatarethey?Wetalkaboutsimpleandcomplexcarbohydrates,thatistotallyirrelevant,it meansabsolutelynothing.Carbohydratesarefiberornonfiber.Fewthingsinlifeareasclearcutasthis.Fiberisgoodfor you,andanonfibercarbisbadforyou.Youcanbankonthat. Thereisnotawholelotofmiddleground.Ifyouhaveacarbohydratethatisnotafiberitisgoingtobeturnedintoasugar, whetheritbeglucoseornot.Itmaybefructoseandwon'tnecessarilyraiseyourbloodglucose,fructoseisworseforyou thenglucose,soifyoujustgobybloodsugar,whichisjustglucose,itdoesn'tmeanthatyouarenotraisingyourblood fructose,oryourbloodgalactosewhichistheotherhalfoflactose. Allofthosesugarsareasbadorworseforyouthanglucose.Youcan'tjustgobysocalledbloodsugarwhichisjustblood
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glucose,becausewejustdon'tmeasurebloodfructoseorbloodgalactose,buttheyareallbadforyou.Whyaretheybad, wellnumberoneweknowthatitprovokesinsulinandeverytimeyouprovokeinsulinitexposesyourselftomoreinsulinand justlikewalkinginasmellyroomitisgoingtobecomemoreresistanttoinsulin. Soeverytimeyouhaveasurgeofsugarandyouhaveasurgeofinsulin,yougetmoreandmoreinsulinresistantandallof theproblemswe'vetalkedabout.

Whatelseisbadaboutsugar?
Weknowitincreasesinsulin,butevenbyitself,sugarisbadforyou.Youcandivideagingintobasicallytwomajor categories,thereisgeneticcausesofaging,weknowthatcellshavealimitedcapacitytodivide,normallyweneverget there,butthemorerapidlyyoumakecellsdivide,themorerapidlytheyage. Oneoftheeffectsofinsulinistostimulatecellularproliferationanddivision.Soweknowthatitincreasestherateofagingof acellpopulationjustbythat,thatisanotherwholediscussion.Let'sgototheotherhalf.Ourcellsaccumulatedamagewith agewecannothelpthat. WhenIsayaging,wereallyaretalkingaboutsomethingcalledsenescence,orthedamageassociatedwithaging,butthe commonusageisthewordaging.Icannotpreventyoufrombeingadayoldertomorrow,thatisaging,tomorrowyouwillbe adayolderthantoday,andthatwecannotdoanythingabout.Whenwetalkaboutagingwenormallythinkaboutthe damagethatisassociatedwiththatday. Wehaveaccumulatedmoredamageduringthatday,thatiscalledsenescence.Whatcausesthatdamage?Thereisoften anexampleoftesttubesinalaboratory.Youdon'tthinkoftesttubesasaging,yetifyoumarktesttubeswithalittlereddot andcountedthenumberoftesttubestherewereattheendoftheyearwithalittlereddotleft,therewouldhardlybeany, why,becausetheyhaveencountereddamage.They'vebroken,soeventhoughthereisnotagingtheydohaveimmortality rates.Agingisanincreaseintherateofmortality.

Inhumans,therateofmortalitydoubleseveryeightyears.
Thatisreallyhowyougaugetherateofaging.Wefoundinanimalstudiesthattherateofagingcanbelargelycontrolledby insulin.Butthedamagethataccumulatesduringthatagingiscausedbylargelybysugar. Thetwomajorcausesofaccumulateddamageareoxygenation,andglycation.I'mnotgoingtospendmytimetalkingabout oxidation.Mostofyouknowallaboutthat.
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Whatisoxidation?
Thereareseveraldefinitionsbutwecanuseaverycommonone,wheneveroxygencombineswithsomething,itoxidizes. Oxygenisaverypoisonoussubstance.ThroughoutmostofthehistoryoflifeonEarththerewasnooxygen.Organismshad todevelopveryspecificmechanismsofdealingwithhighlevelsofoxygenbeforetherecouldeverbelifewithoxygen. Soweevolvedveryquickly,asplantsaroseanddevelopedaveryeasymeansofacquiringenergy,theycouldjustlayback andcatchrays,andtheydealtwiththatoxygenwiththecarbondioxidebyspittingitout,theydidn'twantitaround.Sothe oxygenintheatmosphereincreased.Alltheotherorganismsthenhadtocopewiththattoxicoxygen.Manyperishedifthey didn'thavewaysofdealingwithit. Oneoftheearliestwaysofdealingwithallthatoxygenwasforthecellstohuddletogether,sothatatleasttheinteriorcells wouldn'tbeexposedtoasmuch.So,multicelledorganismsaroseafteroxygendid.Ofcourse,withthatcametheneedfor cellularcommunication.

Solet'stalkaboutglycation.
Everyoneknowsthatoxygencausesdamage,butunfortunately,thepresshasnotbeenaskindtopublicizeglycation. Glycationisthesameasoxidationexceptsubstitutethewordglucose.Whenyouglycatesomethingyoucombineitwith glucose.Glucosecombineswithanythingelsereally,it'saverystickymolecule. Justtakesugaronyourfingers.It'sverysticky.Itsticksspecificallytoproteins.Sotheglycationofproteinsisextremely important.Ifitsticksaroundawhileitproduceswhatarecalledadvancedglycatedendproducts. ThatacronymisnotanaccidentitstandsforA.G.E.'s.Ifyoucanturnover,orremanufacturetheproteinthat'sgood,andit increasestherateofproteinturnoverifyouarelucky.Glycationdamagestheproteintotheextentthatwhitebloodcellswill comearoundandgobbleitupandgetridofit,sothenyouhavetoproducemore,puttingmoreofastrainonyourabilityto repairandmaintainyourbody. Thatisthebestalternativetheworstalternativeiswhenthoseproteinsgetglycatedthatcan'tturnoververyrapidly,like collagen,orlikeaproteinthatmakesupnervetissue.Theseproteinscannotbegottenridof,sotheproteinaccumulates, andtheA.G.E.'saccumulateandtheycontinuetodamage. Thatincludesthecollagenthatmakesupthematrixofyourarteries.A.G.E.'saresobadthatweknowthatthereare receptorsforA.G.E.'s,hundredsofreceptorsforeverymacrophage.TheyaredesignedtotrytogetridofthoseA.G.E.'s,but whathappenswhenamacrophagecombineswithanA.G.E.product?
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Itsetsupaninflammatoryreaction.Weknowthatcardiovascularisaninflammatoryprocess,anytypeofinflammation.You eatadietthatpromoteselevatedglucose,andyouproduceincreasedglycatedproteinsandA.G.E.'s,youareincreasing yourrateofinflammationofanykind.Yougetdowntotheroots,includingarthritis,headaches. Whenyoustartputtingpeopleonadiettoremedyallofthis,mypracticeislargelydiabetes,somypatientsaremore concernedwiththeirbloodsugarandtheirheart,thingslikethat,butitissocommontohavethemcomebackandtellme theyusedtohavehorribleheadachesandnowdon'thavethemanymore,orthattheyhadahorriblepainintheirshoulder,or terribleAchillestendonitisthattheydon'thaveanymore.

