Drug class Generic Name Brand Name Available in

: Dietary Supplement : Multivitamins + Mineral + Lycopene + Lutein + Ginseng

+ Lecithin + Rutin + Ginkgo Biloba + Zeaxanthin + Zinc

: Nutricap Tablet : Tablets x 100s per box

Principal Uses Nutritional support in cases of vitamin deficiencies secondary to restrictive diet, poor appetite, intake of drugs which interfere with absorption and utilization of B-vitamins. Nutritional support during periods of stress or convalescence following medical illnesses or surgical operations. Increased body resistance against common illnesses and infections. Improvement of physical and mental capacity.

How the Drug Works Nutricap provides a comprehensive array of essential vitamins and minerals designed to enhance a healthy lifestyle, promote vitality and improve mental functions. Nutricap includes special natural ingredients derived from plant sources such as Ginkgo Biloba and Ginseng which help enhance mental functions. Aside from incorporating a broad range of vitamins and minerals, what sets Nutricap apart from other dietary supplements are the special ingredients that act synergistically with its other incorporated components to strengthens the bodys defence system. Specifically, Nutricap includes special natural ingredients such as ginkgo biloba, lecithin and ginseng which are stated to enhance mental capabilities. Moreover, Nutricap is reinforced with Zinc, Vit. E and the carotennoids or colourful nutrients such as Lycopene, Lutein, Rutin and Zeaxanthin which are reported to possess antioxidant properties. Another antioxidant, Vitamin C, has been added to help maintain healthy gums, blood vessels, and connective tissues, thus preventing conditions like bruising and bleeding. Vitamin C is also regarded as an anti-stress agent. Vitamin A is present in Nutricap in large amounts in order to maintain healthy eyes, skin and other body tissues. The minerals iron, calcium, magnesium, zinc, selenium, fluoride, potassium and manganese are incorporated to keep various metabolic functions at their optimum levels. Zinc helps improve the sense of taste and smell. Studies indicate that Ginkgo Biloba increases alertness, ability to concentrate and mental responsiveness even in healthy people. A large volume of controlled clinical studies support its use to improve memory. In people with high levels of cholesterol and triglycerides, Ginkgo Biloba improves blood circulation to the brain, ensuring an adequate supply of nutrients to the brain. Because of this property, Ginkgo Biloba has been successfully used in helping treat early stroke, senility, dementia, alzheimers disease, vertigo and tinnitus. Ginkgo Biloba also increases circulation to the eyes, especially to the retina. It has therefore been used for treating some eye disorders including macular degeneration and diabetic vascular disease. Similarly, ear problem are diminished with the intake of Ginkgo Biloba due to enhanced blood flow to the nerves of the inner ear. It has been found to be of benefit in the management of tinnitus or chronic ringing of the ears. Ginseng is widely used as a dietary supplement by individuals seeking to perk up energy and vitality. Other reported uses of ginseng include helping normalize blood sugar, stimulating endocrine glands and immune functions and alleviating symptoms of male impotence and of female discomfort caused by menopause. Several studies have shown that Ginseng can help reduce blood pressure and cholesterol. The risk for some types of cancer also decreases with regular intake of ginseng. At present, the main recognized use of Ginseng is as a tonic during times of stress, fatigue and convalescence. Lecithin (Phosphatidylcholine) is essential in the functioning of every cell in our body. It is an important constituent of cell membrane of different body tissues especially the liver, semen, myelin sheath of nerve cells and brain tissues. It is often called a nerve-building nutrient and is useful in improving memory and in sustaining endurance in heavy physical and mental activities. Lecithin acts as a lipotrophic factor preventing abnormal or excessive accumulation of fats in the liver and helps prevent liver damage. Health practitioners specifically assert its in importance in preventing liver damage caused by alcohol abuse. Lecithin also helps reduce bad cholesterol. A number of epidemiological studies have demonstrated a strong relationship between lycopene intake, the plasma level of lycopene, and reduced risk for certain cancers. The reduced risk seen mainly for cancers of the prostate, stomach and lungs. In those subjects with the highest intake of lycopene, risk for cancer has been reduced by 21% to 41%. Recent studies suggest that lycopene may also retard the progression of coronary artery disease. Research shows that antioxidants such as lycopene reduce the oxidation of LDL, or the bad cholesterol. Oxidation is a step in the formation of atherosclerotic plaques which block the arteries supplying the heart. Most of the dietary lycopene comes from tomatoes and tomato-based products like tomato sauce, tomato paste and catsup. Nutritional surveys indicate that dietary intake of lycopene is highly variable, and may not meet levels required to show cancer-reducing benefits. Supplement are therefore necessary in most cases. Lutein and zeaxanthin are two chemically similar carotenoids that also have proven health benefits. They specifically localize in the macula and lens of the eye and thus exert their effects in these areas. Both lutein and zeaxanthin have antioxidant effects, thus protecting the eyes from deleterious substances. Both nutrients increase macular pigment density. It is known that the amount of

