Audrey Mae L.

Fronda BSN-2A (Group D) Research Assignment Antidote Acetylcysteine Indication Antidote for acute acetaminophen (APAP) poisoning; repeated supratherapeutic ingestion (RSTI) of APAP; Topical anti-infective; pharmaceutical aid; therapeutic neurolysis; replenishment of carbohydrate calories. Antidote for ethylene glycol overdose Treatment of hyperacidity; hyperphosphatemia; Coronary vasodilator in angina pectoris; adjunct treatment of cyanide poisoning; produces intensity of heart murmurs. antidote for acetylcholinesterase inhibitor poisoning (carbamate insecticides, nerve agents. Treatment of piosoning by susceptible organophosphorous nerve agents having acetylcholinesterase-inhibiting activity. adjunctive therapy for hypercalcemia Emergency treatment in poisoning by drugs and chemicals (eg phenobarbital, quinine) Aids in the elimination of certain drugs and improves decontamination of excessive ingestions of sustained-release products Acute iron intoxication or when clinical signs of significant iron toxicity exist. Treatment of known or suspected internal contamination with plutonium, americum orcurium Treatment for digoxin toxicity Antidote to Gold, arsenic, or acute mercury poisoning; adjunct to edetate CALCIUM disodium in lead poisoning Adjunct treatment of respiratory depression cause by curare overdose. Anaphylaxis emergency treatment of insect bites or stings that may occur within minutes of insect sting or exposure to an allergic substance. Treatment of known or suspected internal contamination with radioactive cesium and/or radioactive or nonradioactive thallium Benzodiazepine antagonist; reverses sedative effects of benzodiazepines used in conscious sedation and general

Alcohol (Ethyl)

Aluminum Hydroxide Amyl Nitrite Atropine Atropine and Pralidoxime Calcitonin Charcoal, Activated

Deferoxamine Diethylene Triamine Penta-Acetic Acid Digoxin Immune Fab Dimercaprol Endrophonium and Atropine Epinephrine and chlorpheniramine

Ferric Hexacyanoferrate

Flumazenil

Fomepizole Glucagon

Hydroxocobalamin Ipecac syrup Leucovorin Calcium

LEVOleucovorin Methylene Blue Naloxone Naltexone Sodium Nitrite, Sodium thiosulfate, Amyl Nitrite Succimer Vistonuridine

anesthesia; treatment of benzodiazepine overdose Treatment of methanol or ethylene glycol poisoning alone or in combination with hemodialysis Used with some success as a cardiac stimulant in management of severe cases of beta-adrenergic blocking agent overdosage; treatment of myocardial depression due to calcium channel blocker overdose Treatment of cyanide poisoning Treatment of acute oral drug overdosage and in certain poisonings Antidote for folic acid antagonists (methotrexate, pyrimethamine); Adjunctive cofactor therapy in methanol toxicity Rescue agent after high-dose methotrexate therapy in osteosarcoma; antidote for methotrexate elimination Antidote for cyanide poisoning and drug induced methemoglobinemia, indicator dye Management of known or suspected opiod overdose Treatment of ethanol dependence; blockade of the effects of exogenously administered opiods Treatment of cyanide poisoning

Treatment of lead poisoning in children with serum lead levels >45 mcg/dL Antidote for fluorouracil overdose or overexposure

General list of antidotes

* Anticholinergic poisoning - physostigmine * Atropine poisoning - Anticholinesterase and pralidoxime chloride (2-PAM) * Benzodiazepine overdose - flumazenil * Beta blocker poisoning - glucagon * Carbon monoxide poisoning - oxygen * Cyanide poisoning - 4-Dimethylaminophenol followed up with sodium thiosulphate or cobalamin

* Digoxin poisoning - Fragment antigen binding(Fab) fragments that bind to digoxin (trade names Digibind and Digifab) * Beta blocker poisoning and calcium channel blocker poisoning - Insulin * Extrapyramidal reactions associated with antipsychotic poisoning - diphenhydramine hydrochloride and benztropine (Trihexyphenidyl can be used in place of benztropine) * Heavy metal poisoning - chelators, calcium disodium edetate (EDTA), dimercaprol (BAL), penicillamine, and 2,3-dimercaptosuccinic acid (DMSA, succimer) * Heparin poisoning - protamine * Isoniazid poisoning - pyridoxine * Methanol poisoning - ethanol or fomepizole * Oral hypoglycemic agnt - Octreotide * Paracetamol (acetaminophen) poisoning - N-acetylcysteine * Heparin Sulfate - Protamine Sulfate * Thallium poisoning - Prussian blue * Warfarin poisoning - vitamin K, phytonadione and fresh frozen plasma * In cases of neuroleptic malignant syndrome, the use of dantrolene and dopamine agonists (amantadine and bromocriptine) has been described.