Theglycatedproteinsaremakingthepersonverypro-inflammatory.
Soweageandatleastpartiallyweaccumulatedamagebyoxidation,andoneofthemostimportanttypesoftissuesthat oxygenateisthefattycomponent,thelipid,especiallythepolyunsaturatedfattyacids,theyturnrancid.Andtheyglycate, andthetermforglycationinthefoodindustryiscarmelization. Theyuseitallthetime,thatishowyoumakecaramel.Sothewayweageisthatweturnrancidandwecarmelize.It'svery true.Andthatiswhatgetsmostofus.Ifthatdoesn'tgetus,thenthegeneticcausesofagingwill,becauseeverycellin yourbodyhasgeneticprogramstocommitsuicide.Therearevarioustheoriesforthis,oneisthatiftheydidn't,virtually everycellinyourbodywouldeventuallyturncancerous. Whetherthosesocalledapplopaticgenesdevelopedasameanstopreventcancerornotisopentospeculationbutitisa goodtheory.Weknowthatallcancercellshaveturnedoffthemechanismsforapplotosis,whichisthemedicaltermfor chemicalsuicide.Soweknowthatitplaysarole.

Let'sgettodiet.
Dietreallybecomesprettysimple.Carbohydrateswestartedtalkingabout.You'vegotfiberandnonfiberandthat'sreal clearcut.Fiberisgood,nonfiberisbad.Fibrouscarbs,likevegetablesandbroccoli,thosearegreat.Whatisapotato?A potatoisabiglumpofsugar.That'sallitis.Youchewapotato,whatareyouswallowing?Glucose.Youmaynot remember,butyoulearnedthatineighthgrade,butthemedicalprofessionstillhasn'tlearnedthat.

Whatisthemajorsalivaryenzyme?
Amylase.Whatisamylaseusedfor?Tobreakdownamylosewhichisjustatreeofglucosemolecules.Whatisasliceof bread?Asliceofsugar.Doesithaveanythingelsegoodaboutit?Virtuallyno.Somebodyemailedmewhohaddecidedto doalittleresearch.Andtherearefiftysomeessentialnutrientstothehumanbody.
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Youknowyouneedtobreatheoxygen.Itgivesuslifeanditkillsus.Samewithglucose.Certaintissuesrequiresome glucose.Wewouldn'tbehereiftherewerenoglucose,itgivesuslifeanditkillsus.Weknowthatwehaveessentialamino acidsandwehaveessentialfattyacids.Theyareessentialforlife,webettertaketheminasbuildingblocksorwedie.So whathedidishetookalltheessentialnutrientsthatareknowntomanandpluggeditintothiscomputerdatabankandhe askedthecomputerwhatarethetoptenfoodsthatcontaineachnutrientthatisrequiredbythehumanbody.Eachofthe fiftythreeorfiftyfour,dependingonwhoyoutalkto,essentialnutrientsthattherearewerepluggedin,anddidyouknowthat grainsdidnotcomeupinthetoptenonanyone.

Whatistheminimumdailyrequirementforcarbohydrates?
ZERO.

Whatisthefoodpyramidbasedon?
Atotallyirrelevantnutrient.

Let'sgobeyondCarbohydrates.
Let'sbackupevenfurther?Whydoweeat?Onereasonisenergy.That'shalfofthereason.Itisverysimple,therearetwo reasonswhyweeat,oneistogatherenergy.Weneedtoobtainenergy.Theotheressentialreason(Notjustforfun!Funis agoodone,butyouwon'thavemuchfunifyoueattoomuch)istoreplacetissue,togatherupbuildingblocksfor maintenanceandrepair. Thosearethetwoessentialreasonsthatweneedtoeat.Weneedthebuildingblocksandweneedfuel,nottheleastof whichistohaveenergytoobtainthosebuildingblocksandthentohaveenergytofuelthosechemicalreactionstouse thosebuildingblocks. Sowhatarethebuildingblocksthatareneeded,proteinsandfattyacids.Notmuchinthewayifcarbohydrates.Youcan getallthecarbohydratesyouneedfromproteinsandfats.Sothebuildingblocksarecoveredbyproteinsandfats.

Whataboutfuel?
That'stheotherreasonweeat.Therearetwokindsoffuelthatyourbodycanusewithminorexceptions,sugarandfat.We mentionedearlierthatthebodyisgoingtostoreexcessenergyasfat.Whydoesthebodystoreitasfat?Becausethatis thebody'sdesiredfuel.Thatisthefuelthebodywantstoburnandthatwillsustainyouandallowyoutolive.Thebodycan
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storeonlyalittlebitofsugar. Inanactivedayyouwoulddieifyouhadtorelyonehundredpercentonsugar. Whydoesn'tyourbodystoremoresugarifitissoneeded?Sugarwasnevermeanttobeyourprimaryenergysource.