Updated as of May 2010

macualr pigments in the eye is inversely proportional to ones risk for developing a condition a condition called age-related macular degeneration or AMD. AMD is among the leading causes of vision impairment and blindness. There is also some evidence that cataract formation may be prevented by lutein and zeaxanthin. Studies have shown that those having the highest lutein and zeaxanthin intakes from their diet had as significantly lower risk of developing AMD compared to those with the least intakes. Aside from their antioxidant effects, lutein and zeaxanthin also protect against photodamage of the retina by filtering out blue light, thereby protecting the blood vessels that supply the macula. Rutin is a natural flavonoid, extracted from fruits of the Fava D Anta tree. Flavonoids have a wide range of biological properties. One of the most important of these properties is that of being an antioxidant, or its ability to remove dangerous superoxide anions which can lead to thrombosis or artherosclerosis. Among the flavonoids, rutin has been shown to have the strongest scavenging activity for this purpose. Superoxide anions have been considered as anti-inflammatory agents because they decrease formation of the substances responsible for inflammatory reactions. Flavonoids such as Rutin, are important because of their ability to increase the strength of capillaries and to regulate their permeability. Bruising and circulatory disorders such as varicose veins can be prevented or minimized. This is achieved partly through the more efficient absorption of Vitamin C. Rutin also acts synergistically with Vitamin C and other antioxidants to help maintain a healthy immune system. B vitamins help improve cardiovascular, nervous and gastrointestinal functions by acting as cofactors or coenzyme in various metabolic processes. B vitamins help in fat, glucose and protein metabolism. B vitamins as metabolic activators are involved in energy production. Zinc is essential component of multi-enzyme systems that participate in various metabolic functions. Zinc also promotes the bodys immune system. It is also involved in wound healing and improvement of the sense of taste and sense of smell. Dosage: 1 tablet daily or as prescribed by the physician. Onset of Effect: Unknown Duration of Action: Unknown Dietary Advice : Eat a well-balanced diet. Storage: Store in a tightly sealed container away from heat, moisture, and direct light If You Miss a Dose: No problems are expected. Take the next dose at the regularly scheduled time and do not double the next dose. Stopping the Drug: If prescribed for a deficiency, do not stop taking the vitamin without consulting your doctor first. Prolonged Use: No problems are associated with prolonged use. Precautions : High doses of Gingko Biloba must not be given with anticoagulants and other blood thinners. Elderly (Over 60 years old) No problems are expected at recommended doses Infants and Children Dosage form not recommended to infant and children. Breastfeeding Vitamin E enters breast milk, but no problems have been reported with recommended doses Pregnancy No problems are expected with recommended doses. Alcohol No special precautions are necessary Driving and Performing Hazardous Work No special precautions are necessary Overdose: Fat soluble vitamins like vitamin A, E and D may cause adverse effects if taken in large doses. Ferrous salts overdose: Lethargy, nausea, vomiting, weak and rapid pulse, dehydration, loss of consciousness. Early symptoms: Constipation (especially in children), diarrhea, dry mouth, increased thirst and frequency of urination, persistent headache, loss of appetite, metallic taste, nausea and vomiting, unusual fatigue. Advanced symptoms: bone and muscle pain, irregular heartbeat, persistent itching, extreme drowsiness, mental changes. Severe calcium toxicity may be fatal. Patients who have accidentally taken excessively large doses of the supplement must be referred to a doctor.

