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Osteomalacia causes fatigue and pain in the back, ribs, and hips. Muscles in the
upper arms and thighs become weak. People with osteomalacia may have
trouble getting up from a chair or climbing steps. They may waddle when they
walk. Like osteoporosis, osteomalacia leads to bone fractures.
Doctors diagnose osteomalacia with blood tests, x-rays, and sometimes a biopsy.
Osteomalacia is treated with vitamin D or phosphate supplements depending on
the cause.
2. Based on the data provided by the case, give a basis for such
diagnosis.
- Clinical Manifestations:
- pts generally complain of easy fatigability, malaise, and bone pain;
- pain is diffuse and poorly localized and is accompanied by a general
tenderness of bones;
- frx in an elderly individual that is thought to be the result of osteoporosis may
be first sign of osteomalacia, & these patients must be evaluated carefully;
- all symptomatic elderly patients should be screened for occult disease;
- bizarre complaints may give impression that patient has mental aberration;
- muscular weakness is often seen in severe cases;
- proximal muscle weakness may be evident & pt may haveT-burg gait;
Radiographs:
- Looser's zones:
- osteoid seams are insufficiency types of stress frx which are commonly
seen in patients with osteomalacia;
- they are more common in adults than in children;
- patients may have findings of osteomalacia / renal osteodystrophy such as
decreased mineralization, coarsened texture of the bones, "rugger-jersey"
appearance of spine, and, occasionally, bowed long bones;
- most of these patients have chronic renal disease;
Laboratory Aspects: Osteomalacia:
- hypocalcemia:
- hypophosphatemia:
- phosphorus level is low or very low depending on type of
osteomalacia, except in renal osteodystrophy;
- renal osteodystrophy;
- phosphorus level is invariably high & calcium level will be quite
low;
- alk phos:
- usually elevated in all forms of osteomalacia (except
hypophosphatasia);
Osteomalacia can cause bone pain and muscle weakness, but because the
symptoms are so numerous it is common to be misdiagnosed and confused with
other conditions. Pain is most often felt in the legs, groin, upper thighs, knees
and sometimes in the feet. In some cases pain will be the result of partial
fractures, which are only visible on x-rays. Muscle weakness tends to affect the
thighs and the muscles in the shoulders and main core of the body.
Osteomalacia can be diagnosed by x-ray and with a blood test that will measure
levels of calcium, phosphorus and vitamin D. A blood test can also be measured
for Alkaline phosphatase and parathyroid hormone levels.
Functions:
If your blood levels of calcium or phosphorus are low, you may take supplements
of those minerals as well. In addition, treating any condition affecting vitamin D
metabolism, such as kidney failure or primary biliary cirrhosis, often helps
improve the signs and symptoms of osteomalacia.
After beginning osteomalacia treatment, you may undergo periodic blood tests to
make sure that blood levels of vitamin D and certain minerals are within normal
limits and have X-rays to determine whether your bones are improving. You'll
likely notice that your symptoms lessen within a few weeks. However, your doctor
may suggest that you continue taking vitamin D indefinitely to prevent
osteomalacia from recurring.
Prevention
Using sunscreen regularly helps prevent skin cancer and premature skin
aging, but there's some concern that the frequent application of strong
sunscreen increases your risk of developing osteomalacia. Using
sunscreen won't increase your risk if you follow the American Academy of
Dermatology's guidelines for sunscreen use. If you're going to be in the
sun for more than 20 minutes, the Academy recommends that you
generously apply sunscreen with a sun protection factor (SPF) of at least
15 to all exposed skin surfaces and reapply every two hours or after
swimming or heavy sweating.
• Eat foods high in vitamin D. These include foods that are naturally rich
in vitamin D, including oily fish (salmon, mackerel, sardines) and egg
yolks. If you're a vegetarian, look for foods that are fortified with vitamin D,
such as cereal, bread, milk and yogurt.
• Take supplements, if needed. If you don't get enough vitamins and
minerals in your diet or if you have a medical condition affecting the ability
of your digestive system to absorb nutrients properly, ask your doctor
about taking vitamin D and calcium supplements.
• Dietary Sources :
The only frequently consumed dietary source of vitamin D is milk fortified
with D2, as well as dried whole milk. Cereals, infant formulas, including
soy, are usually also fortified with vitamin D. Cod liver oil and fatty fish oils
are also excellent sources of vitamin D.