Sugarismeanttobeyourbody'sturbocharger.
Everybodyrighthere,rightnowshouldbeburningmostly,almostallfatwithminorexceptions.Yourbrainwillburnsugar,it doesn'thaveto,itcandoverywell,evenbetterbyburningbyproductsoffatmetabolismcalledketones.Thatiswhatithas toburnwhenyoufastforanylengthoftime.Theyhaveshownthatifyourbrainwasreallygoodatburningketonesfromfat thatyoucangetenoughsugarthatyourbrainneedsactuallyfromfatjusteatingonehundredpercentfat. Youcanmakealittlebitofsugaroutoftheglycerolmoleculeoffat.Taketwoglycerolmoleculesandyouhaveamolecule ofglucose.Twotriglycerideswillgiveyouamoleculeofglucose.Thebraincanactuallyexistwithoutawholelotofsugar, contrarytopopularbelief.Glucosewasmeanttobefuelusedifyouhadto,inanemergencysituation,expendandextreme amountofenergy,suchasrunningfromasabertoothtiger. Itisaturbocharger,averyhotburningfuel,ifyouneedfueloverandabovewhatfatcanprovideyouwilldigintoyour glycogenandburnsugar.Butyourprimaryenergysourceaswearehererightnowshouldbealmostallfat.

Butwhathappensifyoueatsugar.
Yourbody'smainwayofgettingridofit,becauseitistoxic,istoburnit.Thatwhichyourbodycan'tburnyourbodywillget ridofbystoringitasglycogenandwhenthatgetsfilledupyourbodystoresitasfat.Ifyoueatsugaryourbodywillburnit andyoustopburningfat. Wetalkedaboutalotoftheeffectsofhighinsulin.Wetalkedaboutinsulincausingtheformationofsaturatedfatfromsugar. Anothermajoreffectofinsulinonfatisitpreventsyoufromburningit.Whathappenswhenyouareinsulinresistantandyou haveabunchofinsulinfloatingaroundallthetime,youwakeupinthemorningwithaninsulinof90. Howmuchfatareyougoingtobeburning?Virtuallynone.Whatareyougoingtoburnifnotfat?Sugarcomingfromyour muscle.Soyouhaveallthisfatthatyou'veaccumulatedovertheyearsthatyourbodyisveryadeptataddingto.Everytime youhaveanyexcessenergyyouaregoingtostoreitasfat,butifyoudon'teat,whereyouwouldotherwisebeabletoburn it,youcannotandyouwillstillburnsugarbecausethatisallyourbodyiscapableofburninganymore.
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Whereisitgoingtogetthesugar?
Wellyoudon'tstoremuchofitintheformofsugarsoitwilltakeitfromyourmuscle.That'syourbody'smajordepotof sugar.Youjusteatupyourmuscletissue.Anytimeyouhaveexcessyoustoreitasfatandanytimeyouaredeficientyou burnupyourmuscle. Gettingbacktothemacronutrients,fuel,fatisyourbestfuelbyfarandthefuelthatyourbodywantstouse.Sothereare tworeasonstoeat,youneedtogatherthebuildingblocksformaintenanceandrepair,that'sproteinandfat,nocarbohydrate needed,andyoueatforfuel,withoutquestion,fatisyourmostefficientfuelandthefuelthatyourbodydesiresthemost.

Sowheredocarbohydratescomein?
Theydon't.Thereisnoessentialneedforcarbohydrates.SOwhyarewealleatingcarbohydrates?Tokeeptherateofaging up,wedon'twanttopaysocialsecuritytoeveryone. Ididn'tsayyoucan'thaveanycarbs,Isaidfiberisgood.Vegetablesaregreat,Iwantyoutoeatvegetables.Thepractical aspectofitisthatyouaregoingtogetcarbs,butthereisnoessentialneed.ThetraditionalEskimodietformostoftheyear subsistsonalmostnovegetablesatall,buttheygettheirvitaminsfromorganmeatsandthingslikeeyeballwhicharea delicacy,orwere. So,youdon'treallyneedit,butsure,vegetablesaregoodforyouandyoushouldeatthem.TheyarepartofthedietthatI wouldrecommend,andthatiswhereyou'llgetyourvitaminC.IrecommendVitaminCsupplements,Idon'thaveanything againsttakingsupplements,Iusealotofthem. Fruitisamixedblessing.Youcandividefoodonacontinuum.TherearesomefoodsthatIreallycan'tsayanythinggood aboutsincethereisnoreasonreallytorecommendthem.Andtheotherendofthespectrumarefoodsthataretotally essential,likeomega3fattyacidsforinstancewhichmostpeopleareverydeficientin,andeventhosehaveadetriment becausetheyarehighlyoxidizable,soyouhadbetterhavetheantioxidantcapacity.Soifyouaregoingtosupplementwith codliveroilyoushouldsupplementwithVitaminEtoooritwillactuallydoyoumoreharmthangood. Butmostfoodsfallinthemiddlesomewhere.Thingslikestrawberries,youaregoingtogetsomethingbadwithstrawberries, youaregoingtogetalotofsugarwithstrawberries,butyouarealsogoingtogetafoodthatisalsothesecondorthird highestinantioxidantpotentialofanyfoodknown,thefirstbeinggarlicthesecondeitherbeingstrawberriesorblueberries. So,thereissomethinggoodtobehadfromit.SoIwillletsomepatientsputsomestrawberriesinlet'ssayaprotein smoothieinthemorning.Butiftheyareahardcorediabetic,strawberriesareout.
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Itdoesn'ttakemuch,ifyouhaveatypeIdiabeticwhoisnotproducinganyinsulintheycantellyouwhatfoodsdototheir bloodsugar.Itdoesn'ttakemuch.Whatisverysurprisingtothesepeopleoncetheyreallymeasureiswhatlittle carbohydrateittakestocauseyourbloodsugartoskyrocket. Onesaltinecrackerwilltakethebloodsugartogoover100andinmanypeopleitwillcausethebloodsugartogoto150for avarietyofreasons,notjustthesugarinit. Whenyouareeatingahighcarbohydratediet,whenyouareborn,yourmother,everbodyistellingyoutoeatabowlof Cheeriosforbreakfast.Youeatthatbowlofcheeriosandthatturnstosugar,andyoursugargoesupveryrapidlyandthat causesabigrushofinsulinandyourbodyallofasuddensensesahugeamountofsugarbeingdeliveredtoitatonce,of whichitwasneverusedto,inanevolutionarysense. Weonlyhaveonehormonethatlowerssugar,andthat'sinsulin.Itsprimaryusewasnevertolowersugar.We'vegota bunchofhormonesthatraisesugar,cortisonebeingoneandgrowthhormoneanother,andepinephrine,andglucagon. Ourprimaryevolutionaryproblemwastoraisebloodsugartogiveyourbrainenoughandyournervesenoughandprimarily redbloodcells,whichrequireglucose.Sofromanevolutionarysenseifsomethingisimportantwehaveredundant mechanisms.Thefactthatweonlyhaveonehormonethatlowerssugartellsusthatitwasneversomethingimportantinthe past. Soyougetthisrushofsugarandyourbodypanics,yourpancreaspanicsanditstores,whenitishealthy,insulininthese granules,readytobereleased.Itletsthesegranulesoutanditpoursoutabunchofinsulintodealwiththisonslaughtof sugarandwhatdoesthatdo? Wellthepancreasgenerallyovercompensates,anditcausesyoursugartogodown,andjustasImentioned,youhavegot abunchofhormonesthentoraiseyourbloodsugar,theyarethenreleased,includingcortisone.Thebiggeststressonyour bodyiseatingabigglucoseload. ThenEpinephrineisreleasedtoo,soitmakesyournervousanditalsostimulatesyourbraintocravecarbohydrates,toseek outsomesugar,mysugarislow.Soyouarecravingcarbohydrates,soyoueatanotherbowlofcheerios,orabigpieceof fruit,youeatsomethingelsesothatafteryoursugargoeslow,andwiththehormonerelease,andwiththesugarcravings andcarbohydratecravingyoursugarsgowayupagainwhichcausesyourpancreastoreleasemoreinsulinandthenitgoes waydown. Nowyouareintothissinusoidalwaveofbloodsugar,whichcausesinsulinresistance.Yourbodycan'tstandthatforvery long.Soyouareconstantlyputtingoutcortisone.
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Wecantalkaboutinsulinresistance.
Wehearalotaboutinsulinresistance,butstopandthinkalittlebit,doyouthinkourcellsonlybecomeresistanttoinsulin? Themorehormonesyourcellsareexposedto,themoreresistanttheywillbecometoalmostanyhormone.Certaincells morethanothers,sothereisadiscrepancy.Theproblemwithhormoneresistanceisthatthereisadichotomyof resistance,thatallthecellsdon'tbecomeresistantatthesametime. Anddifferenthormonesaffectdifferentcells,andtherateofhormoneisdifferentamongdifferentcellsandthiscauseslotsof problemswiththefeedbackmechanisms.Weknowthatoneofthemajorareasofthebodythatbecomesresistanttomany feedbackloopsisthehypothalamus.ThevariousinterrelationshipsthereIreallydon'thavetimetogointohere. Buthypothalamicresistancetofeedbacksignalsplaysaveryimportantroleinagingandinsulinresistancebecausethe hypothalamushasreceptorsforinsulintoo.Imentionedthatinsulinstimulatessympatheticnervoussystem,itdoesso throughthehypothalamus,whichisthecenterofitall.

