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Heart Failure: One study in patients with heart failure showed significant
improvement in functional status,
clinical symptoms, and quality of life in end stage heart failure patients who
were placed on CoQ10 (see
bottom of page).
Each cell in the body needs a source of energy to survive, so cells break
down sugars, fats, and amino
acids to make energy. Small enclosures within cells that make this energy are
called mitochondria. CoQ10
exists naturally in our mitochondria and carries electrons involved in energy
metabolism. CoQ10 is essential
in the production of adenosine triphosphate (ATP), the basic energy molecule
of each cell.
The administration of CoQ10 and warfarin does not significantly affect the
anticoagulant effect of warfarin in
rats. A Human trial shows Co Q10 and Ginkgo biloba do not influence the
clinical effect of warfarin. Those
who take statin drugs may consider taking additional CoQ10.
Side Effects and Cautions
High dosages of CoQ10 can induce restlessness and insomnia. Long term
effects of high dose CoQ10 use
are not clear at this time.
CoQ10 Recommendations
Inflammation and oxidative stress are processes that mark early metabolic
abnormalities in vascular
diseases. We explored the effects of a high-fat, high-cholesterol (HFHC) diet
on vascular responses in
baboons and the potential response-attenuating effects of vitamin E and
coenzyme Q(10) (CoQ10)
supplementation. We used a longitudinal design by subjecting 21 baboons to
sequential dietary challenges.
RESULTS: After being maintained for 3 mo on a baseline diet (low in fat and
cholesterol), 21 baboons were
challenged with an HFHC diet for 7 wk. The serum C-reactive protein (CRP)
concentrations did not change.
Subsequent supplementation of the HFHC diet with the antioxidant vitamin E
(250, 500, or 1000 IU/kg diet)
for 2 wk reduced serum CRP concentrations. Additional supplementation with
CoQ10 (2 g/kg diet) further
reduced serum CRP to approximately 30% of baseline. Introduction of the
HFHC diet itself significantly
decreased serum P-selectin and von Willebrand factor concentrations.
However, neither vitamin E alone nor
vitamin E plus CoQ10 significantly altered the serum concentrations of P-
selectin or von Willebrand factor.
CONCLUSIONS: Dietary supplementation with vitamin E alone reduces the
baseline inflammatory status that
is indicated by the CRP concentration in healthy adult baboons.
Cosupplementation with CoQ10, however,
significantly enhances this antiinflammatory effect of vitamin E.