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VII. Treatment
• Pen G is the drug of choice for all stages of
syphilis. Refer table 153-3
• An infant should be treated at birth if the
seropositive mother has received penicillin
therapy in the 3rd trimester, inadequate
penicillin treatment or therapy w a drug
other than penicillin, of her tx status is
unknown or if the infant may be diff to follow.
• Jarisch-Herxheimer Reaction consists of
fever, chills, myalgia, headache,
tachycardia, inc RR, inc circulating
neutrophil count and vasodilation w. mild
hypotension amd may follow the initiation of
tx for syphilis.
• Follow up response of syphilis to tx should
be determined by monitoring quantitative
VDRL or RPR titer
• Cellular immunity is considered impt in
immunity and healing of early lesions
Marian USTMedB2007