Thereceptorsself-regulate.
Ifyouwanttoknowifinsulinsensitivitycanberestoredtoitsoriginalstate,well,perhapsnottoitsoriginalstate,butyou canrestoreittothestateofaboutatenyearold. Oneofmyfirstexperienceswiththis,Ihadapatientwholiterallyhadsugarsover300.Hewastaking200+unitsofinsulin, hewasabadcardiovascularpatient,anditonlymadesensetomethatyoudon'twanttofeedthesepeoplecarbohydrates, soIputhimonalowcarbohydratediet. Hewasanexceptionalcase,afteramonthtosixweekshewastotallyoffofinsulin.Hehadbeenon200someunitsof insulinfortwentyfiveyears.Hewassoinsulinresistant,onethinggoodaboutitisthatwhenyoulowerthatinsulin,that insulinishavingsuchlittleeffectonhimthatyoucanmassivelylowertheinsulinanditsnotgoingtohavemuchofaneffect onhisbloodsugareither.200unitsofinsulinisnotgoingtoloweryoursugaranymorethat300mg/deciliter. Youknowthattheinsulinisnotdoingmuch.Sowecouldrapidlytakehimofftheinsulinandhewasactuallycuredofhis diabetesinamatterofweeks.Sohebecamesensitiveenough,hewasstillproducingalotofinsulinonhisown,thenwe wereabletomeasurehisowninsulinanditwasstillelevated,andthenittookalongtime,maybesixmonthsorlongerto bringthatinsulindown. Itwillprobablynevergettothepointofthesensitivityofatenyearold,butyes,yournumberofinsulinreceptorsincreases, andtheactivityofthereceptors,thechemicalreactionsthatoccurbeyondthereceptoroccurmoreefficiently.
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Youcanincreasesensitivitybydiet,thatisoneofthemajorreasonsyouwanttotakeOmega3oils.Wethinkofcirculation asthatwhichflowsthrougharteriesandveins,andthatisnotaminorpartofourcirculation,butitmightnotevenbethe majorpart.Themajorpartofcirculationiswhatgoesinandoutofthecell. Thecellmembraneisafluidmosaic.Themajorpartofourcirculationisdeterminedbywhatgoesinandout.Itdoesn'tmake anydifferencewhatgetstothatcellifitcan'tgetintothecell.Weknowthatoneofthemajorwaysthatyoucanaffect cellularcirculationisbymodulatingthekindsoffattyacidsthatyoueat.Soyoucanincreasereceptorsensitivityby increasingthefluidityofthecellmembrane,whichmeansincreasingtheomega3content,becausemostpeoplearevery deficient. Theysaythatyouarewhatyoueatandthatmostlypertainstofatbecausethefattyacidsthatyoueataretheonesthatwill generallygetincorporatedintothecellmembrane.Thecellmembranesaregoingtobeareflectionofyourdietaryfatand thatwilldeterminethefluidityofyourcellmembrane.Youcanactuallymakethemoverfluid. Ifyoueattoomuchandyouincorporatetoomanyomega3oilsthentheywillbecomehighlyoxidizable(soyouhavetoeat VitaminEaswellandmonounsaturatesaswell)Therewasaninterestingarticlepertainingtothiswheretheyhadabreedof ratthatwasgeneticallysusceptibletocancer. Whattheydidwastheyfedthemahighomega3diet,plusiron,withoutanyextraVitaminEandtheywereabletoalmost shrinkdownthetumorstonothing,becausetumorsarerapidlydividing.Thisislikeaformofchemotherapy,andthe membranesthatwerebeingformedinthesetumorcellswereveryhighinomegathreeoils,theironactedasacatalystfor thatoxidation,andthecellswereexplodingfromgettingoxidizedsorapidly.Soomega3oilscanbeadoubleedgedsword.