Updated as of May 2010

Drug Interactions Generally none. Concomitant administration of Tetracycline and some antacids may decrease the amount of iron absorbed and conversely, iron may retard the absorption of tetracyclines and other antibiotics; these products therefore should not be given together within 2 hours. Food may reduce the absorption of iron but will lessen the gastric irritation that may be caused by iron. Consumption of large doses of vitamin E in combination with anticoagulants (such as warfarin) and gingko biloba might lead to uncontrolled bleeding Food Interactions Absorption of fat soluble vitamins like vitamins E and A from the intestine requires the consumption of some dietary fat. Disease Interactions Patients with cardiovascular diseases who are taking antithrombotic/ anticoagulant agents and those with bleeding disorders must consult their doctor for advice. Consumption of large doses of gingko biloba with blood thinners may cause bleeding. Side Effects: Nutricap is safe and well tolerated. As a dietary supplement the concentration of the active ingredients are well within the safe limits. Serious No serious side effects are associated with recommended doses. Ginseng is remarkably safe even in large doses or when taken over a long period of time. One has to consume 3-4 lbs (1.3-1.8 kgs) of pure ginseng at one sitting in order to suffer dangerous effects. FDA USA allowed its sale without restrictions. Toxicity occurs when ginseng is taken in excessive amounts for long periods of time with stimulants like coffee. Common No common side effects are associated with recommended doses. Less Common Large doses of Vitamin E (greater than 400 IU per day) have been associated with diarrhea, nausea, headache, blurred vision, dizziness, and fatigue. Doses greater than 800 IU per day have been reported to increase the danger of bleeding, especially in people deficient in vitamin K. Yellowing of hands, feet, etc, may occur when carotenoids are taken at very high doses for several months.

Formulation: Each Nutricap tablet contains: % RENI Retinyl Acetate (Vit. A) (eq. to 570 mcg) Cholecalciferol (Vit. D) (eq. to 5.25 mcg) d-alpha Tocopherol Acetate (Vit. E) (eq. to 10 mg) Calcium Hydrogen Phosphate dihydrate Lecithin Ascorbic Acid Korean Ginseng Ginkgo Biloba Rutin Lycopene 5% Niacinamide Ferrous Sulfate Magnesium Calcium Pantothenate Potassium Zinc (as sulfate) Pyridoxine HCl Thiamine Mononitrate Riboflavin Manganese Fluoride Lutein 5% Folic Acid Zeaxanthin 5% Selenium Yeast Cyanocobalamin 1,900 IU 210 IU 15 IU 90 mg 65 mg 60 mg 40 mg 28 mg 20 mg 16 mg 15 mg 10 mg 10 mg 10 mg 7 mg 6.4 mg 1.9 mg 1.5 mg 1.5 mg 1 mg 0.2 mg 943 mcg 200 mcg 188.6 mcg 31 mcg 2 mcg 104% 105% 83% 12% * 80% * * * * 94% 83% 4% * * 100% 146% 125% 115% 43% 7% * 50% * 100% 83%

Based on 2002 Philippine RENI (19-29 years old) * No RENI (Recommended Energy and Nutrient Intakes) PRESENTATION AVAILABILITY PRICE : : : red tablet, bisected tablet film coated Box of 100s P 7.17 per tablet

Updated as of May 2010

Target Doctors: NUTRICAP TABLET Primary Targets Secondary Targets Gen. Internist IM- onco IM-Cardio IM-Neuro Gen. Sur IM- Gastro IM-Pulmo Geria/Geron Psychiatrist Ophtha Family Med Fellow Cardio Fellow Onco Fellow Neuro Fellow Geria/Geron Fellow Pulmo Fellow Gastro Hospital Residents- FM Hospital Residents- IM Hospital Residents- Psych Hospital Residents-Ophtha Health Center MD Industrial Med General Practitioner Other Targets IM Endo IM Diab IM Rheuma IM gastro IM- Nephro Fellow gastro Fellow Endo Fellow Diab Fellow Rheuma Ortho Hospital Residents-Psych Hospital Residents-sur

Updated as of May 2010