Mostfoodisadoubleedgedsword.
Likeoxygenandglucose,theykeepusaliveandtheykillus,eatingisthebiggeststressweputonourbodyandthatis whyincaloricrestrictionexperimentsyoucanextendlifeaslongasyoumaintainnutrition.Thisistheonlyprovenwayof actuallyreducingtherateofaging,notjustthemortalityrate,buttheactualrateofaging,becauseeatingisabigstress. Ithasactuallybeenshownbyquiteanumberofpapersthatresistancetrainingforinsulinresistanceisbetterthanaerobic training.Thereareavarietyofotherreasonstoo.Resistancetrainingisreferringtomuscularexercises.Ifyoujustdoabicep curl,youimmediatelyincreasetheinsulinsensitivityofyourbicep.Justbyexercising,andwhatyouaredoingisyouare increasingthebloodflowtothatmuscle.Thatisoneofthefactorsthatdeterminesinsulinsensitivityishowmuchcanget there.Ithasbeenshownconclusivelythatresistancetrainingwillincreaseinsulinsensitivity. Backtothemacronutrientsbecausethatisrealsimple,youdon'twantverymuchinthewayofnonfibercarbs,fibercarbs
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aregreat,youaregoingtogetsomenonfibercarbs.Evenifyoujusteatbroccoliyouaregoingtogetsomenonfibercarbs. ThatisOKsinceatleastforthemostpartyouaregettingsomethingthatisreallyprettygoodforyou.Proteinisan essentialnutrient. Youwanttouseitasabuildingblockbecauseyourbodyrequiresproteintorepairdamageandreplenishenzymes.Allof theencodedinstructionsfromyourDNAaretoencodeforproteins.ThatisalltheDNAencodesfor.Youneedprotein,but youwanttouseitasabuildingblock,butIdon'tbelieveingoingoverandabovetheproteinthatyouneedtousefor maintenance,repairandbuildingblocks. Idon'tthinkyoushouldbeusingproteinasaprimaryfuelsource.Yourbodycanuseproteinverywellasafuelsource.Itis goodtoloseweightwhileusingitasafuelsourcebecauseitisaninefficientfuelsource.Proteinisverythermogenic,it producesalotofheat,whichmeansthatlessofitisgoingintostoredenergy,moreisbeingdissipated.Justlikethrowinga logintoafireplace.

Yourprimaryfuelshouldbecomingfromfat.
Soyoucancalculatetheamountofproteinapersonrequires,oratleastestimateitbytheiractivitylevel.ThebookProtein Poweractuallywentverywellintothis.Youhavetocalculatehowmuchproteinisrequiredbytheiractivitylevelandtheir leanbodymass.Thereisstillsomegrayareaastohowmanygramsperkilogramofleanbodymass,dependingonthe activitythatpersonrequires. Anywhereperhapsonetotwogramsofproteinperkilogramofleanbodymass,maybeevenalittlebithigherifsomeoneis reallyactive. Youdon'twanttogounderthatforverylong.I'dsaythatitisbettertogooverthantogounderthatamountforverylong.But Iespeciallydon'twantmydiabeticpatients,whichmeansallofus,becauseinaveryrealsensewereallyallhavediabetes, itisjustamatterofdegree,weallhaveacertaindegreeofinsulinresistance. Ifyoucancureadiabeticofdiabetes,youcandothesamethingtoasocallednondiabeticpersonandstillimprovethat person.IwanttoimprovemyinsulinsensitivityjustasmuchasIdomydiabeticsbecauseinsulinsensitivityisgoingto determineforthemostparthowlongyouaregoingtoliveandhowhealthyyouaregoingtobe.Itdeterminestherateof agingmoresothananythingelseweknowrightnow.

WhataboutsupplementssuchasChromiumforexample?
Chromium,itdependsonwhomyouaredealingwith,butarewetalkingaboutadiabeticpatient,whoissupposedtobethe
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topicofthistalk,yes,allmydiabeticsgoon1,000mcg.ofchromium,somealittlebitmoreiftheyarereallybigpeople. Usually500mcgforanondiabetic.Itdependsontheirinsulinlevels. Idon'tcaresomuchwhattheirsugarlevelsare,Icarewhattheirinsulinlevelsare,whichisareflectionoftheirinsulin sensitivity.Wearetalkingabouthyperinsulinemiaornonhyperinsulinemia.Itsinsulinweshouldbeconcernedabout. Iusealotofsupplements.Whatyoureallywanttodo,andmypurposemostlyistotrytoconvertthatpersonbackinto beinganefficientburneroffat.Wetalkedaboutwhenyouareveryinsulinresistantandyouarewakingupinthemorning withaninsulinthatiselevated,youcannotburnfat,youareburningsugar. Theydon'tknowhowtoburnfatanymoreandthatisyourbestfuel. Oneofthereasonsthatsugargoesupsohighisbecausethatiswhatyourcellisneedingtoburn,butifitissoinsulin resistantitrequiresabloodsugarof300sothatjustbymassactionsomecangetintothecellandbeusedasfuel.Ifyou eliminatethatneedtoburnsugar,youdon'tneedsuchhighlevelsofsugarevenifyouareinsulinresistant.

Soyouwanttoincreasetheabilityofthecellsinthebodytoburnfat.
Youwanttomakethatglucoseburnerintoafatburner.Youwanttomakeagasolineburningcarintoadieselburningcar. Didanyoneeverlookatthemolecularstructureofdieselfuelinyoursparetime?Itlooksalmostidenticaltoafattyacid. ThereisacompanyrightnowthatcantellyouhowtoaltervegetableoiltouseinyourMercedes.It'sjustamatterof thinningitoutalittlebit.Itisaveryefficientfuel. Youcanlookatothervariablesthatwillgiveyousomeideatoosuchastriglycerides.Iftheyareverysensitivetohighlevels ofinsulin,theycomeinwithinsulinlevelsof14andtheyhavetriglyceridesof1000,thenyouwouldtreatthemjustasyou wouldiftheyhadaninsulinlevelof50.Itgivesyousomeideaoftheeffectofthehyperinsulinemiaonthebody. Youcanusetriglyceridesasagauge,whichIoftendo.Theobjectiveistotrytogettheinsulinleveljustaslowasyou possiblycan.Thereisnolimit.Theyclassifydiabetesnowasafastingbloodsugarof126orhigher.Afewmonthsagoit mighthavebeen140.Itisjustanarbitrarynumber,doesthatmeanthatsomeonewithabloodsugarof125isnondiabetic andfine?Ifyouhaveabloodsugarof125youareworsethanifyouhadabloodsugarof124.Samewithinsulin.Ifyouhave afastinginsulinof10youareworseoffthanifyouhadaninsulinof9.Youwanttogetitjustaslowasyoucan. Withathletes,let'sthinkaboutthat.Whatistheeffectofcarbohydrateloadingbeforeanevent.Whathappensifyoueata bowlofpastabeforeyouhavetorunamarathon.Whatdoesthatbowlofpastado?Itraisesyourinsulin.Whatisthe instructionofinsulintoyourbody?
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Tostoreenergyandnotburnit.IseeafairamountofathletesandthisiswhatItellthem,youwanteverybody,athletes especially,tobeabletoburnfatefficiently.Sowhentheytrain,theyareonaverylowcarbohydratediet.Thenightbefore theirevent,theycanstockuponsugarandloadtheirglycogeniftheywouldlike. Theyarenotgoingtobecomeinsulinresistantinoneday.Justenoughtomakesure,ithasbeenshownthatifyoueatabig carbohydratemealthatyouwillincreaseyourglycogenstores,thatistrueandthatiswhatyouwant.Butyoudon'twantto trainthatwaybecauseifyoudoyouwon'tbeabletoburnfat,youcanonlyburnsugar,andifyouareanathleteyouwantto beabletoburnboth. Fewpeoplehaveproblemsburningsugariftheyareanathlete,buttheyhavelotsofproblemsburningfat,sotheyhitthe wall.Andforacertaineventlikesprintingitislessimportant,truthfully,fortheirhealthitisveryimportanttobeabletoburn fat,butasprinterwillgorightintoburningsugar.Ifyouarea50yarddashman,whetheryoucanburnfatornotisnotgoing tomakeahugedifferenceinyourfinalperformance. Beyondyourathleticyearsifyoudon'twanttobecomeadiabetic,andifyoudon'twanttodieofheartdiseaseandifyou don'twanttoagequicklyItiscertainlynotgoingtodoyouanyharmtobeabletoburnfatefficientlyinadditiontosugar. VanadylSulfateisaninsulinmimic,sothatitcanbasicallydowhatinsulindoesbyadifferentmechanism.Ifitwentthrough thesameinsulinreceptors,thenitwouldn'tofferanybenefit,butitdoesn't,itactuallyhasbeenshowntogothrougha differentmechanismtolowerbloodsugar,soitsparesinsulinandthenitcanhelpimproveinsulinsensitivity.Onsomeone whoIamtryingtoreallygettheirinsulindownIgo25mg3X/daytemporarily. Iputpeopleonglutaminepowder.Glutaminecanactreallyasabrainfuel,soithelpseliminatecarbohydratecravingswhile theyareinthattransitionperiod.IliketogiveittothematnightandItellthemtouseitwhenevertheyfeeltheyarecraving carbohydrates.Theycanputseveralgramsintoalittlewateranddrinkitandithelpseliminatecarbohydratecravings betweenmeals. Itisahighproteindietthatwillincreaseanacidloadinthebody,butnotnecessarilyahighfatdiet.Vegetablesandgreens arealkalinizing,soifyouareeatingalotofvegetablesalongwithyourproteinitequalizestheacidifyingeffectoftheprotein. Idon'trecommendahighproteindiet.Irecommendanadequateproteindiet. Ithinkyoushouldbeusingfatasyourprimaryenergysource,andfatiskindofneutralwhenitcomestoacidifyingor alkalinizing.Ingeneral,over50%ofthecaloriesshouldcomefromfat,butnotfromsaturatedfat.Whenwegettofat,the carbohydratesareclearcut,noscientistoutthereisreallygoingtodisputewhatI'vesaidaboutcarbohydrates. Thereisthesciencebehindit.Youcan'tdisputeit.Thereisalittlebitofadisputeastohowmuchproteinapersonrequires.
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Whenyougettofat,thereisabiggreyareawithinscienceastowhichfatapersonrequires.Wejusthaveonenameforfat, wecallitfatoroil.EskimoshavedozensofnamesforsnowandeastIndianshavedozensofnamesforcurry.Weshould havedozensofnamesforfatbecausetheydomanydifferentthings.Andhowmuchofwhichfattotakeisstillopentoalot ofinvestigationandcontroversy. MytakeonfatisthatifIamtreatingapatientwhoisgenerallyhyperinsulinemicoroverweight,Iwantthemonalow saturatedfatdiet.Becausemostofthefattheyarestoringissaturatedfat.Whentheirinsulingoesdownandtheyareable tostartreleasingtriglyceridestoburnasfat,whattheyaregoingtobereleasingmostlyissaturatedfat.Soyoudon'twant totakeanymoreorally.Thereisarationoffattyacidsthatisdesirable,ifyoutookthemfromthemomentyouwereborn,but wedon't,wearedealingwithanimbalanceherethatwearetryingtocorrectasrapidlyaswecan. Youhaveplentyofsaturatedfat.Mostofusherehaveenoughsaturatedfattolasttherestofourlife.Truthfully.Yourcell membranesrequireabalanceofsaturatedandpolyunsaturatedfat,anditisthatbalancethatdeterminesthefluidity.AsI mentioned,yourcellscanbecomeoverfluidiftheydon'thaveanysaturatedfat. Saturatedfatisahardfat.Wecangetthefatsfromfoodstocomemostlyfromnuts.Nutsareagreatfoodbecauseitis mostlymonounsaturated.Yourprimaryenergysourceideallywouldcomemostlyfrommonounsaturatedfat.It'sagood compromise.Itisnotanessentialfat,butitisamorefluidfat.Yourbodycanutilizeitverywellasanenergysource.

Animalproteinsarefineandaregoodforyou,butnottheonesthatarefedgrains.
Grainfedanimalsaregoingtomakesaturatedfatoutofthegrains.Saturatedfatinnatureoccurstoaverytinydegree.Not inthewildthereisverylittlesaturatedfatoutthere.IfyoutalkaboutthePaleolithicdiet,wedidn'teatasaturatedfatdiet. Saturatedfatdietsarenewtomankind.Wemanufacturedasaturatedfatdietbyfeedinganimalsgrains.Youcanconsider saturatedfattobesecondgenerationcarbohydrates.Weeatthesaturatedfatsthatotheranimalsproducefrom carbohydrates. ZonewasagooddietcomparedtotheAmericandietitwasunusual.Isitanoptimaldiet?No.Isitoptimalforwhatisknown todayaboutnutrition,itisnot.Heisstuckinthismoldhecan'tgetoutofbutnowheistryingtogetoutofitthroughthe backdoor.Initiallytheauthorspokeabouthowitmadenodifferenceifyougotyourcarbohydratefromcandyorvegetables. TheVolkswagenwasagoodcar,buteventuallytheyhadtochangeittokeepupwithmoderntechnology.Whatheisdoing nowischanginghisrecipessothatthe40%carbohydratesarecomingprimarilyfromvegetables,andthecarbohydratesare goingwaydownbecauseheknowsthatifhedoesn'tit'snotasgoodadiet. Iwouldgo20%ofcaloriesfromcarbs.Dependingonthesizeoftheperson,25to30%ofcaloriesfromprotein,and6065% fromfat.Youcangetnongrainfedbeef.
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Insulinisnottheonlycauseofdisease.
Thereareotherconsiderationssuchasiron.Weknowthathighironlevelsarebadforyou.Ifaperson'sferritinishigh,red meatisoutforawhile,tillwegettheirirondown.SOthereareotherthingsinvolvedaboutifwearegoingtoallowaperson toeatredmeatornot. Thereisagreatdealofdifferencebetweenanongrainfedcowandagrainfedcow. Nongrainfedwillhaveonly10%orlesssaturatedfat.Grainfedcanhaveover50%. Thereisabigdifference.AnongrainfedcowwillactuallybehighinOmega3oils.Plantshaveaprettyhighpercentageof Omega3,andifyouaccumulateitbyeatingitallday,everydayformostofyourlife,yourfatgetsaprettyhighproportionof Omega3.Iwouldtryfor50%oleicfat,andtheotherswoulddependontheindividual,butabout25%oftheothertwo. InafatdiabeticIwouldprobablygodownonthesaturatedfatandgo60%oleic.Iwouldgo1to1ontheomega6to3,that wouldbetherapeutic.Themaintenanceratiowouldbeabout2.5to1omega6to3.Arachadonicacid,DHA,toEFA. Therapeutic,Iwouldgolesseronthesaturatedfats.Iwouldtrytodomostofthisthroughdiet.Therearesomepracticalities involved.Iwouldaskthepersoniftheylikefishandiftheypracticallypukeinfrontofmetheyaregoingonatablespoonof codliveroil,thebestbrandismadebyCarlsonwhichdoesn'ttastefishyatall. Thereareprobablysomeotherstoothatareokay.MostpeopleendupgoingonasupplementofOmega3oilsbecause mostofthemarenotgoingtoeatenoughfishtogetit,whichwouldbeaboutfourdaysaweek,anditcan'tbeovercooked etc.,itisalittlehardtogetthatmuchentirelyfromdiet. Ilikesardinesiftheywilleatthem.Sardinesareaverygoodtherapeuticfood.Theyarebabyfishsotheyhaven'thadtimeto accumulateabunchofmetal.Theyaresmokedsotheyarenotcookedandtheoilisnotspoiledinthem.Youhavetoeat thewholething.Notthebonelessandskinless.Youneedtoeatalltheorgansandtheyarehighinvitaminsand magnesium.

DNAglycates.
Soifpeopleareworriedaboutchromosomaldamagefromchromium,whattheyshouldreallybeworriedaboutinsteadis highbloodsugar.DNArepairenzymesglycateaswell.Insulinisbyfaryourbiggestpoison.Theydisprovedthatstudythat wasagainstchromiummanytimes.Theyshowedthatitonlyhappensifyouputcellsinapetriedishwithchromiumbutin vivostudiesproveotherwise.Theloweringofinsulinisgoingtobebetterthananypossibledetrimentofanyofthetherapies
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youareusing.Insulinisassociatedwithcancer,everything. Insulinshouldbetestedoneverybodyrepeatedly,andwhyitisnotisonlystrictlybecausetherehasn'tbeendrugstill recentlythatcouldeffectinsulin,sothereisnowaytomakemoneyoffofit.Fastinginsulinisonewaytolookatit,not necessarilythebestway.Butitisthewaythateverybodycoulddoit.Anyfamilydoctorcanmeasureafastinginsulin. Thereareotherwaystomeasureinsulinsensitivitythataremorecomplexthatwedosometimes. Weuseintravenousinsulinandwatchhowrapidlytheirbloodsugarcrashesinafastingstatein15minutesandthat assessesinsulinsensitivity,thenyougivethemdextrosetomakesuretheydon'tcrashanyfurther.Thereareotherways thatareutilizedtodirectlyassessinsulinsensitivity,butyoucangetaprettygoodideajustbydoingafastinginsulin.

RonRosedale,M.D.1999
Peoplekeeprepeatingthemyths,distortionsandliesaboutthepercentageofsaturatedfatingrassfed,freerangebeef versusgrainfed,feedlotbeef.Again,theyhavethemindsetthatsaturatedfatisunhealthywhenitisnot.Asanexample,Dr. RonRosedaleinthespeechstated, "Thereisagreatdealofdifferencebetweenanongrainfedcowandagrainfedcow.Nongrainfedwillhave only10%orlesssaturatedfat.Grainfedcanhaveover50%.Thereisabigdifference.Anongrainfedcowwill actuallybehighinOmega3oils." Thedifferenceinsaturatedfatcontentbetweengrainfedfeedlotbeefandgrassfedbeefisnegligible,ifanywhatsoever.In anycase,saturatedfatisveryhealthyandhealsthebody.ThesamecanbesaidabouttheOmega3fattyacids.However, thetranscriptisfromaveryinterestingspeechwhichhasgreatinformationaboutdiabetes,heartdisease,osteoporosisand cancer. Theactualpercentageofsaturatedfatinthefatoffreerangebuffalois43%,deer/venisonis38%,elkis37%anddomestic grainfedbeefis39%.Thestatementsthatgrainfedbeefhasahigherpercentageofsaturatedthanwildgameorgrassfed freerangebeefissimplyfalse.Infact,wildgamecanhaveahigherpercentageofsaturatedfatinthefatthanthatofthe feedlot,grainfedsteer.Thiscorrectinformationcanbefoundinthefollowingbook. KnowYourFatsbyDr.MaryG.Enig. TheCompletePrimerforUnderstandingtheNutritionofFats,OilsandCholesterol.

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MEDICALDISCLAIMER:Allinformationisintendedforyourgeneralknowledgeonlyandisnotasubstituteformedical adviceortreatmentforspecificmedicalconditions.Youshouldseekpromptmedicalcareforanyspecifichealthissuesand consultyourphysicianbeforestartinganewfitnessornutritionregimen.Theinformationcontainedinthisonlinesiteand emailispresentedinsummaryformonlyandintendedtoprovidebroadconsumerunderstandingandknowledgeofdietary supplements.Theinformationshouldnotbeconsideredcompleteandshouldnotbeusedinplaceofavisit,call, consultationoradviceofyourphysicianorotherhealthcareprovider.Wedonotrecommendtheselfmanagementofhealth problems.Informationobtainedbyusingourservicesisnotexhaustiveanddoesnotcoveralldiseases,ailments,physical conditionsortheirtreatment.Shouldyouhaveanyhealthcarerelatedquestions,pleasecallorseeyourphysicianorother healthcareproviderpromptly.Youshouldneverdisregardmedicaladviceordelayinseekingitbecauseofsomethingyou havereadhere.Westronglysuggestyouselectaphysicianwhoisknowledgeableandsupportiveofthelowcarbohydrate diet.Manyofthephysicianslistedonthispagehavehealthclinics.

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The proper diet for healing and health preservation is argued fiercely because this is a spiritual battle. Poor health and disease can be caused by believing the worldly myths, distortions, and lies about nutrition which have deceived most people. The following
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distortions, and lies about nutrition which have deceived most people. The following information should be studied carefully to reduce your risk of obesity, diabetes, heart disease, cancer, and inflammatory bowel diseases. This information is healing people worldwide. You can also be healed. Please let us know about your success.

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Nutrition,Healing,Health,Protein,Fat,Carbohydrate,andCholesterolScience. Low-CarbDietPlanPreventsDiabetes,Cancer,Alzheimer's,andHeartDisease. TopTenNutritionalMyths,Distortions,andLies ThatWillDestroyYourHealth. Fibromyalgia,PolymyalgiaRheumatica(PMR), andChronicFatigueSyndrome(CFS). Hypertension,HighBloodPressureControl,Heart Palpitations,Arrhythmias,andBloodTesting. LowCarbohydrateDietConfirmedbyDukeStudy. Ketogenic,LowCarbohydrateDietfor Bodybuilders. BreakingStallsandPlateausontheLow CarbohydrateDiet. Myths,DistortionsandLiesAboutBeef. StudiesProveBeefIsASafeAndHealthyFood.
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TopTenHistoricalEventsThatCreatedOur CurrentHealthandNutritionalQuagmire. ProstateHealthReversingProstatic Hyperplasia(BPH)andPreventingProstate Cancer. AbsoluteScientificProofCarbohydratesAre Pathogenic. TwoStudiesValidatetheLowCarbohydrate, HighProteinDiet. KetosisMythsandFactsontheLow CarbohydrateDiet. EskimosProveAnAllMeatDietProvides ExcellentHealth. AnimalRightsTerroristsStrikeAgain? BoneAnalysisSuggestsNeolithicPeople PreferredMeat.
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ProofSaturatedFatsAreHealthy. EggsDoNotCauseBadCholesterol. ExposingtheMyths,Dangers,andLiesAbout OrganicFood. TheOrganicFarmingMyths. DietaryFiberTheory.ScientificProofFiberinthe DietisUnhealthy. TheMythsofVegetarianism. VegetarianDietDeficienciesAreaProvenFact. Atkins'DietHealthierThantheAmericanHeart Association'sDiet. GeneticallyModifiedCornStudyRevealsHealth DamageandCoverup.

7,700YearOldBonesProveEarlyHumans wereHighlyCarnivorous. FeedingtheIrrationalFearofCholesterol. AminoAcidsTheBuildingBlocksofLifeand Healing. AnthropologicalResearchRevealsOptimal HumanDietbyH.LeonAbrams,Jr. Vegetarianism:AnotherView byH.LeonAbrams,Jr. TheCaseAgainstMilkbySheilaBuff. VitaminDeficienciesandVitaminToxicities. Dr.WestonA.PriceFoundation.

TheMediterraneanDietisaBigFATLie.

Pregnant?Pregnancy,Adoption,Abortion,Infertility, andProperDietDuringPregnancyforaHealthyBaby MommyGoesShoppingforBabyFood. ReadWhyMommy'sDietCausesInfantAutism. TopTenExerciseHealthMythsAboutRunning,Jogging,Biking,Marathons,andTriathlons TopTenEmbryonicStemCellandHumanCloningResearchClaims,Promises,Facts, Expectations,Exaggerations,Hype,andMyths

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Mypersonalvitamin,mineral,andsupplementprogrambyKentR.Rieske TopTenMythsAboutNutritionandDietintheBible TheTruth,Myths,andLiesAbouttheHealthandDietofthe"Long-Lived"PeopleofHunza, Pakistan,HunzaBread,andPieRecipes TheTruthAbouttheBalancedDietTheoryandthe FourorFiveGroupsoftheFoodGuidePyramid StudyWithMiceShowstheHigh-Fat,Low-CarbohydrateDietImprovesAlzheimer's DiseaseandMostLikelyWillPreventAlzheimer'sDisease

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